A population genomic characterization of copy number variation in the opportunistic fungal pathogen Aspergillus fumigatus. by Shu Zhao, John G Gibbons

“…Molecular studies have shaped our understanding of the genes, proteins, and molecules that contribute to A. fumigatus pathogenicity, but few studies have characterized genome-wide patterns of genetic variation at the population level. …”
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phylospatial: An R package for spatial phylogenetic analysis with quantitative community data by Matthew M. Kling

“…It also integrates with raster and vector data formats, providing efficient workflows for geospatial data. phylospatial provides an integrated framework for performing various types of analyses, including calculating alpha PD and endemism, testing significance using community null models, identifying beta‐PD patterns including biogeographic regions, and conducting spatial conservation prioritization. …”
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Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway by Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…BackgroundToll-like receptor 3 (TLR3) is a pattern recognition receptor known to play a crucial role in the immune response to cancer. …”
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Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo by Essha Chatterjee, Essha Chatterjee, Ram Sharma, Biswajit Dey, Biswajit Dey, Hoshiyar Singh, Aliva Naik, Anjesh Khan, Santanu Basak, Ankush Bansode, Ritika Sachdeva, Anamika Sharma, Rahul Kumar, Pradeep Naik, Pankaj Kumar Singh, Kunal Nepali, Santosh Kumar Guru

“…Different in silico studies were also conducted to check the clinical relevance and expression pattern of the RM-3-22-induced gene. …”
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Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning by Zi-hang Li, Shi-pian Li, Shi-pian Li, Ya-hao Li, Yu-cheng Wang, Zhen-yu Tang, Kai-yang Xu, Xiao-rong Li, Zhen Tan, Jiao-yi Pan, Jin-tao Liu, Hong Jiang, Zhi-jia Ma, Yu-xiang Dai, Yu-xiang Dai, Yu-xiang Dai, Peng-fei Yu

“…To further validate these findings, we collected human blood specimens and conducted in vitro experiments. ELISA assays confirmed that CBS and FASLG are crucial biomarkers of IVDD, with distinct expression patterns in patients with moderate versus severe degeneration.DiscussionThese results highlight the diagnostic potential of AIDEGs and provide a new perspective for early intervention and treatment strategies in IVDD.…”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…The role of N6-methyladenosine (m6A) modification in regulating immune cell function has been recognized, but its impact on TEX dynamics across cancer types and clinical outcomes remains unclear. …”
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Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming by Pengcheng Liu, Fuxin Huang, Peixu Lin, Jiayao Liu, Pincheng Zhou, Jie Wang, Huanhuan Sun, Fan Xing, Haiqing Ma

“…In vivo and in vitro experiments were conducted to validate how histidine treatment affects macrophage and T-cell function. …”
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Association between Life's Crucial 9 and Cardiorenal syndrome: the mediating role of weight-adjusted-waist index by Huanjie Fu, Zhichao Liu, Hao Yu, Yisheng Zhao, Yongkang Gan, Jinhong Chen, Eryue Liu

“…Tertile analysis of LC9 and WWI demonstrated consistent patterns, with significant p-values for trends < 0.001. …”
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Thoracic dysfunction in whiplash associated disorders: A systematic review. by Nicola R Heneghan, Richard Smith, Isaak Tyros, Deborah Falla, Alison Rushton

“…Thoracic spine pain prevalence is reported ~66%; perhaps unsurprising given the forceful stretch/eccentric loading of posterior structures of the spine, and the thoracic spine's contribution to neck mobility/function. Approximately 50% WAD patients develop chronic pain and disability resulting in high levels of societal and healthcare costs. …”
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Genomic and Transcriptomic Analysis to Explore the Biological Characteristics of <i>Cyclocybe chaxingu</i> by Qiang Yang, Haiyan Song, Ge Su, Xuncheng Wang, Haijing Hu, Zhijun Zhai, Minghui Chen, Jianping Zhou, Hua Yin, Yang Gao, Dianming Hu

“…Transcriptomic analysis revealed distinct gene expression patterns in mycelia, stipe, and cap, reflecting their functional specialization. …”
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Effect of Chlorhexidine and Benincasa Hispida Pretreatment on Microshear Bond Strength of Universal Adhesive System on Dentin: A Pilot Study by Girija S Sajjan, Manda Sri Swathi, P Arun Bhupathi, Madhu Varma Kanumuri, Rajulapati Kalyan Satish, Rama Krishna Alla, Tippireddy Srija, Ch Uma Shalini

“…Benincasa hispida is a natural plant-based functional food containing minerals and vitamins that help prevent osteoporosis and improve bone health. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…We then performed functional validation using a mouse colorectal cancer graft tumor model established with the CT26 cell line characterized by its high content of CSCs. …”
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The transcription factor PbeNAC83 positively regulates the Valsa canker resistance in apple and pear by DOU Zhiqi, CAI Minrui, DU Chenglong, HU Huanhuan, ZUO Cunwu

“…To identify the potential roles of PbeNAC83 in resistance to Valsa canker, we treated the suspension cells of Duli-G03 with 20% VpM and analyzed them using qRT-PCR to detect the expression pattern of PbeNAC83 to signals from the Valsa canker pathogens. …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Among the depressed cohort, 25 participants adhered to the treatment protocol and completed MRI scans. Resting-state functional MRI (rs-fMRI) scans were conducted for all participants, with a subsequent scan for the depression group after 8 weeks of sertraline therapy. …”
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The novel diagnostic markers for systemic lupus erythematosus and periodontal disease by Xuedi Cheng, Jinfeng Zhang, Jiali Hou, Xiaocui Han, Bin Han, Jun Zhou, Zhongjun Wang, Junzheng Wang

“…Protein-protein interaction (PPI) network analysis was conducted to explore relationships between hub genes. …”
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Interplay of a non-conjugative integrative element and a conjugative plasmid in the spread of antibiotic resistance via suicidal plasmid transfer from an aquaculture Vibrio isolate... by Lisa Nonaka, Tatsuya Yamamoto, Fumito Maruyama, Yuu Hirose, Yuki Onishi, Takeshi Kobayashi, Satoru Suzuki, Nobuhiko Nomura, Michiaki Masuda, Hirokazu Yano

“…Tn6283 is unusual among integrative elements in that it apparently does not encode transfer function and its excision barely generates unoccupied donor sites. …”
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Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation by Victòria Ayala, Laia Fontdevila, Santiago Rico-Rios, Mònica Povedano, Pol Andrés-Benito, Pascual Torres, José C. E. Serrano, Reinald Pamplona, Manuel Portero-Otin

“…Of note, different studies do not agree on common patterns of microbiota being linked to ALS, supporting the need for further, more extensive studies. …”
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Seasonal Self-Purification Process of Nutrients Entering Coastal Water from Land-Based Sources in Tieshan Bay, China: Insights from Incubation Experiments by Fang Xu, Peng Zhang, Yingxian He, Huizi Long, Jibiao Zhang, Dongliang Lu, Chaoxing Ren

“…Nutrients function as essential biological substrates for coastal phytoplankton growth and serve as pivotal indicators in marine environmental monitoring. …”
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Cardiovascular and renal comorbidities among saudi patients with type 2 diabetes: A cross-sectional observational study. by Syed Irfan Karim, Kamran Sattar, Tauseef Ahmad, Mustafa Kamal Memon, Abdulfattah S Alqahtani, Abdulrahman M Alsubiheen, Fahad Abdulaziz Alrashed

“…<h4>Objective</h4>This study aims to investigate the prevalence and patterns of cardiovascular and renal complications among patients with T2DM in the Saudi population and elucidate the extent of these comorbidities and their potential risk factors.…”
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Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Adult female and male offspring underwent behavioral testing for learning, memory, anxiety-like behavior and sleep–wake patterns. Results HET-Kmo +/– mice exhibited reduced brain KMO activity, increased KYNA levels, and disrupted sleep architecture and electroencephalogram (EEG) power spectra. …”
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