Facile expression of proteins with desired N-terminal amino acid via an engineered cysteine protease domain by Xiangman Zou, Zhi Liu, Fengnan Song, Wei Zhou, Jiaying Hang, Chenchen Feng, Tianhong Yuan, Jinhua Dong, Wei Shi, Feng Tang, Wei Huang

“…Overall, the established approach enables high-yield protein expression and enzyme-independent, single-step removal of the redundant tag to yield proteins with the desired N-terminal residues, offering a valuable option for investigating N-terminal modifications and their functional implications.…”
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Person-Centered Care in the Home Setting for Parkinson’s Disease: Operation House Call Quality of Care Pilot Study by Nawaz Hack, Umer Akbar, Erin H. Monari, Amanda Eilers, Amanda Thompson-Avila, Nelson H. Hwynn, Ashok Sriram, Ihtsham Haq, Angela Hardwick, Irene A. Malaty, Michael S. Okun

“…All seven patients have been followed up longitudinally every 3 to 6 months in the home setting, and they remain functional and independent. None of the patients have been hospitalized for PD related complications. …”
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Combining Stable Isotope Labeling and Candidate Substrate–Product Pair Networks Reveals Lignan, Oligolignol, and Chicoric Acid Biosynthesis in Flax Seedlings (<i>Linum usitatissimu... by Benjamin Thiombiano, Ahlam Mentag, Manon Paniez, Romain Roulard, Paulo Marcelo, François Mesnard, Rebecca Dauwe

“…Functional foods like flax (<i>Linum usitatissimum</i> L.) are rich sources of specialized metabolites that contribute to their nutritional and health-promoting properties. …”
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Analysis of m7G-related signatures in the tumor immune microenvironment and identification of clinical prognostic regulators in ovarian cancer by Kunyu Wang, You Wu, Miao Ao, Wei Mao, Haixia Luo, Yan Song, Bin Li

“…We further explored the effects of the genes on cellular function and prognosis. In conclusion, this study provided a new perspective for the development mechanism of ovarian cancer.…”
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Machine learning-driven integration of time-series InSAR and multiple surface factors for landslide identification and susceptibility assessment by Qianyu Wang, Wen Zhang, Jinglin Li, Ziyang Li, Zhi Luo, Qiang Zhao, Jianbo Jian, Fang Shangguan, Yuanxing Yang, Yangyang Ma, Zhen Zhang, Shuangming Zhao, Linyi Li, Lingkui Meng

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Economic Situation in the Far Eastern Federal District in 2024 by Olga Mikhailovna Prokapalo, Anna Borisovna Bardal, Artyom Gennadyevich Isaev, Marina Gamilovna Mazitova

“…The authors consider the issues of functioning of industries of the real sector of the economy, social sector, and foreign economic activity under the continuing sanction pressure. …”
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ARCTIC «UPGRADE» OF V. V. PUTIN, PRESIDENT OF THE RUSSIAN FEDERATION by I. S. Zonn

“…After establishment of the Soviet power the Arctic for seven decades had been in the focus of attention accomplishing the heroic, repressive, “educational”, economic, political and ideological functions. In 1930-1950 General Secretary of the Central Committee of the Bolshevik Communist Party I.V. …”
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FROM STATE TO PUBLIC ADMINISTRATION: AN ANALYSIS OF MANAGERIAL TRAINING IN HIGHER EDUCATION SYSTEM OF UKRAINE by S. Andreiev, S. Geraskov, R. Dymenko, A. Kostrubitska, O. Lukianov

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Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury by Bin Ren, Jifang Liang, Leifang Yang, Xiaocong Wei, Min Guo, Hong Li

“…Machine learning analysis highlighted AKR1C2, QDPR, CYP3A5, CNTF, and PNPT1 as key genes with diagnostic potential (AUC &gt; 0.6). Functional analysis revealed significant involvement of these genes in immune processes and metabolic regulation. …”
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Engineering fibroblast with reprogramming and spheronization for bone defect repair by Yanjiao Li, Bin Jiang, Zhen Wu, Zhaoxia Ma, Lihua Qiu, Wen Cui, Yunhui Zhao, Jinghe Yan, Daiping Ma, Xingfei Wu, Shu Liang, Sitao Wang, Yanqun Zhao, Mengting Wang, Min Hu

“…These material-free iOB-Sps function as self-scaffolding building blocks for biofunctional constructs, offering a promising avenue for clinical autologous bone defect repair, especially for the elderly.…”
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A Data-Driven Framework for Smart Urban Domestic Wastewater: A Sustainability Perspective by Jing Du, Biao Kuang, Yifan Yang

“…Therefore, this study aimed to systematically analyze the functions that SUDW can achieve from a sustainability perspective and to construct a framework of SUDW. …”
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Considerations on civil aircraft design assurance system review by MENG Xianzhang, LI Honglin, WANG Kai

“…By studying the requirements of domestic and foreign airworthiness authorities on design institutions, the core contents and relationship of the DAS three major functions are identified, the main architecture of DAS manual is proposed. 11 modules and 28 elements of DAS review and the corresponding review points are analyzed, and a review idea based on modularity and a review mode based on process intervention are proposed, which can help authorities and industry better carry out the construction and review of DAS.…”
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Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection by Ming Yuan, Mingrou Wu, Yunyi Hu, Siyu Zhao, Jehangir Khan, Zhanhong Yuan, Yun Huang, Tianqiong He, Zhijun Zhou, Jia Shen, Zhongdao Wu

“…BRD4-associated gene expression patterns were analyzed through correlation-based classification, followed by protein–protein interaction network construction and functional enrichment analyses. In addition, BRD4 was pharmacologically inhibited in vivo using JQ1, and hepatic inflammation and worm load were evaluated at 14 days post-infection. …”
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Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets by Hongyu Zhou, Jianhui Pang, Baiyang Wu, Yanan Zhuang, Shenjun Li, Jing Jiang, Jing Jiang

“…These analyses predicted seven putative targets implicated in functional categories including neurodegeneration, apoptosis, and DNA modification. …”
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Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing by Zixiong Jiang, Yu Luo, Liangdong Song, Jindong Zhang, Chengcheng Wei, Shuai Su, Delin Wang

“…Patients were classified into subgroups using consensus clustering. Functional enrichment and Gene Set Enrichment Analysis (GSEA) were applied to explore the potential pathways. …”
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The molecular mechanism and utilization of ZmMs7-mediated dominant nuclear sterility in Oryza sativa L by Yusheng Xu, Yusheng Xu, Dingyang Yuan, Meijuan Duan

“…This system comprises three modules: first, a dominant nuclear male-sterile (NMS) functional module driven by p5126, designed to achieve the dominant nuclear male-sterile trait; second, a fluorescence-based selection module driven by the endosperm-specific promoter LTP2, which facilitates the expression of the red fluorescent protein gene DsRed; and finally, a herbicide resistance screening module driven by the constitutive CaMV35S promoter, enabling the expression of the selectable marker Bar gene. …”
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Boosting disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment by introducing stimuli‐responsive drug‐mates by Wenzhe Xu, Ruixu Yang, Yingke Xue, Yang Chen, Shuwei Liu, Songling Zhang, Yonggang Wang, Yi Liu, Hao Zhang

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Erosion Characteristics and Its Simulation of Erosion Amount for an Artificial Forest in an Exposed Feldspathic Sandstone Area by Qin Fucang, Dong Xiaoyu, Yang Zhenqi

“…[Conclusion] Under erosive rainfall conditions in a bare feldspathic sandstone area there is a certain functional relationship between rainfall, runoff, and sand production in forest plantation land, and the erosion on forest plantation land is smaller than on bare slope.…”
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Physical–Mathematical Modeling and Simulations for a Feasible Oscillating Water Column Plant by Fabio Caldarola, Manuela Carini, Alessandro Costarella, Gioia De Raffele, Mario Maiolo

“…Lastly, the study also discusses the additional structural and functional benefits of inclined walls over traditional parallelepiped-shaped chambers, both from a structural and construction point of view, and for the possible use for coastal defense.…”
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Risk Assessment of Community-Scale High-Temperature and Rainstorm Waterlogging Disasters: A Case Study of the Dongsi Community in Beijing by Pei Xing, Ruozi Yang, Wupeng Du, Ya Gao, Chunyi Xuan, Jiayi Zhang, Jun Wang, Mengxin Bai, Bing Dang, Feilin Xiong

“…In this study, the Dongsi Community in the functional core area of Beijing was explored, and the risk assessment of high temperatures and rainstorm waterlogging was implemented at the community scale. …”
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