TMT-Opsins differentially modulate medaka brain function in a context-dependent manner. by Bruno M Fontinha, Theresa Zekoll, Mariam Al-Rawi, Miguel Gallach, Florian Reithofer, Alison J Barker, Maximilian Hofbauer, Ruth M Fischer, Arndt von Haeseler, Herwig Baier, Kristin Tessmar-Raible

“…This expression feature is present from fishes to human and appears to be particularly prominent in diurnal vertebrates. Despite their conserved widespread occurrence, the nonvisual functions of opsins are still largely enigmatic. …”
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Lysosomal Exoglycosidase Profile and Secretory Function in the Salivary Glands of Rats with Streptozotocin-Induced Diabetes by Mateusz Maciejczyk, Agnieszka Kossakowska, Julita Szulimowska, Anna Klimiuk, Małgorzata Knaś, Halina Car, Wiesława Niklińska, Jerzy Robert Ładny, Adrian Chabowski, Anna Zalewska

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The functional of cathepsin L in the ontogenesis and reproductive regulation of the Asian corn borer, Ostrinia furnacalis by Jin-Shan Zhang, Jin Li, Jian-Yu Meng, Xue Tang, Hajra Saddique, Chang-Yu Zhang

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Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. by Giosalba Burgio, Gaspare La Rocca, Anna Sala, Walter Arancio, Dario Di Gesù, Marianna Collesano, Adam S Sperling, Jennifer A Armstrong, Simon J van Heeringen, Colin Logie, John W Tamkun, Davide F V Corona

“…Nucleosome remodeling and covalent modifications of histones play fundamental roles in chromatin structure and function. However, much remains to be learned about how the action of ATP-dependent chromatin remodeling factors and histone-modifying enzymes is coordinated to modulate chromatin organization and transcription. …”
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Experimental evolution partially restores functionality of bacterial chemotaxis network with reduced number of components. by Manika Kargeti, Irina Kalita, Sarah Hoch, Maryia Ratnikava, Wenhao Xu, Bin Ni, Ron L Dy, Remy Colin, Victor Sourjik

“…The chemotaxis signaling pathway, which enables bacteria to follow chemical gradients in their environment, is highly conserved among motile bacteria. It is assumed that Escherichia coli contains the minimal and non-redundant set of protein activities that are necessary for bacterial chemotaxis and nearly universally conserved among bacterial chemotaxis pathways. …”
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In silico analysis of hypothetical proteins in Pseudomonas aeruginosa PAC1: Structural and functional insights by Mutaz Mohammed Abdallah, Ruaa Abdalla Ibrahim Suliman, Yousra Tagelsir Ahmed, Mawada Yahia

“…Subcellular localization tools predicted cytoplasmic localization for 58 proteins. Functional annotation identified conserved domains, and homology modeling generated 3D structures for proteins with >80 % similarity to known templates. …”
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The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet by Ibanez, Sébastien, Foulquier, Arnaud, Brun, Charles, Colace, Marie-Pascale, Piton, Gabin, Bernard, Lionel, Gallet, Christiane, Clément, Jean-Christophe

“…This highlights the multidimensional feature of the impacts of herbivory on ecosystem functioning, both in space and time. …”
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Identification and functional analysis of novel precursor genes in cyclic peptide biosynthesis in Pseudostellaria heterophylla by Jiao Xu, Wei Zheng, Xiaohong Ou, Hua He, Changgui Yang, Lanping Guo, Chenghong Xiao, Weike Jiang, Guoping Shu, Tao Zhou

“…Abstract Background Pseudostellaria heterophylla, a member of the Caryophyllaceae family, is widely used in traditional Chinese medicine due to its bioactive cyclic peptides (CPs) with immunomodulatory functions. Caryophyllaceae- like CPs, one of the largest types plant-derived CPs, typically consist of 5–12 amino acids and are derived from ribosomally synthesized peptide precursors. …”
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Cloning and functional analysis of a novel DREB transcription factor from Nicotiana benthamiana by GENG Fang, GUO Wei-hua, GUO Yu-shuang, MENG Xian-mei, ZHANG Fang

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Mammalian PI-Phospholipase C Isozymes: Structural and Functional Insights and Roles in Health and Disease by May Hamdi, Mohammed Al-Matwi, Nour Elghoul, Hissa Al-Kuwari, Tahseen S. Sayed, Emna Riguene, Michail Nomikos

“…Herein, we carry out a comprehensive analysis of the structure, function, regulation, and implications of the PI-PLC family enzymes in both physiological and pathological contexts. …”
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The ALX4 dimer structure provides insight into how disease alleles impact function by Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A. Kovall, Brian Gebelein

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HP1 loses its chromatin clustering and phase separation function across evolution by Sanâa Bensaha, Dominika Lewandowska, Fernando Muzzopappa, Stephanie Hutin, Mark D. Tully, Michela Anfossi, Florence M. Cammas, Christophe Normand, Fabian Erdel

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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function by Szymon P. Kordon, Kristina Cechova, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, Demet Araç

“…Abstract Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECRs) containing a conserved GAIN domain that precedes their seven-pass transmembrane domain (7TM). …”
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Structural basis for assembly and function of the Salmonella flagellar MS-ring with three different symmetries by Miki Kinoshita, Fumiaki Makino, Tomoko Miyata, Katsumi Imada, Keiichi Namba, Tohru Minamino

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Functional and aesthetic rehabilitation in posterior tooth with bulk-fill resin composite and occlusal matrix by Luciana Fávaro Francisconi-dos-Rios, Johnny Alexandre Oliveira Tavares, Luanderson Oliveira, Jefferson Chaves Moreira, Flavia Pardo Salata Nahsan

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Multi-material functionally graded additive manufacturing of zirconia ceramic: A systematic review by Sinan A. Shwailiya, Mahammed Rashid Hameed

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Improving the Accuracy of Fictitious Domain Method Using Indicator Function from Volume Intersection by Guoliang Chai, Junwei Su, Le Wang, Chunlei Yu, Yigen Zhang, Zhaolin Gu

“…In this work, a new indicator function through volume intersection is developed for FDM. …”
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METTL9 sustains vertebrate neural development primarily via non-catalytic functions by Azzurra Codino, Luca Spagnoletti, Claudia Olobardi, Alessandro Cuomo, Helena Santos-Rosa, Martina Palomba, Natasha Margaroli, Stefania Girotto, Rita Scarpelli, Shi-Lu Luan, Eleonora Crocco, Paolo Bianchini, Andrew J. Bannister, Stefano Gustincich, Tony Kouzarides, Riccardo Rizzo, Isaia Barbieri, Federico Cremisi, Robert Vignali, Luca Pandolfini

“…Overall, we demonstrate a developmental function of Mettl9 and link it to a 1MH-independent pathway, namely, the maintenance of the secretory system, which is essential throughout neural development.…”
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Genetic analysis and functional assessment of a TGFBR2 variant in micrognathia and cleft palate. by Jes-Rite Michaels, Paul P R Iyyanar, Ammar Husami, Andrew M Vontell, Samantha A Brugmann, Rolf W Stottmann

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Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteins by Panos Kakoulidis, Eleni I. Theotoki, Vasiliki I. Pantazopoulou, Ioannis S. Vlachos, Ioannis Z. Emiris, Dimitrios J. Stravopodis, Ema Anastasiadou

“…Abstract The four human Argonaute (AGO) proteins, critical in RNA interference and gene regulation, exhibit high sequence and structural similarity but differ functionally. We investigated the underexplored structural relationships of these paralogs through microsecond-scale molecular dynamics simulations. …”
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