Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers by Lingyu Xie, Lingyu Xie, Xin Zeng, Xin Zeng, Hui Luo, Hui Luo, Bin Xie, Xuefeng Wang, Nan Wu, Junrong Zou, Junrong Zou, Junrong Zou, Guoxi Zhang, Guoxi Zhang, Guoxi Zhang, Xiaofeng Zou, Xiaofeng Zou, Xiaofeng Zou, Hui Xu, Hui Xu, Hui Xu

“…Functional enrichment and protein interaction network analyses were also performed to explore its potential involvement in cancer-related pathways.ResultsOur findings revealed that ZNF433 is significantly downregulated in most cancer types, with stage-dependent expression patterns observed in KIRC and KIRP. …”
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Effect of Chlorhexidine and Benincasa Hispida Pretreatment on Microshear Bond Strength of Universal Adhesive System on Dentin: A Pilot Study by Girija S Sajjan, Manda Sri Swathi, P Arun Bhupathi, Madhu Varma Kanumuri, Rajulapati Kalyan Satish, Rama Krishna Alla, Tippireddy Srija, Ch Uma Shalini

“…Benincasa hispida is a natural plant-based functional food containing minerals and vitamins that help prevent osteoporosis and improve bone health. …”
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Spatiotemporal dynamics of soil moisture and the occurrence of hysteresis during seasonal transitions in a headwater catchment by Shangqiang Hui, Li Guo, Haochen Liu, Xuemei Wu, Ping Lan, Elizabeth W. Boyer, Carlos R. Mello, Hongxia Li

“…While extensive research has been conducted on soil moisture patterns within distinct dry or wet seasons, the transitions between these seasons have received relatively little attention. …”
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Identification of DNA Methylation Differences in Pituitary Tissues of Sichuan White Geese Using Whole-Genome Bisulfite Sequencing (WGBS) by Lin Ma, Xianzhi Zhao, Guoda A, Tongtong Song, Meng Wu, Zhihao Yan, Min Xiao, Wenbo Jiang, Yixiao Gao, Haiwei Wang, Zhuping Chen, Keshan Zhang, Jiajia Xue, Yi Luo, Chao Wang, Youhui Xie, Ying Chen, Guangliang Gao, Qigui Wang

“…Integrated GO and KEGG enrichment analysis conducted to explore the role of regulatory networks of epigenetic modification on egg-laying traits in Sichuan White geese identified multiple metabolic pathways associated with egg-laying traits (promoting egg transport, ovulation, and yolk protein synthesis and secretion), thus providing a basis for subsequent functional verification.…”
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…Methods We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickness in bvFTD with C9orf72 repeat expansions or pathogenic variants in GRN or MAPT. Functional enrichment analyses were conducted on each gene list significantly associated with cortical thickness. …”
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Completeness of repeated patient-reported outcome measures in adult rehabilitation: a randomized controlled trial in a diverse clinical population by Anne-Lene Sand-Svartrud, Ingvild Kjeken, Renate Foss Skardal, Gunhild M. Gjerset, Tonje Jossie Johnsen, Anne Dorte Lyken, Hanne Dagfinrud, Rikke Helene Moe

“…This study aimed to analyse response patterns and degree of data completeness in systematic outcome assessments conducted within a clinical study in a multidisciplinary rehabilitation setting, comparing completeness of a brief and a longer set of PROMs. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…We then performed functional validation using a mouse colorectal cancer graft tumor model established with the CT26 cell line characterized by its high content of CSCs. …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Among the depressed cohort, 25 participants adhered to the treatment protocol and completed MRI scans. Resting-state functional MRI (rs-fMRI) scans were conducted for all participants, with a subsequent scan for the depression group after 8 weeks of sertraline therapy. …”
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The novel diagnostic markers for systemic lupus erythematosus and periodontal disease by Xuedi Cheng, Jinfeng Zhang, Jiali Hou, Xiaocui Han, Bin Han, Jun Zhou, Zhongjun Wang, Junzheng Wang

“…Protein-protein interaction (PPI) network analysis was conducted to explore relationships between hub genes. …”
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Is avoidable diabetes-related hospitalization in older patients with type 2 diabetes mellitus associated with increased health expenditure?: A nationwide retrospective cohort study... by Woo-Ri Lee, Gyeong-Min Lee, Noorhee Son, Kyu-Tae Han, Sungyoun Chun, Yehrhee Son, Ki-Bong Yoo

“…Regression analysis was performed using the generalized estimating equation (GEE) with a gamma distribution and log-link function. Inverse Probability of Treatment Weighting (IPTW) analysis was conducted to enhance the robustness of the results. …”
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Real-world use of inhaled corticosteroid/formoterol as needed in adults with mild asthma: the PRIME study by Guy Brusselle, Francesco Blasi, Christian Gessner, Piotr Kuna, Peter Wark, Glauco Cappellini, Emilie Oosterom, Marielle Van Der Deijl, Enrica Bucchioni, Eva Topole

“…This real-world study provides additional support to the use of ICS/FF as needed as preferred treatment for patients with mild asthma, whereas SABA as needed was associated with a fall in lung function and more severe exacerbations.…”
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SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma by Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li

“…To investigate the biological functions of SMYD2, we conducted a series of functional assays in vitro and in vivo. …”
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Graph Neural Network Learning on the Pediatric Structural Connectome by Anand Srinivasan, Rajikha Raja, John O. Glass, Melissa M. Hudson, Noah D. Sabin, Kevin R. Krull, Wilburn E. Reddick

“…Architecture exploration experiments were conducted to evaluate the impact of network depth, pooling techniques, and skip connections on the ability of GNN models to capture connectomic patterns. …”
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Non-invasive detection of Parkinson’s disease based on speech analysis and interpretable machine learning by Huanqing Xu, Wei Xie, Mingzhen Pang, Ya Li, Luhua Jin, Fangliang Huang, Xian Shao

“…ObjectiveParkinson’s disease (PD) is a progressive neurodegenerative disorder that significantly impacts motor function and speech patterns. Early detection of PD through non-invasive methods, such as speech analysis, can improve treatment outcomes and quality of life for patients. …”
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Autobiographical memory in Alzheimer’s disease: a systematic review by Chiara Stramba-Badiale, Fabio Frisone, Fabio Frisone, Fabio Frisone, Fabio Frisone, Diana Biondi, Giuseppe Riva, Giuseppe Riva

“…Emotional processing patterns were also modified, with some studies indicating a positivity bias in memory recall. …”
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Kernel Density Estimation: a novel tool for visualising training intensity distribution in biathlon by Craig A. Staunton, Craig A. Staunton, Andreas Kårström, Andreas Kårström, Hannes Kock, Hannes Kock, Marko S. Laaksonen, Glenn Björklund

“…Sessions were dichotomised into those planned as low-intensity training (LIT) or those planned with high-intensity training (HIT). KDE analyses were conducted in MATLAB (Version R2020b) using the “ksdensity” function to create 2D KDE plots that visualise HR intensity accumulation across each programme, session type (e.g., Low-intensity training: LIT; High-intensity training: HIT), and individual athlete responses. …”
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Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn’s Disease: A Cross-Sectional Study by Sun S, Chen Y, Zheng M, Zhou M, Weng C, Fan Y, Lv B

“…Latent profile analysis (LPA) was conducted to categorize individuals with CD into classes based on PROs. …”
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Changes in shoulder range of motion following arthroscopic rotator cuff repair: a systematic review by Carla Antonacci, Umile Giuseppe Longo, Emiliano Schena, Mariajose Villa Corta, Greta Di Sabatino, Adriana Elvira Arab Orozco, Alessandro de Sire, Arianna Carnevale

“…Surgical treatments are the recommended approach for patients with acute symptomatic RC tears that aim to restore shoulder movement function. Kinematic outcomes, following arthroscopic RC repair lack consensus, needing clarity on changes in shoulder kinematics. …”
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The Risk of Vestibular Disorders with Semaglutide and Tirzepatide: Findings from a Large Real-World Cohort by Eman A. Toraih, Awwad Alenezy, Mohammad H. Hussein, Shahmeer Hashmat, Saitej Mummadi, Nawaf Farhan Alrawili, Ahmed Abdelmaksoud, Manal S. Fawzy

“…While their metabolic benefits are well-established, their potential effects on vestibular function remain unexplored. This study investigated the association between GLP-1RA use and the risk of vestibular disorders. …”
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Determinants of Success in Revision Cochlear Implant Surgeries: A Comprehensive Evaluation of Patient, Surgical, and Radiological Factors by Sarah Alshehri, Thikra Khalid Hamdi Alasmari

“…The primary outcome was surgical success, defined by improved auditory function, stable device positioning, and absence of postoperative complications. …”
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