Sistem Informasi Geografis Pemetaan Data Terpadu Kesejahteraan Sosial di Kabupaten Garut by Dede Kurniadi, Asri Mulyani, Marshal Firmansyah, Nia Abania

“…The RAD method has succeeded in streamlining time in the construction of this GIS. In addition to this, the results of the BlackBox testing assessment show that the test results have met all the results expected by users on functional requirements, with these results expected to make it easier for the public to find information and check the registered status in DTKS, one of which is through the data search feature based on NIK (Citizenship Identification Number). …”
Get full text

INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…The establishment of functional indicators of the judiciary has been undertaken, which are convergent in combination with economic indicators of the population's well-being, conditions for opening one's own business, ensuring financial and banking stability, GDP growth, the level of development of relevant sectors of industry and the economic sphere as a whole, etc. …”
Get full text

Sustainable Development Clauses in the International Law of the Sea by A. N. Vylegzhanin, A. M. Korzhenyak

“…The research involves methods of legal construction, legal modeling, analysis and synthesis, systematic, struc­tural-functional, formal-logical, formal-legal, histori­cal and chronological methods.  …”
Get full text

The identification and validation of histone acetylation-related biomarkers in depression disorder based on bioinformatics and machine learning approaches by Lu Zhang, Lu Zhang, YuJing Lv, Mengqing Ma, Jile Lv, Jie Chen, Shang Lei, Yi Man, Guimei Xing, Yu Wang

“…Candidate genes were selected by intersecting DEGs, key module genes, and HAC-RGs, followed by functional analysis. Two machine learning algorithms were used to identify hub genes, which were used for drug prediction, immunological infiltration studies, nomogram construction, and regulatory network building. …”
Get full text

Integrating network pharmacology and molecular modeling to decipher the anti-esophageal squamous cell carcinoma mechanisms of Bidens pilosa L by Zhenzhen Yang, Cheng Chang, Na Gao, Pan Gao, Yinsen Song, Ruiting Feng, Jingjie Meng, Chen Wang, Haozhe Zhang, Tianli Fan

Get full text

Adeno-associated virus mediated artificial circular RNA for triggering cancer immunotherapy to treat prostate cancer by Chujin Ye, Chujin Ye, Zhiye Liu, Zhiye Liu, Qifan Xie, Qifan Xie, Yanlin Tang, Yanlin Tang, Jiayi Zeng, Jiayi Zeng, Ziwei Feng, Ziwei Feng, Jiumin Liu, Jiumin Liu, Haibiao Xie, Haibiao Xie

“…In addition, we used the ScircRNA inhibiting CDK5 expression to trigger T-cell mediated cancer immunotherapy for treating prostate cancer in vivo.DiscussionThe ScircRNAs possessed the advantages of stable structure and simple construction, and can specifically inhibit the function of target miRNAs, which has a potential therapeutic application prospect in prostate cancer.…”
Get full text

TD-CFD-DPM Coupled method for multi-objective optimization of collision pollination parameters in hybrid rice seed production by Te Xi, Rongkai Shi, Huaiqu Feng, Bo Chen, Nian Li, Yongwei Wang, Jun Wang

“…This model was then combined with a response surface experimental design to construct an objective function, which was used to visualize the pollen movement trajectory and deposition distribution. …”
Get full text

Transcriptomic and glucose metabolism of connectome dynamics variability in temporal lobe epilepsy revealed by simultaneous PET-fMRI by Jie Hu, Bixiao Cui, Zhenming Wang, Jingjuan Wang, Xiaoyin Xu, Jie Lu

“…Simultaneous positron emission tomography and function magnetic resonance imaging (PET/fMRI) data were collected from 66 patients with TLE and 38 healthy controls (HCs). …”
Get full text

Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs by Atiyeh Peiravan, Mazdak Salavati, Androniki Psifidi, Mellora Sharman, Andrew Kent, Penny Watson, Karin Allenspach, Dirk Werling

“…Here, building on our previous results, we performed a targeted next-generation sequencing (NGS) of a two Mb region on Chr 9 and 11 that included 14 of the newly identified candidate genes, to identify potential functional SNPs that could explain these association signals. …”
Get full text

CRISPR-Cas9-mediated deletions of FvMYB46 in Fragaria vesca reveal its role in regulation of fruit set and phenylpropanoid biosynthesis by Arti Rai, Magne Nordang Skårn, Abdelhameed Elameen, Torstein Tengs, Mathias Rudolf Amundsen, Oskar S. Bjorå, Lisa K. Haugland, Igor A. Yakovlev, May Bente Brurberg, Tage Thorstensen

“…The MYB46 transcription factor is a key regulator of secondary cell wall structure, lignin and flavonoid biosynthesis in many plants, but little is known about its activity in flowers and berries in F. vesca. For functional analysis of FvMYB46, we designed a CRISPR-Cas9 construct with an endogenous F. vesca-specific U6 promoter for efficient and specific expression of two gRNAs targeting the first exon of FvMYB46. …”
Get full text

Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury by Yi Kang, Yijie Song, Zhongju Shi, Qiang Li, Yigang Lv, Mengfan Hou, Cui Ding, Jing Xie, Yongfu Lou, Chi Zhang, Huan Jian, Xueying Li, Hengxing Zhou, Shiqing Feng

“…Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DE lncRNAs and mRNAs were subsequently carried out to explore crucial biological processes and signaling pathways. …”
Get full text

Synthetic Phage for Tissue Regeneration by So Young Yoo, Anna Merzlyak, Seung-Wuk Lee

“…This review demonstrated how functional synthetic phage is designed and subsequently utilized for tissue regeneration that offers potential cell therapy.…”
Get full text

Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis by Anqi Wang, Sitong Yan, Weijia Jiang, Xiang Chen, Yuhan Huang, Xiangyu Zu, Xiao Du, Lulu Fan, Jiatao Liu, Guoping Sun

“…In addition, the ERS-RELA-miR-222-5p-CLIP4 transcriptional network was constructed to clarify the role of CLIP4. Cell function experiments confirmed that it promotes the proliferation, migration, and EMT of HCC cells. …”
Get full text

Seismic fault identification method based on CBAM-TransUNet by Xin WANG, Wei ZHANG, Tongjun CHEN, Ao ZHANG, Dang ZHAO

“…Firstly, the CBAM-Block attention module is integrated into the TransUNet network, and the module is added into the CNN tomography encoder part and the 3-layer jump connection part connecting the tomography encoder and the tomography decoder, respectively, to enhance the recognition ability of the seismic tomography image from two dimensions, namely, the channel and the space; secondly, the loss function optimised jointly by the Dice loss function and the cross-entropy loss function is selected to make the segmentation of the tomography image more accurate. function and cross-entropy loss function to make the fault image segmentation more accurate, and the DICE and IOU values obtained by the CBAM-TransUNet fault identification network on the synthetic seismic dataset are increased to 0.84 and 0.75, respectively, and the experimental results show that the continuity of the fault identification is stronger, which is obviously superior to other classical segmentation methods; finally, the constructed model is used to interpret the faults on the real seismic dataset of the F3 block of the North Sea, off the coast of the Netherlands. …”
Get full text

Genome-wide identification and characterization of BASIC PENTACYSTEINE transcription factors and their binding motifs in coconut palm by Zifen Lao, Jiali Mao, Runan Chen, Ran Xu, Zhuang Yang, Ying Wang, Junjie Zhou, Zhihua Mu, Hang Xu, Fengmei Li, Dongyi Huang, Yong Xiao, Jie Luo, Wei Xia

“…However, research on the functional characteristics and target genes of BPCs in coconut (Cocos nucifera) is limited.MethodsIn this study, we systematically characterized the gene structure, conserved protein domains, gene expansion, and target genes of CnBPCs in the coconut genome. …”
Get full text

Comprehensive analysis of housekeeping genes, tissue-specific genes, and dynamic regulation across developmental stages in pearl millet by Wei Luo, Min Sun, Ailing Zhang, Chuang Lin, Yarong Jin, Xiaoshan Wang, Linkai Huang

“…We provided valuable options for transcript normalization and crucial targets for exploring gene function for the plant growth and development in pearl millet. …”
Get full text

Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma by Yixuan Huo, Wei Zhang, Fan Yang, Wenhua Shao, Guozheng Cong, Shoukai Zhang, Shoukai Zhang

“…Transcriptome sequencing revealed that the expression levels of 320 genes differed significantly, with 189 upregulated and 131 downregulated genes.ConclusionIn this study, a TU212 laryngeal squamous cell carcinoma cell line overexpressing NK4 was constructed using a lentiviral packaging system. Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”
Get full text

Reference equations for the six-minute walk distance in the healthy Chinese population aged 18-59 years. by He Zou, Xiuruo Zhu, Jia Zhang, Yi Wang, Xiaozhen Wu, Fang Liu, Xiaofeng Xie, Xiaoshu Chen

“…<h4>Background</h4>The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity of patients with chronic respiratory disease. …”
Get full text

Molecular characterization of Neospora caninum major antigens NcSAG1 and NcSRS2 by Soledad Echeverría, Federico Carrión, Martín Soñora, Andrés Cabrera, Carlos Robello

“…This comprehensive analysis bridges sequence divergence, structural conservation and biological function, providing a robust framework for investigating SRS proteins’ roles in pathogenesis and immunity. …”
Get full text

Development and field test of the child and adolescent sleep checklist for parents of community junior high school students by Kentaro Kawabe, Saori Inoue, Yu Matsumoto, Maya Kusunoki, Shu-Ichi Ueno, Yasunori Oka, Fumie Horiuchi

Get full text