Phenome-wide association studies between SERINC2 and neuropsychiatric disorders by Ping Liu, Xinqun Luo, Liping Cao, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Xinghua Pan, Ruilan Yang, Zewen Tan, Yunlong Tan, Chiang-shan Li, Xiaoyun Guo, Zhiren Wang, Xingguang Luo, Xingguang Luo

“…SNP-disease associations were tested and then meta-analyzed, followed by FDR correction, to identify significant disease-risk SNPs. Finally, functional studies on the differential SERINC2 mRNA expression in brains and the potential regulatory effects of disease-risk alleles on SERINC2 mRNA expression, gray matter volumes (GMVs) of subcortical structures, cortical surface area (SA) and average thickness (TH) were conducted.ResultsIn European descent, alcoholism was most significantly associated with SERINC2 variants (245 SNPs with 5.5×10-8≤p ≤ 0.049 and 4.9×10-5≤q ≤ 0.034) that were largely shared across cocaine dependence, marijuana dependence, nicotine dependence, polysubstance dependence, schizophrenia, OCD, and autism (8.2×10-8≤p ≤ 0.050 and 1.9×10-5≤q ≤ 0.049); in Chinese population, bipolar disorder was also significantly associated with SERINC2 variants (10 SNPs: 1.3×10-4≤p ≤ 4.7×10-4 and 0.025≤q ≤ 0.031). …”
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Case Report: Arthroscopic treatment of cedell fracture, shepherd fracture, and avulsion fracture at the insertion of the calcaneofibular ligament by Sitong Zhang, Dejian Li, Qian Wang

“…The objective of this report is to demonstrate that arthroscopy offers a well-defined surgical field, aids in reduction and internal fixation, and to suggest a novel treatment approach for this uncommon fracture pattern.…”
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The Portal to a Magic World. An Alternative Model of Introduction to Art by Ushkarev Alexander A.

“…However, the later this process begins, the more difficult it is, and the more effort may be required to catch up. This pattern is explained in P. Bourdieu’s theory of cultural capital and has been repeatedly confirmed by empirical studies on art audiences conducted in Russia and abroad. …”
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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration by Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson

“…Given that systemic plasma changes are complex, a larger sample cohort may be required to identify patterns in blood relating to IVD degeneration progression. …”
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Integrin beta‐like 1 is regulated by DNA methylation and increased in heart failure patients by Lauren Kerrigan, Kevin Edgar, Adam Russell‐Hallinan, Oisin Cappa, Nadezhda Glezeva, Carlos Galan‐Arriola, Eduardo Oliver, Borja Ibanez, John Baugh, Patrick Collier, Mark Ledwidge, Ken McDonald, David Simpson, Sudipto Das, David J. Grieve, Chris J. Watson

“…Abstract Aims Dynamic alterations in cardiac DNA methylation have been implicated in the development of heart failure (HF) with evidence of ischaemic heart disease (IHD); however, there is limited research into cell specific, DNA methylation sensitive genes that are affected by dysregulated DNA methylation patterns. In this study, we aimed to identify DNA methylation sensitive genes in the ischaemic heart and elucidate their role in cardiac fibrosis. …”
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Genome-wide identification and gene expression analysis of the malate dehydrogenase (MDH) gene family in Eucalyptus grandis by Yifan Xing, Yifan Xing, Huiming Xu, Deming Yang, Lichuan Deng, Guolong Li, Guolong Li, Zhixin Zhao, Zhixin Zhao, Zhaohua Lu, Liuyin Ma, Guangyou Li

“…Malate dehydrogenases are pivotal in plant metabolism and stress responses, yet their evolutionary dynamics and functional diversification in woody angiosperms remain underexplored. …”
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Combined effects of acidification and warming on soil denitrification and microbial community by Peiyuan Xu, Peiyuan Xu, Mengke Gao, Mengke Gao, Yuchen Li, Yuchen Li, Jun Ye, Jianqiang Su, Jianqiang Su, Hu Li, Hu Li

“…In light of the challenges posed by contemporary global warming and soil acidification, the respective effects of pH and temperature on soil microbiome and functions have been explored. However, the combined influence of acidification and warming on soil denitrification and active microbial communities are still unclear. …”
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Status and trends in transcranial magnetic stimulation research: a bibliometric analysis by Qi Deng, Fei Xing, Dan Li, Dan Li, Maomao Huang, Maomao Huang, Zhangyu Xv, Yue Yang, Lei Li, Jiayi Zhu, Rongnan Shi, Guoya Meng, Qin Wang, Jianxiong Wang, Jianxiong Wang, Jianxiong Wang

“…BackgroundTranscranial magnetic stimulation (TMS), as a rapidly advancing non-invasive brain stimulation technique, has demonstrated reliable therapeutic efficacy and significant potential in brain function assessment and research. However, comprehensive bibliometric analyses of the overall TMS field remain limited. …”
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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Further analysis revealed high heterogeneity in tissue preference, gene expression, functional enrichment, immunodynamics, transcriptional regulatory factors, metabolic changes, and communication patterns in fibroblasts and myeloid cells. …”
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CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation by Juan Juan Chen, Zhang Ze Lu, Yu Xin Jing, Xing Mei Nong, Yi Qin, Jin Yang Huang, Na Lin, Jie Wei

“…Immune cell profiling highlighted distinct infiltration patterns, with severe cases showing elevated naïve B cells and M0 macrophages versus activated NK cells and M1 macrophages in mild cases. …”
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Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach by Zihan Li, Jun Li, Jiahui Li, Mengying Wang, Andi Xu, Yushu Huang, Qi Yu, Lingzhi Zhang, Yingjun Li, Zilin Li, Xifeng Wu, Jiajun Bu, Wenyuan Li

“…Brain age gap exhibited clinical feasibility combined with Functional Activities Questionnaire, with improved discriminative capacity in models achieving lower MAEs (AUC of 0.945 vs 0.923 and 0.911; AUC of 0.935 vs 0.900 and 0.881). …”
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FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…The high-risk group was linked to advanced stage, higher MSI, CMS4 subtype enrichment, distinct mutation patterns, and increased genome integrity pathway mutations (79% vs. 66%). …”
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Three different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study by Safaa A. Hussein, Gharib M. Taha, F. A. Adam, Marwa A. Moghazy

“…FTIR analysis approves that combining ZnO with RGO affects the functional groups of the three nanocomposite surfaces. …”
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Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated Inflammatory Diseases: Observational Study by Adrien Bennetot, Rana Zia Ur Rehman, Robbin Romijnders, Zhi Li, Victoria Macrae, Kristen Davies, Wan-Fai Ng, Walter Maetzler, Jennifer Kudelka, Hanna Hildesheim, Kirsten Emmert, Emma Paulides, C Janneke van der Woude, Ralf Reilmann, Svenja Aufenberg, Meenakshi Chatterjee, Nikolay V Manyakov, Clémence Pinaud, Stefan Avey

“…ObjectiveThis study aimed to evaluate the feasibility and acceptability of using a high-frequency eDiary to capture intraday variability in fatigue and to compare eDiary data with scores obtained from the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), a validated weekly recall PRO. …”
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Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancer by Yuan Liu, Yuan Liu, Yang Zhong, Yang Zhong, Yaodong Sang, Yaodong Sang, Siqiang Zhu, Siqiang Zhu, Kang Xu, Kang Xu, Xingyu Zhu, Xingyu Zhu, Xiaoling Cui, Xiaoling Cui, Xinyu Liu, Xinyu Liu, Xiaohan Wang, Xiaohan Wang, Hao Chen, Changqing Jing, Changqing Jing, Wei Chong, Wei Chong, Leping Li, Leping Li

“…LDL receptor-related protein 1B (LRP1B) may play a crucial role in tumorigenesis and disease progression.MethodsWe performed a comparative analysis of differential gene expression, mutation patterns, drug sensitivity, and cellular phenotypes across different subgroups with varying LRP1B expression levels. …”
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Research on Optimized Algorithm for Deep Learning Based Recognition of Sediment Particles in Turbulent Flow by WANG Hao, YANG Feiqi, ZHANG Lei, WU Wei, XIE Haonan, ZHAO Lin

“…The YOLOv5 deep learning network structure is enhanced by improving convolutional blocks, incorporating attention mechanisms, and optimizing loss function processing, boosting the detector's overall performance in accurately capturing the motion of particles over short distances. …”
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DualDyConvNet: Dual-Stream Dynamic Convolution Network via Parameter-Efficient Fine-Tuning for Predicting Motor Prognosis in Subacute Stroke by Yunjeong Jang, Joohye Jeong, Yun Kwan Kim, Da-Hye Kim, Wanjoo Park, Laehyun Kim, Yun-Hee Kim, Minji Lee

“…The proposed framework holds significant potential in facilitating early rehabilitation planning by predicting motor function prognosis in stroke patients. Furthermore, it can contribute to enhancing the quality of life by providing patients with prognostication.…”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Results SLCs displayed distinct expression patterns across various cell types within the osteosarcoma microenvironment, with myeloid cells exhibiting a preference for amino acid uptake. …”
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Identification and expression characterization of apple β-tubulin gene family in apple by HUANG Huiling, WANG Yanxiang, WANG Yue, NING Qinqin, LI Ming, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, JIAO Jian, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo

“…However, little is known about apple tubulin family genes and their potential functions. Therefore, the present study was to identify the apple β-tubulin family genes and to determine the candidate β-tubulin genes involved in regulating apple dwarfing. …”
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Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models by Colleen S. Curran, Xizhong Cui, Yan Li, Tom Gamble, Junfeng Sun, Samuel Minkove, Alicia A. Livinski, Peter Q. Eichacker, Parizad Torabi-Parizi

“…Abstract Disruption of nicotinamide adenine dinucleotide (NAD) biosynthesis and function during infection may impair host defenses and aggravate inflammatory and oxidative organ injury. …”
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