Genome wide identification and characterization of Bax inhibitor-1 gene family in cucumber (Cucumis sativus) under biotic and abiotic stress by Samia Anwar, Riffat Siddique, Shakeel Ahmad, Muhammad Zeshan Haider, Haider Ali, Adnan Sami, Rosa Sanchez Lucas, Muhammad Shafiq, Bader Un Nisa, Bilal Javed, Jannat Akram, Javaria Tabassum, Muhammad Arshad Javed

“…A study on cucumber identified and characterized five BI-1 genes: CsBI1, CsBI2, CsBI3, CsBI4, and CsBI5. These genes share conserved domains, indicating common evolutionary history and function. …”
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Advances of GADD45b in hepatic glucose and lipid metabolism by WANG Renjie, HUA Hui, ZHU ChaoYu, WEI Li

“…Research has shown that GADD45b is closely associated with signaling pathways such as p38/MAPK and TGFβ/Smad3, and it has functions including improving tissue fibrosis and inflammation progression, inhibiting cell autophagy, and enhancing neural function recovery. …”
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TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…Previous studies implied and/or demonstrated that TAp63α, which contains an N-terminal activation domain conserved in p53, functions as a tumor suppressor by regulating an array of genes for growth suppression. …”
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Cryo-EM structure of an activated GPR4–Gs signaling complex by Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song

“…This study provides a framework for future signaling and functional investigation of psGPCRs.…”
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Specific modes of exercise to improve rotator cuff-related shoulder pain: systematic review and meta-analysis by Dianxuan Wu, Dianxuan Wu, Dianxuan Wu, Zhicheng Wen, Zhicheng Wen, Zhicheng Wen, Haolin Ke, Haolin Ke, Haolin Ke, Jiexin Zhang, Jiexin Zhang, Jiexin Zhang, Shaozi Zhong, Shaozi Zhong, Shaozi Zhong, Jiachen Teng, Jiachen Teng, Jiachen Teng, Lan Xu, Lan Xu, Jintao Li, Jintao Li, Jintao Li, Yan Shao, Yan Shao, Yan Shao, Yan Shao, Chun Zeng, Chun Zeng, Chun Zeng, Chun Zeng

“…It is indicated that: (1) specific exercises led to modest improvements in performance of pain (SMD = −0.31, 95% CI: 0.46 to −0.16, P < 0.0001) and function, with enhancements in CMS (SMD = 0.59, 95% CI: 0.44 to 0.74, P < 0.00001) and DASH (SMD = −0.60, 95% CI: 0.80 to −0.39, P < 0.00001). (2) Interventions lasting less than 2 months were slightly more effective than those lasting 2 months or longer, observed in VAS (SMD = −0.35, 95% CI: 0.56 to −0.15, P = 0.0007), CMS (SMD = 0.71, 95% CI: 0.47 to 0.96, P < 0.00001), and DASH (SMD = −0.71, 95% CI: 0.99 to −0.43, P < 0.00001). (3) Subgroup analyses revealed that handgrip strength exercises enhanced shoulder pain relief, shoulder mobilization/stretching improved both function and pain levels over 2 months, scapular stabilization exercise improved pain and DASH performance over 2 months, eccentric exercises boosted CMS and DASH performance over 2 months, while proprioceptive exercises showed no significant improvement in pain or CMS performance.ConclusionCompared to non-specific exercises, specific exercise programs moderately alleviate RCRSP symptoms, with shorter interventions (<2 months) demonstrating marginally superior outcomes. …”
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PALATE FRACTURE PROFILE IN PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY OF DR. SOETOMO GENERAL ACADEMIC HOSPITAL: JANUARY 2012- DECEMBER 2017 by Priscilla Valentine N., Agus Santoso Budi, Lobredia Zarasade

“…The diagnosis and management of palatal fractures in the midface area is a challenge for a plastic surgeon in restoring function and aesthetics. With the results of this study, it is expected to be a database of maxillofacial fractures treated at SMF Reconstructive Plastic Surgery and Aesthetic Dr. …”
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Transcriptomic and Metabolomic Analysis Reveals Multifaceted Impact of Gcn5 Knockdown in <i>Drosophila</i> Development by Youfeng Li, Yue Xu, Ruike Li, Sirui Huang, Qiong Wu, Jing Yan, Zhigang Jiang, Xiushan Wu, Fang Li, Yuequn Wang, Yongqing Li, Xiongwei Fan, Wuzhou Yuan

“…In <i>Drosophila</i>, Gcn5 is crucial for embryonic development, with maternal Gcn5 supporting early development. However, the functional mechanisms of Gcn5 after the depletion of maternal deposits remain unclear. …”
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Quality of life in early breast cancer patients after adjuvant accelerated partial-breast irradiation (APBI) in randomized trial by Petr Burkon, Iveta Selingerova, Miroslav Vrzal, Milos Holanek, Oldrich Coufal, Katerina Polachova, Vera Andraskova, Sachin R. Jhawar, Pavel Slampa, Tomas Kazda, Marek Slavik

“…Patients in the APBI arm reported more favorable global health status at M6 (p = 0.055). Other functional scales showed a decrease in the WBI arm at M0 (p = 0.027 for physical functioning). …”
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Genome-wide identification, characterization, and expression analysis of the MADS-box gene family in grass pea (Lathyrus sativus) under salt stress conditions by Mohamed Abdelsattar, Ahmed E. Nassar, Khaled H. Mousa, Ahmed Hussein, Manal M. S. El-Baghdady, Khaled H. Radwan, Manar S. Ibrahim, Achraf El Allali, Aladdin Hamwieh, Alsamman M. Alsamman, Zakaria Kehel

“…The grass pea (Lathyrus sativus), a crop grown predominantly in arid and semi-arid regions, could benefit greatly from the functions of MADS-box genes, which are not yet well characterized in this promising plant. …”
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T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome by Yan Zhao, Hanshuo Zhu, Jinqian Li, Hang Xu, Li Sun

“…Together these results revealed the function and molecular mechanism of EseB to induce host cell pyroptosis and suggested a highly conserved inflammasome-activation mechanism of T3SS translocon in bacterial pathogens.…”
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Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization by Yu Zhao, Yueqing Zhou, Weipan Zhang, Mingzhe Liu, Jun Duan, Xiaopeng Zhang, Qiwang Ma, Yujia Wang, Yuzhen Zhang, Zhongliang Guo, Ting Zhang, Wei Zuo

“…Mechanistically, the engrafted human progenitor cells do not function by differentiating into mature alveolar cells in mouse lung; instead, they differentiate into saccular cells expressing multiple tight junction proteins such as CLDN4, which help the lung to re-establish epithelial barriers. …”
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EXPLORING THE EFFECT OF CLIMATE CHANGE VIA PARITY-BASED PULSED TIMES OF COSINUSOIDAL WAVES IN SUSTAINABLY CONTROLLED MARINE BIOSYSTEMS by Ilias Elmouki, Amine Hamdache, Imane Abouelkheir, Fadwa El Kihal, Kanza Chouayakh, Abdelilah Jraifi, Aziz Darouichi

“…Since it does not also seem that obvious to introduce the disruptions that may be caused by the climate change in such well-known and practical types of models, this work introduces the effect of such phenomena through bang-bang climate waves that we believe could be described using a periodic function like the cosine of πt with t the time variable and that takes the values of either 1 when the pulsed t of climate induced stability is an even number promoting the increase of the vegetation or -1 when the pulsed t of climate change is an odd number leading to the extinction of that biomass. …”
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Anti-RNA virus crRNA targets efficient screening platform based on bioinformatics and CRISPR detection by Mengwei Niu, Zhuofan Dong, Lifang Yu, Xue Dong, Jing An, Yao Han, Yujie Yan, Wenyanbo Yi, Yansong Sun, Hao Li

“…We successfully designed and screened effective crRNA targeting SARS-CoV-2 conserved N gene regions and demonstrated its inhibition function in HEK 293T cells. …”
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Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling by Chongzhao You, Shimeng Guo, Tianwei Zhang, Xinheng He, Tianyu Gao, Wenwen Xin, Zining Zhu, Yujie Lu, Youwei Xu, Zhen Li, Yumu Zhang, Xi Cheng, Yi Jiang, Xin Xie, H. Eric Xu

“…Abstract Maintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. …”
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A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility by Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong

“…Importantly, the phase separation property is required for the function of SR30 in disease susceptibility and the regulation of genes AS. …”
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Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment by Luana Alexandrescu, Ionut Eduard Iordache, Alina Mihaela Stanigut, Laura Maria Condur, Doina Ecaterina Tofolean, Razvan Catalin Popescu, Andreea Nelson Twakor, Eugen Dumitru, Andrei Dumitru, Cristina Tocia, Alexandra Herlo, Ionut Tiberiu Tofolean

“…<b>Objectives:</b> This review looks at the many local and systemic factors that contribute to the pathogenesis of the causative, including dietary habits, genetic factors, colon function and absorption, social and economic factors, lifestyle, and biological and drug factors. …”
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Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing by Madeline M Keenen, Liheng Yang, Huan Liang, Veronica J Farmer, Rizban E Worota, Rohit Singh, Amy S Gladfelter, Carolyn B Coyne

“…These findings establish TOs as a robust platform to model STB differentiation and nuclear heterogeneity, providing insight into the regulatory networks that shape placental development and function.…”
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Aurora kinase as a putative target to tick control by Bruno Moraes, Helga Gomes, Luiz Saramago, Valdir Braz, Luís Fernando Parizi, Gloria Braz, Itabajara da Silva Vaz, Carlos Logullo, Jorge Moraes, Ala Tabor

“…Based on deduced amino acid sequences, it was possible to identify non-conserved threonine residues which are essential to AURK functions in vertebrates and which are not present in R. microplus sequences. …”
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Acute Myocardial Infarction Due to Spontaneous Coronary Dissection in Pregnancy: A Case Report and Management Considerations by Hrebenyk M, Komorovsky R, Zhehestovska D, Oryshchyn L, Kotsyuba O, Zelenenka L

“…Follow-up evaluation one year post-intervention showed overall improvement, with only minor residual sequelae, including mildly reduced left ventricular function and subtle electrocardiographic changes. This case underscores the complexities of diagnosing and managing SCAD-related AMI in pregnancy, emphasizing the need for individualized treatment strategies that balance maternal cardiovascular risks with fetal safety. …”
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Cytotoxicity to cells revealed the virulence-associated protein E gene as a potential virulence factor in methicillin-resistant Staphylococcus aureus by Dengyuan Li, Yu Shi, Ning Zou, Tingting Yang, Wenpeng Gu, Feng Liao

“…The aim of this study was to explore the structure and function of the virE gene of MRSA, and to provide a basis for subsequent in-depth study of this gene. …”
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