Modular Combinatorial DNA Assembly of Group B Streptococcus Capsular Polysaccharide Biosynthesis Pathways to Expediate the Production of Novel Glycoconjugate Vaccines by Mark A. Harrison, Elizabeth Atkins, Alexandra Faulds-Pain, John T. Heap, Brendan W. Wren, Ian J. Passmore

“…We show that transferase genes with homologous function can be used interchangeably between pathways, obviating the need to clone a complete locus for each new CPS assembly. …”
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Induced variation in BRASSINOSTEROID INSENSITIVE 1 (BRI1) confers a compact wheat architecture by Manpartik S. Gill, Andrew L. Phillips, Danuše Tarkowská, John Addy, Patrycja Sokolowska, M. John Foulkes, Stephen Pearce, Stephen G. Thomas, Peter Hedden

“…Conclusion Our study gives a better understanding of BRI1 function in wheat and provides mutants that could potentially be explored for improving grain yields when sown at high density.…”
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Arginyltransferase1 drives a mitochondria-dependent program to induce cell death by Akhilesh Kumar, Corin R. O’Shea, Vikas K. Yadav, Ganapathi Kandasamy, Balaji T. Moorthy, Evan A. Ambrose, Aliya Mulati, Flavia Fontanesi, Fangliang Zhang

“…However, studies of Ate1 were conventionally focused on its function in inducing protein degradation via the N-end rule pathway in the cytosol, leading to an incomplete understanding of the role of Ate1 in cell death. …”
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B by Katherine Bronson, Jewel Banik, Juchan Lim, Milla M. Reddick, Linda Hardy, Gwen V. Childs, Melanie C. MacNicol, Angus M. MacNicol

“…Abstract The Musashi family of sequence-specific RNA binding proteins (Musashi1 and Musashi2) serve a critical role in mediating both physiological and pathological stem cell function in many tissue types by repressing the translation of target mRNAs that encode proteins that promote cell cycle inhibition and cell differentiation. …”
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Comprehensive Identification of <i>HD-Zip</i> Family Genes in <i>Coix lacryma-jobi</i> L. and Their Potential Roles in Response to Abiotic Stress by Yongle Wang, Hongjuan Wang, Xianyong Lu, Chun Yu, Benli Jiang, Jiabao Zhu, Yujiao Wang

“…In summary, these results laid a foundation for further research on the resistance function of the Coix <i>HD-Zip</i> gene.…”
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Chloroplast genome features and intraspecific variation of Rosa praelucens by WANG Qigang1, CAO Shirui1,2, WANG Huichun1, MA Changle2, YAN Huijun1, QIU Xianqin1, JING Weikun1, JIAN Hongying1*

“…The genomes encoded 132 function genes, mainly related with photosynthesis and self-replication. …”
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Pilot investigation of the rhizosphere microbial communities and metabolism of two cultivars of Polygonatum cyrtonema Hua by Fang Liu, Wenlong Dong, Yi An, Hongyu Qian, Chunlin Gui, Chunlin Gui, Yunjian Xu

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Comorbidity of esophageal achalasia, mixed anxiety and depressive reaction in a young female patient: problems of diagnosis and treatment by N.. P. Garganeeva, M. F. Belokrylova, A. K. Kostin, A. P. Koshel, E. M. Epanchintseva, V. F. Lebedeva, M. M. Aksenov, O. E. Perchatkina, I. G. Kartashova, V. A. Rudnitsky, Yu. N. Gorbatsevich, E. V. Tsybulskaya, V. A. Alekseev

“…Achalasia cardia (“cardiospasm”, “phrenospasm”, “dolichoesophagus”, “megaesophagus”, “stenosis of cardia”) represents a primary impairment of esophageal motor function associated with impaired lower esophageal sphincter relaxation and peristalsis defects of the thoracic esophagus. …”
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Unveiling the evolution of antimicrobial peptides in gut microbes via foundation-model-powered framework by Wenhui Li, Baicheng Huang, Menghao Guo, Zihan Zeng, Tao Cai, Linqing Feng, Xinpeng Zhang, Ling Guo, Xianyue Jiang, Yanbin Yin, Ercheng Wang, Xingxu Huang, Jinfang Zheng

“…Protein language models (PLMs) have advanced protein structure and function predictions, facilitating AMP discovery. We developed antimicrobial peptide structural evolution miner (AMP-SEMiner), an AI-driven framework that integrates PLMs, structural clustering, and evolutionary analysis to systematically identify AMPs encoded by small open reading frames and AMP-containing proteins in metagenome-assembled genomes. …”
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A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula by Nicolás Vidal-Vázquez, Ismael Hernández-Núñez, Pablo Carballo-Pacoret, Sarah Salisbury, Paula R. Villamayor, Francisca Hervas-Sotomayor, Xuefei Yuan, Francesco Lamanna, Céline Schneider, Julia Schmidt, Sylvie Mazan, Henrik Kaessmann, Fátima Adrio, Diego Robledo, Antón Barreiro-Iglesias, Eva Candal

“…Abstract The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. …”
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EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation by Cai‐hong Chen, Yang Chen, Yi‐nan Li, Heng Zhang, Xiu Huang, Ying‐ying Li, Zhi‐yang Li, Jing‐xia Han, Xin‐ying Wu, Hui‐juan Liu, Tao Sun

“…Abstract The mechanism and function of the expression of Schwann characteristics by nevus cells in the mature zone of the dermis are unknown. …”
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Effectiveness of the GAEC standard of cross compliance retain terraces on soil erosion control by Paolo Bazzoffi, Lorenzo Gardin

“…Thus, they continue to exert a valuable environmental function in terms of production of public goods and services; in particular, in the decrease of hydrogeological risk.…”
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Cervical spinal cord injury following osteophyte excision for respiratory distress caused by diffuse idiopathic skeletal hyperostosis associated with ossification of posterior long... by Keisuke Masuda, Hideki Shigematsu, Akinori Okuda, Sachiko Kawasaki, Yusuke Yamamoto, Takahiro Mui, Yasuhito Tanaka

“…Dysphagia caused by cervical DISH is initially treated conservatively, but surgical treatment is performed when conservative treatment is ineffective. …”
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Genome-wide identification of the H3K27ac signals reveals key thermogenic cis-regulatory elements of brown adipose tissues in Oryctolagus cuniculus by Kun Du, Qian Wu, Yu-Xuan Gan, Xin-Yue Tang, Jia-Xin Zan, Wen-Qiang Sun, Gang Luo, Xi-Wen Chen, Dai-Hua Wang

“…However, the epigenetic mechanisms underlying BAT function remain poorly understood. In this study, we performed genome-wide profiling of H3K27ac signals in BAT and white adipose tissue (WAT) of rabbits. …”
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Analysis of the CRK expressions in bottle gourd (Lagenaria siceraria) under Fusarium oxysporum f. sp. lagenariae stress by using genome-wide identification strategy by Preetinanda Sahoo, Ikram Ullah, Debarpita Sahoo, Chirasmita Bose, Muhammad Amir Zia, Sumaira Salahuddin Lodhi, Mahmoud F. Seleiman, Nawab Ali, Gagan Kumar, Suhail Asad, Satyabrata Nanda

“…Abstract Background The cysteine-rich receptor-like kinases (CRKs) family in plants have been reported to perform multiple functions against various stresses. However, the CRK family in bottle gourd (Lagenaria siceraria) has not been well-explored. …”
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Comparison of 2 mm single locking miniplates versus 2 mm two non-locking miniplates in symphysis and parasymphysis fracture of mandible by Arpit Vashistha, Manpreet Singh, Manoj Chaudhary, Nimish Agarwal, Gagandeep Kaur

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A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. by Jinglan Zhang, Véronik Lachance, Adam Schaffner, Xianting Li, Anastasia Fedick, Lauren E Kaye, Jun Liao, Jill Rosenfeld, Naomi Yachelevich, Mary-Lynn Chu, Wendy G Mitchell, Richard G Boles, Ellen Moran, Mari Tokita, Elizabeth Gorman, Kaytee Bagley, Wei Zhang, Fan Xia, Magalie Leduc, Yaping Yang, Christine Eng, Lee-Jun Wong, Raphael Schiffmann, George A Diaz, Ruth Kornreich, Ryan Thummel, Melissa Wasserstein, Zhenyu Yue, Lisa Edelmann

“…Our data shows that the C846G mutation causes aberrant ubiquitination and accelerated turnover of VPS11 protein as well as compromised VPS11-VPS18 complex assembly, suggesting a loss of function in the mutant protein. Reduced VPS11 expression leads to an impaired autophagic activity in human cells. …”
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Drugs of abuse drive neurotransmitter plasticity that alters behavior: implications for mental health by Marta Pratelli, Marta Pratelli, Nicholas C. Spitzer, Nicholas C. Spitzer

“…The ability of neurons to express multiple transmitters and/or switch them in response to environmental stimuli likely evolved to provide flexibility and complexity to neuronal circuit function in an ever-changing environment. However, this adaptability can become maladaptive when generating behavioral alterations that are unfit for the environment in which the animal lives or the tasks it needs to perform. …”
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Arabidopsis Calcium Dependent Protein Kinase 3, and Its Orthologues OsCPK1, OsCPK15, and AcCPK16, Are Involved in Biotic and Abiotic Stresses by Gardette R. Valmonte-Cortes, Colleen M. Higgins, Robin M. MacDiarmid

“…These findings highlight the importance of <i>AtCPK3</i> and its orthologues in drought and pathogen responses and suggest such function must be conserved in its orthologues in a wide range of plants.…”
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Identification and Characterization of Flavonoid Biosynthetic Gene Families in <i>Paeonia</i> Species and Their Roles in Stamen Petalization of <i>Paeonia lactiflora</i> by Yanyi Zheng, Yongming Fan, Xiang Ji, Xiaopei Wu

“…Molecular docking identified <i>PlaF3’H07</i> as a key enzyme with strong substrate-binding affinity (ΔG = −4.7 kcal/mol), supporting its catalytic function in quercetin synthesis. The expression pattern of key flavonoid biosynthetic genes was also confirmed across three developmental stages of floral buds by real-time quantitative PCR. …”
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