Ustilago maydis Trf2 ensures genome stability by antagonizing Blm-mediated telomere recombination: Fine-tuning DNA repair factor activity at telomeres through opposing regulations. by Shahrez Syed, Sarah Aloe, Jeanette H Sutherland, William K Holloman, Neal F Lue

“…Herein we investigated the mechanisms and functions of the Trf2 ortholog in the basidiomycete fungus Ustilago maydis, which manifests strong resemblances to metazoans with regards to the telomere and DNA repair machinery. …”
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Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate. by Yueh-Fu O Wu, Annamarie T Bryant, Nora T Nelson, Alexander G Madey, Gail F Fernandes, Holly V Goodson

“…Moreover, bioinformatic studies demonstrate that the presence of intrinsically disordered regions is conserved in key +TIPs, implying that these regions are functionally significant. …”
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An Analysis of Lighting Quality in University Buildings in District 6 of Tehran: Proposing Improvement Strategies Aligned with Relevant Requirements and Life Cycle Cost Assessment by Mohammad Kazemi, Aliyeh Kazemi

“…Lighting within educational environments is critical in establishing an optimal atmosphere that supports health, conserves energy, enhances the utility of educational spaces, and fosters effective learning. …”
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Identification and expression profiling of microRNAs in leaf tissues of Foeniculum vulgare Mill. under salinity stress by Luis Alberto Bravo-Vázquez, Mariana García-Ortega, Sara Medina-Feria, Aashish Srivastava, Sujay Paul

“…MicroRNAs (miRNAs) are tiny, endogenous, and extensively conserved non-coding RNAs (ncRNAs) typically ranging from 20 to 24 nucleotides (nt) in length that play a major role in a myriad of biological functions. …”
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Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior. by Hee-Kyung Hong, Jason L Chong, Weimin Song, Eun Joo Song, Amira A Jyawook, Andrew C Schook, Caroline H Ko, Joseph S Takahashi

“…While these "clock genes" are well conserved among animals, their specific functions remain to be fully understood and their roles in central versus peripheral circadian oscillators remain to be defined. …”
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Digital state in the context of legal reform in Ukraine: theoretical and legal aspect by E. Najafli

“…It has been established that the legal reform in the field of the formation of a digital state should be recognized as a type of legal reform aimed at a holistic, comprehensive change in the conditions and legal basis of the organization and functioning of the state apparatus in the direction of its optimization and the widest application of information and communication technologies in order to simplify the state administration system, significantly increasing its effectiveness and including society and individual citizens in solving the most significant issues of social and state life. …”
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The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence. by Zoë N Freeman, Steve Dorus, Nicholas R Waterfield

“…Given the central role of K(+) in virulence, we propose that KdpD/KdpE, as a regulator of a high-affinity K(+) pump, has evolved virulence-related regulatory functions. In support of this hypothesis, we review the role of KdpD/KdpE in bacterial infection and summarize evidence that (i) KdpD/KdpE production is correlated with enhanced virulence and survival, (ii) KdpE regulates a range of virulence loci through direct promoter binding, and (iii) KdpD/KdpE regulation responds to virulence-related conditions including phagocytosis, exposure to microbicides, quorum sensing signals, and host hormones. …”
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The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes. by Yanmei Zhao, Chieh-Hsiang Tan, Amber Krauchunas, Andrea Scharf, Nicholas Dietrich, Kurt Warnhoff, Zhiheng Yuan, Marina Druzhinina, Sam Guoping Gu, Long Miao, Andrew Singson, Ronald E Ellis, Kerry Kornfeld

“…The zipt-7.1 gene is expressed in the germ line and functions in germ cells to promote sperm activation. …”
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The Impact of Knee Orthoses on Lameness and Weight Distribution in Canine After Rupture of the Cranial Cruciate Ligament by Aljaž Muršec, Monika Pavlović, Tomaž Lampe, Vladimira Erjavec

“…Shifts in body weight distribution between forelimbs and hindlimbs highlighted improved functionality; for instance, Dog 1 adjusted from 70% forelimb loading on day 1 to 62% on day 32, while Dog 2 improved from 60% to 55%. …”
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Ceramic-carbon Janus membrane for robust solar-thermal desalination by Yingchao Dong, Camille Violet, Chunyi Sun, Xianhui Li, Yuxuan Sun, Qingbin Zheng, Chuyang Tang, Menachem Elimelech

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Long non-coding RNAs and autophagy: dual drivers of Hepatocellular carcinoma progression by Himanshi Goyal, Jyotdeep Kaur

“…This review describes how autophagy contributes to HCC at different stages, outlines the dual functions of lncRNAs as oncogenic drivers or tumor suppressors, and illustrates their integration into key signaling networks of autophagy (e.g., PI3K/AKT/mTOR, AMPK, Beclin-1). …”
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Somatic genome architecture and molecular evolution are decoupled in "young" linage-specific gene families in ciliates. by Xyrus X Maurer-Alcalá, Auden Cote-L'Heureux, Sergei L Kosakovsky Pond, Laura A Katz

“…Here we explore the origins of lineage-specific genes in ciliates, a ~1 billion year old clade of microeukaryotes that are defined by their division of somatic and germline functions into distinct nuclei. Previous analyses on conserved gene families have shown the effect of ciliates' unusual genome architecture on gene family evolution: extensive genome processing-the generation of thousands of gene-sized somatic chromosomes from canonical germline chromosomes-is associated with larger and more diverse gene families. …”
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Identification of two Legionella pneumophila effectors that manipulate host phospholipids biosynthesis. by Ram Viner, David Chetrit, Marcelo Ehrlich, Gil Segal

“…Genetic analysis using yeast deletion mutants, strains expressing relevant yeast genes and point mutations constructed in the Dgk1 and Pah1 conserved domains indicated that LecE functions similarly to the Nem1-Spo7 phosphatase complex that activates Pah1 in yeast. …”
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An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. by Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A Parkhitko

“…Insulin/insulin growth factor signaling is a conserved pathway that regulates lifespan across many species. …”
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Advances in study on phytochelatin synthase in plants by MEI Lei, ZHU Ye, XIAO Qinzhi, CHEN Jinhong, ZHU Shuijin

“…At the last part of this review, further discussions and prospects are given on multiple functions, gene expression, activating mechanism of PCS, as well as application regarding to the genes, aiming to provide some insights and references for further study.…”
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Panhypopituitarism in adults: modern views and case analysis by L. M. Farkhutdinova

“…Pangypopituitarism is diagnosed when all pituitary tropic functions are affected, which is observed in case of damage to 90% of the adenohypophysis cells. …”
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ANTHOLOGIES AND DISCUSSION ON ESSENTIALISM AND ANTI-ESSENTIALISM IN AMERICAN FEMINIST EXPERIMENTAL POETRY by Dubravka Đurić

“…Female poets in canonical anthologies and narratives of the history of poetry usually functioned as tokens, exceptions to the rule, which confirmed the belief that female poets could not produce significant, universal poetic value. …”
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Analysis of histone modification interplay reveals two distinct domains in facultative heterochromatin in Pyricularia oryzae by Thach A. Dang, Atsumi Morimoto, Natsuki Kobayashi, Kieu Pham, Ken-ichi Ikeda, Hitoshi Nakayashiki

“…These findings suggest that K4-fHC functions as a reservoir of genes highly responsive to chromatin context and environmental cues.…”
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Differential expression of alpha-synuclein in hippocampal neurons. by Katsutoshi Taguchi, Yoshihisa Watanabe, Atsushi Tsujimura, Harutsugu Tatebe, Seiji Miyata, Takahiko Tokuda, Toshiki Mizuno, Masaki Tanaka

“…However, the precise relationship between the pathogenicity and physiological functions of α-synuclein remains to be elucidated. …”
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Data-driven prediction and design of bZIP coiled-coil interactions. by Vladimir Potapov, Jenifer B Kaplan, Amy E Keating

“…Our model, which expresses interaction energies as a sum of interpretable residue-pair and triplet terms, achieves a correlation with experimental binding free energies of R = 0.68 and significantly out-performs other scoring functions. To use our model in protein design applications, we devised a strategy in which synthetic peptides are built by assembling 7-residue native-protein heptad modules into new combinations. …”
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