Recurrent Fibrillary Glomerulonephritis Secondary to Chronic Lymphocytic Leukemia: Remission of Kidney Disease with Ibrutinib by Rafeea Shah, Bindu Vydianath, Guy Pratt, Jennifer Pinney

“…Renal biopsy showed FGN, and treatment was targeted to the CLL with bendamustine and rituximab, which led to partial remission of nephrotic syndrome and improvement in renal function. After 3 years of clinical remission, the nephrotic syndrome relapsed, and he underwent a repeat renal biopsy confirming ongoing FGN. …”
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Current trends in the treatment of focal cartilage lesions: a comprehensive review by Halah Kutaish, Arnaud Klopfenstein, Susan Nasif Obeid Adorisio, Philippe M Tscholl, Sandro Fucentese

“…These lesions can lead to pain, impaired joint function and, if left untreated, may contribute to the development of degenerative joint diseases. …”
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Thrombosis of extrahepatic portal vein aneurysm immediately after laparoscopic distal gastrectomy: A case report by Kazunori Fukasawa, MD, Hiroshi Baba, MD, Akira Okubo, MD, Masayuki Hirata, MD, Sho Kakinouchi, MD, Yuta Sato, MD, Akinori Egashira, MDPhD, Hiromu Hidaka, MD

“…Although the D-dimer levels were elevated, liver function remained normal, indicating preserved blood flow. …”
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Fabella Syndrome as an Uncommon Cause of Posterolateral Knee Pain after Total Knee Arthroplasty: A Case Report and Review of the Literature by Eriko Okano, Tomokazu Yoshioka, Takaji Yanai, Sho Kohyama, Akihiro Kanamori, Masashi Yamazaki, Toshikazu Tanaka

“…Fabellectomy provided immediate resolution of posterolateral knee pain and the clicking sound with knee flexion, with the patient remaining symptom-free 18 months after fabellectomy and with no limitations in knee function. Fabellectomy eliminated symptoms in all of five case reports that have been previously published and is regarded as an effective first choice for treating fabella syndrome after total knee arthroplasty.…”
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Mitogenome Phylogenetics of Spiruromorpha Porpoise Parasite: Insights Into Phylogeny of <i>Crassicauda magna</i> by Lei Han, Yuling Yang, Maolin Lu, Hongyan Yu, Yaxian Lu, Mengchao Zhou, Tianlu Liu, Ruisi Zhang, Bingyao Chen, Zhijun Hou

“…Mitochondria have an important function in revealing taxonomic and evolutionary history. (2) Methods: In this study, we sequenced the mitochondrial genome of <i>C. magna</i> and conducted a phylogenetic analysis with the mitochondrial sequences of species belonging to the Habronematoidea family. (3) Results: The complete mitochondrial genome was 13,604 bp and it has an AT-rich sequence and one non-coding region (NCR). …”
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Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives by Yong-Sung Choi, Yoon-Jung Kim, Yeram Jeon, Jong Soon Kang, Juhee Lee, Eunmi Hong, Young-Hoon Park, Wantae Kim, Boksik Cha, Raok Jeon

“…Transcriptional enhanced associate domain (TEAD) transcription factors undergo auto-palmitoylation, which is critical to mediate their function and maintain stability. Targeting the palmitate binding pocket of TEAD holds considerable promise for drug discovery, and it can be characterised into three components: a conserved cysteine, a hydrophobic main pocket, and a hydrophilic side pocket. …”
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Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation by Dina Rady, Marwa M. S. Abbass, Aiah A. El-Rashidy, Sara El Moshy, Israa Ahmed Radwan, Christof E. Dörfer, Karim M. Fawzy El-Sayed

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Updates in the management of lateral patellar instability by Amber M. Parker, Naofumi Hashiguchi, Miho J. Tanaka

“…Conclusions: Successful management of patellar instability requires a comprehensive evaluation of anatomical risk factors and individualized treatment approaches. While conservative management is appropriate for first-time dislocations without significant risk factors, surgical intervention through MPFC reconstruction and associated procedures shows promising outcomes in preventing recurrence and improving function in high-risk patients.…”
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Validation of masquelet technique excluding the septic context: Management of open comminuted fractures in the acute trauma by Amine El Farhaoui, Sohaib El Mahjoubi, Anass Sefti, Adnane Lachkar, abdeljaouad Najib, Hicham Yacoubi

“…The bone healing process was assessed through standard X-rays with two views, anteroposterior and lateral, of the affected limb segment, and clinical evaluation was performed using specific functional scores. The average follow-up for our patients was 8.54 months. …”
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Therapeutic effect of two muscle strengthening programs in patients with patellofemoral pain syndrome. A randomized controlled clinical trial by Luisa Fernanda Prieto-García, Edgar Cortés-Reyes, Gilberto Lara-Cotacio, Lizeth Catherine Rodríguez-Corredor

“…Introduction: Patellofemoral pain syndrome (PFPS) is one of the most common musculoskeletal disorders affecting the knee joint. Conservative treatment reduces pain and improves functional capacity in the short and medium-term. …”
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Raider of the lost N-glycans – Localizing rare and frequently overlooked IgG N-glycans with sulfation or bisecting LacNAc by Robert Burock, Léa Chuzel, Thilo Kähne, Udo Reichl, Udo Reichl, Erdmann Rapp, Erdmann Rapp, René Hennig

“…Consequently, they are disregarded in studies of IgG N-glycosylation, which in general is well understood. But functional knowledge is mainly based on N-glycans found in IgGs Fc region that contains a conserved N-glycosylation site. …”
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Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer by Nickolas Steinauer, Chun Guo, Jinsong Zhang

“…These corepressors share highly conserved domain structures yet have distinct biological functions and tissue specificity. …”
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Relationship between seawater temperature, brain GnRH-like peptide expression, and gonadal development in wild bigfin reef squid (Sepioteuthis lessoniana) by Umina Kubo, Lee Jaewoo, Ryosuke Murata, Takashi Aoshima, Yuji Mushirobira, Kiyoshi Soyano

“…Results We identified coding sequences for peptides with conserved functional regions similar to those of other mollusks. …”
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Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. by Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldman

“…We decided to study whether non-mammalian orthologs of these three proteins have conserved their function: can they activate the human counterparts? …”
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Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. by Amanda L Evans, Tiago Faial, Michael J Gilchrist, Thomas Down, Ludovic Vallier, Roger A Pedersen, Fiona C Wardle, James C Smith

“…<h4>Conclusions/significance</h4>Our work identifies the genomic targets of a key regulator of mesoderm formation in the early mouse embryo, thereby providing insights into the Brachyury-driven genetic regulatory network and allowing us to compare the function of Brachyury in different species.…”
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The B22 Dilemma: Structural Basis for Conformational Differences in Proinsulin B-Chain Arg22 Mutants by Srivastav Ranganathan, Anoop Arunagiri

“…Proinsulin has three distinct regions: the well-folded A- and B-chains and the dynamic disordered C-peptide. The highly conserved B-chain is a hotspot for diabetes-associated mutations, including the severe loss-of-function R(B22)Q mutation linked to childhood-onset diabetes. …”
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Designing and implementing healthcare technology for rehabilitation processes—a wicked problem? Lessons learned from a collaboration between healthcare personnel and technologists... by Jo Inge Gåsvær, Ilona Heldal, Tobba Sudmann

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Analysis of Clade V MLO Gene Expressions in Hazelnut Leaves upon Exposure to Powdery Mildew by Ulku Baykal, Kadriye Özcan

“…This fungal disease causes significant economic losses by reducing the yield and quality of hazelnuts. Loss-of-function mutations in the mildew resistance locus o (MLO) gene family of many plants confer high levels of broad-spectrum resistance to powdery mildew. …”
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Severe Hypocalcemia and Dramatic Increase in Parathyroid Hormone after Denosumab in a Dialysis Patient: A Case Report and Review of the Literature by Ravinder D. Bhanot, Jasleen Kaur, Zeenat Bhat

“…Unlike the bisphosphonates, the pharmacokinetics and pharmacodynamics of denosumab are not influenced by the renal function and are being increasingly used for patients having CKD-MBD with low bone mineral density (BMD) to reduce the risk of fragility fractures. …”
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The Small RNA MicF Represses ObgE and SeqA in <i>Escherichia coli</i> by Aaron Y. Stibelman, Amy Y. Sariles, Melissa K. Takahashi

“…Our study suggests that, beyond its established role in membrane permeability management, MicF exerts control over chromosome dynamics in response to distinct environmental cues, implicating a more multifaceted regulatory function in bacterial stress adaptation.…”
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