Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function. by Saskia Hüsken, Annika Röder, Johannes Ptok, Anne E Meyer, Mats Georg, Yannick Schwarz, Christian Roos, Kerstin Mätz-Rensing, Michael C Hutter, Doreen M Floss, Allan E Rettie, Marco Girhard, Helmut Hanenberg, Constanze Wiek

“…A hallmark of the highly conserved CYP4B1 enzyme in mammals is the capability to bioactivate both xenobiotic and endobiotic substrates. …”
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In silico guided structural and functional analysis of genes with potential involvement in resistance to coffee leaf rust: A functional marker based approach. by Geleta Dugassa Barka, Eveline Teixeira Caixeta, Sávio Siqueira Ferreira, Laércio Zambolim

“…The characterized candidate RGA is of particular importance for further biological function analysis in coffee.…”
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Use of intraoperative functional luminal imaging probe to guide decision making in an open achalasia case: Converting an esophagectomy to a more conservative open Heller myotomy with Dor fundoplicationCentral Message by Skylar Nahi, BA, Amy Holmstrom, MD, Matthew Snyder, MD, MS, David Odell, MD, MMSc

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Evaluating the effects of land management policy on waterbird habitats in the Liaohe River Delta wetland by Haozheng Dong, Houlang Duan

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Intraspecific Functional Trait Variation and Coordination in Schizachyrium scoparium by Jacob Zeldin, Tessa Dethlefs, Stacy Caeiro, Daniel Puga, Andrea Kramer

“…ABSTRACT Plant functional traits are vital tools in ecological restoration and biodiversity conservation. …”
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Functional Implications of Local DNA Structures in Regulatory Motifs by Qian Xiang

“…Here, we use hydroxyl radical cleavage pattern as a measure of local DNA structure. We compared the conservation between DNA sequence and structure in terms of information content and attempted to assess the functional implications of DNA structures in regulatory motifs. …”
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Spatial variation of functional structure of fish communities in the Bohai Sea by Jianyu Zou, Hanxu Wang, Xiujuan Shan, Harry Gorfine, Yiping Ren

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Novel functional drainage density for Blue Carbon Ecotones by Jiaqi Zhang, Matteo Convertino

“…Our results emphasize that the optimal BCE portfolio should consider FDD for enhancing BCEs function and services, as well as other ecotones at the basin-scale, via conservation and restoration strategies.…”
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Sphingolipids and mitochondrial function, lessons learned from yeast by Pieter Spincemaille, Bruno P.A. Cammue, Karin Thevissen

“…Next, we will discuss recent findings in yeast SL research concerning a crucial signaling role for SLs in orchestrating mitochondrial function, and translate these findings to relevant disease settings such as WD and NPC. …”
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Phylogenetic and functional assessment of orthologs inference projects and methods. by Adrian M Altenhoff, Christophe Dessimoz

“…Furthermore, orthology is typically only assessed in terms of function conservation, despite the phylogeny-based original definition of Fitch. …”
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Functional Foods in Clinical Trials and Future Research Directions by Zsuzsa Emma Hajzer, Walaa Alibrahem, Nihad Kharrat Helu, Csaba Oláh, József Prokisch

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Fish functional groups of the North Atlantic and Arctic oceans by M. S. A. Thompson, I. Preciado, F. Maioli, F. Maioli, V. Bartolino, A. Belgrano, A. Belgrano, A. Belgrano, M. Casini, M. Casini, P. Cresson, E. Eriksen, G. Hernandez-Milian, I. G. Jónsdóttir, S. Neuenfeldt, J. K. Pinnegar, S. Ragnarsson, S. Schückel, S. Schückel, U. Schückel, B. E. Smith, M. Á. Torres, T. J. Webb, C. P. Lynam

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Functional significance of SRJ domain mutations in CITED2. by Chiann-mun Chen, Jamie Bentham, Catherine Cosgrove, Jose Braganca, Ana Cuenda, Simon D Bamforth, Jürgen E Schneider, Hugh Watkins, Bernard Keavney, Benjamin Davies, Shoumo Bhattacharya

“…Our results also suggest that coding sequence mutations observed in case-control studies need validation using in vivo models and that predictions based on structural conservation and in vitro functional assays, or even in vivo global loss of function models, may be insufficient.…”
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Foot darkening with age in Spheniscus penguins: applications and functions by Ginger A. Rebstock, K. Pearl Wellington, P. Dee Boersma

“…The timing of foot darkening within species was consistent with foot color functioning in protection from UV radiation, and not with foot color functioning in thermoregulation. …”
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Structure and function of the topsoil microbiome in Chinese terrestrial ecosystems by Yuqiang Li, Yuqiang Li, Yuqiang Li, Yulong Duan, Yulong Duan, Yulong Duan, Junbiao Zhang, Evangelos Petropoulos, Jianhua Zhao, Fasi Wu, Lilong Wang, Lilong Wang, Yun Chen, Yun Chen, Xuyang Wang, Xuyang Wang, Xuyang Wang

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Kidneys functional state in patients suffered purulent pyelonephritis by L. A. Sinyakova, E. V. Bernikov, O. B. Loran

“…Restoration of renal function occurred in shorter observation periods after the use of percutaneous kidney drainage and conservative treatment.Conclusion. …”
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Identification and functional characterization of cardiac pacemaker cells in zebrafish. by Federico Tessadori, Jan Hendrik van Weerd, Silja B Burkhard, Arie O Verkerk, Emma de Pater, Bastiaan J Boukens, Aryan Vink, Vincent M Christoffels, Jeroen Bakkers

“…Although cardiac development and function are strikingly conserved amongst animal classes, in lower vertebrates neither structural nor molecular distinguishable components of a conduction system have been identified, questioning its evolutionary origin. …”
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Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling by Lei Wang, Rui Zhu, Zehua Wen, Hua-Jun Shawn Fan, Teresa Norwood-Jackson, Danielle Jathan, Ho-Jin Lee

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Function and mechanism of cohesin REC8 during meiosis by DAI Jingling, YU Chao

“…Cohesin is a functionally and evolutionarily conserved multi-subunit protein complex that is required for sister chromatid cohesion and chromatin loop structure in both mitosis and meiosis. …”
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Functions and applications of RNA interference and small regulatory RNAs by Feng Xuezhu, Guang Shouhong

“…Since its discovery, RNAi has been widely applied in functional genomic studies and a range of practical applications. …”
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