Rapid Simulation of Floods by Considering the Spatial and Temporal Characteristics of Inundation by Rukai Wang, Jijian Lian, Ximin Yuan, Fuchang Tian, Kuang Li, Zhanyou Liu

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Investigating factors affecting the quality of water resources by multivariate analysis and soft computing approaches by Bing Cheng, Xinyu Liu, Keke Guo, Ahmad Rastegarnia

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Operational Modes and Technical Points for Empowering Urban Park Green Spaces by Digital Technology by Yang ZHANG, Changlin LI, Ninglu ZHANG, Fei WU

“…ObjectiveAs an important urban public open space, park green spaces bear multiple social functions such as ecology, recreation, and culture. …”
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ARCHITECTONICS OF THE SILENCE IN VERCORS’ NOVEL “THE SILENCE OF THE SEA” by Tatyana A. Pakhareva

“…Therefore, silence as a key concept of Vercors’ text attracts attention of researchers and is usually considered as a semiotic complex which a researcher has to decipher and identify its meaning-making functions. But the very architectonical structure of the text of silence as the “surface of the sea”, hiding a turbulent raging life, has not yet been sufficiently understood, including the approaches to the meaning structuring logic and the text construction logic. …”
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Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion by Shufeng Xie, Shufeng Xie, Jinlan Long, Ruiheng Wang, Ruiheng Wang, Rufang Xiang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu

“…In this study, we aim to enhance CAR-T cell function by focusing on the solely transmembrane domain design.MethodsUtilizing plasmid construction and lentivirus generation, we get two different transmembrane CAR-T cells [19CAR-T(1a) and 19CAR-T(8α)]. …”
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The bioinfomatics analysis of the M1 macrophage-related gene CXCL9 signature in cervical cancer by Wenxin Liao, Tingting Liu, Yang Li, Hua Liang, Juexiao Deng, Fujin Shen

“…And the CXCL9-expressing tumour-associated macrophage has been poorly reported in cervical cancer.Methods To clarify the regulatory gene network of M1 macrophage in cervical cancer, we downloaded gene expression profiles of cervical cancer patients in TCGA database to identify M1 macrophage coexpression genes. Then we constructed the protein–protein interaction networks by STRING database and performed functional enrichment analysis to investigate the biological effects of the coexpression genes. …”
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Study of the diagnostic significance of telomere length in patients with cerebral atherosclerosis by M. S. Yehorova, D. S. Krasnienkov, V. H. Hurianov, V. Ye. Kondratiuk

“…Objective – to determine the relationship between telomere length and lipid spectrum, structural and functional state of the heart and cerebral vessels and heart rate variability in patients with 1–3 degree cerebral atherosclerosis (CA). …”
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The endometrial cancer A230V-ALK5 (TGFBR1) mutant attenuates TGF-β signaling and exhibits reduced in vitro sensitivity to ALK5 inhibitors. by Eun-Jeong Yu, Daphne W Bell

“…Here, we aimed to determine the functional consequences of ALK5 mutations in human endometrial cancer (EC). …”
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M2 macrophage-derived mitochondrial transplantation promotes periodontal bone regeneration by regulating metabolic homeostasis via activating p38-MAPK signaling pathway by Yuzhuo Ma, Xiang Han, Ke Yan, Yiyang Yang, Kewei Zhang, Yue Wang, Xuerong Lv, Feiyang Wang, Xiaoqian Wang

“…Methods The inflammatory microenvironment was constructed by P.g-LPS. After isolating and inducing functional M2-MT and co-culturing them with hPDLSCs under inflammatory states, the expression levels of osteogenesis-related genes and proteins such as ALP, RUNX2, OCN were detected, the impact of M2-MT on the osteogenic differentiation ability of hPDLSCs under inflammatory conditions was also investigated. …”
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Prospects for 3D Bioprinting Research and Transdisciplinary Application to Preclinical Animal Models by HU Min, DONG Lexuan, GAO Yi, XI Ziqi, SHEN Zihao, TANG Ruiyang, LUAN Xin, TANG Min, ZHANG Weidong

“…Additionally,the review examines the role of 3D bioprinting in tissue engineering, discussing its contributions to the construction of functional tissues such as bone, cartilage, skin, and blood vessels, as well as the latest progress in regeneration and replacement. …”
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<i>Agave schidigera</i> Transcriptome Reveals Stress-Responsive <i>Phenylalanine ammonia-lyase</i> Genes in <i>Agave</i> by Xuxia Wang, Xiaoli Hu, Chen Lin, Qingqing Liu, Yubo Li, Dengxiang Du, Dietram Mkapa, Weiyi Zhang, Xing Huang, Kexian Yi

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Unveiling the Temporal Dynamics and Molecular Regulation Profiles of Neutrophil Extracellular Traps Following Spinal Cord Injury by Li J, Chang C, Li Y, Cui S, Bai J, Zhang C, Wang X, Li K, Jian F

“…Regulatory networks were constructed, and potential therapeutic compounds were predicted using DSigDB and molecular docking.Results: We identified seven key NRGs (Casp1, Ccl3, Fcgr2b, Itgam, Itgb2, Tlr2, Tlr4) in SCI. …”
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Mechanisms and regulatory pathways of recessive land use transition by TAN Lin, CHEN Lan

“…These three forms are closely interconnected and interact with each other. (2) Implicit land use transition is the process of significant and fundamental changes in efficiency, functional, and power forms. It is rooted in the intervention system composed of regional resource endowments, engineering and technological systems, policy and institutional environments, cultural value recognition, and socio-economic development, featuring inherent relevance and dynamic adjustability. (3) Based on the underlying logic of “comprehensive land benefits - dominant land functions - land development rights”, regulatory pathways with element-coordinated governance, classification-based management guidelines, and well-improved institutional structure are constructed, which facilitate recessive land use transition. …”
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Geometric Modeling of Disc Furrow Profile by Petro Yablonskyi, Ivan Rogovskii, Gennadii Virchenko, Kinga Borek, Mykola Volokha, Olga Golova

“…However, their effective functioning is impossible without developing appropriate mathematical models. …”
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Instant Writing of Conductive Interface on MOF Single Crystal by Ultrafast Laser by Dongsheng Huang, Shuailong Guo, Peng Chen, Yanan Liu, Zhenhua Wang, Ye Ding, Hao Li, Huijun Wu, Zhiyuan Ma, Haoqing Jiang, Lijun Yang, Hongxing Xu

“…This method sheds new light on the construction of functional interface on single MOF crystal, providing a novel strategy for MOF‐based electronics.…”
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Cell deconvolution-based integrated time-series network of whole blood transcriptome reveals systemic antiviral activities and cell-specific immunological changes against PRRSV inf... by Byeonghwi Lim, Chiwoong Lim, Min-Jae Jang, Young-Jun Seo, Do-Young Kim, Christopher K. Tuggle, Kyu-Sang Lim, Jun-Mo Kim

“…We utilised a cell deconvolution approach to calculate cell type enrichment, constructed a time-serial gene co-expression network with differentially expressed genes, and conducted functional annotations. …”
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Research progress in predicting the conversion from mild cognitive impairment to Alzheimer’s disease via multimodal MRI and artificial intelligence by Min Ai, Yu Liu, Dan Liu, Chengxi Yan, Xia Wang, Xun Chen

“…Multimodal magnetic resonance imaging (MRI) techniques (including structural MRI, functional MRI, and cerebral perfusion MRI) can yield information on the morphology, structure, and function of the brain from multiple dimensions, providing a key basis for revealing the pathophysiological mechanisms during the conversion from MCI to AD. …”
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Plant AT-rich protein and zinc-binding protein (PLATZ) family in Dendrobium huoshanense: identification, evolution and expression analysis by Fangli Gu, Yanshuang Ren, Muhammad Aamir Manzoor, Tingting Wang, Renshu Huang, Naifu Chen, Cheng Song, Yingyu Zhang

“…The genome-wide identification of D. huoshanense elucidates the functions and regulatory processes of the gene family. …”
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Distribution and diversity of classical deacylases in bacteria by Leonie G. Graf, Carlos Moreno-Yruela, Chuan Qin, Sabrina Schulze, Gottfried J. Palm, Ole Schmöker, Nancy Wang, Dianna M. Hocking, Leila Jebeli, Britta Girbardt, Leona Berndt, Babett Dörre, Daniel M. Weis, Markus Janetzky, Dirk Albrecht, Daniela Zühlke, Susanne Sievers, Richard A. Strugnell, Christian A. Olsen, Kay Hofmann, Michael Lammers

“…Systematic structural and functional characterization of representative enzymes from each cluster reveal high functional diversity, including polyamine deacylases and protein deacylases with various acyl-chain type preferences. …”
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Integrated bioinformatics analysis and machine learning approach for the identification of immune-related genes in the diagnosis of aortic valve calcification with periodontitis by Duolikun Mutailifu, Abudousaimi Aini, Abudunaibi Maimaitiaili

“…The study included functional enrichment, protein-protein interaction (PPI) network construction, and immune infiltration analyses. …”
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