Genome-wide identification and gene expression pattern analysis of the carotenoid cleavage oxygenase gene family in Fagopyrum tataricum by Huan Li, Xin Yao, Ailing He, Guoxing Xue, Haizhu Yang, Yu Fan, Sanwei Yang, Jingjun Ruan

“…Results We identified the FtCCO gene family based on Tartary buckwheat genomic data and analyzed the biological function of the FtCCO genes using bioinformatics methods and the expression pattern of the gene using fluorescence quantitative PCR. …”
Get full text

Evolution analysis of GH3 gene family in five Rosaceae species and FaGH3.17, FaGH3.18 improve drought tolerance in transgenic Arabidopsis by Lili Guo, Shixiong Lu, Huimin Gou, Jiaxuan Ren, Juanbo Yang, Baozhen Zeng, Juan Mao, Baihong Chen

“…However, the evolutionary analysis of the GH3 gene family in Rosaceae species has not been well-studied and the specifc functions of Fragaria ananassa are not well-documented. …”
Get full text

Pancreatico-cutaneous fistula following complicated perforated peptic duodenal ulcer repair by Richard Adams, DO, Mena Louis, DO, Nathaniel Grabill, MD, Jasmine Lake, BS, Timothy Stevens, MD, Nelson Royall, MD

“…Nutritional support, including pancreatic enzyme replacement therapy, may be necessary for patients with impaired pancreatic function to aid in digestion and reduce pancreatic strain. …”
Get full text

Structural analysis of an Asterias rubens peptide indicates the presence of a disulfide‐directed β‐hairpin fold by Rozita Takjoo, David T. Wilson, Justine Le Quilliec, Casey A. Schmidt, Guangzu Zhao, Michael J. Liddell, Naeem Y. Shaikh, Kartik Sunagar, Alex Loukas, Michael J. Smout, Norelle L. Daly

“…However, the three‐dimensional structure and function of several of these injury‐responsive peptides, including the peptide KASH2, are yet to be investigated. …”
Get full text

Effect of calcium hydroxide and adipose-derived stem cell conditioned medium (ADSCs-CM) combination on reparative dentin formation in Wistar rats through RUNX-2 and OPN expression by Radixtio Auzan Fepiosandi, Dian Agustin Wahjuningrum, Galih Sampoerno, Anuj Bhardwaj, Ajinkya M. Pawar

Get full text

Evaluation of the marginal fit and fracture resistance of interim restorations fabricated using different techniques: an in vitro study by Mostafa Elashkar, Yehia Aboushady, Merna Ihab, Mohamed T. El Halawani

Get full text

Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena by Jyoti Garg, Alejandro Saettone, Syed Nabeel-Shah, Steven Dang, Abdul Hadi Khalid, Jérémy Loehr, Alexandra Petrova, James D. Burns, Peter Karabatsos, Sherin Shibin, Suzanne Wahab, Sean D. Taverna, Jack F. Greenblatt, Jean-Philippe Lambert, Jeffrey Fillingham

“…While the H2A.Z-related functions of INO80 and SWR1 are well characterized in budding yeast and metazoans, much less is known about their composition and chromatin-targeting mechanisms outside of the Opisthokonts. …”
Get full text

Screening and identification of host factors interacting with the nucleocapsid protein of SARS-CoV-2 omicron variant using the yeast two-hybrid system by Chunhua Wang, Tingyu Yu, Moyue Xie, Dongang Zhan, Shuaijie Zhang, Wenqi Chai, Jianzhong Zhao, Lijuan Yin, Yang Yang, Liang Shen, Ying Xia

“…Results To further investigate the functions of SARS-CoV-2 N protein, the Matchmaker Gold Yeast Two-Hybrid System was used to identify potential interacting partners of the N protein in human peripheral blood mononuclear cells (PBMCs). …”
Get full text

Evaluation of the impact of ecological factors on the habitat suitability and bioactive components accumulation of the medicinal holoparasitic plant Cynomorium songaricum using mac... by Jiacheng Ji, Jiacheng Ji, Xinxin Wei, Xinxin Wei, Huan Guan, Huan Guan, Zikang Jin, Zikang Jin, Xin Yue, Zhuoran Jiang, Youla Su, Youla Su, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…BIO6 served as a key shared positive regulator for catechin and total phenolics, while functioning as a key negative regulator for ursolic acid. …”
Get full text

Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask by Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee

“…Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway. …”
Get full text

POSITIVE INTERACTION IN AN INCLUSIVE EDUCATION: MANIFESTATION OF THE INTERNATIONAL CHILD DEVELOPMENT PROGRAMME (ICDP) by Farid Alamdar oglu Suleymanov

“…Fundamental caregiving skills function as particularly important contribution to the quality and effectiveness all caregiving. …”
Get full text

BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. by Yulong Liang, Hong Gao, Shiaw-Yih Lin, Guang Peng, Xingxu Huang, Pumin Zhang, John A Goss, Francis C Brunicardi, Asha S Multani, Sandy Chang, Kaiyi Li

“…Recent in vitro studies suggest that BRIT1/MCPH1 functions as a novel key regulator in the DNA damage response pathways. …”
Get full text

Identification and analysis of heat shock transcription factor gene in Zizania latifolia by CAI Licong, TANG Mingjia, XU Jin, QI Zhenyu, FAN Feijun, ZHOU Yanhong

“…To explore the function and potential applications of heat shock transcription factor (HSF) gene family on heat tolerance of Zizania latifolia of ‘Longjiao No. 2’, twenty-eight HSF proteins were identified and analyzed by bioinformatics methods. …”
Get full text

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo. by Jiangtao Ma, Margaret R Duffy, Lin Deng, Rachel S Dakin, Taco Uil, Jerome Custers, Sharon M Kelly, John H McVey, Stuart A Nicklin, Andrew H Baker

“…Furthermore, through this gain-of-function approach we demonstrate the dual functionality of FX in protecting Ad26.HVR5C against innate immune factors whilst determining liver targeting.…”
Get full text

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. by Anju Singh, Vikas Misra, Rajesh K Thimmulappa, Hannah Lee, Stephen Ames, Mohammad O Hoque, James G Herman, Stephen B Baylin, David Sidransky, Edward Gabrielson, Malcolm V Brock, Shyam Biswal

“…<h4>Methods and findings</h4>Here we report a systematic analysis of the KEAP1 genomic locus in lung cancer patients and cell lines that revealed deletion, insertion, and missense mutations in functionally important domains of KEAP1 and a very high percentage of loss of heterozygosity at 19p13.2, suggesting that biallelic inactivation of KEAP1 in lung cancer is a common event. …”
Get full text

A Narrative Review and Clinical Study on Er:YAG Laser Debonding of Ceramic and Composite Veneers by Jose Villalobos-Tinoco, Fabio Andretti, Clint Conner, Silvia Rojas-Rueda, Nicholas G. Fischer, Margiezel Pagan-Banchs, Carlos A. Jurado

“…In the case study, after a 3-year follow-up, the restorations exhibited optimal function and esthetics. Conclusions: Laser-assisted debonding provides a safe and predictable method for replacing failing composite veneers with ceramic alternatives, aligning with contemporary biomimetic principles.…”
Get full text

Chlorophyll-binding protein AtSep2 overexpression causes leaf yellowing and enhances tolerance to high light stress in poplar by Donghui Chao, Xiaoou Zhai, Lulu Ren, Shan Fu, Jin Zhang, Shuang Feng, Haizhen Zhang, Aimin Zhou

“…Poplar is a tree species used in urban greening, and colored leaf poplar is in great demand because of its higher ornamental value and function. In this study, we generated a golden leaf 84 K poplar (Populus alba × Populus glandulosa) by overexpressing the AtSep2 (stress-enhanced protein) gene from Arabidopsis. …”
Get full text

Plastid-localized ZmENR1/ZmHAD1 complex ensures maize pollen and anther development through regulating lipid and ROS metabolism by Shaowei Zhang, Xueli An, Yilin Jiang, Quancan Hou, Bin Ma, Qingping Jiang, Kai Zhang, Lina Zhao, Xiangyuan Wan

“…Many lipid-metabolic genic male-sterility (GMS) genes function in the anther tapetal endoplasmic reticulum, while little is known about GMS genes involved in de novo fatty acid biosynthesis in the anther tapetal plastid. …”
Get full text

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks by Christopher D. Todd, Jannat Ijaz, Fereshteh Torabi, Oleksandr Dovgusha, Stephen Bevan, Olivia Cracknell, Tim Lohoff, Stephen Clark, Ricard Argelaguet, Juliette Pierce, Ioannis Kafetzopoulos, Alice Santambrogio, Jennifer Nichols, Ferdinand von Meyenn, Ufuk Günesdogan, Stefan Schoenfelder, Wolf Reik

“…Moreover, we outline a generalizable strategy to use naturally occurring human genetic variation to delineate important sequence determinants of primed enhancer function. Conclusions Our findings identify an evolutionarily conserved program of enhancer priming and begin to dissect the temporal dynamics and mechanisms of its establishment and maintenance during early mammalian development.…”
Get full text

Role of high-dose interleukin-2 for melanoma in the age of cellular therapy by Mario Sznol, Elizabeth Buchbinder, Rodabe Amaria, Amod Sarnaik, David F McDermott, Michael B Atkins, Ann W Silk, Kim A Margolin, Michael T Lotze, Zeynep Eroglu, Virginia Seery, Allison Betof Warner, Harriet M Kluger, Karam Khaddour

“…However, its potential for life-threatening side effects and requirement for inpatient administration limits its use to patients with excellent organ function treated at experienced centers. In 2024, following decades of foundational work at the National Cancer Institute, lifileucel became the first FDA-approved tumor-infiltrating lymphocyte (TIL) therapy for cancer. …”
Get full text