THE SIGNIFICANCE OF FUNCTIONAL AND ETIOLOGICAL DIAGNOSTIC FOR TREATMENT STRATEGY DECISION IN PATIENTS WITH DILATED CARDIOMYOPATHY by Yu. V. Frolova

“…Depending on etiological factors, initial functional state of the patient as well as the severity of valvular regurgitation and the degree of interventricular dyssynchrony, 24 patients were implanted with cardioverter defibrillator (ICD) and 38 patients — with cardiac resynchronization therapy with cardioverter defibrillator function (CRT-D): in total, 62 patients with DCM; 24 patients underwent organ conserving reverse cardiac remodeling; orthotopic heart transplantation was performed in 13 patients; conservative treatment group consisted of 57 patients with DCM for whom surgical treatment was not recommended or impossible at the moment of the examination. …”
Get full text

Case Report: Effect of testicular adenomatoid tumors on testicular endocrine function in children by Yan Li, Junfeng Zhao, Yi Chen, Jing Zhang, Hehe Chen

“…This study demonstrates the progressive decline of Sertoli cell function in pediatric adenomatoid tumor survivors, detectable through longitudinal monitoring of INHB, AMH, and TV. …”
Get full text

Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis by Jeong Seon Kim, Zhenhang Chen, Sara Andrea Espinosa Garcia, Christoph Buhlheller, Botao Zhang, Stephen J. Richards, Tingfei Chen, Jingjing Wu, Ronald C. Bruntz, Marisa E. Gilliam, Mitsuo Yamauchi, Bo Liang, Houfu Guo

“…These insights inform glucosyltransferase function and open new avenues for inhibitor development and kojibiose biosynthesis.…”
Get full text

Functional characterization of the Csm1-like protein TITAN 9 in Arabidopsis thaliana by Zhijian Zhang, Franziska Böwer, Shinichiro Komaki, Aladár Pettkó-Szandtner, Anastasiia O. Skuba, Eelco C. Tromer, Zoltán Magyar, Maren Heese, Arp Schnittger

“…These findings suggest that Csm1-like proteins contribute to conserved kinetochore functions across eukaryotes.…”
Get full text

Plant PP2A: A Versatile Enzyme with Key Physiological Functions by Juan I. Cortelezzi, Martina Zubillaga, Victoria R. Scardino, María N. Muñiz García, Daniela A. Capiati

“…Notably, PP2A can act as both a positive and negative regulator within the same pathway, while individual subunits often participate in multiple processes. This functional diversity arises from the structural flexibility of PP2A. …”
Get full text

Pleiotropic regulatory function of the RNA chaperone Hfq in the Pseudomonas protegens FD6 by Deyu Wen, Jieyu Hu, Ziying Gao, Chenglin Xing, Yao Xiao, Tao Wu, Xiaogang Wu, Qingxia Zhang

“…Additionally, mutation of hfq abolished the function of the type VI secretion system (T6SS) due to a decrease in the expression of T6SS-related genes. …”
Get full text

Lognormal Distribution Function for Describing Seepage Damage Process of Single-Cracked Rock by Xinyu Liu, Zhende Zhu, Aihua Liu, Yuan Tian

Get full text

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies by Opeyemi Ernest Oludada, Giulia Costa, Clare Burn Aschner, Anna S Obraztsova, Katherine Prieto, Caterina Canetta, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmüller, Rajagopal Murugan, Jean‐Philippe Julien, Elena A Levashina, Hedda Wardemann

Get full text

PATHOGENESIS-RELATED PROTEINS: identification, evolution and functional analysis in pear (Pyrus bretschneideri) by Chenyang Han, Qi Wang, Zhiyuan Su, Chaohui Li, Baodian Guo, Fanhang Zhang, Bao Tang, Yancun Zhao, Fengquan Liu, Shaoling Zhang

“…These findings offer valuable insights for future functional analyses and breeding strategies to enhance pear resistance to pathogens.…”
Get full text

Identification of microRNA in Houttuynia cordata Thunb and prediction of cross kingdom functions by Jiajian He, Ting Chen, Qingyun Xi, Jiajie Sun, Junyi Luo, Meng Li, Haojie Zhang, Bin Zeng, Jiahan Wu, Yongliang Zhang

“…It had been reported to have potential functions such as anti-bacterial, anti-cancer, and anti-inflammatory in human. …”
Get full text

Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders by Juanjuan Han, Jiale Zhang, Xiaoyi Zhang, Wenxin Luo, Lifei Liu, Yuqing Zhu, Qingfeng Liu, Xin-an Zhang

Get full text

Review and Validation of Plant Gene Function Research Methods Bypassing Tissue Culture by Huanghuang Jiang, Suya Huang, Jiayi Wang, Deming Sun, Min Wang, Su Lin, Jinhua Liu, Kai Xu, Bei Liu, Haijie Ma

“…Here, we review the advances in plant genetic transformation research, performing analysis of three methods for plant gene function analysis that bypass tissue culture: <i>Agrobacterium rhizogenes</i>-mediated root genetic transformation, developmental regulators (DRs)-mediated genetic transformation, and virus-mediated genome editing. …”
Get full text

Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion. by Xiaojie Ji, Lihong Zhao, Ankita Umapathy, Bernard Fitzmaurice, Jieping Wang, David S Williams, Bo Chang, Jürgen K Naggert, Patsy M Nishina

“…Here we show striking evidence that deficiency in LYST protein function leads to accumulation of photoreceptor outer segment phagosomes in retinal pigment epithelial cells, and reduces adhesion between photoreceptor outer segment and retinal pigment epithelial cells in a mouse model of Chediak-Higashi syndrome. …”
Get full text

Characterization and functional analysis of the BAM gene family in peanut (Arachis hypogaea L.) by Chaonan Shi, Peilin Li, Long Li, Long Li, Zhitao Qi, Tong Lu, Jinming Shi, Haodong Yang, Jin Wu, Jingyu Guo, Minghui Liu, Xiaozong Wu

“…This comprehensive analysis provides a holistic view of the potential functions of the AhBAM families in peanuts and lays the foundation for future experimental validation of their roles in enhancing peanut stress resistance and productivity.…”
Get full text

Genetic analyses and functional validation of ruminant SLAMs reveal potential hosts for PPRV by Xi Wei, Kejia Lu, Zhengwu Chang, Hanwei Guo, Qinfeng Li, Binxuan Yuan, Chen Liu, Zengqi Yang, Haijin Liu

Get full text

Initial function of microRNAs as a defence mechanism against invading organisms by Xiaoshuang Liu, Xinyuan Zang, Helian Feng, Quan Zhao, Chenyu Zhang, Jin Wang

“…Abstract Background Although microRNA (miRNA) regulation is widely considered as a mechanism to regulate gene expression in metazoans, plants and viruses, there are recent reports that show the interaction between viruses and their mammal hosts via miRNAs produced from both sides. MiRNAs are highly conserved among mammals, whereas the early miRNAs seem to be more diverse, implying a dynamic functional evolution of miRNAs in the early species. …”
Get full text

Functional analysis of human hematopoietic stem cell gene expression using zebrafish. by Craig E Eckfeldt, Eric M Mendenhall, Catherine M Flynn, Tzu-Fei Wang, Michael A Pickart, Suzanne M Grindle, Stephen C Ekker, Catherine M Verfaillie

“…We next performed a morpholino antisense oligonucleotide (MO)-based functional screen in zebrafish to determine the hematopoietic function of 61 genes that had no previously known function in HSC biology and for which a likely zebrafish ortholog could be identified. …”
Get full text

Assessment of Pulmonary Function After Treatment of Scoliosis: Meta-Analysis and Review Article by Majdi Hashem

“…<i>Background and Objectives:</i> Pulmonary function is a key outcome in scoliosis management, as both the condition and its treatments can impact respiratory mechanics. …”
Get full text

Structure and function of A41, a vaccinia virus chemokine binding protein. by Mohammad W Bahar, Julia C Kenyon, Mike M Putz, Nicola G A Abrescia, James E Pease, Emma L Wise, David I Stuart, Geoffrey L Smith, Jonathan M Grimes

“…The biological and structural data suggest that A41 functions by forming moderately strong (nM) interactions with certain chemokines, sufficient to interfere with chemokine-glycosaminoglycan interactions at the cell surface (microM-nM) and thereby to destroy the chemokine concentration gradient, but not strong enough to disrupt the (pM) chemokine-chemokine receptor interactions.…”
Get full text

Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex by A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova

“…Thus, the incorporation of PHF10 isoforms with different phosphorylation patterns and different stability into the PBAF complexes alters the functions of the entire PBAF complex and determines the range of genes undergoing remodelling.…”
Get full text