A Novel ABCA12 Mutation in Two Families with Congenital Ichthyosis by D. M. Walsh, S. H. Shah, M. A. Simpson, N. V. Morgan, S. Khaliq, R. C. Trembath, S. Q. Mehdi, E. R. Maher

“…Comparison to previously reported cases was consistent with the hypothesis that severe loss of function ABCA12 mutations are associated with Harlequin Ichthyosis and missense mutations are preferentially associated with milder phenotypes. …”
Get full text

Promising therapeutic role of miR-27b in tumor by Li Ding, Jie Ni, Fan Yang, Lingli Huang, Heng Deng, Yang Wu, Xuansheng Ding, Jinhai Tang

“…As a frequently dysregulated microRNA in human cancers, microRNA-27b could function as a tumor suppressor or an oncogenic microRNA. …”
Get full text

Six new bacterial species isolated from the phycosphere of marine macroalgae: a joint analysis based on taxonomy and polysaccharide utilization loci by De-Chen Lu, De-Chen Lu, Ying Yuan, Xin-Yun Tan, Le Liu, Jin-Hao Teng, Xue Cui, Tian-He Liu, Tian-He Liu, Jing Zhang, Zong-Jun Du, Zong-Jun Du, Ming-Yi Wang

“…Marine macroalgae-associated Bacteroidota play crucial roles in global carbon cycling through polysaccharide degradation, yet their taxonomic and functional diversity remains understudied. Here, we describe six novel species (strains 3-376T, 4-2040T, 2-473AT, 4-528T, 4-911T and 463T) within the families Flavobacteriaceae, Crocinitomicaceae, and Cytophagaceae isolated from macroalgal surfaces in the coastal area of Weihai, China. …”
Get full text

Effect of minimally invasive posterior veneer Preparation designs on failure load and mode after fatigue (in-vitro study) by Islam Mohamed Mady, Ahmed Safwat El Kady, Moustafa Nabil Aboushelib, Mohamed Hussein A. Hussein

“…Abstract Background Ceramic veneers are a common option for enhancing dental aesthetics by improving tooth form, shade, and function. Preparation design is considered a critical factor in the success of dental veneers, as it influences the failure load and fatigue survival of posterior minimally invasive ceramic veneer restorations. …”
Get full text

Genome-wide identification of the wall-associated kinase gene family and their expression patterns under various abiotic stresses in soybean (Glycine max (L.) Merr) by Xiangnan Li, Sifei Qi, Lingzhi Meng, Peisen Su, Yongwang Sun, Nan Li, Dan Wang, Yinglun Fan, Yong Song

“…The wall-associated kinase (WAK) gene family encodes functional cell wall-related proteins. These genes are widely presented in plants and serve as the receptors of plant cell membranes, which perceive the external environment changes and activate signaling pathways to participate in plant growth, development, defense, and stress response. …”
Get full text

PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters by Chaogang Wang, Mingyang Du, Zhuxiang Jiang, Rihao Cong, Wei Wang, Taiping Zhang, Jincheng Chen, Guofan Zhang, Li Li

“…Abstract Cysteine-aspartic proteases (caspases) are critical drivers of apoptosis, exhibiting expansion and domain shuffling in mollusks. However, the functions and regulatory mechanisms of these caspases remain unclear. …”
Get full text

Phenotypic and Proteomic Characteristics of Human Dental Pulp Derived Mesenchymal Stem Cells from a Natal, an Exfoliated Deciduous, and an Impacted Third Molar Tooth by Gurler Akpinar, Murat Kasap, Ayca Aksoy, Gokhan Duruksu, Gulcin Gacar, Erdal Karaoz

“…Sixty-one of these conserved spots were identified by MALDI-TOF/TOF analysis. …”
Get full text

Identification and characterization of DFR gene family and cloning of candidate genes for anthocyanin biosynthesis in pepper (Capsicum annuum L.) by Yu An, Na Li, Ruiling Zhang, Shu Wang, June Wang

“…This study provides an important reference for improving fruit colour and lays a foundation for further exploring the function of the DFR gene family.…”
Get full text

Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos by Yong-feng Wang, Yu-ting Wan, Qian-rong Qi, Qing Tian, Xin-mei Liu, Qing-zhen Xie, Ying Yin, Li-quan Zhou

“…However, its function in early embryonic development remains largely unexplored. …”
Get full text

Detection of pharyngeal perforation during fiberoptic endoscopic evaluation of swallowing in a person with cervical spinal cord injury in the intensive care unit: a case report by Min Soo Choi, Sang Hun Han, Yong Beom Shin, Myung Hun Jang

“…After successful extubation, the patient underwent FEES to assess swallowing function. During FEES, the metallic plate was found to be exposed through mucosal erosion, and swelling was observed at the surgical site at the hypopharynx. …”
Get full text

FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1 by Fábio J. Ferreira, Mafalda Galhardo, João M. Nogueira, Joana Teixeira, Elsa Logarinho, José Bessa

“…Finally, we demonstrate that FOXM1 ectopic expression in elderly cells partially resets chromatin accessibility to a youthful state due to FOXM1’s repressive function on several members of the AP-1 complex, which is known to trigger the senescence transcriptional program. …”
Get full text

Genome-Wide Identification of the GRAS Transcription Factor Family in <i>Medicago ruthenica</i> and Expression Analysis Under Drought Stress by Xingli Wang, Xueming Dong, Pengzhen Li, Mingyu Li, Zhaoming Wang, Qiang Zhou, Zhipeng Liu, Longfeng Yan

“…Overall, this study analyzed the phylogenetic relationships, conserved domains, <i>cis</i>-regulatory elements and expression patterns of the <i>GRAS</i> gene family in <i>M. ruthenica</i>, filling the gap in the identification of the <i>MrGRAS</i> gene family and laying the foundation for functional analysis of the <i>MrGRAS</i> gene family.…”
Get full text

Identification of a novel aminoglycoside nucleotidyltransferase ANT(3″)-Ic from Citrobacter telavivum S24 by Junwan Lu, Mei Zhu, Jingzeng Ye, Leyao Xu, Chunhan Song, Kewei Li, Qiyu Bao, Xi Lin

“…This gene exhibits 52% similarity with the previously functionally characterized resistance gene aadA23. It distinguishes itself from ant(3″)-Ia and ant(3″)-Ib genes, and represents an independent branch. …”
Get full text

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs by John R. Horton, Meigen Yu, Jujun Zhou, Melody Tran, Rithvi R. Anakal, Yue Lu, Robert M. Blumenthal, Xiaotian Zhang, Yun Huang, Xing Zhang, Xiaodong Cheng

“…These distinctive properties, apparently conserved among vertebrates, provide essential functional flexibility to this crucial regulator.…”
Get full text

Genome-Wide Analysis of the TCP Gene Family in Switchgrass (Panicum virgatum L.) by Yuzhu Huo, Wangdan Xiong, Kunlong Su, Yu Li, Yawen Yang, Chunxiang Fu, Zhenying Wu, Zhen Sun

“…Taken together, the PvTCP gene family was analyzed at a genome-wide level and their possible functions in salt stress, which lay the basis for further functional analysis of PvTCPs in switchgrass.…”
Get full text

Influence and Mechanism of Fertilization and Irrigation of Heavy Metal Accumulation in Salinized Soils by Dandan Yu, Qingfeng Miao, Haibin Shi, Zhuangzhuang Feng, Weiying Feng, Zhen Li, José Manuel Gonçalves

Get full text

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. by Eveline Kindler, Cristina Gil-Cruz, Julia Spanier, Yize Li, Jochen Wilhelm, Huib H Rabouw, Roland Züst, Mihyun Hwang, Philip V'kovski, Hanspeter Stalder, Sabrina Marti, Matthias Habjan, Luisa Cervantes-Barragan, Ruth Elliot, Nadja Karl, Christina Gaughan, Frank J M van Kuppeveld, Robert H Silverman, Markus Keller, Burkhard Ludewig, Cornelia C Bergmann, John Ziebuhr, Susan R Weiss, Ulrich Kalinke, Volker Thiel

“…This evasion strategy suggests an evolutionary conserved viral function that has evolved to prevent RNA-based sensing of infection in vertebrate hosts. …”
Get full text

RENAL REVASCULARIZATION AND LONGTERM CARDIOVASCULAR SURVIVAL OF PATIENTS WITH ATHEROSCLEROTIC RENOVASCULAR DISEASE by D. V. Semyonov, N. A. Yaitsky, V. A. Dobronravov, E. P. Turobova, M. A. Ryabikov, K. M. Vakhitov

“…The disease was detected by one- (62%) and two- (38%) hemodynamic value (>50%) of renal artery stenosis. Renal function, arterial pressure, cardiovascular death cases were estimated in 4 groups of patients during the period of 2,5–126 months (on the average 33 months). …”
Get full text

Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels by Wei Xue, Xiao-Li Lu, Tian-Min Zhang, Yi Guo, Yong-Hu Li, Gang Li, Chang Xu, Hui-Meng Lu

“…This study provides valuable insights into the regulatory mechanism of insect olfaction and has significant implications for function modification and the development of bionic electronic noses.…”
Get full text

Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases by Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl

“…tRNA nucleotidyltransferase represents a ubiquitous and essential activity that adds the indispensable CCA triplet to the 3’-end of tRNAs. To fulfill this function, the enzyme contains a set of highly conserved motifs whose coordinated interplay is crucial for the sequence-specific CCA polymerization. …”
Get full text