The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. by Ana Neves-Costa, W Ryan Will, Anna T Vetter, J Ross Miller, Patrick Varga-Weisz

“…A point mutation in the ATP-binding site abrogates the silencing function of Fun30 as well as its toxicity upon overexpression, indicating that the ATPase activity is essential for these roles of Fun30. …”
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Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans by Iman Man Hu, Marte Molenaars, Yorrick R. J. Jaspers, Bauke V. Schomakers, Michel van Weeghel, Amber Bakker, Melanie Modder, Joseph P. Dewulf, Guido T. Bommer, Arwen W. Gao, Georges E. Janssens, Riekelt H. Houtkooper

“…Using multi-omics and functional in vivo screening, we identify the ethylmalonyl-CoA decarboxylase orthologue C32E8.9 in C. elegans as an essential factor for longevity induced by mitochondrial translation inhibition. …”
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The Role of Botulinum Toxin for Masseter Muscle Hypertrophy: A Comprehensive Review by Martina Ferrillo, Eleonora Sommadossi, Loredana Raciti, Dario Calafiore, Kamal Mezian, Valeria Tarantino, Michele Vecchio, Umile Giuseppe Longo, Luigi Losco, Alessandro de Sire

“…Moreover, MMH may also have significant functional repercussions, including pain in the masseter region, often associated with temporomandibular disorders, fatigue, and discomfort during mastication. …”
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Identification and characterization of the GH3 gene family in maize by Dong-feng ZHANG, Nan ZHANG, Tao ZHONG, Chao WANG, Ming-liang XU, Jian-rong YE

“…Maize GH3 protein sequences share a conserved domain which occupies nearly the entire protein. …”
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An acidic microenvironment produced by the V-type ATPase of Euprymna scolopes promotes specificity during Vibrio fischeri recruitment by Alexis C. Hargadon, Joani W. Viliunas, Sabrina Koehler, Angus B. Thies, Grischa Y. Chen, Mark S. Ladinsky, Jill Kuwabara, Viridiana Avila-Magana, Edward G. Ruby, Martin Tresguerres, Margaret J. McFall-Ngai

“…Thus, VHA provides a mechanistic link between host modulation of microenvironmental acidity, immune function, and selection of microbial symbionts, a strategy for specificity that may govern other symbioses.…”
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GPR180 is a new member of the Golgi-dynamics domain seven-transmembrane helix protein family by Sarah-Ana Mitrovic, Chamalee Demalgiriya-Gamage, Lisa-Maria Winter, Tobias Kiechle, Rebecca Ebenhoch, Heike Neubauer, Birgit Stierstorfer, Lee Frego, Christian Wolfrum, Sophia Reindl, Herbert Nar

“…The results reveal GPR180’s role in intracellular vesicles and offer insights into the pH-dependent function of this conserved GOST protein.…”
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Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila by Jean-François De Backer, Thomas Karges, Julia Papst, Zeynep Nigar Pınar, Cristina Coman, Robert Ahrends, Yanjun Xu, Cristina García-Cáceres, Ilona C. Grunwald Kadow

“…Instead, glia fulfill this highly evolutionarily conserved function in addition to modulating neuronal activity and behavior. …”
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The histone core domain evolves at single-residue resolution to directly orchestrate transcription by Zachary H. Harvey, Kathryn M. Stevens, Jian Yi Kok, Akihisa Osakabe, Jiaying Liu, Tobias Warnecke, Frédéric Berger

“…We conclude that even minimal changes in histone sequences can transform their function, underscoring the evolutionary potential of the histone core domain to drive regulatory innovation and highlighting a previously unappreciated role of the histone core domain in transcriptional regulation.…”
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A single base pair substitution in zebrafish distinguishes between innate and acute startle behavior regulation. by Elelbin A Ortiz, Philip D Campbell, Jessica C Nelson, Michael Granato

“…By generating animals in which we deleted the syt7a open reading frame, and subsequent complementation testing with the escapist line, we demonstrate that loss of syt7a function is not the cause of the escapist behavioral phenotype. …”
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DYNAMIC CORRELATION BETWEEN CORNEAL SENSITIVITY AND SUBJECTIVE SYMPTOMS IN PATIENTS WITH CHRONIC CORNEAL ULCERS by R. Hristova, A. Oscar, S. Kostova, I. Petkova, Y. Zdravkov

“…Conclusions: Cochet-Bonnet aesthesiometry is a useful diagnostic tool for evaluating corneal nerve function and monitoring the effect of treatment.…”
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Liver laceration as a post-cardiopulmonary resuscitation complication in a person with breast implants: a case report by Min-Jeong Cho

“…In this case, had there been no blood loss from the liver injury, the patient might have maintained better cerebral perfusion and function.…”
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CTP sensing and Mec1ATR-Rad53CHK1/CHK2 mediate a two-layered response to inhibition of glutamine metabolism. by Arta Ajazi, Ramveer Choudhary, Laura Tronci, Angela Bachi, Christopher Bruhn

“…We describe a function of Ura8 as inducible CTP synthase responding to inhibition of glutamine metabolism and propose a model for its regulation by CTP levels and Nrd1-dependent transcription termination at a cryptic unstable transcript. …”
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The Impact of Bone Mineral Biomarkers on Cardiac Dysfunction in Predialysis Chronic Kidney Disease Children by Safaa Ali, Mohamed Saber, Mohamed Kassem

“…The children who had a normal diastolic function were 32 (53.33%), while those who had diastolic dysfunction were 28 (46.67%). …”
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Distal Arthrogryposis in Newborn: Clinical Case by Vasily P. Gavrilyuk, Yana V. Evseeva, Oleg V. Cherevko, Dmitry A. Severinov

“…Early initiation of treatment is expected to increase the amplitude of both passive and active movements in the hand joints, whereas, it will improve the function of hand grasping and self-care capacities of patients.…”
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Gone and forgotten? Predictors of birth history omissions in India by Sharan Sharma, Sonalde Desai, Debasis Barik, Om Prakash Sharma

“…Omissions in the second wave are modeled as a function of several child, mother, household, and survey interviewer variables. …”
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The mre11 A470 alleles influence the hereditability and the segregation of telosomes in Saccharomyces cerevisiae. by In-Joon Baek, Daniel S Moss, Arthur J Lustig

“…The Mre11 complex is involved in multiple cellular roles in DNA repair and structure in the regulation and function of telomere size homeostasis. In this study, we characterize yeast telomere chromatin structure, phenotypic heritability, and chromatin segregation in both wild-type [MRE11] and A470 motif alleles. …”
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A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals. by Tiit Örd, Tarmo Puurand, Daima Örd, Tarmo Annilo, Märt Möls, Maido Remm, Tõnis Örd

“…In this article, we report that human TRIB3 promoter contains a 33-bp variable number tandem repeat (VNTR) and characterize the heterogeneity and function of this genetic element. Analysis of human populations around the world uncovered the existence of alleles ranging from 1 to 5 copies of the repeat, with 2-, 3- and 5-copy alleles being the most common but displaying considerable geographical differences in frequency. …”
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Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase. by Matti Myllykoski, Petri Kursula

“…The 2H phosphoesterase family contains enzymes with two His-X-Ser/Thr motifs in the active site. 2H enzymes are found in all kingdoms of life, sharing little sequence identity despite the conserved overall fold and active site. For many 2H enzymes, the physiological function is unknown. …”
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Research on the Synergistic Mechanism of Maize–Soybean Rotation and Bio-Organic Fertiliser in Cold Regions by Zijian Wang, Hao Tian, Nan Sun, Haocheng Wang, Songyan Tang, Shengjie Chen, Xuebing Wang, Shiwei Ren, Xiangyuan Zuo, Xingbo Zhao

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The peptidoglycan-associated protein NapA plays an important role in the envelope integrity and in the pathogenesis of the lyme disease spirochete. by Marisela M Davis, Aaron M Brock, Tanner G DeHart, Brittany P Boribong, Katherine Lee, Mecaila E McClune, Yunjie Chang, Nicholas Cramer, Jun Liu, Caroline N Jones, Brandon L Jutras

“…These studies further our understanding of the B. burgdorferi cell envelope, provide critical information that underlies its pathogenesis, and highlight how a highly conserved bacterial protein can evolve mechanistically, while maintaining biological function.…”
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