Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells by Katarzyna Gaweda-Walerych, Vanessa Aragona, Simona Lodato, Emilia J. Sitek, Ewa Narożańska, Emanuele Buratti

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CLC gene family in Solanum lycopersicum: genome-wide identification, expression, and evolutionary analysis of tomato in response to salinity and Cd stress by Jun Ma, Shan Li, Shah Zaman, Ali Anwar

“…Whereas their genomic wide indentification and functional divergence in tomato (Solanum lycopersicum) remain largely unexplored.Methods and resultsIn this study, we identified nine CLC genes in the tomato genome, classifying them into two evolutionarily distinct clades (Group I and II) based on phylogenetic analysis. …”
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Elucidating the role of brassinosteroid signaling genes and their promoters in Arabidopsis revealed regulatory mechanisms in plant development and responses to different abiotic st... by Sunny Ahmar, Muhammad Sohaib Shafique, Marcin Rapacz, Ewa Pociecha

“…Although the BR signaling pathway is well-characterized in the dicot model species Arabidopsis (Arabidopsis thaliana), our knowledge of this pathway at the transcriptional level remains limited and requires further investigation. Moreover, the functional roles of several other conserved genes involved in the BR signaling pathway in Arabidopsis are not yet fully understood. …”
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A wheat gene TaSAP17-D encoding an AN1/AN1 zinc finger protein improves salt stress tolerance in transgenic Arabidopsis by Qiao-fang XU, Xin-guo MAO, Yi-xue WANG, Jing-yi WANG, Ya-jun XI, Rui-lian JING

“…The stress-associated protein (SAP) multigene family is conserved in both animals and plants. Its function in some animals and plants are known, but it is yet to be deciphered in wheat (Triticum aestivum L.). …”
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110 Computational methods to monitor treatment response and toxicity in immune-checkpoint-inhibitor treated metastatic melanoma using methylated cell-free DNA by Arthur McDeed, Siddarth Jain, Amber Alley, Harry Sun, Megan McNamara, Jaeil Ahn, Anton Wellstein

“…Results/Anticipated Results: We demonstrated improved precision in DMR detection evidenced by a higher area under the receiver operator characteristic curve (AUROC) of 0.85 on average. Pathway and functional annotation analysis revealed melanocyte-specific methylation marker regions regulated genes related to melanocyte development and differentiation, including MITF, SOX9/10, and FOXD3. …”
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Extracellular proteome of Trichoderma harzianum to identify proteins with biotechnological value by Ambrosino P, Scala V, Marra R, Vinale F, Soriente I, Ferraioli S, Carbone V, Ruocco M, Woo S L, Lorito M

“…Proteome technology has greatly enhanced our ability to conduct functional genomics studies. Nevertheless only a few studies have been published so far on the fungal extracellular proteome. …”
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Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. by Marco Cassano, Stefano Biressi, Amanda Finan, Laura Benedetti, Claudia Omes, Renata Boratto, Frank Martin, Marcello Allegretti, Vania Broccoli, Gabriella Cusella De Angelis, Paolo M Comoglio, Cristina Basilico, Yvan Torrente, Paolo Michieli, Giulio Cossu, Maurilio Sampaolesi

“…Crossing of Magic-F1 transgenic mice with alpha-sarcoglycan knock-out mice -a mouse model of muscular dystrophy- or adenovirus-mediated Magic-F1 gene delivery resulted in amelioration of the dystrophic phenotype as measured by both anatomical/histological analysis and functional tests.<h4>Conclusions/significance</h4>Because of these features Magic-F1 represents a novel molecular tool to counteract muscle wasting in major muscular diseases such as cachexia or muscular dystrophy.…”
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Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. by Mônica Colombini, Anderson M Rocha, Luciana A Freitas-de-Sousa, Alison F A Chaves, Solange M T Serrano, Vinicius C Souza, Vincent L Viala, Inácio L M Junqueira-Azevedo, Felipe A Cerni, Marco A Sartim, Jacqueline A G Sachett, Wuelton M Monteiro, Felipe G Grazziotin, Fan Hui Wen, Manuela B Pucca, Ana M Moura-da-Silva

“…The structure of Crotoxin chains was well conserved compared to C. d. terrificus Crotoxin. However, the SVMP sequences exhibited multiple substitutions in functional and immunoreactive regions compared to Bothropasin, resulting in low hemorrhagic activity and limited reactivity/neutralization by the Bothrops antivenom. …”
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Characterization of microRNA candidates at the primary site of infectious bronchitis virus infection: A comparative study of in vitro and in vivo avian models. by Kelsey O'Dowd, Safieh Vatandour, Sadhiya S Ahamed, Martine Boulianne, Charles M Dozois, Carl A Gagnon, Neda Barjesteh, Mohamed Faizal Abdul-Careem

“…We identified several candidate microRNAs suitable for future functional studies, such as gga-miR-155, gga-miR-1388a, gga-miR-7/7b and gga-miR-21-5p. …”
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Cloning of nucleobindin-2/Nesfatin-1 gene and its differential expression in diencephalon and hepatopancreas of Chinese sucker (Myxocyprinus asiaticus) by SU Shiping, LI Qingqing, XIE Qiming, LIU Fan, ZHANG Jun, LI Xilei

“…Two propeptide cleavage sites were in NUCB2 peptide region, lysine (Lys) 106-arginine (Arg) 107 and Lys179-Arg180, then three functional peptides of Nesfatin-1, Nesfatin-2, and Nesfatin-3 were divided according to the two cleavage sites. …”
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CLINICAL PROFILES OF FROSTBITE IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL: A CASE SERIES by Thomas Eduardus Sudrajat Wahyu Nugroho, Beta Subakti Nata’atmadja

“…Conclusions: Long-term follow-up management is necessary to achieve a good functional outcome. Preservation and if necessary reconstruction of the finger should become a priority in the patient management.…”
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Aurora kinase-a expression heterogeneity and potential benefit of combination therapy in prostate adenocarcinoma by Ru Chen, Qianyi Qiu, Weiting Xie, Jun Lin, Rong Liu, Jianhui Chen, Shaoxing Zhu, Yiming Su

“…We then used single-cell RNA sequencing to resolve the functional heterogeneity of AURKA in the PRAD epithelial cell subpopulation and verified its impact on the malignant phenotype of desmoplasia-resistant prostate cancer cells in in vitro experiments. …”
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Exploring genetic diversity and genomic insights of Bacillus subtilis isolates from cassava rhizosphere using molecular barcoding and whole genome sequencing by Supajit Sraphet, Bagher Javadi

“…Genome annotation identified 3,575 proteins with functional assignments, including 1,055 enzymes classified by Enzyme Commission numbers. …”
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Assessment of Personalized Exercise Prescriptions Issued by ChatGPT 4.0 and Intelligent Health Promotion Systems for Patients with Hypertension Comorbidities Based on the Transtheo... by Xu Y, Liu Q, Pang J, Zeng C, Ma X, Li P, Ma L, Huang J, Xie H

“…However, when patients exhibited certain functional movement disorders, GPT’s exercise prescriptions involved higher health risks, whereas the more conservative approach of IHPS was advantageous.Conclusion: The path of generating exercise prescriptions using artificial intelligence, whether via ChatGPT or IHPS, cannot achieve a completely satisfactory state.But can serve as a supplementary tool for professionals issuing exercise prescriptions to patients with hypertension comorbidities, especially in alleviating the financial burden of consulting costs. …”
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Experimental Study on Foam Stability in Tailwater Discharge from Coastal Power Plants in Marine Environments by Da Liu, Hui Lin, Xiangju Cheng, Lubin Sun, Lei Guo, Changhong Hong

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Differentiated Approach to the Surgical Treatment of Chronic Uveitis in Juvenile Idiopathic Arthritis by A. V. Tereshchenko, I. G. Trifanenkova, M. S. Tereshchenkova, E. V. Erokhina, N. N. Yudina

“…Visual acuity after the surgery varied from 0.2 to 0.5.Conclusion. High functional results in children with uveitis associated with JIA were achieved due to modern methods of preoperative diagnosis, advanced surgical techniques, as well as proper management of the patients in the postoperative period.…”
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The pneumococcal bacteriocin streptococcin B is produced as part of the early competence cascade and promotes intraspecies competition by J. D. Richardson, Emily Guo, Ryan M. Wyllie, Paul Jensen, Suzanne Dawid

“…In this work, we demonstrate that three-fourths of S. pneumoniae strains contain a highly conserved scb locus that encodes an active lactococcin 972-like bacteriocin called streptococcin B. …”
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Increase in Strength After Multimodal Pain Management Concept in Patients with Cervical Radiculopathy—A Non-Randomized, Uncontrolled Clinical Trial by Gerd Zirkl, Jens Schaumburger, Matthias Gehentges, Moritz Kaiser

“…The increase in cervical muscle strength is closely associated with pain relief and improved functional outcomes, highlighting the value of conservative pain management strategies for these patients.…”
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Seasonal Variations and Structure-Specific Phytochemical Profiles of <i>Glochidion chodoense</i> by Nari Yoon, Jajung Ku, Yang-Ho Kang, Sanghyun Lee

“…These findings provide valuable insights into the phytochemical composition of <i>G. chodoense</i>, emphasizing its potential applications in pharmaceuticals, cosmetics, and functional foods, while highlighting the critical importance of conserving this endangered species.…”
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Immune counter-evolution: immortalized B cell clones can undergo ex vivo directed evolution to counteract viral escape by Casper Marsman, Jurgen Heinen, Vanessa Clerico Mosina, Kelly Maijoor, Arjen Q. Bakker, Michael Koslowski, Alessandra Villa, Stefano Gullà

“…Through high-throughput functional screening of approximately 40,000 B cells per library, we identified 12 unique clones with neutralization activity for SARS-CoV-2, leading to selection of monoclonal antibodies with robust neutralization activity against Delta and BA.5 variants. …”
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