Hemoglobin-associated CALR in proximal tubule cells can be used as a biomarker for idiopathic membranous nephropathy by Shuting Pang, Shuting Pang, Qiuyan Tan, Qiuyan Tan, Boji Xie, Boji Xie, Bingmei Feng, Rongbin Zhou, Zige Liu, Zige Liu, Haiyuan Wei, Yian Huang, Mujia Jili, Yuli Xie, Yuli Xie, Shanshan Li, Shanshan Li, Binran Zhao, Binran Zhao, Wei Li, Rirong Yang, Rirong Yang

“…Functionally, CALR plays crucial roles in both immune response (particularly in antigen presentation) and physiological processes (notably in hemoglobin production).…”
Get full text

DualDyConvNet: Dual-Stream Dynamic Convolution Network via Parameter-Efficient Fine-Tuning for Predicting Motor Prognosis in Subacute Stroke by Yunjeong Jang, Joohye Jeong, Yun Kwan Kim, Da-Hye Kim, Wanjoo Park, Laehyun Kim, Yun-Hee Kim, Minji Lee

“…The proposed framework holds significant potential in facilitating early rehabilitation planning by predicting motor function prognosis in stroke patients. Furthermore, it can contribute to enhancing the quality of life by providing patients with prognostication.…”
Get full text

Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…LASSO regression analysis was conducted to identify prognostic genes and construct an SLC-related prognostic signature. …”
Get full text

Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models by Colleen S. Curran, Xizhong Cui, Yan Li, Tom Gamble, Junfeng Sun, Samuel Minkove, Alicia A. Livinski, Peter Q. Eichacker, Parizad Torabi-Parizi

“…Abstract Disruption of nicotinamide adenine dinucleotide (NAD) biosynthesis and function during infection may impair host defenses and aggravate inflammatory and oxidative organ injury. …”
Get full text

Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation by Dídac Llop, Pere Rehues, Silvia Paredes, Montse Guardiola, Josefa Girona, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Joan-Carles Vallvé, Josep Ribalta

“…We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. …”
Get full text

Age-Onset-Related Particularities of Pediatric MS—Understanding the Spectrum: A Tertiary Center Experience by Alice Denisa Dică, Dana Craiu, Florentina Ionela Linca, Magdalena Budișteanu, Catrinel Iliescu, Carmen Sandu, Cristina Pomeran, Diana Bârcă, Niculina Butoianu, Carmen Burloiu, Ioana Minciu, Ina Ofelia Focșa, Dana Surlică, Oana Tarța-Arsene, Cristina Cazacu, Andreea Badea, Alexandru Stefan Niculae, Daniela Adriana Ion

“…Intermediate-onset patients presented overlapping features of both early and late-onset MS and had the highest proportion of fully preserved motor function (EDSS 0) at the end of follow-up. MRI findings revealed more extensive and confluent lesions in younger patients, particularly in the first two years after onset. …”
Get full text

Raman spectroscopy and bioinformatics-based identification of key genes and pathways capable of distinguishing between diffuse large B cell lymphoma and chronic lymphocytic leukemi... by Haoyue Liang, Haoyue Liang, Zhijie Cao, Zhijie Cao, Yansong Ren, Yansong Ren, Yihan Li, Yihan Li, Haoyu Wang, Haoyu Wang, Fanfan Sun, Fanfan Sun, Mei Xue, Guoqing Zhu, Guoqing Zhu, Yuan Zhou, Yuan Zhou

“…In this study, bioinformatics analyses of these two NHL subtypes were conducted, identifying key patterns of gene expression and then experimentally validating the results. …”
Get full text

Cloning, Identification, and Light Response Analysis of Two Circadian Clock Genes Cryptochrome and Period in Boring Giant Clam Tridacna crocea by Wenhong YANG, Yihan NAN, Meng LI, Chunsheng LIU, Yi YANG, Feng YU, Zhifeng GU

“…The software SignalP 5.0 Server and SMART 4.0 were used to conduct online analysis and prediction of giant clam Cryptochrome and Period functional domains. …”
Get full text

Population prevalence and correlates of prolonged and shortened QTc intervals in a nationwide survey of adults in China: a report from Chinese arrhythmia epidemiology cross-section... by Li-Guo Tan, Li-Guo Tan, Jing-Xuan Liu, Fei Guo, Jing Lin, Ran Xiong, Hao Fu, Hao-Ming You, Liu He, Shi-Jun Xia, Xin Du, Jian-Zeng Dong

“…This study aimed to elucidate the distribution of the QT interval (QTc) patterns in Chinese adults and the risk factors associated with a prolonged QTc interval and shortened QTc interval.MethodsThis study was based on data from the Chinese Arrhythmia Epidemiology Cross-Sectional Study conducted in seven provinces of China between 2014 and 2016. …”
Get full text

The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking by Ren Li, Ren Li, Ren Li, Bingqing Zheng, Bingqing Zheng, Bingqing Zheng, Yuqiong Zhang, Yuqiong Zhang, Yuqiong Zhang, Lu He, Chaomin Ren, Chaomin Ren, Chaomin Ren, Linlin Guan, Linlin Guan, Linlin Guan, Huan Yang, Huan Yang, Huan Yang, Jiayu Tian, Jiayu Tian, Jiayu Tian, Xingyi Chen, Xingyi Chen, Xingyi Chen, Dongxing Shi, Dongxing Shi, Dongxing Shi, Lifang Zhao, Lifang Zhao, Lifang Zhao, Zhihong Zhang, Zhihong Zhang, Zhihong Zhang

“…By integrating information from multiple databases, we identified key target genes linked to these compounds and conducted functional enrichment analyses to elucidate their roles in pathological processes.ResultsOur results demonstrate that these phthalates affect the pathogenesis of asthma and COPD by modulating various target genes, including PTGS2, MMP9, and CASP3, which are involved in essential biological pathways such as apoptosis and immune response. …”
Get full text

Using five exposure metrics to explore the association between ambient PM2.5 and the hospital admissions for COPD in Tianshui city, China by Deshun Li, Jiyuan Dong, Xiaoju Liu, Juan Shu, Lisha Zhu, Hairong Bao

“…Stratified analyses were conducted to examine the effect modifications of gender, age, and season. …”
Get full text

Study on the mechanical traits, failure mechanisms, energy responses, and influencing factors of columnar jointed basalts under direct and indirect tensile conditions by Dan Liang, Dan Liang, Dan Liang, Haiqing Yang, Haiqing Yang, Zekang Ping, Zekang Ping, Yongyi Wang, Yongyi Wang, Kanglei Song, Kanglei Song, Chiwei Chen, Chiwei Chen, Hao Li, Hao Li, Xingyue Li, Xingyue Li, Lixin Peng, Lixin Peng, Anhua Ju, Anhua Ju

“…In this study, by merging mesoscopic damage mechanics, the probabilistic strength principle, and continuum mechanics, the visuals of columnar jointed basalts (CJBs) featuring various joint arrangement patterns are converted into inhomogeneous numerical models utilizing the digital visual analysis based on the digital image correlation (DIC)-enhanced rock failure process analysis (RFPA). …”
Get full text

Regreening Practices and Effectiveness Evaluation for Rocky Slope Drawdown Zones in Pumped Storage Power Station Reservoirs by YANG Zhi-chao, MA Xiao-xiao, CHANG Shi-ju, TANG Yu-shuang, ZHAO Rui-yi, WAN Dan, ZHANG Qian-zhu

“…[Methods] To address the severely impaired ecological function of the drawdown zone, this study conducted systematic analysis of habitat characteristics, including hydrological patterns, bank characteristics, non-point source pollution, and plant communities. …”
Get full text

Haematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Northwest Ethiopia by Abraham Belete Temesgen, Tadegegn Mitiku, Mastewal Birhan, Mersha Chanie Kebede, Mohammed Yesuf, Muluken Yayeh Mekonnen, Moges Maru Alemayehu, Birhan Anagaw Malede, Abdo Megra Geda, Aregash Wendimu Tumebo, Kefale Ambachew Shiferaw, Zerihun Getie Wassie, Genetu Kassahun Berie, Bemrew Admassu Mengistu, Melaku Getahun Feleke, Fikadu Edenshaw, Mulusew Tesfaye Yitie, Gashaw Enbiyale Kasse, Elias Melkamu Tsehay, Samuel Atalay Shiferaw

“…Haematology and biochemical tests should be part of routine diagnosis for early detection and liver function assessment, while histopathology confirms the infection stage. …”
Get full text

Identification and expression characterization of apple β-tubulin gene family in apple by HUANG Huiling, WANG Yanxiang, WANG Yue, NING Qinqin, LI Ming, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, JIAO Jian, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo

“…However, little is known about apple tubulin family genes and their potential functions. Therefore, the present study was to identify the apple β-tubulin family genes and to determine the candidate β-tubulin genes involved in regulating apple dwarfing. …”
Get full text

The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective by Jian-Di Li, Li-Li Deng, Jia-Yuan Luo, Chao-Hua Mo, Bang-Teng Chi, Wan-Ying Huang, Rong-Quan He, Di-Yuan Qin, Chang Song, Wen Zou, Gang Chen

“…Abstract Background Collagen type VI alpha 6 chain (COL6A6), an essential component of epithelial cell basal lamina, is hypothesized to function as a tumor suppressor in various cancers, yet its role in breast cancer remains unclear. …”
Get full text

Measurement report: Long-term assessment of primary and secondary organic aerosols in the Shanghai megacity throughout China's Clean Air actions since 2010 by H. Yu, Y. Chang, L. Cheng, Y. Duan, J. Hu

“…Potential sources from distant regions were analyzed using the potential source contribution function (PSCF), indicating that the geographical potential source area is concentrated near the middle and lower Yangtze River.…”
Get full text

TWO CASES OF PRIMARY AMYLOIDOSIS PRESENTING WITH VERTEBRAL AMYLOIDOMA by Ebru Kavak Yavuz, Vehbi Demircan, Abdullah Karakus, Orhan Ayyildiz

“…Cardiac examination ECHO showed normal heart chambers, normal left ventricular functions, EF%60. ECG examination was normal. VCD chemotherapy was started in the patient's treatment. …”
Get full text

Identification and expression analysis of ACBPs family members of Hippophae rhamnoides subsp. sinensis Rousi in response to lead stress by CHEN Ke, LI Xinjuan, ZHANG Tian, REN Qiandan, SUN Jing, ZHOU Wu

“…Group 3 contained the most exons, increasing the likelihood of alternative splicing and enhancing functional diversity. The gene family's promoter regions contain various cis-acting elements responsive to plant hormones, meristematic activity, and stress stimuli, suggesting that HrLACBPs have multiple biological functions. …”
Get full text

GUEST EDITORS’ NOTE by Piero Amodio, Edward W. Legg, Ljerka Ostojić

“…In their review paper, Grabner and colleagues summarise research on vocal isochrony in different animal species to inform hypotheses about its adaptive function. The authors discuss how comparative work on vocal isochrony – which refers to sounds that are repeated at regular intervals - can contribute to our knowledge on how rhythms in human language and music may have evolved. …”
Get full text