Altered Expression of Cell Cycle Regulators and Factors Released by Aged Cells in Skeletal Muscle of Patients with Bone Fragility: A Pilot Study on the Potential Role of SIRT1 in M... by Angela Falvino, Roberto Bonanni, Beatrice Gasperini, Ida Cariati, Angela Chiavoghilefu, Amarildo Smakaj, Virginia Veronica Visconti, Annalisa Botta, Riccardo Iundusi, Elena Gasbarra, Virginia Tancredi, Umberto Tarantino

“…<b>Background/Objectives</b>: Cellular aging represents a crucial element in the progression of musculoskeletal diseases, contributing to muscle atrophy, functional decline, and alterations in bone turnover, which promote fragility fractures. …”
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Identification of single nucleotide polymorphisms (SNPs) associated with heat stress and milk production traits in Chinese holstein cows by Jingyi Xu, Lirong Hu, Jingyang Ning, Fan Zhang, Qing Xu, Yachun Wang

“…And g.44,660,065 C > T in the HSPA4 gene could be used as functional molecular markers for the genetic selection of dairy cows for improving heat tolerance without compromising their high milk performance.…”
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The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19 by Jiahui Zhu, Jiamin Shao, Peng Wang, Yuan Liu, Gangming Cheng, Qi Zhou, Zhuoran Li, Jiayi Li, Mingqia Wang, Zhuokai Zhang, Xuan Dong, Chuan Shi

“…Then clinical symptoms, cognitive performance, and functional assessments were conducted at recruitment. …”
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Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation by Victòria Ayala, Laia Fontdevila, Santiago Rico-Rios, Mònica Povedano, Pol Andrés-Benito, Pascual Torres, José C. E. Serrano, Reinald Pamplona, Manuel Portero-Otin

“…Of note, different studies do not agree on common patterns of microbiota being linked to ALS, supporting the need for further, more extensive studies. …”
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Comparative metagenomics highlights the habitat-related diversity in taxonomic composition and metabolic potential of deep-sea sediment microbiota by Rui Lu, Denghui Li, Yang Guo, Zhen Cui, Zhanfei Wei, Guangyi Fan, Weijia Zhang, Yinzhao Wang, Ying Gu, Mo Han, Shanshan Liu, Liang Meng

“…In this study, the significant differences in the taxonomic composition and functional potential of microbial communities inhabiting various deep-sea environments were investigated. …”
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Seasonal Self-Purification Process of Nutrients Entering Coastal Water from Land-Based Sources in Tieshan Bay, China: Insights from Incubation Experiments by Fang Xu, Peng Zhang, Yingxian He, Huizi Long, Jibiao Zhang, Dongliang Lu, Chaoxing Ren

“…Nutrients function as essential biological substrates for coastal phytoplankton growth and serve as pivotal indicators in marine environmental monitoring. …”
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Cardiovascular and renal comorbidities among saudi patients with type 2 diabetes: A cross-sectional observational study. by Syed Irfan Karim, Kamran Sattar, Tauseef Ahmad, Mustafa Kamal Memon, Abdulfattah S Alqahtani, Abdulrahman M Alsubiheen, Fahad Abdulaziz Alrashed

“…<h4>Objective</h4>This study aims to investigate the prevalence and patterns of cardiovascular and renal complications among patients with T2DM in the Saudi population and elucidate the extent of these comorbidities and their potential risk factors.…”
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Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Conclusions These findings suggest that Kmo deficiency impacts KP biochemistry, sleep behavior, and brain mitochondrial function. Even though WT-Kmo +/+ inherit identical genetic material as WT-Control, their development might be shaped by the parent’s physiology, behavior, or metabolic state influenced by their Kmo genotype, leading to phenotypic sex-specific differences in offspring.…”
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A study of morpho-phonological processes in the Zanjani dialect of Azerbaijani Turkish based on optimality theory by farnaz ebadi, Mohammad Reza Oroji, Sakine Jafari, Mehri Talkhabi

“…(McCarthy, 2008: 19):     Generator  Evaluator   Input →                                → Candidates →                              →  Output Optimal Theory Model (McCarthy, 2002: 10) In order to show the function of GEN and EVAL, Optimality Theory utilizes the tables labeled as tableau. …”
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Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input by Katherine Regalado Núñez, Katherine Regalado Núñez, Daniel Bronson, Daniel Bronson, Ryan Chang, Radha Kalluri, Radha Kalluri, Radha Kalluri

“…Patch-clamp recordings showed that biophysical diversity of vestibular ganglion neurons in the Vglut3-ko mice is comparable to that found in wild-type controls, with a similar range firing patterns at both immature and juvenile ages. However, our results suggest a subtle biophysical alteration to the largest ganglion cells (putative somata of central zone afferents); those in the knockout had smaller net conductance and were more excitable than those in the wild type.DiscussionThus, unlike in the auditory nerve, glutamatergic signaling is unnecessary for producing biophysical diversity in vestibular ganglion neurons. …”
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Inter and intrasentential code switching among late bilinguals by Barzan Jaafar Ali

“…PhD thesis Chan, B. and Hock-Shing. (2015) A diachronic-function approach to explaining grammatical patterns in code-switching: Postmodification in Cantonese English noun phrase. …”
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Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma by Yan Liao, Hao Yao, Weidong Chen, Yutong Zou, Ji Fang, Jiongfeng Zhang, Zehao Guo, Jian Tu, Junkai Chen, Zijun Huo, Lili Wen, Xianbiao Xie

“…In vitro coculture functional assays were performed to validate the role of macrophage migration inhibitory factor (MIF) in macrophage polarization and chemotaxis. …”
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Phenome-wide association studies between SERINC2 and neuropsychiatric disorders by Ping Liu, Xinqun Luo, Liping Cao, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Xinghua Pan, Ruilan Yang, Zewen Tan, Yunlong Tan, Chiang-shan Li, Xiaoyun Guo, Zhiren Wang, Xingguang Luo, Xingguang Luo

“…SNP-disease associations were tested and then meta-analyzed, followed by FDR correction, to identify significant disease-risk SNPs. Finally, functional studies on the differential SERINC2 mRNA expression in brains and the potential regulatory effects of disease-risk alleles on SERINC2 mRNA expression, gray matter volumes (GMVs) of subcortical structures, cortical surface area (SA) and average thickness (TH) were conducted.ResultsIn European descent, alcoholism was most significantly associated with SERINC2 variants (245 SNPs with 5.5×10-8≤p ≤ 0.049 and 4.9×10-5≤q ≤ 0.034) that were largely shared across cocaine dependence, marijuana dependence, nicotine dependence, polysubstance dependence, schizophrenia, OCD, and autism (8.2×10-8≤p ≤ 0.050 and 1.9×10-5≤q ≤ 0.049); in Chinese population, bipolar disorder was also significantly associated with SERINC2 variants (10 SNPs: 1.3×10-4≤p ≤ 4.7×10-4 and 0.025≤q ≤ 0.031). …”
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Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression by Tingting Xu, Jianmin Huang, Jiajing Lin, Yuanyuan Liu, Yi Wang, Wenkang Shen, Jianjie He, Shuyun Chen, Xi Zhu, Yuqin Que, Mengting Hu, Yu Chen, Liming Cheng, Honghao He, Xin Liu, Si Liu

“…Analysis of key glycogenes revealed differential expression patterns, implicating a functional role for IgG N-glycosylation in GC. …”
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Filling knowledge gaps: A methodological approach for the rapid investigation of species with restricted populations by André Cesar Furlaneto Sampaio, Pablo Melo Hoffmann, Elivelton Marcos Gurski, Ollyver Rech Bizarro, Santiago José Elías Velazco, Marcos Bergmann Carlucci, Marília Borgo, Mayara Monteiro Ferreira, Alessandro Camargo Angelo, Christopher Thomas Blum

“…In the third phase, we analyzed spatial patterns using Morisita’s Index and Ripley’s K function. …”
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Automatic detection of lucky bamboo nodes based on Improved YOLOv7 by Jing Zhang, Jing Zhang, Jing Zhang, Ruoling Deng, Ruoling Deng, Ruoling Deng, Chengzhi Cai, Erpeng Zou, Haitao Liu, Haitao Liu, Mingxin Hou, Xinzhi Chen, Huamin Lin, Zhenye Wei

“…Future work will address limitations in detecting nodes obscured by mottled patterns or severe occlusions by expanding label categories during training.…”
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Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway by Shengnan Shi, Jiaming Gao, Yehao Zhang, Min Zhan, Zhanfei Tan, Peili Wang, Jianhua Fu, Jianxun Liu

“…Inflammation markers, platelet aggregation function, and CD62p levels were assessed using flow cytometry. …”
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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration by Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson

“…Results Our data revealed that the abundance of 31 proteins was significantly increased in severe degenerated IVD tissues compared to mild. Functional analyses showed that more than 40% of these proteins were matrisome-related, indicating differences in ECM protein composition between severe and mild degenerate IVD tissues. …”
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Integrin beta‐like 1 is regulated by DNA methylation and increased in heart failure patients by Lauren Kerrigan, Kevin Edgar, Adam Russell‐Hallinan, Oisin Cappa, Nadezhda Glezeva, Carlos Galan‐Arriola, Eduardo Oliver, Borja Ibanez, John Baugh, Patrick Collier, Mark Ledwidge, Ken McDonald, David Simpson, Sudipto Das, David J. Grieve, Chris J. Watson

“…Subsequent in vitro analyses were conducted to elucidate a role for ITGBL1 in human cardiac fibroblasts. …”
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Genome-wide identification and gene expression analysis of the malate dehydrogenase (MDH) gene family in Eucalyptus grandis by Yifan Xing, Yifan Xing, Huiming Xu, Deming Yang, Lichuan Deng, Guolong Li, Guolong Li, Zhixin Zhao, Zhixin Zhao, Zhaohua Lu, Liuyin Ma, Guangyou Li

“…Malate dehydrogenases are pivotal in plant metabolism and stress responses, yet their evolutionary dynamics and functional diversification in woody angiosperms remain underexplored. …”
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