Identification of the Plant Defensin (MsPDF) Gene Family in <i>Medicago sativa</i> and Analysis of Expression Patterns Under Abiotic Stress by Meiyan Guo, Xiuhua Chen, Shuaixian Li, Jiang Tian, Wangqi Huang, Yongjun Shu

“…In this study, a total of 11 MsPDF gene family members were identified in the alfalfa genome and classified into three groups. Phylogenetic and conserved motif analyses revealed that the MsPDF genes are highly conserved. …”
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Paddy soil fertility shifts microbial metabolic quotient by regulating the selective enrichment of specific bacterial groups by Yali Kong, Jie Wang, Chunquan Zhu, Wenhao Tian, Lianfeng Zhu, Xiaochuang Cao, Yupei Chen, Xiaoxia Liu, Haimin Kong, Yijun Yu, Gengmiao Zhang, Junhua Zhang

“…The heterogeneous distribution of specific microbial taxa with diverse physiological traits, caused by changes of soil fertility level, controls community-level functions. However, how specific microbial taxa mediate community-level carbon (C) metabolic efficiency across various fertility conditions in paddy soils is limited. …”
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Structures of the human leading strand Polε–PCNA holoenzyme by Qing He, Feng Wang, Nina Y. Yao, Michael E. O’Donnell, Huilin Li

“…We propose that the multi-point interface prevents other PIP-containing factors from recruiting to PCNA while PCNA functions with Polε. Comparison of the two states reveals that the finger domain pivots around the [4Fe-4S] cluster-containing tip of the P-domain to regulate nucleotide exchange and incoming nucleotide binding.…”
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Genome-Wide Identification and Characterization of <i>TaCRY</i> Gene Family and Its Expression in Seed Aging Process of Wheat by Guoqing Cui, Xiuyan Cui, Junjie Wang, Menglin Lei, Xia Liu, Yanzhen Wang, Haigang Wang, Longlong Liu, Zhixin Mu, Xia Xin

“…TaCRYs contain the conserved PHR and CCT domains and diverse gene structures. …”
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Defining the optimal animal model for translational research using gene set enrichment analysis by Christopher Weidner, Matthias Steinfath, Elisa Opitz, Michael Oelgeschläger, Gilbert Schönfelder

“…Abstract The mouse is the main model organism used to study the functions of human genes because most biological processes in the mouse are highly conserved in humans. …”
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Heat shock proteins in hypothermia: a review by Shang-Jin Song, Shang-Jin Song, Guo-Cheng Wu, Li Yi, Li Yi, Xin Liu, Ming-Min Jiang, Xiao-Chen Zhang, Zi-Fei Yin, Wei Gu, Yi Ruan, Yi Ruan

“…In response to thermal stress, cells activate protective mechanisms, often synthesizing heat shock proteins (HSPs). These highly conserved proteins are crucial in cellular stress responses, primarily functioning as chaperones. …”
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Cytotoxic cationic peptides as а ligands for receptor nucleolin by A. A. Lushnikova, A. V. Kostarev, D. A. Ponkratova, A. V. Onyan, E. G. Glubokova, S. M. Andreev

“…Chaperone proteins nucleolin (NCL, or C23) and nucleophosmin (NPM, or B23) regulate key cell functions. The most tumors are characterized by over-expression of these proteins, especially in cell nuclei and on the сell surface, as NCL. …”
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Genome-wide analysis of the SCPL gene family in grape (Vitis vinifera L.) by Xi-cheng WANG, Wei-min WU, Bei-bei ZHOU, Zhuang-wei WANG, Ya-ming QIAN, Bo WANG, Li-chun YAN

“…Although SCPL proteins have been studied in many plants, the biological functions of SCPL genes in grape are still unknown. …”
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Reversible proliferative arrest induced by rapid depletion of RNase MRP by Yuan Liu, Shiyang He, Kawon Pyo, Reuben Franklin, Ibrahim B. Maaz, Chen Cai, Kriti Shah, Sihem Cheloufi, William F. Marzluff, Jernej Murn

“…Severely compromised biogenesis of rRNAs along with acute transcriptional reprogramming precede a gradual decline of the critical cellular functions. Unexpectedly, many arresting cells show increased levels of histone mRNAs, which accumulate locally in the cytoplasm, and S-phase DNA amount. …”
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Crystal Structure of an Aldo-keto Reductase MGG_00097 from Magnaporthe grisea by Xiaofang Huang, Hui Jiang, Yahong Lin, Xiang Li, Chuyun Bi, Shiqian Qi, Dan Tang, Zonghua Wang, Shiqiang Lin

“…A Y56A mutation reveals the open conformation of the cofactor-binding pocket, with Glu29 and Gln226 functioning as hinge residues for the conformational changes upon cofactor binding. …”
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Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma by Jiazhou Ye, Yan Lin, Zhiling Liao, Xing Gao, Cheng Lu, Lu Lu, Julu Huang, Xi Huang, Shilin Huang, Hongping Yu, Tao Bai, Jie Chen, Xiaobo Wang, Mingzhi Xie, Min Luo, Jinyan Zhang, Feixiang Wu, Guobin Wu, Liang Ma, Bangde Xiang, Lequn Li, Yongqiang Li, Xiaoling Luo, Rong Liang

“…Moreover, endothelial cells exhibited phenotypically conserved but executed differential functions in a space-dependent manner. …”
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Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria by Belen Sotomayor, Thomas C. Donahue, Sai Pooja Mahajan, May N. Taw, Sophia W. Hulbert, Erik J. Bidstrup, D. Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A. Alabi, Parastoo Azadi, Jeffrey J. Gray, Michael C. Jewett, Lai-Xi Wang, Matthew P. DeLisa

“…Abstract Human immunoglobulin G (IgG) antibodies are a major class of biotherapeutics and undergo N-linked glycosylation in their Fc domain, which is critical for immune functions and therapeutic activity. Hence, technologies for producing authentically glycosylated IgGs are in high demand. …”
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MicroRNA155 in non-small cell lung cancer: a potential therapeutic target by Xiangju Wei, Xiangju Wei, Xianmin Xiong, Xianmin Xiong, Ze Chen, Bi Chen, Cantang Zhang, Wenhui Zhang

“…This review elucidates the biological functions and roles of miR-155 in NSCLC and discusses its potential significance as a therapeutic target for future research directions and clinical applications.…”
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TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors by Tanja Bhuiyan, Niccolò Arecco, Paulina Karen Mendoza Sanchez, Juhyeong Kim, Carsten Schwan, Sophie Weyrauch, Sheikh Nizamuddin, Andrea Prunotto, Mehmet Tekman, Martin L. Biniossek, Bettina Knapp, Stefanie Koidl, Friedel Drepper, Pitter F. Huesgen, Robert Grosse, Thorsten Hugel, Sebastian J. Arnold

“…The TFIID complex consists of the TATA binding protein (TBP) and 13 TBP-associated factors (TAFs) that contain intrinsically disordered regions (IDRs) with currently unknown functions. Here, we show that a conserved IDR drives TAF2 to nuclear speckle condensates independently of other TFIID subunits. …”
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Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1 by Katrina Warner, Moritz Hunkeler, Kheewoong Baek, Anna Schmoker, Shourya S. Roy Burman, Daan Overwijn, Cyrus Jin, Katherine A. Donovan, Eric S. Fischer

“…Tom1 is one of five HECT ubiquitin E3 ligases in budding yeast S. cerevisiae and is prototypical for a ligase with pleiotropic functions such as ubiquitin chain amplification, orphan quality control, and DNA damage response. …”
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Utopian Projects of Russian History in Modern Historical Fiction by A. M. Lobin

“…The author raises the question of the specifics of modern readership and functions of historical fiction in the public consciousness. …”
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Decoding biomolecular condensate dynamics: an energy landscape approach. by Subhadip Biswas, Davit A Potoyan

“…Understanding how the molecular sequence grammar of LCDs governs condensate dynamics is essential for uncovering their biological functions and the evolutionary forces that shape these sequences. …”
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Annotation-free delineation of prokaryotic homology groups. by Yongze Yin, Huw A Ogilvie, Luay Nakhleh

“…Phylogenomic studies of prokaryotic taxa often assume conserved marker genes are homologous across their length. …”
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Soil microplastic pollution in China: Current insights and future perspective by ZHANG Yan, DOU Ming, HAO Songze, LI Ping, WANG Guohao, ZHOU Yuze, LIANG Zhijie

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Identification and expression characterization of apple β-tubulin gene family in apple by HUANG Huiling, WANG Yanxiang, WANG Yue, NING Qinqin, LI Ming, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, JIAO Jian, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo

“…Gene structure analysis showed that all 13 apple β-tubulin family genes contained 3 exons and 2 introns, and the amino acid sequences contained 10 conserved motifs, indicating that the functions of apple β-tubulin family members were probably highly conserved. …”
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