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5921
Toward precision oncology in LUAD: a prognostic model using single-cell sequencing and WGCNA based on a disulfidptosis relative gene signature
Published 2025-05-01“…Immune response characteristics and functional enrichment patterns were further evaluated in these cohorts.ResultsOur study delved into disulfidptosis in LUAD through a series of analyses: scRNA-seq data processing, WGCNA analysis, construction of a prognostic model, evaluation of clinical features and risk, enrichment analysis, mutation landscape assessment, and examination of the tumor microenvironment. …”
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5922
Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis
Published 2024-12-01“…Further studies are required to validate their clinical applicability in larger cohorts and to elucidate their functional roles in CRC pathogenesis, ultimately enhancing diagnostic strategies and personalized treatment approaches.…”
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5923
Coal burst risk monitoring method based on the drilling powder of destressing drilling in coal seam and its application
Published 2025-05-01“…By carrying out the laboratory tests of drilling in coal specimens, the functional relationship among the drilling diameter, powder, initial stress and stress after pressure relief is obtained. …”
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5924
MiR-485-3p/MELK cascade mediates tumor progression in pancreatic cancer
Published 2025-05-01“…The identification of differentially expressed genes (DEGs) and subsequent analyses, including signaling pathway enrichment, functional classification, and protein-protein interaction (PPI) network construction, were conducted using three public datasets: GSE32676, GSE71989, and GSE16515. …”
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5925
Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction
Published 2025-05-01“…Flow cytometry confirmed functional differences in immune activation: OV-IL15Fu expanding cytotoxic lymphocytes (CD8⁺ T/NK cells), OV-IFNG preferentially promote Th1 polarization and innate immune activation, and OV-GMCSF failed to activate T cells despite myeloid infiltration. …”
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5926
Assembly of ascovirus HvAV-3h long DNA fragment using the Transformation-Associated Recombination (TAR) approach in yeast cells
Published 2025-05-01“…The process is cost-effective and can be scaled up to synthesize the entire genome for gene functional studies.…”
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5927
Evaluation Methods for the Human–Land Coupling Coordination Relationship in a Metro Station Area: A Case Study of Chengdu Metro Line 1
Published 2025-02-01“…Finally, some improvement strategies are put forward, such as optimizing the network layout, building multi-level centers, strengthening functional connections, and enhancing the development intensity. …”
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5928
Anomaly Usage Behavior Detection Based on Multi-Source Water and Electricity Consumption Information
Published 2025-01-01“…The construction of smart cities contributes to promoting residents’ life convenience and sustainable energy development. …”
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5929
Characterization and Application of Different Types of Pineapple Leaf Fibers (PALF) in Cement-Based Composites
Published 2025-04-01“…An anatomical analysis of the leaves was conducted to identify fiber distribution and structural function. Cement-based composites reinforced with 1.5% (by volume) of long and aligned pineapple leaf fibers were produced and tested in bending. …”
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5930
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5931
RETRACTED: Mir-124 Attenuates STAT3-Mediated TH17 Differentiation in Colitis-Driven Colon Cancer
Published 2020-12-01“…The binding of STAT3 to the promoter region of IL-17 gene was analyzed by Chip assay. miR-124 binding to the 3′UTR of STAT3 gene was detected by reported plasmid construction and luciferase assay. Furthermore, DSS-induced colitis mice model and T cell transfer model were used to confirm the function of miR-124 in vivo. …”
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5932
Designated confirmer threshold signature and its applications in blockchains
Published 2024-12-01“…We also implement these schemes, and the experiment results show that our schemes are practical with rich functionalities. Finally, we demonstrate interesting applications for blockchains, such as verifiable asset auctions in blockchain and traditional electronic bidding.…”
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5933
Experimental Characterization of Commercial Scroll Expander for Micro-Scale Solar Organic Rankine Cycle Application: Part 2
Published 2025-05-01“…The comparison revealed a deviation between the experimental and simulated absorbed power of the pump—expressed as a function of the evaporation pressure—of less than 10% in the majority of the tested operating conditions. …”
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5934
Entity class-restricted twin attention-based aggregation for geographic knowledge graph inference
Published 2025-08-01“…Abstract Geographic knowledge graphs (GeoKGs) describe and simulate geographic phenomena by storing geographic entities with their semantic relations, providing a foundation for many real-world tasks such as urban function identification. However, GeoKGs are often incomplete due to manual construction, leading to inaccurate and/or suboptimal decision-making. …”
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5935
Unmasking Greenwashing in the Building Materials Industry Through an Evolutionary Game Approach via Prospect Theory
Published 2025-06-01“…Second, a greater degree of diminishing sensitivity in the value function promotes the adoption of authentic green behavior by enterprises. …”
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5936
Research on design strategies for wellness towns from the perspective of spatial resilience
Published 2025-01-01“…With the intensification of population aging in China, the wellness industry has experienced significant development opportunities, leading to rapid advancements in wellness town construction. However, the planning and development of wellness towns are currently hindered by issues such as severe homogeneity, limited disturbance resistance, and inadequate functionality, which contribute to increased spatial vulnerability. …”
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5937
Prototyping of a concrete maturity sensor with a hermetically sealed housing made of two-component plastic
Published 2021-09-01“… The construction industry, traditionally considered quite conservative, is now going through a marked change. …”
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5938
Applications of Shape Memory Polymers in Kinetic Buildings
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5939
Features of regional parameters of soil fluctuations as a basis for making an optimal design decision
Published 2022-08-01“…The construction of buildings should be based on the parameters of the vibrations of the soils of the construction site, taking into account the lithological composition of the soil and other physical and mechanical properties.…”
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5940
Research on a virtual-real fusion experimental system for the cutting part of a boom-type roadheader.
Published 2025-01-01“…This system incorporates functions including digital modeling of coal-rock, simulation of mechanical properties of the cutting unit, and integration of virtual and physical experiments. …”
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