A systematic analysis of the network of lncRNAs and mRNAs regulated by TP53 and TP53 mutants with hotspot mutations by Hong Chen, Zhongrong Guo, Peilong Li, Wanxiang Liao, Yunhao Li, Bo Li, Yan Li, Qingqing Zhu, Yingsi Lu, Lifen Huang, Xiaoyu Xu, Yunjun Xiao, Chengming Zhu, Song He, Guoxing Zheng

“…From this convergence, we curated a list of predicted TP53-regulated lncRNAs exhibiting differential expression patterns. Further pathway enrichments focusing on these lncRNAs converged on DNA replication and cell cycle processes, mirroring the well-established functions of TP53. …”
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Genome-wide identification and expression profiles of NAC transcription factors in Poncirus trifoliata reveal their potential roles in cold tolerance by Tian Fang, Yue Wang, Haowei Chen, Jing Qu, Peng Xiao, Yilei Wang, Xin Jiang, Chunlong Li, Ji-Hong Liu

“…This study aims to elucidate the genomic characteristics and evolution of the NAC genes in P. trifoliata, and to analyze their expression patterns and conduct functional validation under cold stress. …”
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Leveraging 'golden-hour' WUE for developing superior vegetable varieties with optimal water-saving and growth traits by Rujia Jiang, Ting Sun, Zheng Shi, Menachem Moshelion, Pei Xu

“…However, while reducing stomatal conductance can boost water use efficiency (WUE), it results in a decline in photosynthetic assimilation capacity, because stomata function as a shared conduit for both CO2 intake and water evaporation. …”
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Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats by Jiangzihui Guo, Qingying Cao, Huicong Jie, Yuqing Li, Wenwen Bai, Tiaotiao Liu, Xuyuan Zheng

“…Through simultaneous monitoring of behavioral patterns and local field potentials (LFPs) in both mPFC and BLA during open-field exploration, we conducted comparative analyses between chemogenetically activated and sham-stimulated groups. …”
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Characterization and prognostic of CD8 + TIM3 + CD101 + T cells in glioblastoma multiforme by Hong-Liang Wang, Sai Li, Chun-Chun Ma, Xiang-Hu Zheng, Hao-Yuan Wu, Chen-Xi Chang, Zhi-Hao Yang, Jia-Wei Wang, Fa-Ming Pan, Bing Zhao

“…DEGs were identified, and cell trajectories were constructed using Seurat, Monocle 2, and CellChat packages. Functional enrichment analysis was conducted with clusterProfiler, and a prognostic model was developed. …”
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Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial by Hannah Berg, Timothy J. McDermott, Rayus Kuplicki, Hung-Wen Yeh, Wesley K. Thompson, Ryan Smith, Elisabeth Akeman, Namik Kirlic, Ashley Clausen, Mallory Cannon, Evan White, Christopher R. Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, James L. Abelson, Martin P. Paulus, Robin L. Aupperle

“…Participants completed an AAC task during functional magnetic resonance imaging pre-treatment. …”
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Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective by Xinhua Peng, Xinhua Peng, Rongrong Zhu, Ke Zhang, Jianghong Ji, Chuanguo Lv, Feng Feng, Feng Feng

“…Future priorities should focus on biomarker discovery, equitable global collaborations, and AI-enhanced frameworks to transform survival into functional recovery worldwide.…”
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Exploring the role of LOX family in glioma progression and immune modulation by Chen Liu, Chen Liu, Chen Liu, Huilian Qiao, Hongqi Li, Xiaolong Hu, Maohui Yan, Zhiguang Fu, Hengheng Zhang, Yingjie Wang, Nan Du, Nan Du

“…Knockdown of LOX genes impaired glioma cell functions, induced apoptosis, and altered immune cell behavior by reducing M2 macrophage polarization and enhancing CD8+ T cell activity.ConclusionsThe LOX family is overexpressed in glioma and is associated with poor prognosis and altered immune infiltration patterns. …”
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Knowledge mapping and emerging trends in pediatric hemiplegia research: a bibliometric study spanning 1982–2025 by Xiaoli Li, Ya Guo, Lingchuan Niu

“…BackgroundPediatric hemiplegia is a significant neurological condition that impacts motor function and quality of life. This bibliometric analysis aimed to evaluate research trends, collaboration patterns, and emerging topics in pediatric hemiplegia research.MethodsPublications were retrieved from the Web of Science Core Collection database spanning from 1982 to 2025. …”
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Down-regulation of miR-125b by HPV16 E6 might promote cervical cancer progression through TAZ/TEAD by Yongli Hou, Lili Zhang, Wenhao Wang, Keyan Cheng, Hui Wang, Yanfei Ji, Xiaoqiang Su, Min Hao

“…Functional assays using a miR-125b mimic revealed inhibited proliferation, migration, and invasion of SiHa cells along with enhanced apoptosis, concomitant with decreased expression of HPV16 E6, TAZ, and TEAD mRNA. …”
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Trends in emergency department visits for acute intoxication: a 3-year retrospective study in Hangzhou, East China by Chengle Li, Chengle Li, Hong Zhang, Hong Zhang, Bo Yang, Bo Yang

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Foreign experience of the social consequences of scientific and technological development: a place of education by N. E. Khristolyubova, E. A. Hudorenko

“…In order to ensure the comprehensiveness and reliability of research results publications on research topic in the press and the Internet were used in the work.When conducting research and presenting the material philosophical and scientific methods and approaches, specific institutional methods of analysis: system-structural, functional, comparative, evolutionary, interdisciplinary, comparative analysis method were applied.Results: The study data were obtained, indicating the complex nature of the impact and far ambiguous and contradictory infl uence of NTP on the life of human, taking place «lag» awareness of the consequences of scientific and technical progress.Conclusion: Formation of the scientific and technical policy of the state must be carried in the conditions of state control systems for development of the of NTP in a risk society.Key importance in this system belongs to education as one of the major factors directly affecting the understanding of the effect of NTP on all aspects of human life, the formation of advanced consciousness, and, as a consequence, enhance the security of human society life.…”
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Toward precision oncology in LUAD: a prognostic model using single-cell sequencing and WGCNA based on a disulfidptosis relative gene signature by Panpan Li, Han Zhang, Limin Sun, Xiaojuan Wu

“…Immune response characteristics and functional enrichment patterns were further evaluated in these cohorts.ResultsOur study delved into disulfidptosis in LUAD through a series of analyses: scRNA-seq data processing, WGCNA analysis, construction of a prognostic model, evaluation of clinical features and risk, enrichment analysis, mutation landscape assessment, and examination of the tumor microenvironment. …”
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Epidemiology of Pickleball-Related Foot and Ankle Injuries (2015 – 2023) by Kiera Kingston MD, Emily Belle Parker BS, Alexander Higgins DO, Jeremy T. Smith MD

“…Further research is needed examining functional outcomes and return to sport after pickleball-related foot and ankle injuries.…”
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Allelic variation in a cluster of epsilon glutathione S-transferase genes contributes to DDT and pyrethroid resistance in the major African malaria vector Anopheles funestus by Mersimine F. M. Kouamo, Sulaiman S. Ibrahim, Abdullahi Muhammad, Mahamat Gadji, Jack Hearn, Charles S. Wondji

“…Methods Transcriptomic and genomic analyses of GSTe genes were conducted, followed by in silico structural analysis, and functional characterization of GSTe3, GSTe4 and GSTe6 using metabolic assay and transgenic expression in Drosophila flies. …”
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FOXO1 and FYN Expression Trends in Breast Cancer Stem Cells: An Integrative Study of Single Nucleotide Polymorphism (SNP) Array and Quantitative PCR (qPCR) Analysis by Ay Ly Margaret, Septelia Inawati Wanandi, Fadilah Fadilah, Rafika Indah Paramita

“…These findings suggest a possible, but as yet unverified, association between gene mutations and expression patterns, emphasizing the importance of further functional studies to validate FOXO1 and FYN as biomarkers for BCSCs. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Immune “hot” tumor-related genes were identified, and their functional roles were validated through biological behavior analysis. …”
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Immune intrinsic escape signature stratifies prognosis, characterizes the tumor immune microenvironment, and identifies tumorigenic PPP1R8 in glioblastoma multiforme patients by Ran Du, Lijun Jing, Denggang Fu

“…TIME analysis was carried out using multiple deconvolution algorithms. Additionally, functional assays including CCK8, cell cycle, and apoptosis assays were conducted on PPP1R8-silenced U251 cells using CRISPR/Cas9 technologyResultsThirty-six IERGs were associated with GBM outcomes, with 20 linked to poor survival and 16 to better outcomes. …”
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Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach by Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li

“…Results Functional enrichment studies revealed that PFAS targets were associated with metabolic signaling pathways, which are actively involved in lipid, glucose, drug metabolism, etc. …”
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Genome-wide identification of PP2A gene family in Camellia sinensis reveals the potential role of CsPP2A-TON2/FASS1 in abiotic stress by Surjit Bhattacharjee, Abhirup Paul, Aradhana Jana, G. Meher Unnati, Deepak R., Ye Miao, Honglin Lu, Guoxin Shen, Neelam Mishra

“…Conclusion This study offers potential goals for further in-depth investigation and functional analysis, alongside enhancing our understanding of the regulatory network of PP2A genes in C. sinensis.…”
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