Exploring the role of ferroptosis in pemphigus: identification of diagnostic markers and regulatory mechanisms by Jing Mao, Jianping Lan, Zheyu Zhuang, Ying Chen, Ying Chen, Yushan Ou, Xinhong Su, Xueting Zeng, Fuchen Huang, Zequn Tong, Xiaoqing Lv, Xiaoqing Lv, Xiaoqing Lv, Hui Ke, Zhenlan Wu, Ying Zou, Bo Cheng, Bo Cheng, Bo Cheng, Chao Ji, Chao Ji, Chao Ji, Ting Gong

“…BackgroundPemphigus is an autoimmune blistering disorder characterized by the loss of cell adhesion in the epidermis. …”
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Dip-coating of nylon/chitosan/hydroxyapatite/TiO2 biocoatings to improve durability of metallic prostheses by César A. García-Pérez, Carmina Menchaca-Campos, Jorge Arturo Sandoval-Espino, E. Eduardo Antunez, Alejandro Flores Nicolás, Mayra Alejandra Santillán-Urquiza, Jorge Uruchurtu

“…These findings highlight the potential of biocoating as an effective alternative for the protection and functionality of metallic implants, paving the way for further research focused on optimization and clinical application.…”
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Dynamic changes and drives of surface urban heat islands in China by Qiumeng Zhang, Baoquan Jia, Tong Li, Yarong Yang, Youxin Fang

“…This phenomenon can disrupt the functions of urban ecosystems, affect residents’ comfort and health, and even pose life-threatening risks. existing research has predominantly focused on developed cities during urbanization, often overlooking smaller towns. …”
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Candidate Phyla Radiation (CPR) bacteria from hyperalkaline ecosystems provide novel insight into their symbiotic lifestyle and ecological implications by Yu He, Shiyan Zhuo, Meng Li, Jie Pan, Yongguang Jiang, Yidan Hu, Robert A. Sanford, Qin Lin, Weimin Sun, Na Wei, Shuming Peng, Zhou Jiang, Shuyi Li, Yongzhe Li, Yiran Dong, Liang Shi

“…Abstract Background Candidate Phyla Radiation (CPR) represents a unique superphylum characterized by ultra-small cell size and symbiotic lifestyle. …”
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Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension by Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele Miragoli

“…Methods In this study, we investigate the late-stage effects of PAH on both electrical and mechanical functions, as well as their coupling, in each ventricle using the monocrotaline-treated rat model. …”
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Lipoprotein combine index is associated with non-alcoholic fatty liver disease: a 5-year longitudinal cohort study in non-obese Chinese populations with normal lipids by Weitao Wu, Weitao Wu, Donghai Wu, Donghai Wu, Changchun Cao, Ronghua Zhou, Shihua Ding, Shihua Ding, Ying Ying, Ying Ying, Dayong Sun, Dayong Sun, Haofei Hu, Haofei Hu

“…We applied cubic spline functions and curve fitting to characterize the non-linear association between LCI and NAFLD. …”
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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges by Saeid Safiri, Saeid Safiri, Amir Ghaffari Jolfayi, Asra Fazlollahi, Soroush Morsali, Soroush Morsali, Aila Sarkesh, Amin Daei Sorkhabi, Behnam Golabi, Reza Aletaha, Kimia Motlagh Asghari, Sana Hamidi, Sana Hamidi, Seyed Ehsan Mousavi, Sepehr Jamalkhani, Nahid Karamzad, Nahid Karamzad, Ali Shamekh, Reza Mohammadinasab, Mark J. M. Sullman, Mark J. M. Sullman, Fikrettin Şahin, Ali-Asghar Kolahi

“…BackgroundAlzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired reasoning. …”
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A potent and broad CD4 binding site neutralizing antibody with strong ADCC activity from a Chinese HIV-1 elite neutralizer by Yingdan Wang, Ping Ji, Qianying Liu, Nannan Jia, Yunping Ma, Tianyi Yuan, Palizhati Rehati, Jiali Chen, Yumei Wen, Fan Wu, Jinghe Huang

“…Our findings provide valuable insights into the mechanisms of FD22 in viral neutralization and ADCC. The dual functionality of FD22 enhances its potential as a promising therapeutic antibody and offers new avenues for designing CD4bs-targeting vaccines with enhanced ADCC capabilities.…”
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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…Despite advancements in tendon injury repair techniques, outcomes remain suboptimal due to inferior tissue quality and functionality. Tissue engineering offers a promising avenue for tendon regeneration, with biocompatible scaffolds playing a crucial role. …”
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Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…TPL can enter RhoA, Rock1, and Rock2 target protein binding domains with stable binding activities, and may cause conformational changes of Rock1 related to molecular functions.ConclusionTPL inhibits RA-FLS in motility by regulating actin cytoskeleton remodeling through action on the RhoA/Rho-associated kinase signaling pathway.…”
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Diversity of performance patterns in dairy goats: multi-scale analysis of the lactation curves of milk yield, body condition score and body weight by Gafsi, Nicolas, Martin, Olivier, Bidan, Fabrice, Grimard, Bénédicte, Puillet, Laurence

“…At the lactation scale, no major association was found among phenotypic curves suggesting a diversity of energy partitioning strategies between life functions. At the lifetime scale, change among clusters occurred primarily between first and second lactation, whereas a pattern of stable cluster membership appeared for multiparous goats. …”
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Stages of Carboniferous-Triassic magmatism in the Black Sea region based on isotope-geochronological study of detrital zircons from jurassic coarse clastic strata of the Mountainou... by T. V. Romanyuk, N. V. Kuznetsov, S. V. Rud’ko, A. A. Kolesnikova, D. V. Moskovsky, A. S. Dubensky, V. S. Sheshukov, S. M. Lyapunov

“…Magmatic stages II (315–270 Ma) and III (270–200 Ma) correlate with functioning of the Scythian-Pontian volcanic suprasubduction belt. …”
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(R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors. by Eleni Gourni, Coline Canovas, Victor Goncalves, Franck Denat, Philipp T Meyer, Helmut R Maecke

“…<h4>Methods</h4>The PSMA-based inhibitor-lysine-urea-glutamate-coupled to the spacer Phe-Phe-D-Lys(suberoyl) and functionalized with the enantiomerically pure prochelator (R)-1-(1-carboxy-3-carbotertbutoxypropyl)-4,7-carbotartbutoxymethyl)-1,4,7-triazacyclononane ((R)-NODAGA(tBu)3), to obtain (R)-NODAGA-Phe-Phe-D-Lys(suberoyl)-Lys-urea-Glu (CC34). …”
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Histone H4 lysine 20 methylation marks genes dynamically regulated during erythroid maturation by Kristin Murphy, Michael Getman, Xiurui Lv, Zachary Murphy, Deanna Abid, Nabil Rahman, Michael Bulger, Laurie Steiner

“…Abstract Background Methylation of H4K20 has been implicated in the regulation of gene expression but also plays essential roles in numerous cellular functions, making studies of its effects on transcription challenging. …”
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COGNITIVE SEMANTICS OF NOUNS IN DENUMERATIVE WORD FORMATION (BASED ON UKRAINIAN LANGUAGE) by Olha V. Kostryba

“…To mitigate mental-verbal dissonance, a verbalized slot within the frame structure of the word-form- ing nest has been established. This slot functions analogously to the “motivational sema” in motivation- al process. …”
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A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study by Shahzad Mumtaz, Megan McMinn, Christian Cole, Chuang Gao, Christopher Hall, Magalie Guignard-Duff, Huayi Huang, David A McAllister, Daniel R Morales, Emily Jefferson, Bruce Guthrie

“…An exemplary result for gout as an index condition is presented to demonstrate the tool’s functionality. Guideline developers from the National Institute for Health and Care Excellence and the Scottish Intercollegiate Guidelines Network provided positive feedback on the tool. …”
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Identification and Mechanistic Studies of Key Genes in Thalamic Hemorrhage Pain by Multi-omics by Chen Yang, Ju Gao, Yaqun Li, Yinggang Xiao, Tianfeng Huang

“…Multi-omics analyses yielded distinct profiles of DEGs, single-cell DEGs, DEPs, RF-DEGs, and DEMs, which were functionally annotated through enrichment strategies. …”
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Quantitative and structural features of the SMN1 and SMN2 genes in patients with spinal muscular atrophy 5q by A. I. Vlasenko, V. D. Nazarov, S. V. Lapin, A. V. Mazing, E. A. Surkova, T. V. Blinova, T. M. Alekseeva

“…The clinical picture of the disease is heterogeneous and varies depending on the age of onset and the ability to perform motor functions. Several genetic and molecular modifiers have been identified that are thought to influence the severity of SMA. …”
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Integrating bioinformatics and machine learning to identify glomerular injury genes and predict drug targets in diabetic nephropathy by Li Zhang, ZhenPeng Sun, Yao Yuan, Jie Sheng

“…Subtype classification based on these biomarkers revealed distinct enrichment pathways and immune cell infiltration profiles, underscoring the close relationship between these genes and immune functions in DN. Drug prediction and molecular docking analyses demonstrated excellent binding affinities of candidate drugs to target proteins. …”
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Cognitive Disorders In Acquired Sensorineural Hearing Loss, At The Ent Department Of The &ldquo;Village Bondeko&rdquo; Center, In Kinshasa by Masamba GR, Sokolo Gedikondele J, Longo-Mbenza B, Nganga Nkanga MS, Matanda Nzanza R, Matonda-ma-Nzuzi T, Ikanga J, Nge Okwe A, Lema Mabwaka G, Mawalala Malengele H, Nangi Mampuya C, Lumbu Malundama D

“…Sensorineural hearing loss was confirmed by tonal threshold audiometry and characterized according to WHO criteria; cognitive disorders were defined according to the MoCA scale.Results: In total, 150 adults, including 78 men and 72 women, were collected in the present study. …”
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