Structural mechanism of DDX39B regulation by human TREX-2 and a related complex in mRNP remodeling by Bradley P. Clarke, Shengyan Gao, Menghan Mei, Dongqi Xie, Alexia E. Angelos, Ashley Vazhavilla, Pate S. Hill, Tolga Cagatay, Kimberly Batten, Jerry W. Shay, Yihu Xie, Beatriz M. A. Fontoura, Yi Ren

“…Together, our findings lead to a mechanistic understanding of the functional cycle of DDX39B and its regulation by TREX-2 and TREX-2.1 in mRNP processing.…”
Get full text

Integrated Multi-Omics Analysis of the Developmental Stages of <i>Antheraea pernyi</i> Pupae: Dynamic Changes in Metabolite Profiles and Gene Expression by Shuhui Ma, Yongxin Sun, Yajie Li, Xuejun Li, Zhixin Wen, Rui Mi, Nan Meng, Xingfan Du

“…These findings provide a scientific foundation for leveraging pupal resources in functional food innovation and bioactive compound discovery for pharmaceutical applications.…”
Get full text

Dynamic Coordination of Alternative Splicing and Subgenome Expression Bias Underlies Rusty Root Symptom Response in <i>Panax ginseng</i> by Jing Zhao, Juzuo Li, Xiujuan Lei, Peng Di, Hongwei Xun, Zhibin Zhang, Jian Zhang, Xiangru Meng, Yingping Wang

“…Integrative analysis of differentially expressed genes uncovered 671 loci under dual regulation; functional classification categorized these genes in receptor-like kinase signaling and chromatin-remodeling modules, underscoring the synergy between AS and transcriptional control. …”
Get full text

Clinical case: experience in the treatment of hyperplastic gingivitis in a patient with poor oral hygiene by P. A. Voronin, A. G. Prityko, A. E. Kazakova, V. A. Voronin, I. A. Nikolskaya

“…The fibrous form of hyperplastic gingivitis is a complex condition characterized by chronic inflammation of the gingiva accompanied by fibrotic tissue transformation. Conservative treatment approaches are often insufficient, and surgical intervention is required to restore both esthetics and function. …”
Get full text

Genome-wide identification and classification of MYB superfamily genes in peach. by Chunhua Zhang, Ruijuan Ma, Jianlan Xu, Juan Yan, Lei Guo, Juan Song, Ruchao Feng, Mingliang Yu

“…This study laid the foundation for further functional analysis of MYB superfamily genes in peach and enriched the knowledge of MYB superfamily genes in plant species.…”
Get full text

Nucleoporins shape germ granule architecture and balance small RNA silencing pathways by Kun Shi, Ying Zhang, Zhenzhen Du, Symonne C. Liu, Ivan Leon, Xinyu Fan, Heng-Chi Lee, Donglei Zhang

“…In Caenorhabditis elegans, piRNA pathway components are organized into sub-compartments within germ granules near nuclear pore complexes, but the basis and function of this association have remained unclear. …”
Get full text

Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma by David A. Thompson, Yvonne B. Wabara, Sarai Duran, Anna Reichenbach, Laura Chen, Kayla Collado, Changsuek Yon, John M. Greally DMed, Deepa Rastogi

“…NR3C1, coding for the glucocorticoid receptor, was downregulated, while genes coding for NLRP3 inflammasome were upregulated, in clusters with CDC42 upregulation and Th1 responses. Conserved genes in these clusters correlated with pulmonary function deficits in obese asthma. …”
Get full text

Emerging West African Genotype Chikungunya Virus in Mosquito Virome by Pengpeng Xiao, Yujia Hao, Yuge Yuan, Wenzhou Ma, Yiquan Li, He Zhang, Nan Li

“…Mutations in the CHIKV-E1-1 protein A226V may increase infectivity in Ae. albopictus. Three non-conservative mutations of CHIKV-E1-1 (D45H, D70H and V290D) may have an impact on the function. …”
Get full text

Land ecological security assessment for Yancheng city based on catastrophe theory by Wang Liang, Bian Zhengfu, Chen Hongquan

“…During this period, the land use pattern of Yancheng city was under tremendous pressure from the conflict between rapid urbanization and economic development, as well as conservation and rehabilitation of the eco-environment. …”
Get full text

Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir by Derek Hansen, Matthew R. Hendricks, Silvia Chang, Arthur Cai, Jason K. Perry, Thomas Aeschbacher, Ross Martin, Tomas Cihlar, Stephen R. Yant

“…Collectively, these results indicate that existing CA natural HIV-1 sequence diversity within the LEN-binding site is rare and should minimally impact LEN efficacy in treatment-naïve individuals.IMPORTANCEHIV-1 capsid protein mediates multiple essential functions throughout the viral replication cycle, making it an attractive target for therapeutic intervention. …”
Get full text

Genome-wide analysis of phytochrome-interacting factor (PIF) families and their potential roles in light and gibberellin signaling in Chinese pine by Yingtian Guo, Chengyan Deng, Guizhi Feng, Dan Liu

“…Phylogenetic analysis revealed that the PtPIF1 and PtPIF3 proteins belong to the PIF7/8 and PIF3 groups, respectively, and were relatively conserved among gymnosperms. Additionally, a class of PIF lacking APA/APB motif was identified in conifers, suggesting its function may differ from that of traditional PIFs. …”
Get full text

Multi-Step Prediction of TBM Tunneling Speed Based on Advanced Hybrid Model by Defu Liu, Yaohong Yang, Shuwen Yang, Zhixiao Zhang, Xiaohu Sun

Get full text

Reconstruction Using Frozen Autograft for Disseminated Phosphaturic Mesenchymal Tumor of the Humerus after a Pathological Fracture by Hiroshi Kobayashi, Toshihide Hirai, Naohiro Makise, Tetsuo Ushiku, Nobuaki Ito, Minae Koga, Masachika Ikegami, Yusuke Shinoda, Toru Akiyama, Sakae Tanaka

“…Liquid nitrogen was used as an adjuvant therapy after curettage of the tumor, and the frozen autograft, using a pedicle freezing method, conserved the function of the shoulder joint. To our knowledge, this is the first case of a disseminated PMT in the bone that was treated with a frozen autograft, and this treatment method may be effective for cases in which curettage for PMT in the bone would be inevitably inadequate.…”
Get full text

Reverse shoulder arthroplasty for fracture sequelae: How the initial fracture treatment influences the outcomes of joint replacement by Fernando Santana, Eduard Alentorn-Geli, Pau Guirro, Carlos Torrens

“…There were 9 patients (7 females and 2 males; mean age: 79.11 years) treated with RSA due to a fracture sequelae following conservative treatment and 18 patients (15 females and 3 males; mean age: 76.83 years) treated with a RSA owing to a fracture sequelae after ORIF.The functional outcome was recorded with the aid of the pre-surgery Constant Score and at the latest follow-up (minimum of two years). …”
Get full text

Kienbock's disease: Case report and review of the literature by Soukaina Beyyato, MD, Hajar Slaoui, MD, Hajar Ouazzani, PhD, Ismail Chaouche, PhD, Amal Akammar, PhD, Nizar El Bouardi, PhD, Meriem Haloua, PhD, Moulay Youssef Alaoui Lamrani, PhD, Meryem Boubbou, PhD, Mustapha Maaroufi, PhD, Badreeddine Alami, PhD

“…Kienböck’s disease is a rare form of avascular necrosis affecting the lunate bone, typically seen in young adults and often resulting in chronic wrist pain and functional impairment. We present a case-based review of 3 young adults (2 males aged 20 and 30 years, and 1 female aged 28) with progressive dorsal wrist pain, reduced grip strength, and limited range of motion. …”
Get full text

Congenital Arthrogryposis: An Extension of the 15q11.2 BP1-BP2 Microdeletion Syndrome? by K. M. Usrey, C. A. Williams, M. Dasouki, L. C. Fairbrother, M. G. Butler

“…The BP1-BP2 region spans approximately 500 kb and contains four evolutionarily conserved genes. The genes in this region are known to play a role in central nervous system development and/or function. …”
Get full text

Spontaneous Hemoperitoneum due to Rupture of Uterine Varicose Veins during Labor Successfully Treated by Percutaneous Embolization by Rebeca Díaz-Murillo, Pablo Tobías-González, Sara López-Magallón, Fernando Magdaleno-Dans, José L. Bartha

“…Hemodynamic stability is needed to decide this conservative management.…”
Get full text

Global profiling of protein lactylome in porcine granulosa cells by Shuhao Fan, Ren Zhou, Haoyu Wen, Haibo Ye, Shuya Ma, Yu Bu, Peihuan Wang, Xianrui Zheng, Yueyun Ding, Zongjun Yin, Xiaodong Zhang

“…Conclusions Our study provides a comprehensive understanding of lactylation in mammalian GCs and lays the foundation for subsequent studies on the lactylation-mediated regulation of female reproductive function.…”
Get full text

Acute Kidney Injury due to Anticoagulant-Related Nephropathy : A Suggestion for Therapy by Letizia Zeni, Chiara Manenti, Simona Fisogni, Vincenzo Terlizzi, Federica Verzeletti, Mario Gaggiotti, Giovanni Cancarini

“…., withdrawal of dabigatran and infusion of its specific antidote) along with administration of fluids, sodium bicarbonate, steroids, and mannitol resulted in conservative management of AKI and fast recovery of renal function. …”
Get full text

The draft genome sequences of the cosmopolitan centric diatom, the genus Skeletonema by Satoshi Nagai, Ryuhei Minei, Ikuyo Takemura, Hiromasa Tabata, Mats Töpel, Matthew Pinder, Olga Kourtchenko, Kang Lee-Kuo, Nguyen Van Nguyen, Sirje Sildever, Atsushi Ogura, Takashi Gojobori

“…The draft genomes of Skeletonema will facilitate further study, such as population dynamics, phylogeography, the process of speciation, and the evolution of gene function, and help to provide deep insight into the cosmopolitanism of this most successfully prosperous genus.…”
Get full text