Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling by Tongqing Li, Steven E. Stayrook, Wenxue Li, Yueyue Wang, Hengyi Li, Jianan Zhang, Yansheng Liu, Daryl E. Klein

“…Together, our data reveal the structure and clarify functional studies of this enigmatic protein.…”
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Functional and Radiological Outcome of Surgical Management in Lumbar Spinal Stenosis – A Comparative Study by Makesh Ram Sriraghavan, Kandasamy Natesan, Pavalan Louis, Harish Shanmugam Punniakotti, Naveen Venkidusamy, Namala Sai Vinay Bharadwaj

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Loss of Hoxa5 function affects Hox gene expression in different biological contexts by Béatrice Frenette, Josselin Guéno, Nicolas Houde, Kim Landry-Truchon, Anthony Giguère, Theyjasvi Ashok, Abigail Ryckman, Brian R. Morton, Jennifer H. Mansfield, Lucie Jeannotte

“…We applied bulk RNA-seq assays to characterize the transcriptional impact of the loss of Hoxa5 gene function in seven different biological contexts, including developing respiratory and musculoskeletal tissues that present phenotypes in Hoxa5 mouse mutants. …”
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The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function. by Stephen W Tuffs, David B A James, Jovanka Bestebroer, Amy C Richards, Mariya I Goncheva, Marie O'Shea, Bryan A Wee, Keun Seok Seo, Patrick M Schlievert, Andreas Lengeling, Jos A van Strijp, Victor J Torres, J Ross Fitzgerald

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Induction of flowering in Arabidopsis through functional peptide-mediated FT mRNA delivery by Masaki Odahara, Maai Mori, Shougo Ishio, Satoshi Kogawara, Keiji Numata

“…In this study, we focused on FLOWERING LOCUS T (FT), a pivotal flowering inducer conserved in many flowering plants. We developed a non-transgenic flowering induction system in the model plant Arabidopsis, employing the exogenous introduction of FT mRNA through a functional peptide-mediated delivery. …”
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Identification and functional analysis of α-farnesene synthase gene from the cabbage Brassica oleracea by ZHANG Tong, WANG Yiping, GE Yang, NTIRI Eric, ZHOU Wenwu

“…In order to illuminate the biological function of α-farnesene synthase gene (BoTPSa) from the cabbage Brassica oleracea, the BoTPSa gene was cloned and its expression levels were measured in the plants treated by different environmental stresses. …”
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Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. by Kwok-Ho Lam, Jacqueline M Tremblay, Kay Perry, Konstantin Ichtchenko, Charles B Shoemaker, Rongsheng Jin

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Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32 by Samara Mishelle Ona Chuquimarca, Jonah Beenstock, Salima Daou, Jennifer Porat, Alexander F. A. Keszei, Jay Z. Yin, Tobias Beschauner, Mark A. Bayfield, Mohammad T. Mazhab-Jafari, Frank Sicheri

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Genome-wide identification and functional analysis of PEL gene family in Brassica napus L by Man Xing, Yu Kang, Mengjie Lv, Bheem Raj Serani, Qi Shen, Wenfang Jiao, Wen Mu, Shan Chen, Zechuan Peng, Luyao Huang

“…Abstract Background The function of the PEL gene has recently been studied in rice and Arabidopsis. …”
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Identifying and understanding novel ecosystem functions: a scientific approach to nature restoration law by Agnieszka K. Hutniczak, Wojciech Bryś, Roman Dychkovskyi, Renata Gaj, Artur Dyczko, Agnieszka Błońska, Karolina Bierza, Barbara Bacler-Żbikowska, Gabriela Woźniak

“…It presents the role of novel ecosystems in ecosystem functioning and their significance within urban-industrial landscapes. …”
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Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang by Wenqiang Tang, Yongcheng Yue, Bin Shi, Xialing Zhao, Yang Hong

“…This study focuses on the molecular characterization and functional analysis of thioredoxin glutathione reductase (TGR) from O. turkestanicum, a key enzyme involved in the parasite’s antioxidant defense system. …”
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Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development. by Sokol V Todi, Elena Sivan-Loukianova, Julie S Jacobs, Daniel P Kiehart, Daniel F Eberl

“…<h4>Conclusions</h4>Our findings indicate that MyoVIIA plays evolutionarily conserved roles in auditory organ development and maintenance in invertebrates and vertebrates, enhancing our understanding of auditory organ development and function, as well as providing significant clues for future research.…”
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Turtle functions downstream of Cut in differentially regulating class specific dendrite morphogenesis in Drosophila. by Mikolaj J Sulkowski, Srividya Chandramouli Iyer, Mathieu S Kurosawa, Eswar Prasad R Iyer, Daniel N Cox

“…Neurons display a myriad diversity of dendritic geometries which serve as a basis for functional classification. Several types of molecules have recently been identified which regulate dendrite morphology by acting at the levels of transcriptional regulation, direct interactions with the cytoskeleton and organelles, and cell surface interactions. …”
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The Effect of Detethering Surgery on the Bladder Function and Psychology of Children with Primary Tethered Cord Syndrome by Shuai Yang, Zhaokai Zhou, Xingchen Liu, Zhan Wang, Yanping Zhang, He Zhang, Lei Lv, Yibo Wen, Qingwei Wang, Wei Jia, Jinhua Hu, Jian Guo Wen

“…It was hypothesized that the DS might have a significant effect on bladder function and psychology. Therefore, the purpose of this study was to investigate the effect of DS on bladder function and quality of life in children with primary TCS. …”
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Long-Term Follow-Up of Vestibular Function in Cochlear-Implanted Teenagers and Young Adults by Niki Karpeta, Eva Karltorp, Luca Verrecchia, Maoli Duan

“…Background: Vestibular function implements head position regulation and body spatial navigation. …”
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Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome by Jiao Sun, Jin-Young Kim, Semo Jun, Meeyeon Park, Ebbing de Jong, Jae-Woong Chang, Sze Cheng, Deliang Fan, Yue Chen, Timothy J. Griffin, Jung-Hee Lee, Ho Jin You, Wei Zhang, Jeongsik Yong

“…Furthermore, our investigation into the isoform-specific functions of JMJD6 intronic APA events supported the hypothesis that alterations in unstructured C-terminal protein regions lead to functional differences. …”
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Implantable bone conduction devices enhance functional ear reconstruction in patients with pediatric microtia by Ying Chen, Ying Chen, Chen-long Li, Chen-long Li, Liu-Jie Ren, Liu-Jie Ren, Xu Wu, Na Gao, Na Gao, Ai-juan He, Yao-yao Fu, Yao-yao Fu, Ya-ying Zhu, Ya-ying Zhu, Tian-yu Zhang, Tian-yu Zhang, Tian-yu Zhang

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Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity by Amanat Ali, Zhengdong D. Zhang, Tina Gao, Sandra Aleksic, Evripidis Gavathiotis, Nir Barzilai, Sofiya Milman

“…This study investigated the whole exome sequencing data from 2,108 individuals in a cohort of Ashkenazi Jewish centenarians, their offspring, and controls without familial longevity to identify functional IGF-1 coding variants. We identified two likely functional coding variants IGF-1:p.Ile91Leu and IGF-1:p.Ala118Thr in our longevity cohort. …”
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Structural and functional assessment of TBX20 gene variants in pediatric ventricular septal defect by Zhenzhen Qin, Caixia Liu, Jie Wang, Yanmei Jin

“…Bioinformatic analysis supported the deleterious functional impact of the p.Gly193Ser variant and its potential contribution to VSD pathogenesis. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. Results: Short sequence insertions (5 amino acids) were tolerated at four distinct sites in the C-terminal region of the ORF2 protein, without significantly affecting viral capsid expression and subcellular localization as well as virus production. …”
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