Mycorrhizal and nutrient controls of carbon sequestration in tropical rainforest soil by Jie Chen, Xin Tang, Han Xu, Yanpeng Li, Adriana Corrales, Yide Li, Yakov Kuzyakov, Zhanfeng Liu, Shirong Liu

“…Tree mycorrhizal associations have substantial consequences for soil organic carbon (SOC), but it remains unclear how nutrient availability will regulate the performance of arbuscular mycorrhizal (AM) and ectomycorrhizal (ECM) trees, and then consequently affect SOC sequestration in tropical forest soils. This study characterized the performances of AM and ECM trees, SOC content, and soil microbial functions under variable soil nitrogen (N) and phosphorus (P) content across an intact tropical rainforest based on the spatial dataset from a 60-ha dynamic plot and fitted statistical models to examine the mycorrhizal and nutrient controls on SOC stocks. …”
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An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment by Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu

“…Methods We developed a new combination strategy for the synthesis of penetrating peptides functionalized with targeting of integrin α6. The linear peptide S5 was multimerized with 4 copies in linear sequential order spaced by GSG between each copy to yield the 4S5 peptide. …”
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Photodynamic therapy in treatment of squamous cell carcinoma of oral cavity with chlorine e6 photosensitizer with long-term follow up by Y. A. Panaseykin, V. N. Kapinus, E. V. Filonenko, V. V. Polkin, F. E. Sevrukov, M. A. Smirnova, P. A. Isaev, S. A. Ivanov, A. D. Kaprin

“…Photodynamic therapy is an effective method for treating superficial forms of malignant neoplasms, characterized by a minimal risk of damage to normal tissues. …”
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Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions by Tarikul I. Milon, Titli Sarkar, Titli Sarkar, Yixin Chen, Jordan M. Grider, Feng Chen, Jun-Yuan Ji, Seetharama D. Jois, Konstantin G. Kousoulas, Vijay Raghavan, Wu Xu

“…In some instances, a direct correlation between structures and functions was successfully established.…”
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A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model by Abraham Tettey-Matey, Viola Donati, Chiara Cimmino, Chiara Di Pietro, Damiano Buratto, Mariateresa Panarelli, Alberto Reale, Arianna Calistri, Maria Vittoria Fornaini, Ruhong Zhou, Guang Yang, Francesco Zonta, Daniela Marazziti, Fabio Mammano

“…Abstract Connexins (Cxs) are fundamental in cell–cell communication, functioning as gap junction channels (GJCs) that facilitate solute exchange between adjacent cells and as hemichannels (HCs) that mediate solute exchange between the cytoplasm and the extracellular environment. …”
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Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis by Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Arkaitz Mucientes, Arkaitz Mucientes, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Rocío Redondo-Rodriguez, Rocío Redondo-Rodriguez, Laura Cano-García, Laura Cano-García, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…The gut microbiota was analyzed using 16S rRNA gene sequencing; bioinformatics analysis was performed using QIIME2, and its functionality was inferred through PICRUSt. We recorded data on clinical findings, inflammation, and cytokines. …”
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COMPARATIVE ANALYSIS OF QUALITY OF LIFE AFTER THORACIC ENDOVASCULAR AORTIC REPAIR AND OPTIMAL MEDICAL THERAPY IN PATIENTS WITH UNCOMPLICATED TYPE B AORTIC DISSECTION by Anna Yu. Shkandala, Oleh V. Zelenchuk, Serhii M. Furkalo, Borys M. Todurov, Andrii V. Khokhlov, Nataliia O. Yashchenko, Serhii M. Sudakevych

“…Patients of group A had significantly higher total values of the physical component of quality of life compared to group B (51.0 (41.5; 54.5) points versus 42.0 (38.0; 47.0) points, p=0.032 ), while patients of group A were characterized by significantly higher values of the parameter "Physical functioning" (59.5; 75.0) points versus 64 (51.0; 68.0) points, p=0.043 and "Pain" (89 ( 71.5;95) points against 77(61.0;91.0) points, p=0.038) in comparison with patients of group B. …”
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Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry by Shen Qu, Juliang Wang, Keyi Zhang, Mengyu Fan, Yuanzhen Zhao, Xu Yang, Zhongli Wang, Helena I. Gomes, Rachel L. Gomes, Limin Duan, Shaogang Dong, Ruihong Yu

“…Microbial analysis revealed higher diversity (ace index = 1751 ± 577) in groundwater, while surface water PTE had a more pronounced impact on microbial functionality than groundwater (p < 0.001). Health risk assessment demonstrated elevated hazards in PTE contaminated groundwater, posing higher non-carcinogenic (non-carcinogenic risk-HI: 1.43 vs 1.25) and carcinogenic risks (carcinogenic risk assessment-CR: 0.005 vs 0.003) than surface water, with children being more vulnerable (5, 8 and 7 cases per 1000 children were found at carcinogenic risk). …”
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Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma by Ke Ma, Jie Xu, Jie Xu, Congyue Wang, Congyue Wang, Xu Cao, Xu Cao, Wenjie Yu, Jingjing Xi, Xuan Zhang, Jiamin Zhan, Yang Liu, Aoyang Yu, Aoyang Yu, Shuhan Liu, Yanhua Liu, Yanhua Liu, Chong Chen, Chong Chen, Xiaoli Mai, Xiaoli Mai

“…Single-cell RNA-sequencing (scRNA-seq) data were integrated to characterize subtype-specific immune microenvironments. …”
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The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and -Resistant Neuroblastoma Cells by Silvana Alfei, Paolo Giannoni, Maria Grazia Signorello, Carola Torazza, Guendalina Zuccari, Constantinos M. Athanassopoulos, Cinzia Domenicotti, Barbara Marengo

“…Triphenyl phosphonium salts (TPPs) are mitochondria-targeting compounds that exert anticancer effects, impair mitochondria functions, and damage DNA at the same time. Despite several biochemical applications, TPP-based bola-amphiphiles self-assembling nanoparticles (NPs) in water have never been tested as antitumor agents. …”
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Depalmitoylase ABHD16A negatively regulates the anti-hepatitis B virus activity of IFITM1 by Xin Wen, Mingyang Liu, Yali Fan, Junfei Xu, Zhaoyan Wang, Lin Mao, Weizhen Gu, Xuemeng Shi, Jun Xu

“…Collectively, our findings demonstrated for the first time that ABHD16A catalyzes the depalmitoylation of IFITM1 to regulate its antiviral activity against HBV, which expands the biological functions of ABHD16A in immune regulation and provides potential targets for HBV infection-related disease therapy.IMPORTANCENowadays, hepatitis B virus (HBV) infection remains a major global public health problem, with over 375 million people worldwide having been infected. …”
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Ductular reaction or hepatic reparative complex: immunohistochemical features in liver cirrhosis in patients with chronic hepatitis by V. A. Tumanskiy, S. V. Fen’

“…The reparative process, activating by liver cirrhosis on the background of the disturbed portal-lobular intercellular matrix and the progressive deficit of hepatocytes, does not provide the reconstruction of full-fledged liver structures, it is discordant towards the creation of new, functionally low-value hepatocellular pseudolobes and the accumulation of biliary terminals in fields of portal-septal fibrosis.…”
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Synthesis and properties of magnetically sensitive nanocomposites based on magnetite and gemcitabine by A. L. Petranovska, M. V. Abramov, N. M. Opanashchuk, S. P. Turanska, N. V. Kusyak, P. P. Gorbyk

“…Research direction includes synthesis of nanosized one-domain magnetite as a magnetically sensitive carrier, modification of its surface by carbon covering with the aim of stabilization and chemical functionalization, biofunctionalization of NC by GC immobilization. …”
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Performance Study on Zn-Doped α-FeOOH in Removing H2S from Blast Furnace Gas by Bin WANG, Xudong LIU, Yuran LI, Li LIU, Wenqing XU, Tingyu ZHU

“…In situ infrared spectroscopy analysis revealed that Zn functions as a catalyst component and also directly interacts with H2S to form ZnS. …”
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The role of proline P325 residue in the recognition of the MX35 epitope of the sodium-dependent phosphate transporter NaPi2b by monoclonal antibodies in ovarian carcinoma cells by L. F. Bulatova, I. A. Slidzuk, A. V. Kilunov, V. S. Skripova, R. G. Kiyamova

“…One of the key components of cell membranes are membrane proteins, which provide a wide range of functions – from transport and signal transmission to coordination of intercellular interactions. …”
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Clinical characteristics and outcomes of COVID-19 in kidney transplant recipients by R. O. Kantariya, Ya. G. Moysyuk, E. I. Prokopenko, A. R. Karapityan, A. A. Ammosov, A. V. Makevnina, A. A. Gaydarova

“…The pandemic caused by the SARS-CoV-2 coronavirus is characterized by significant morbidity and mortality. …”
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Exploring the complex interplay between oral Fusobacterium nucleatum infection, periodontitis, and robust microRNA induction, including multiple known oncogenic miRNAs by Syam Jeepipalli, Aravindraja C, William Duncan, V. M. Krishna, Bikash Sahay, Edward K. L. Chan, L. Kesavalu

“…Recently, microRNAs have emerged as critical players in the interactions between host and microbes, and many host functions have been reported to be regulated by miRNAs during infection. …”
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tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer’s disease via the EphA7-ERK1/2-p70S6K signaling pathway by Zihao Deng, Yudi Li, Wenjun Chi, Wanzhou Zhang, Fangming Li, Li Ling

“…Abstract Background Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder clinically characterized by memory decline, cognitive dysfunction, language impairment, deterioration of visuospatial skills, and personality changes. …”
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Continuity of Ideas and Generations. Historical Facts About the Activities of the Sheremetev Hospital (for the 100th Anniversary of the N.V. Sklifosovsky Research Institute for Eme... by S. A. Kabanova, Yu. S. Goldfarb, E. V. Grafova, E. E. Lukyanova, S. S. Petrikov, M. L. Rogal, M. Sh. Khubutiya

“…Since 1919, the hospital functioned as a state institution, and also became the base for the revival of the ambulance service in Moscow.CONCLUSION A review of the activities of the Sheremetev Hospital indicates that the organization of emergency medical care for the population of Moscow, pedagogic work, participation in the treatment of the wounded patients, high surgical activity and versatility were the foundation on which its work was widely developed. …”
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Platelet Membrane-Coated Poly (Lactic-Co-Glycolic Acid) Nanoparticles as a Targeting Drug Delivery System for Multidrug-Resistant Breast Cancer by Song B, Na YG, Kim BJ, Jin M, Song YH, Kim DE, Hwang S, Baek JS, Lee HK, Cho CW

“…To overcome these challenges, we developed a triple-functionalized nanocarrier system incorporating poly(lactide-co-glycolide) (PLGA)-based nanoparticles (PNs), D-α-tocopheryl polyethylene glycol succinate (TPGS) for P-gp inhibition, and platelet membrane (PM) coating for targeted tumor delivery.Methods: The PM-coated TPGS-modified PNs with PTX (PTPNs) was characterized by particle size analysis, transmission electron microscopy (TEM), and protein assay to confirm PM coating. …”
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