Expression Analysis and SNP Mining of the Parkin Co-Regulated Gene (PACRG) and parkin in Penaeus vannamei Against White Spot Syndrome Virus by Qian XUE, Xupeng LI, Yang LI, Sheng LUAN, Kun LUO, Jie KONG, Qun XING, Xianhong MENG

“…Post-WSSV infection, PACRG and parkin exhibited similar expression patterns in the eyestalk. The location of PACRG mRNAs mostly overlapped with the WSSV replication site in the shrimp muscle, suggesting that PACRG plays a functional role in the interaction between P. vannamei and WSSV. …”
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Next-generation sequencing in early-stage multiple primary lung cancer: The prognostic significance of genomic accumulation status and BCL2L11del by Mu-Ting Wang, Chen-Hui Ni, Yan-Qi Lu, Wei Zheng, Shu-Liang Zhang, Mao-Hui Chen, Bin Zheng, Chun Chen

“…Additionally, the study sought to explore the biological functions and prognostic significance of PRMT8 in BCL2L11del lung cancer. …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…We applied Bayesian occupancy modelling and quantified spatiotemporal determinants of black bear occurrence as a function of date palms, distance to agriculture, elevation, precipitation, and protected area (PA) size. …”
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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Further analysis revealed high heterogeneity in tissue preference, gene expression, functional enrichment, immunodynamics, transcriptional regulatory factors, metabolic changes, and communication patterns in fibroblasts and myeloid cells. …”
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CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation by Juan Juan Chen, Zhang Ze Lu, Yu Xin Jing, Xing Mei Nong, Yi Qin, Jin Yang Huang, Na Lin, Jie Wei

“…Clinical validation in 92 children confirmed CD79A suppression and GADD45A elevation in severe RSV (p < 0.001), aligning with younger age, lower weight, and respiratory distress. Functional enrichment implicated endoplasmic reticulum stress and neutrophil extracellular traps in disease progression. …”
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Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach by Zihan Li, Jun Li, Jiahui Li, Mengying Wang, Andi Xu, Yushu Huang, Qi Yu, Lingzhi Zhang, Yingjun Li, Zilin Li, Xifeng Wu, Jiajun Bu, Wenyuan Li

“…Brain age gap exhibited clinical feasibility combined with Functional Activities Questionnaire, with improved discriminative capacity in models achieving lower MAEs (AUC of 0.945 vs 0.923 and 0.911; AUC of 0.935 vs 0.900 and 0.881). …”
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FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…The high-risk group was linked to advanced stage, higher MSI, CMS4 subtype enrichment, distinct mutation patterns, and increased genome integrity pathway mutations (79% vs. 66%). …”
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Three different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study by Safaa A. Hussein, Gharib M. Taha, F. A. Adam, Marwa A. Moghazy

“…FTIR analysis approves that combining ZnO with RGO affects the functional groups of the three nanocomposite surfaces. …”
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Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated Inflammatory Diseases: Observational Study by Adrien Bennetot, Rana Zia Ur Rehman, Robbin Romijnders, Zhi Li, Victoria Macrae, Kristen Davies, Wan-Fai Ng, Walter Maetzler, Jennifer Kudelka, Hanna Hildesheim, Kirsten Emmert, Emma Paulides, C Janneke van der Woude, Ralf Reilmann, Svenja Aufenberg, Meenakshi Chatterjee, Nikolay V Manyakov, Clémence Pinaud, Stefan Avey

“…ObjectiveThis study aimed to evaluate the feasibility and acceptability of using a high-frequency eDiary to capture intraday variability in fatigue and to compare eDiary data with scores obtained from the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), a validated weekly recall PRO. …”
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Ocean alkalinity enhancement approaches and the predictability of runaway precipitation processes: results of an experimental study to determine critical alkalinity ranges for safe... by N. Suitner, G. Faucher, C. Lim, J. Schneider, C. A. Moras, U. Riebesell, J. Hartmann

“…The experiments lasted for 20–25 <span class="inline-formula">d</span> to monitor the temporal development of carbonate chemistry parameters after alkalinity addition and the subsequent triggered carbonate precipitation process. Identified uniform patterns before and during the triggered runaway process can be described by empirical functional relationships. …”
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Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury by Lingyan Li, Xingjie Wu, Qianqian Guo, Yu'e Wang, Zhiyong He, Guangqiong Zhang, Shaobo Liu, Liping Shu, Babu Gajendran, Ying Chen, Xiangchun Shen, Ling Tao

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Multi-element Accurate Analysis of Sulfide Minerals by Low-temperature Ablation LA-ICP-MS by Huilai LI, Fan LI, Dingwen ZHANG, Wei GUO, Lanlan JIN, Shenghong HU

“…The LA-ICP-MS low temperature ablation cell is an ablation system developed in recent years, whose main function is to provide a low temperature ablation environment to realize the effective analysis of cells, blood and other samples. …”
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Wogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway by Zhiyong Du, Zhiyong Du, Zhiyong Du, Zhiyong Du, Cuiping Sun, Cuiping Sun, Cuiping Sun, Cuiping Sun, Jiawei Wu, Jiawei Wu, Hongwei Gao, Hongwei Gao, Hongwei Gao, Hongwei Gao, Jialong Wu, Jialong Wu, Jialong Wu, Jialong Wu, You Zhou, You Zhou, You Zhou, You Zhou, Xuechao Wu, Xuechao Wu, Liping Shen, Liping Shen, Qing Wang, Qing Wang, Qing Wang, Qing Wang

“…Functional and pathway enrichment analyses were executed utilizing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) methodologies. …”
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Alteration in motor control in patients with low back pain and myotonic syndrome of lumbar osteochondrosis by V.A. Kolesnichenko, H.H. Holka, I.V. Hresko, V.V. Burlaka, V.V. Vesnin, B.P. Vvedensky, D.B. Vvedensky

“…The majority of studies associate low back pain with limitation of motor function of the spine and muscle control of the lumbar-pelvic area, however, in a number of reports such a connection was not found. …”
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Assessment of the attractiveness of a region for coffee production: the case of Karo Regency by Syahbudin Hasibuan, Zulkarnain Lubis, Sri Ariani Safitri, Zahraturrahmi Zahraturrahmi, Marizha Nurcahyani

“…Culturally, coffee remains integral to Karo society, with over 85% of respondents recognising its role in tradition and daily life, supporting its value beyond economic function. Economically, polyculture systems combining coffee with vegetables offer the highest profitability and stability across all regions. …”
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Deep Learning–Based Chronic Obstructive Pulmonary Disease Exacerbation Prediction Using Flow-Volume and Volume-Time Curve Imaging: Retrospective Cohort Study by Eun-Tae Jeon, Heemoon Park, Jung-Kyu Lee, Eun Young Heo, Chang Hoon Lee, Deog Kyeom Kim, Dong Hyun Kim, Hyun Woo Lee

“…Acute exacerbations (AE) of COPD (AE-COPD) are key determinants of disease progression; yet, existing predictive models relying mainly on spirometric measurements, such as forced expiratory volume in 1 second, reflect only a fraction of the physiological information embedded in respiratory function tests. Recent advances in artificial intelligence (AI) have enabled more sophisticated analyses of full spirometric curves, including flow-volume loops and volume-time curves, facilitating the identification of complex patterns associated with increased exacerbation risk. …”
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Effect of traditional Chinese medicine combined with conventional Western medicine for patients with severe/very severe chronic obstructive pulmonary disease: a multi-center, rando... by Jiansheng Li, Yang Xie, Minghang Wang, Suyun Li, Xuefeng Yu, Nianzhi Zhang, Zhengang Zhu, Wei Zhang, Jihong Feng, Zikai Sun, Lin Lin, Zhijia Sun, Hailong Zhang, Xueqing Yu

“…This study aimed to evaluate the clinical efficacy of comprehensive therapy based on TCM patterns for patients with stable, severe to very severe COPD. …”
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An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers by Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…A correlation analysis between the Anoscore, the tumor microenvironment and drug sensitivity was conducted in GI cancers. The expression and function of some candidate genes were validated in vitro.ResultsIn terms of prognostic ARGs, two anoikis-related patterns, ARG clusters A and B, were identified. …”
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Status and trends in transcranial magnetic stimulation research: a bibliometric analysis by Qi Deng, Fei Xing, Dan Li, Dan Li, Maomao Huang, Maomao Huang, Zhangyu Xv, Yue Yang, Lei Li, Jiayi Zhu, Rongnan Shi, Guoya Meng, Qin Wang, Jianxiong Wang, Jianxiong Wang, Jianxiong Wang

“…BackgroundTranscranial magnetic stimulation (TMS), as a rapidly advancing non-invasive brain stimulation technique, has demonstrated reliable therapeutic efficacy and significant potential in brain function assessment and research. However, comprehensive bibliometric analyses of the overall TMS field remain limited. …”
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Transcriptomic profiling and bioinformatic insights into myocardial injury following aneurysmal subarachnoid hemorrhage by Zuoli Wu, Zuoli Wu, Wenbo He, Weihao Ye, Shang Xu, Shengwei Wei, Baozi Huang, Pingping Li, Yanyan Tang, Chao Qin, Ying Liu, Ziming Ye

“…While RNA plays a critical role in pathophysiological processes, its expression patterns and functions in myocardial injury after aSAH (aSAH-MI) remain poorly understood.ObjectiveTo construct the RNA expression profile of aSAH-MI patients, explore their biological functions, and establish a gene expression regulatory network for aSAH-MI. …”
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