Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy by San Pin Steve Wu, Elvis Quiroz, Tianyuan Wang, Skylar G Montague Redecke, Xin Xu, Lin Lin, Matthew L Anderson, Francesco J DeMayo

“…Using CRISPR activation, we assessed the functionality of a PGR putative enhancer 35 kilobases upstream of the contractile-restrictive gene PLCL2. …”
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EIN3/EIL (Ethylene Insensitive3 / Ethylene Insensitive3 Like) Protein Family in Phaseolus vulgaris: Identification, Evolution and Expression Analysis within the Genome by Simay Ezgi Akbulut, Zehra Şafak, Aybüke Okay, Kimia Amirina, Ilker Büyük

“…According to cis-element analysis, Pvul-EIL genes are engaged in a wide range of functions, including tissue-specific, stress, and hormone-sensitive expression. …”
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aac(6’)-Iaq, a novel aminoglycoside acetyltransferase gene identified from an animal isolate Brucella intermedia DW0551 by Naru Lin, Naru Lin, Wanna Xu, Dawei Huang, Chaoqun Liu, Junwan Lu, Mei Zhu, Qiyu Bao, Qiyu Bao, Wei Pan

“…The amino acid sequence of AAC(6’)-Iaq shared the highest identity (52.63%) with the functionally characterized aminoglycoside acetyltransferase AAC(6’)-If. …”
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Plasmonic optical fiber biosensors for ultra-low detection of respiratory syncytial virus via point-of-care tests by Federica Passeggio, Luigi Zeni, Massimiliano Galdiero, Francesco Arcadio, Carla Zannella, Anna De Filippis, Chiara Marzano, Ines Tavoletta, Fabiana Napolitano, Rosalba Pitruzzella, Giuseppe Portella, Nunzio Cennamo

“…In this frame, for the first time, a plasmonic RSV biosensor based on modified plastic optical fibers (POFs) has been developed and tested by functionalizing the plasmonic platform with a specific antibody targeting the RSV fusion (F) protein. …”
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Carnosine Synthase (<i>Ts</i>ATPGD) Alleviates Lipid Peroxidation Under Transcriptional Control by an <i>Nfe2</i>-like Gene in <i>Tridacna Squamosa</i> by Zhuo Yang, Nai-Kei Wong, Fan Mao, Siwei Wu, Wenjie Yi, Ziniu Yu, Yang Zhang

“…Gene structure and phylogenetic analysis reveal that <i>T. squamosa</i> possesses a single transcription factor <i>Ts</i>Nfe2l in contrast to mammalian Nfe2l1 (Nrf1) and Nfe2l2 (Nrf2), belonging to protein members of the bZIP-NFE2 subfamily and functionally resembling the mammalian Nfe2l1. A conserved bZIP domain permits its binding to the antioxidant response element (ARE) in vitro and in HEK293T cells. …”
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DPV pUL15 possesses a potential NLS, which is important for the location of the terminase complex and for viral proliferation and genome cleavage by Qiao Yang, Yaya Feng, Lizhen Liu, Linlin Yang, Mingshu Wang, Ying Wu, Bin Tian, Xumin Ou, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Di Sun, Yu He, Zhen Wu, Ling Zhang, Yanling Yu, Anchun Cheng

“…These findings indicate that the NLS is important for the functions of DPV pUL15. Overall, a potential NLS and the key amino acids in DPV pUL15 were identified. …”
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Strategies for Digital Economy Operation of Urban Parks Guided by Gamification Methods by Zhaochen WANG

“…ObjectiveIn the mid-to-late stages of China’s urbanization process, the high-quality development of existing urban areas has placed higher demands on the functions and benefits of park green spaces, making operations a new focus for the renewal and construction of urban parks. …”
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MvfR Shapes <i>Pseudomonas aeruginosa</i> Interactions in Polymicrobial Contexts: Implications for Targeted Quorum-Sensing Inhibition by Kelsey M. Wheeler, Myung Whan Oh, Julianna Fusco, Aishlinn Mershon, Erin Kim, Antonia De Oliveira, Laurence G. Rahme

“…Using a collection of <i>P. aeruginosa</i> QS mutants of the three major systems, LasR/LasI, MvfR/PqsABCDE, and RhlR/RhlI, and mutants of several QS-regulated functions, we reveal that MvfR and, to a lesser extent, LasR and RhlR, control competition between <i>P. aeruginosa</i> and other microbes, possibly through their positive impact on pyoverdine, pyochelin, and phenazine genes. …”
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Comparative genomics of the Natural Killer Complex in carnivores by Jan Futas, April L. Jelinek, Pamela A. Burger, Petr Horin, Petr Horin

“…Identification of expressed genes, pseudogenes and gene fragments in the context of expanded gene families would allow the assessment of functionally important variability in particular species.…”
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Genome-wide identification and analysis of the FLA gene family in maize (Zea mays L.) and its expression in response to abiotic stresses by Yongyan Cao, Xuanxuan Chen, Bo Wei, Tuo Zeng, Hongcheng Wang, Bin Zhu, Xuye Du, Lei Gu

“…Conclusion Taken together, the comprehensive analysis of ZmFLAs in the whole genome provides a novel perspective on the evolutionary relationship among maize FLA genes and lays a foundation for further analysis of the biological functions of ZmFLAs.…”
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Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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Research on Multi-objective Shielding Intelligent Optimization Method Based on Non-dominated Sorting Genetic Algorithm NSGA-Ⅲ by WANG Mengqi, ZHENG Zheng, MEI Qiliang, PENG Chao, GAO Jing, ZHOU Yan

“…This study is dedicated to exploring an advanced intelligent multi-objective shielding optimization method based on the third generation non-dominated sorting genetic algorithm (NSGA-Ⅲ). The program’s functionality was tested and validated to improve the efficiency and effectiveness of shielding design for spent fuel transport ship. …”

Combined Intrastromal Implantation of a Semipermeable Hydrogel Membrane in Case of Corneal Graft Failure and Multiple Keratoplasty (Clinical Observation) by G. A. Osipyan, V. M. Sheludchenko, N. Y. Youssef, Kh. Khraystin, R. A. Dzhalili, E. I. Krasnolutskaya

“…Rekeratoplasty is conducted in case of rapid decrease of transplant functions, but even with multiple rekeratoplasty iterations, the result can be unstable.Patient and methods. …”
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Effects of polyamines and indole on the expression of ribosome hibernation factors in <i>Escherichia coli</i> at the translational level by E. A. Khaova, A. G. Tkachenko

“…Ribosome hibernation factors reversibly inhibit translation under stress conditions, including exposure to antibiotics, to avoid resource waste and to conserve ribosomes for a quick restoration of their functions when favorable conditions occur. …”
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HIGHER EDUCATION SERVICES: THE STRUCTURE OF THE PROPOSAL AND THE LEVEL OF COMPETITION by D.M. Zagirniak

“…The renewal of the development strategy requires that higher education establishments make a determining decision — to continue functioning in the developed field of knowledge, expending the specialties spectrum, or to investigate new fields. …”
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Melatonin regulates rabbit sperm motility and kinematics via the MT1/PKC signaling pathway by Chongchong Wang, Yanyan Zhang, Shiwen He, Biao Jiang, Jinglei Huang, Hui Peng

“…Objective Melatonin, a highly conserved molecule, plays an essential role in various physiological functions. …”
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Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets by Tao Liu, Fazal Rahim, Meng-Lei Yang, Meftah Uddin, Jing-Wei Ye, Imtiaz Ali, Yousaf Raza, Abu Mansoor, Muhammad Shoaib, Mujahid Hussain, Ihsan Khan, Basit Shah, Asad Khan, Ahmad Nisar, Hui Ma, Bo Xu, Wasim Shah, Qing-Hua Shi

“…Mammalian sperm-associated antigen 17 (SPAG17) encodes a conserved axonemal protein of cilia and flagella, forming part of the C1a projection of the central apparatus, with functions related to ciliary/flagellar motility, skeletal growth, and male fertility. …”
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Restoration of riparian forest cover increases carbon stocks in the Pacific Northwest by Regina O’Kelley, Rose A Graves, Holly Amer, Lucas C R Silva

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miR-144/451 in hematopoiesis and beyond by Ting Wang, Fan Wu, Duonan Yu

“…Consistent with the findings in animals, disruption of miR-144/451 expression and their abnormal functions are observed in human hematopoietic and non-hematopoietic organs. …”
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mRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer by E. D. Kulaeva, E. S. Muzlaeva, E. V. Mashkina

“…Changes in gene activity in tumors reflect the biological diversity of cellular phenotype and physiological functions and can be an important diagnostic marker. …”
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