The Acute-Phase Serum Amyloid A Promotes Cytokines Production in Oyster <i>Crassostrea gigas</i> by Junlei Cheng, Weilin Wang, Xuemei Cheng, Xuesong Li, Luyi Lun, Xingye Lian, Lingling Wang, Linsheng Song

“…By comparison, SAA is rarely identified in aquatic species and its physical functions are also not well studied. The present study identified the only one gene encoding SAA protein in oyster <i>Crassostrea gigas</i>. …”
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Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ligand binding predictions by Amara Jabeen, John Graham Oakeshott, Siu Fai Lee, Shoba Ranganathan, Phillip W. Taylor

“…However, experimental analysis of their structures and functions faces significant challenges. Computational methods such as template-based modeling (TBM) and AlphaFold3 (AF3) could facilitate the structural characterisation of ORs. …”
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Clergy of the Russian Orthodox Church and West-Siberian farmers’ uprising of 1921 by Tsys Valeriy

“…It distinguishes main directions of the policy of rebels as to the religion and church, namely the employment of religious slogans in propaganda, granting back to the church certain functions in registering the population, return of religious attributes to state institutions and schools, permission to teach religion at schools, acknowledging the offi cial status of religious holidays, defending church property from Communist authorities and their supporters. …”
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Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens by Karthik Hullahalli, Katherine G. Dailey, Ryan Acbay, Masataka Suzuki, George I. Balazs, Matthew K. Waldor

“…The anti-inflammatory effects of NRTIs were also apparent in response to lipopolysaccharide (LPS) and Staphylococcus aureus, suggesting that the molecular mechanisms underlying the immunomodulatory functions of NRTIs are likely conserved across distinct immune signaling pathways. …”
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The status of clinical trials regarding root canal sealers by Ahmad AL Malak, Yasmina EL Masri, Mira Al Ziab, Nancy Zrara, Tarek Baroud, Pascale Salameh

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N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation by Valentin Babosha, Natalia Klimenko, Anastasia Revel-Muroz, Evgeniya Tikhonova, Pavel Georgiev, Oksana Maksimenko

“…In this study, we demonstrated that the N-terminal region of MSL1 is critical for stability and functions of MSL1. Amino acid deletions and substitutions in the N-terminal region of MSL1 strongly affect both the interaction with roX2 RNA and the MSL complex binding to HAS on the X chromosome. …”
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Exploring Alternative Splicing in Response to Salinity: A Tissue-Level Comparative Analysis Using <i>Arabidopsis thaliana</i> Public Transcriptomic Data by Jesús Hernández-Urrieta, José Miguel Álvarez, José Antonio O’Brien

“…Furthermore, cross-stress comparisons showed that roots have a core set of AS-regulated genes associated with stress response and development, with functionally distinct sets of genes when comparing salt with other stresses, while also conserving a relevant condition-specific response. …”
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Occlusive denture for the management of medication-related osteonecrosis of the jaw with oronasal communication: A case report by Arthur Augusto Martins e Silva, Andréa Gomes de Oliveira

“…Due to limited prior documentation and challenges with follow-up appointments, a conservative treatment approach was chosen. The patient received an occlusive upper complete denture with a soft liner to minimize mucosal trauma, restore stomatognathic functions, and enhance comfort. …”
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<i>Trypanosoma cruzi</i>: Genomic Diversity and Structure by Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Núria Gironès, Manuel Fresno

“…Trans-sialidases are the most prevalent genes in the genome with a key role in the infection process, while mucins and MASPs are also significant glycosylated proteins expressed on the parasite surface, essential for its biological functions, as host–parasite interaction, host cell invasion or protection against the host immune system, in both insect and mammalian stages. …”
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SCFβ-TrCP targets Ajuba for degradation in a GSK3β-dependent manner in colorectal cancer by Liangshan Li, Feng Zhu, Yupei Liang, Yuanyuan Chen, Yongfu Pan, Lijun Jia, Shiwen Wang, Hu Zhao

“…Ajuba (ajuba LIM protein, JUB) is a member of the Ajuba family, and its oncogenic biological functions in colorectal cancer (CRC) have been extensively reported including proliferation, metastasis and resistance to chemotherapy. …”
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Structural Basis and Mechanism of a Unique Haemophore in the Haem‐Iron Acquisition by Riemerella anatipestifer by Mengying Wang, Dandan Zhang, Xiu Tian, Jiangyang Tong, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Bin Tian, Di Sun, Yu He, Zhen Wu, Songying Ouyang, Mafeng Liu, Anchun Cheng

“…Finally, the homologues of RhuH in Riemerella columbina, Flavobacterium columnare, and Flavobacterium soli are used as a proof of concept, demonstrating that these homologues exhibit conserved structures and functions.…”
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Snhg18 regulates Yap subcellular localization to maintain bone homeostasis by Jie Huang, Yuteng Weng, Yanhuizhi Feng, Di Wu, Yongliang Chen, Zeyuan Li, Xue Jiang, Haicheng Wang, Zuolin Wang

“…Here, we identify small nucleolar RNA host gene 18 (lnc-Snhg18), a functionally conserved lncRNA enriched in the osteolineage of leptin receptor–positive (LepR⁺) cells within bone, as a key regulator promoting osteogenesis. …”
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Autophagy in mycobacterial infections: molecular mechanisms, host-pathogen interactions, and therapeutic opportunities by Jinyan Li, Jinyan Li, Haibo Feng, Haibo Feng, Dechun Chen, Dechun Chen, Huanrong Zhang, Huanrong Zhang, Yi Liao, Yi Liao

“…Consequently, autophagy exhibits a dichotomous role in mycobacterial infection: functioning as a protective mechanism of host while simultaneously serving as a virulence determinant hijacked by bacteria for their survival. …”
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Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO2 and carbon black by Laeticia Perez, Jérôme Ambroise, Bertrand Bearzatto, Antoine Froidure, Charles Pilette, Yousof Yakoub, Mihaly Palmai-Pallag, Caroline Bouzin, Laurence Ryelandt, Cristina Pavan, François Huaux, Dominique Lison

“…Currently, these particles are conservatively considered as possible human carcinogens. …”
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Alternative Splicing of a Novel Inducible Exon Diversifies the CASK Guanylate Kinase Domain by Jill A. Dembowski, Ping An, Maritsa Scoulos-Hanson, Gene Yeo, Joonhee Han, Xiang-Dong Fu, Paula J. Grabowski

“…Alternative pre-mRNA splicing has a major impact on cellular functions and development with the potential to fine-tune cellular localization, posttranslational modification, interaction properties, and expression levels of cognate proteins. …”
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Phage Anti-Pycsar Proteins Efficiently Degrade β-Lactam Antibiotics by Pallav Joshi, Stefan Krco, Samuel J. Davis, Lachlan Asser, Thomas Brück, Rochelle M. Soo, Mikael Bodén, Philip Hugenholtz, Liam A. Wilson, Gerhard Schenk, Marc T. Morris

“…Metallo-β-lactamases (MBLs) are members of the structurally conserved but functionally diverse MBL-fold superfamily of metallohydrolases. …”
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Identification of GSK3 Family Genes in Pear and Their Expression Analysis Under Drought Stress by Kairan Hu, Ziyi Zhang, Guoliang Li, Shuliang Zhao, Yali Zhang, Qingjiang Wang, Fuhou Cheng

“…The findings would provide a scientific foundation for further exploration of the potential functions of the GSK3 genes in pears.…”
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Serine clamp of Clostridium perfringens binary toxin BECb (CPILEb)-pore confers cytotoxicity and enterotoxicity by Toru Yoshida, Chie Monma, Yuki Ninomiya, Sotaro Takiguchi, Shoko Fujita, Yuto Uchida, Noriaki Sakoda, Vladimir A. Karginov, Jun-ichi Kishikawa, Tomohito Yamada, Ryuji Kawano, Hideaki Tsuge

“…These results suggest that BECb functions as a pore-forming toxin and as a translocation channel for BECa.…”
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Sex‐dependent and sex‐independent regulatory systems of size variation in natural populations by Hirokazu Okada, Ryohei Yagi, Vincent Gardeux, Bart Deplancke, Ernst Hafen

“…In contrast, we find that between‐line size variation is largely regulated by genes with a diverse range of cellular functions, most of which have never been implicated in growth. …”
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A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses by Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A. Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang

“…Notably, this cryptic epitope reveals a signature motif that extends throughout the core region of coronaviruses and is also present in various RNA viruses, including HIV and Marburgvirus. 3D1 functions as a natural or background antibody capable of binding to a diverse array of non-self antigens. 3D1’s cross-reactivity underscores the effectiveness of the library approach, which encompasses the entire antibody repertoire.…”
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