Functional unknomics: Systematic screening of conserved genes of unknown function. by João J Rocha, Satish Arcot Jayaram, Tim J Stevens, Nadine Muschalik, Rajen D Shah, Sahar Emran, Cristina Robles, Matthew Freeman, Sean Munro

“…We applied RNA interference (RNAi) in Drosophila to 260 unknown genes that are conserved between flies and humans. Knockdown of some genes resulted in loss of viability, and functional screening of the rest revealed hits for fertility, development, locomotion, protein quality control, and resilience to stress. …”
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Conserving / Not Conserving Cultural Heritage by Using by Gamze Fahriye Pehlivan

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Conservation of dark CPD photolyase function in blind cavefish by Hongxiang Li, Carina Scheitle, Giuseppe Di Mauro, Silvia Fuselli, Susanne Fritsch-Decker, Takeshi Todo, Carsten Weiss, Daniela Vallone, Tilman Lamparter, Cristiano Bertolucci, Nicholas S. Foulkes

“…Thereby we document selective conservation of light-independent photolyase function in blind cavefish, enabling the repair of DNA damage encountered in an extreme subterranean environment.…”
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Water Conservation Function of Artificial Forests in Kubuqi Desert by Han Qingchi, Wang Haichao, Sun Kai, Pei Zhiyong, Wang Han, Su Xiaoming, Yang Jianjun, Chen Hongwei

“…The water-holding capacity of litter and soil were determined using field measurements and the indoor immersion method, and the water conservation function of each forest was assessed using a combination of the analytic hierarchy process (AHP) and the entropy-weight method (EWM). …”
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Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. by Emily E Hare, Brant K Peterson, Venky N Iyer, Rudolf Meier, Michael B Eisen

“…In exploring this diverse collection of sequences to identify the shared features that account for their similar functions, we found a small number of short (20-30 bp) sequences nearly perfectly conserved among the species. …”
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Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites by Yuange Duan, Ling Ma, Tianyou Zhao, Jiyao Liu, Caiqing Zheng, Fan Song, Li Tian, Wanzhi Cai, Hu Li

“…It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic diversity in a temporal-spatial manner. The function and essentiality of a few conserved recoding sites are recognized. …”
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Research on Water Conservation Function of Forest Ecosystem in Karst Mountain Area by LI Wenfang, YU Chunya, WANG Xiaonian, LIU Yiling

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Proteasome associated function of UCH37 is evolutionarily conserved in Plasmodium parasites by Mohsen Hajisadeghian, Annie M. Geiger, Carla Briggs, Cameron Smith, Katerina Artavanis-Tsakonas

“…We confirm a direct interaction with the proteasome and demonstrate that the interaction mechanism is evolutionarily conserved. Notably, we discover a divergence in localization compared to the human enzyme and identify novel interacting partners, suggesting alternative functions for PfUCH37 in Plasmodium. …”
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Effective Microbial Strategies to Remediate Contaminated Agricultural Soils and Conserve Functions by Carolina E. Demaman Oro, Bruna M. Saorin Puton, Luciana D. Venquiaruto, Rogério M. Dallago, Marcus V. Tres

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Evolutionary conservation of the functional modularity of primate and murine LINE-1 elements. by Bradley J Wagstaff, Miriam Barnerssoi, Astrid M Roy-Engel

“…Although amino acid conservation varies from ∼35% to 63% for the L1 ORF1p and ORF2p, most human and mouse L1 sequences can be functionally exchanged. …”
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Modified Incision For Orbicularis Oris Function Conservation In Intra Oral Lesions by Dr. Mira Sen, Dr. Asit Ranjan Dasgupta, Dr. Meera Chatterjee, Dr. Dipankar Chatterjee, Dr. N. Vani, Dr. Amit Bhowmik

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SH3 interactome conserves general function over specific form by Xiaofeng Xin, David Gfeller, Jackie Cheng, Raffi Tonikian, Lin Sun, Ailan Guo, Lianet Lopez, Alevtina Pavlenco, Adenrele Akintobi, Yingnan Zhang, Jean‐François Rual, Bridget Currell, Somasekar Seshagiri, Tong Hao, Xinping Yang, Yun A Shen, Kourosh Salehi‐Ashtiani, Jingjing Li, Aaron T Cheng, Dryden Bouamalay, Adrien Lugari, David E Hill, Mark L Grimes, David G Drubin, Barth D Grant, Marc Vidal, Charles Boone, Sachdev S Sidhu, Gary D Bader

“…Our results suggest a model of network evolution where general function of the SH3 domain network is conserved over its specific form.…”
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Evolutionary Dynamics and Functional Conservation of <i>amh</i> Signaling in Teleost Lineages by Lingqun Zhang, Qingke Zhang, Kai Hu, Wei Lu, Weigang Li, Fengchi Wang, Jie Cheng

“…However, their evolution and function in reproduction among diverse teleost lineages may represent species-specific patterns and still need more explanation. …”
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Metabolic network structure and function in bacteria goes beyond conserved enzyme components by Jannell V. Bazurto, Diana M. Downs

“…For this approach to provide accurate predictions, one must assume that the conservation of metabolic components leads to conservation of metabolic network architecture and function. …”
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Hierarchical partitioning of metazoan protein conservation profiles provides new functional insights. by Jonathan Witztum, Erez Persi, David Horn, Metsada Pasmanik-Chor, Benny Chor

“…The availability of many complete, annotated proteomes enables the systematic study of the relationships between protein conservation and functionality. We explore this question based solely on the presence or absence of protein homologues (a.k.a. conservation profiles). …”
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Enhancing the Functional Biodiversity of Ground-Dwelling Arthropods with Henbit (Lamium amplexicaule) Conservation by Hidehiro Inagaki, Okamoto Naoya, Toyoda Yuta, Kunwar Jung

“…In European countries, considerable research has focused on the conservation and improvement of biodiversity of functional groups which are useful organisms in agricultural lands. …”
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Left-right function of dmrt2 genes is not conserved between zebrafish and mouse. by Raquel Lourenço, Susana S Lopes, Leonor Saúde

“…On the basis of evolutionary sub-functionalization and neo-functionalization theories we discuss this absence of functional conservation.…”
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Sprengel deformity: What is the functional outcome of conservative treatment versus surgical correction? by C. Antfang, A. Frommer, G. Gosheger, G. Toporowski, A. Laufer, J. D. Rölfing, R. Roedl, B. Vogt

“…Surgical reconstruction is an option to treat patients with severe deformity and functional impairment. This retrospective single centre study evaluated 19 patients with 21 Sprengel deformities treated from 2016 to 2023. 11/19 patients had mild ROM limitations of the affected shoulder with a median abduction of 130° (interquartile range (IQR) 100–150) and were treated conservatively. 8/19 patients with severe Sprengel deformity and functional impairment underwent surgery (median age 6 years (IQR 4–6)). …”
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Construction of Evaluation Model for Soil and Water Conservation Function of Vegetation at Community Scale by Zhang Hongda, Zhao Chuanpu, Dai Yuting, Yuan Li, Yang Qimengdi, Wu Ao, Liu Xia

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The Role of a Conserved Arg-Asp Pair in the Structure and Function of Tetanus Neurotoxin by Elizabeth A. Wilson, Ashtyn N. Bevans, Michael R. Baldwin

“…This is achieved, in part, through pH-triggered membrane insertion of the translocation (HCT) domain, which delivers the catalytic light-chain (LC) domain to the cytosol. While the function of HCT is well defined, the mechanism by which it accomplishes this task is largely unknown. …”
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