Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer by Junzuo Lin, Qian Xu, Zhengfei Zhao

“…Phenome-wide association study (PheWAS), protein–protein interaction (PPI) network construction, and enrichment analyses were performed to elucidate the functional profiles of the targets. …”
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Saturated Transposon Analysis in Yeast as a one-step method to quantify the fitness effects of gene disruptions on a genome-wide scale. by Enzo Kingma, Floor Dolsma, Leila Iñigo de la Cruz, Liedewij Laan

“…Transposon insertion site sequencing (TIS) is a powerful tool that has significantly advanced our knowledge of functional genomics. For example, TIS has been used to identify essential genes of Saccharomyces cerevisiae, screen for antibiotic resistance genes in Klebsiella pneumoniae and determine the set of genes required for virulence of Mycobacterium tuberculosis. …”
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Development and validation of a four‐lipid metabolism gene signature for diagnosis of pancreatic cancer by Yanrong Ye, Zhe Chen, Yun Shen, Yan Qin, Hao Wang

“…Survival analysis data showed that the model could stratify the prognosis of patients with different clinical characteristics, and the model has clinical independence. Functional analysis indicated that the model is associated with multiple cancer‐related pathways. …”
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Lead Coupon Reactivity to Organic Acids, Aldehydes, and Esters in an Oddy Test Environment by Kylie Blake, Hanna Konicki, Michael J. Samide, Gregory D. Smith

“…Interpreting the reactivity of these potential pollutants, however, relies on ‘chemical intuition’ based on observed functional groups since the reactivity of only a handful of common VOCs has been studied intensively with regard to artworks. …”
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A full-section asphalt concrete waterproof sealing structure for the high-speed railway subgrade by Qinghong Fu

“…Purpose – This study aims to investigate the service performances of a new full-section asphalt concrete waterproof sealing structure (FSACWSS) for the high-speed railway subgrade through on-site tracking, monitoring and post-construction investigation. Design/methodology/approach – Based on the working state of the waterproof sealing structure, the main functional characteristics were analyzed, and a kind of roller-compacted high elastic modulus asphalt concrete (HEMAC) was designed and evaluated by several groups of laboratory tests. …”
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Baobab shell powder as a bio-filler in HDPE composites: mechanical, and physical properties by Daniel S. Sudi, Haruna Wante, Ndubuisi Mbada, Isah Baba, Bamidele Boluwatife, Solomon Adeleke

“…FTIR confirmed lignocellulosic functional groups (O–H, C–H, C=O, C–O). Tensile strength peaked at 10.996 N/mm2 (20 wt%, +6.14% vs. neat HDPE); yield strength peaked at 26.35 N/mm2 (15 wt%), suggesting improved matrix interaction. …”
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Comprehensive analysis of lncRNA biomarkers in kidney renal clear cell carcinoma by lncRNA-mediated ceRNA network. by Ke Gong, Ting Xie, Yong Luo, Hui Guo, Jinlan Chen, Zhiping Tan, Yifeng Yang, Li Xie

“…<h4>Material and methods</h4>All KIRC data were downloaded from the TCGA database and screened to find the possible target lncRNA; a ceRNA network was designed. Next, GO functional enrichment and KEGG pathway of differentially expressed mRNA related to lncRNA were performed. …”
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Discovery, design, and engineering of enzymes based on molecular retrobiosynthesis by Ancheng Chen, Xiangda Peng, Tao Shen, Liangzhen Zheng, Dong Wu, Sheng Wang

“…We also summarize methods for de novo enzyme generation for nonnatural or orphan reactions, focusing on AI‐based enzyme functional annotation and enzyme discovery techniques based on reaction or small molecule similarity. …”
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Integrated bioinformatics, machine learning, and molecular docking reveal crosstalk genes and potential drugs between periodontitis and systemic lupus erythematosus by Junjie Wang, Qingao Deng, Lu Qi

“…We employed multi-omics methodologies, encompassing differential expression analysis, weighted gene co-expression network analysis (WGCNA), functional enrichment (GO/KEGG), LASSO regression, diagnostic model construction, protein-protein interaction (PPI) networks, immune infiltration profiling, computational drug prediction, molecular docking, and disease subtyping, to analyze PD and SLE expression datasets from the Gene Expression Omnibus (GEO) database (GSE10334, GSE16134, GSE50772, and GSE81622). …”
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Artificial Intelligence Methods Applied to Catalytic Cracking Processes by Fan Yang, Mao Xu, Wenqiang Lei, Jiancheng Lv

“…AI methods applied in product yield analysis build models based on massive data. By fitting the functional relationship between operating variables and products, the excessive simplification of mechanism model can be avoided, resulting in high model accuracy. …”
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Revisiting the establishment of the legal system in Dagestan in 1920–30s by N. T. Muslimova

“…Since the late 1920s, the time of the «forced» construction of socialism in the country, the traditional legal structures in the Republic have been liquidated. …”
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Is additive manufacturing of patient-specific implant is beneficial for orthopedics by Aleena Ariz, Ilma Tasneem, Devyani Bharti, Abhishek Vaish, Abid Haleem, Mohd Javaid

“…The purpose of this article is to explore the application of this technology for patient-specific implants to improve the functional outcomes of orthopedics' patients. Methods: A brief review of AM and its applications in orthopedics are performed. …”
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Bacterial Diversity in Different Positions in the Iraqi Marine Area by Raghad Shubbar Jaafar, Asaad Al-Taee, Fadhil Neamah Al-Kanany

“… Microorganisms establish both structural and functional construction in the marine environment, despite scientific advances, the identification of marine bacterial species is still considered as a common challenge in microbiology. …”
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Determinants of the use of physiotherapy services among individuals with Parkinson's disease living in Brazil by Fátima Rodrigues-de-Paula, Raquel de Carvalho Lana, Larissa Karlla Rodrigues Lopes, Francisco Cardoso, Ana Raquel Rodrigues Lindquist, Maria Elisa Pimentel Piemonte, Clynton Lourenço Correa, Vera Lúcia Israel, Felipe Mendes, Lidiane Oliveira Lima

“…Goals should aim towards the development of physical exercise programs to improve the patients’ functional performance for a longer period.…”
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NOTCH1 promotes the elevation of GM-CSF and IL-6 through the EZH2/STAT3 pathway to facilitate the fibrotic state of the myocardium in DLBCL. by Huimin Zhang, Wen Dong, Lihong Zhang, Bing Ma, Jianying Wang, Yang Shen, Dan Zhao, Wanyi Yin, Yuexian Li, Qingchi Liu

“…Various assays were conducted including stable cell line construction, myocardial infarction modeling, imaging, Western Blot, ELISA, staining, and functional assays.…”
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Investigation of The Sufficiency of Antalya Parks by Orhun Soydan, Nefise Çetin

“…Parks are the basic components of urban landscapes that provide environmental and social functional value. Urban parks, in particular, provide spaces for outdoor physical activities. …”
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The Integrated Management of Sustainable Development: Methodological Prerequisitesand Their Practical Realization by Vladimir A. Chernov, Anna D. Tikhova

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MTHFD1L is a novel prognostic marker and therapeutic target in cutaneous melanoma by Xinlian Xie, Guangfu Shi, Kebin Ning, Zhenjie Wu

“…Experimental validation involved: (1) RT-qPCR, Western blot, and IHC staining to compare MTHFD1L expression between SKCM and normal tissues; (2) establishment of MTHFD1L knockdown models in A375 and 2058 cell lines for functional characterization. Results The MTHFD1L level was increasing in SKCM tissues from GSE15605/GSE19234 and TCGA-SKCM, and high MTHFD1L expression correlated with poor overall survival. …”
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Corrosion inhibition of mild steel in 0.5 M HCL by substituted 1,3,4-oxadiazole by K. Raviprabha, Ramesh S. Bhat

“…The experimental results are supported by Density functional theory (DFT) simulations, indicating a potential corrosion inhibition behaviour of MOD on MS in acidic environments. …”
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The Use of Road Microsimulation Software within BIM Environments: A Preliminary Assessment by Marilisa Botte, Amedeo Zampi, Cristina Oreto, Luca D’Acierno

“…The use of Building Information Modelling (BIM) is becoming increasingly adopted worldwide to support the creation and management of digital environments in which physical and functional features of a facility are modelled. Due to its characteristic flexibility and interoperability, it rapidly extends beyond the boundaries of applications for which it was originally conceived, thus being implemented in other contexts such as the infrastructure sector. …”
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