Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda by Esther Uwibambe, Abdoulaye Yalcouyé, Elvis Twumasi Aboagye, Lettilia Xhakaza, Kalinka Popel, Norbert Dukuze, Thashi Bharadwaj, Carmen de Kock, Isabelle Schrauwen, Suzanne M. Leal, Leon Mutesa, Ambroise Wonkam

“…Cell-based experiment in HEK293T showed that the variant significantly affected the TRMT61 A protein localization which is thought to impact the mitochondrial and cytosolic functions. Conclusion We reported a novel biallelic variant in TRMT61 A, [NM_152307.3:c.665C > T p.…”
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A small heat shock protein Fmp28 influences virulence by regulating Als3 expression via the cAMP-PKA signaling pathway in Candida albicans by Junjun Tan, Qiong Liu, Zhiping Liu, Yanli Cao, Xiaomin Yu, Qianjun Zhao, Niya Hu, Yanling Liu, Yuwei Wan, Yeming Zhang, Huizhen Tian, Lingbing Zeng, Xiaotian Huang

“…However, our understanding of their functions in pathogenic microorganisms remains limited. …”
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Distribution patterns of fungal community diversity in the dominant tree species Dacrydium pectinatum and Vatica mangachapoi in tropical rainforests by Kepeng Ji, Yaqing Wei, Xin Wang, Yu Liu, Rui Sun, Yuwu Li, Guoyu Lan

“…This compartment-aware perspective enhances our ability to leverage microbial functions to improve the resilience of endangered trees in the face of climate change.…”
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Modified transforaminal epidural steroid injection combined with pulsed radiofrequency: an effective treatment measure for lumbar radiculopathy by Qi Yan, Xianggu Zhong, Jiarong Li, Leyu Zhao, Junjie Niu, Dawei Song, Jinning Wang, Yun Teng, Tianyi Wu, Xiao Sun, Rui Chen, Shuangfei Wang, Jun Zou

“…Consequently, clinicians require an expedited and efficacious approach to address radicular discomfort resulting from lumbar radiculopathy and promptly reinstate the patient's normal functionality.ObjectivesThis study seeks to assess the effectiveness of a modified transforaminal epidural steroid injection (TFESI) in conjunction with pulsed radiofrequency (PRF) for treating lumbar radiculopathy using a retrospective analysis.MethodsOur study examined patients with unilateral lower limb radicular pain persisting for three months or more due to LDH, in whom conservative therapies were ineffective, from January 1, 2023, to October 31, 2023. …”
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New genomic resources inform transcriptomic responses to heavy metal toxins in the common Eastern bumble bee Bombus impatiens by Amy L. Toth, Christopher D. R. Wyatt, Rick E. Masonbrink, Katherine S. Geist, Ryan Fortune, Sarah B. Scott, Emeline Favreau, Sandra M. Rehan, Seirian Sumner, Mary M. Gardiner, Frances S. Sivakoff

“…In the brain, differentially expressed genes had biological functions related to chaperone activity and protein folding. …”
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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening by Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A. Comini

“…Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular target for drug development against pathogens causing severe and fatal diseases in mammals. …”
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Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomisti... by Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady Verkhivker

“…According to our results, the E1 and F3 groups of Abs effectively exploit binding hotspot clusters of hydrophobic sites that are critical for spike functions along with the selective complementary targeting of positively charged sites that are important for ACE2 binding. …”
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Effect of osteopathic manipulative treatment on comorbid depressive symptoms in patients with chronic low back pain: study protocol for a randomised controlled trial by Meike Shedden-Mora, Robert Schleip, Francesco Cerritelli, Tobias Schmidt, Lucas Bohlen, Michael Eggart, Bruno Müller-Oerlinghausen, Jürgen Lorenz, Torsten Liem, Jorge E Esteves

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Pan-cancer analysis identified CD248 as a potential target for multiple tumor types by Li Guo, Yan Liao, Xuyang Zhang, Rongjuan Guo, Zheng Wang, Deqin Yang, Deqin Yang, Deqin Yang

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Analysis and Case Study of Internal Forces in Nut Column Transmission System of Shiplifts by WANG Di, LIAO Le-kang, JIN Liao

“…To describe axial load transmission at the interface with complex contact mechanics, exponential distribution functions were introduced. The model integrated elastic foundation beam theory with fundamental mechanics of materials, enabling the derivation of closed-form expressions for deflection, internal forces (bending moments and shear forces), and stresses (normal and shear) in both the nut column and adjustment beam. …”
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Young Scientists’ Motivation for the Research Activity in Russian Regional Universities by R. A. Dolzhenko, V. A. Karpilianskii, R. A. Hady, A. S. Didenko

“…In-depth interviews were conducted with the most successful respondents (N = 20) to comprehensively assess the factors of their professional activity, since it is the leaders, who primarily determine the effectiveness of functioning system.Results and scientific novelty. The motivation of a young scientist is considered as a key factor in the productivity of his or her research behaviour, which, in turn, depends on the needs of the individual and the degree of his or her satisfaction with self-realisation in the process of targeted scientific search. …”
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A Dirigent Gene, <i>ZmDIR11</i>, Positively Regulates Drought Tolerance in Maize by Zhixiong Zhao, Yuan Guan, Tao Qin, Hongjian Zheng, Hui Wang, Wen Xu, Wei Gu, Diansi Yu, Jihui Wei, Yinxiong Hu

“…The <i>DIR</i> gene family, which encodes Dirigent proteins, plays a crucial role in plant development and stress responses. However, the functions and mechanisms of this family in maize remained underexplored. …”
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Designing host-associated microbiomes using the consumer/resource model by Germán Plata, Karthik Srinivasan, Madan Krishnamurthy, Lukas Herron, Purushottam Dixit

“…For example, there has been a boom in machine-learning models aiding in the design of proteins with user-specified structures or functions. Host-associated microbiomes play important roles in animal health and disease, as well as the productivity and environmental footprint of livestock species. …”
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Identification of GRAS Gene Family in Paper Mulberry and Analysis of Its Expression in Stem Development by Tanxing CHEN, Huannan LI, Pinsheng WANG, Yajun JIANG, Jinbin XIAO, Lingmin YAN, Yang WANG, Yi FAN

“…The analysis of cis-acting elements showed that this family may have potential functions in the related biological processes of plant photoreaction, response to adversity stress, and regulation of plant-derived hormones. …”
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Genome-Wide Identification and Expression Analysis of <i>NAC</i> Gene Family Members in Seashore Paspalum Under Salt Stress by Xuanyang Wu, Xiaochen Hu, Qinyan Bao, Qi Sun, Pan Yu, Junxiang Qi, Zixuan Zhang, Chunrong Luo, Yuzhu Wang, Wenjie Lu, Xueli Wu

“…This study established a theoretical basis for understanding the molecular functions and regulatory mechanisms of the <i>NAC</i> gene family in seashore paspalum under salt stress.…”
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A potent and broad CD4 binding site neutralizing antibody with strong ADCC activity from a Chinese HIV-1 elite neutralizer by Yingdan Wang, Ping Ji, Qianying Liu, Nannan Jia, Yunping Ma, Tianyi Yuan, Palizhati Rehati, Jiali Chen, Yumei Wen, Fan Wu, Jinghe Huang

“…Our findings provide valuable insights into the mechanisms of FD22 in viral neutralization and ADCC. The dual functionality of FD22 enhances its potential as a promising therapeutic antibody and offers new avenues for designing CD4bs-targeting vaccines with enhanced ADCC capabilities.…”
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GESTÃO DEMOCRÁTICA NO ESTADO DE MATO GROSSO: conquista ameaçada pela implantação de políticas educacionais conservadoras by Cassia Domiciano, Márcia Cossetin, Nádia Drabach

“…It makes the appointment for public school principals an executive power decision since the majority of the Supreme Federal Court ministers understood that the appointment of trust functions is the responsibility of the executive power, thus ruling against the democratic election of candidates for this position. …”
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Analgesic efficacy and safety of erector spinae plane block versus serratus anterior plane block in breast surgery—a meta-analysis and systematic review of randomized controlled tr... by Samiullah Shaikh, Umm E Salma Shabbar Banatwala, Paranshi Desai, Muhammad Arham Khan, Rimsha Bint-e-Hina, Sidra Samad, Muhammad Hamza Sikandari, Ali Nawaz, Rana Ijaz, Shayan Asmat, Abeer Fatima, Harim Mirza, Noor Mahal Azam, Qurat Ul Ain Muhammad, Satesh Kumar, Mahima Khatri

“…Abstract Background Mastectomy and breast-conserving surgery are key interventions for breast cancer, a leading cause of cancer-related mortality in women. …”
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Treatment decision-making and care among older adults with kidney failure: protocol for a multicentre, prospective observational cohort study with nested substudies and linked qual... by Martin Gallagher, Vasi Naganathan, Gian Luca Di Tanna, Celine Foote, Angela Makris, Chris Gianacas, Nicholas A Gray, Isaac Yeboah Addo, Amanda Siriwardana, Chenlei Kelly Li, Kenneth Yong, Yachna Mehta, Jannel Ramos, Sarah Roxburgh

“…There are limited data on several key outcomes for the elderly population including survival, quality of life, symptom burden, changes in physical functioning and experienced burden of healthcare. Patients, caregivers and clinicians consequently face significant uncertainty when making life-impacting treatment decisions. …”
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Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress by Zongmao He, Yi Yan, Xijun Guo, Tong Wang, Xinqiao Liu, Ren-Bo Ding, Yuanfeng Fu, Jiaolin Bao, Xingzhu Qi

“…Thioredoxin-1 (Trx-1) is an important redox protein found in almost all prokaryotic and eukaryotic cells, which has a highly conserved active site sequence: Trp-Cys-Gly-Pro-Cys. …”
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