Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of... by John M Powers, Zoe L Lyski, Whitney C Weber, Michael Denton, Magdalene M Streblow, Adam T Mayo, Nicole N Haese, Chad D Nix, Rachel Rodríguez-Santiago, Luisa I Alvarado, Vanessa Rivera-Amill, William B Messer, Daniel N Streblow

“…In addition to serology, we also performed memory B-cell analysis, finding chikungunya-specific memory B-cells in all subjects in this study as remotely as 24 years post-infection. We functionally assessed the ability of memory B-cell derived antibodies to bind to chikungunya virus, and related Mayaro virus, as well as the highly conserved B domain of the E2 glycoprotein thought to contribute to cross-reactivity between related Old-World alphaviruses. …”
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Volumetric osteoconchoplasty method by B. M. Zargaryan, S. D. Litvinov

“…At the same time, after the operation, the shell remains full anatomically and functionally, i.e. consists of the bone skeleton and the corresponding volume of soft tissues.Conclusion. …”
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Model of adaptive behavior of enterprises in the context of transformational changes associated with the aggravation of the climate crisis by A.M. Tkachenko, O.V. Hryhorieva

“…It is stated that in the current conditions of the activity of enterprises, the external environment acts as a catalyst for adaptive organizational changes, which in recent years has been increasingly acquiring cardinal transformations, thereby predetermining the VUCA conditions for the functioning of business entities, which requires the mandatory formation of an adaptation policy by them, as an integral part of the management system. and fundamental basis for further development. …”
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METHODOLOGY OF MANAGING THE REAL ESTATE PORTFOLIO CONSISTING OF OWN CAPITAL AND BANK ASSETS by M. Fedotova, S. Sternik, G. Teleshev

“…Reasoning from the given provision the article formulates the concepts system about the key aspects and risks based on principles, methods and functions of complex effective managing the real estate portfolio consisting of own capital and bank assets. …”
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Aptamer‑mediated modulation of eEF1 enhances salt stress tolerance in rice by Yongxiang Huang, Haomin Chen, Zhihao Xie, Daming Chen, Mingming Chen

“…Site-directed mutagenesis and fluorescence polarization assays identified Ile585, Lys621, and Arg625 as critical for the aptamer–eEF1 interaction, with the K621A mutation causing the most pronounced loss of binding. Functionally, rice seedlings transfected with S2-A aptamer under 150 mM NaCl stress exhibited improved growth, enhanced chlorophyll content, reduced lipid peroxidation, and a coordinated upregulation of key salt stress-responsive genes (OsSOS1, OsHKT1, OsDREB2A). …”
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DYNAMICS IN DIAGNOSING THE QUALITY OF THE GOOD TEACHER by M. Teneva

“…In his or her professional activity, the teacher enters into different interactions and realizes a complex of functions and professional roles, on the basis of which different types of teachers can be differentiated. …”
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Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells by Yi-Yang Chen, Ying-Hsuan Wang, Chih-Cheng Chen, Cih-En Huang, Chia-Chen Hsu, Shu-Huei Hsiao, Yu-Wei Leu

“…The induction route is functionally conserved, according to exogenously produced miRNA and gene expression. …”
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Applications of Growth Factors in Implant Dentistry by Balen Hamid Qadir, Mohammed Aso Abdulghafor, Mohammed Khalid Mahmood, Faraedon Mostafa Zardawi, Mohammed Taib Fatih, Handren Ameer Kurda, Zana Fuad Noori, Herve Tassery, Delphine Tardivo, Arthur Falguiere, Vincent Romao, Romain Lan

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Genome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L by Zhengwei Tan, Dandan Lu, Yongliang Yu, Lei Li, Lanjie Xu, Wei Dong, Qing Yang, Chunming Li, Xiufu Wan, Huizhen Liang

“…Safflower, valued for its ornamental, medicinal, and culinary uses, exhibits significant resilience to salt, alkali, and drought. By elucidating the functions and expression patterns of WRKY genes, we aim to enhance breeding strategies for improved stress tolerance and metabolic traits in crops. …”
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The Transcription Factor LoTDF1 Plays a Role in Early Anther Development in Lily (<i>Lilium</i> Oriental Hybrids) by Juanjuan Sui, Yan Tang, Xing Cao, Jingxia Yang

“…Subcellular localization and transcriptional activation assays demonstrated that LoTDF1 localized to the nucleus and functioned as a transcription activator. The transcriptional activation domain was located within the last 195 amino acids (117–311a) of the C-terminus, and there may be more than one transcriptional activation domain in the region. …”
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Mumps-associated hepatitis: A rare clinical presentation by Mikiyas G. Teferi, Abel K. Gulma, Meron T. Akalu, Getaw W. Hassen, Elias M. Gashaw, Nahom D. Gerer

“…Consistent with a self-limiting course of mumps associated with hepatitis, liver functions normalized over four weeks. Discussion: Mumps virus is an RNA paramyxovirus that affects glandular tissues. …”
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Identification of the methionine transporter MetQ in Streptococcus suis and its contribution to virulence and biofilm formation by Camila Bosch, Carla García, Luis Saralegui, Lucille van Beek, Marien I. de Jonge, Clara Marín, Jesús Arenas

“…We examined whether MetQ functions as a methionine-binding protein and its role in bacterial infection. …”
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Genome-wide identification and expression analysis of the JMJ-C gene family in melon (Cucumis melo L.) reveals their potential role in fruit development by Wuyun Jin, Wei Yan, Ming Ma, Agula Hasi, Gen Che

“…Conclusions This study provides a comprehensive understanding of the gene structure, classification, and evolution of JMJ-C in melon and supports the clarification of the JMJ-C functions in further research.…”
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Redox Mechanisms Driving Skin Fibroblast-to-Myofibroblast Differentiation by Marzieh Aminzadehanboohi, Manousos Makridakis, Delphine Rasti, Yves Cambet, Karl-Heinz Krause, Antonia Vlahou, Vincent Jaquet

“…H₂O₂ functions as a signalling molecule, regulating various cellular processes mostly through post-translational redox modifications of cysteine thiol groups of specific proteins. …”
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Characterization of the NAC gene family in ‘Fengdan’ peony (Paeonia ostii) insights into the evolution and expression patterns under abiotic stresses and ABA treatment by Xiangli Yu, Qirui Meng, Hongyan Hou, Qiang Guo, Qingjie Wang, Yuqing Yang, Yanzhao Zhang

“…GO analysis results suggested that the functions of PoNAC genes were mostly concentrated in the “biological process” GO category. …”
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Identification of Nuclear Localization Sequence (NLS) Sites in R2R3-MYB Transcription Factor Involved in Anther Development by Si-Da Zhou, Que Zhou, Yan-Dan Cui, Xiang Zhong, Xing Chen, Xue-Rong Lin, Zhong-Nan Yang, Jun Zhu

“…These findings suggest that the NLS at AAs 18–22 is sufficient for nuclear localization. To confirm the NLS functions in vivo, we constructed the vectors including the <i>MS188</i> gene without the NLS sites, which failed to complement the male sterile phenotype of <i>ms188</i>. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…The SARS-CoV-2 main protease (Mpro or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2 Mpro. …”
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Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis by Jing Shi, Zhenzhen Feng, Qian Song, Aijia Wen, Tianyu Liu, Liqiao Xu, Zonghang Ye, Simin Xu, Fei Gao, Liuxiang Xiao, Jiapeng Zhu, Kalyan Das, Guoping Zhao, Jie Li, Yu Feng, Wei Lin

“…However, the molecular mechanisms underlying the transcriptional regulation that define its differential functions remain largely unclear. In the present study, we determine three cryo-EM structures of Mycobacterium tuberculosis (Mtb) PhoP-dependent transcription activation complexes (PhoP-TACs) and build one preliminary cryo-EM structure model of Mtb PhoP-dependent transcription repression complex (PhoP-TRC). …”
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Genome-Wide Characterization of the <i>ANN</i> Gene Family in <i>Corydalis saxicola</i> Bunting and the Role of CsANN1 in Dehydrocavidine Biosynthesis by Han Liu, Jing Wang, Zhaodi Wen, Mei Qin, Ying Lu, Lirong Huang, Xialian Ou, Liang Kang, Cui Li, Ming Lei, Zhanjiang Zhang

“…This study sheds light on the profiles and functions of the <i>CsANN</i> gene family and paves the way for unraveling the molecular mechanism of BIA accumulation, which is regulated by Ca²⁺ through CsANNs.…”
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CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer by Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio, Paolo Remondelli, Valentina Pagliara, Maria Rita Milone, Roberta Guadagno, Cristofaro De Stefano, Ferdinando De Vita, Geppino Falco, Francesco Albano

“…Abstract Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffuse-type gastric cancer (dGC) showing increased expression in tumors. …”
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