A small heat shock protein Fmp28 influences virulence by regulating Als3 expression via the cAMP-PKA signaling pathway in Candida albicans by Junjun Tan, Qiong Liu, Zhiping Liu, Yanli Cao, Xiaomin Yu, Qianjun Zhao, Niya Hu, Yanling Liu, Yuwei Wan, Yeming Zhang, Huizhen Tian, Lingbing Zeng, Xiaotian Huang

“…However, our understanding of their functions in pathogenic microorganisms remains limited. …”
Get full text

An Integrated Approach Utilizing Single-Cell and Bulk RNA-Sequencing for the Identification of a Mitophagy-Associated Genes Signature: Implications for Prognostication and Therapeu... by Yuke Zhang, Li Ding, Zhijin Zhang, Liliang Shen, Yadong Guo, Wentao Zhang, Yang Yu, Zhuoran Gu, Ji Liu, Aimaitiaji Kadier, Jiang Geng, Shiyu Mao, Xudong Yao

“…Furthermore, the cellular functions of the genes of interest were verified in vitro. …”
Get full text

Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy by Xin Liu, Yang Du, Ningyan Zhang, Zhiqiang An, Wei Xiong, Yixiang Xu, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Tianhao Duan, Helen Y Wang, John S. Yu, Rongfu Wang

“…The biological functions of CAR-T cells were evaluated against target tumor cells in vitro. …”
Get full text

Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5’tRFAla/DVL/β-catenin pathway inhibition by Zhipeng Zhang, Yanmei Wu, Wenqiang Liang, Zhifang Liao, Hongbo Liao, Xingxing Xing, Wenxin Yi, Zixuan Liu, Yicheng Li, Mengya Shi, Dongling Lin, Ting Gu, Biao Wu, Mingzhi Zou, Huilai Miao, Xin Wu

“…Abstract Although tsRNA has been demonstrated to modulate various physiological processes analogous to miRNA, the potential regulatory functions and mechanisms of tsRNAs related to the pharmacological effects of small molecule drugs remain unclear. …”
Get full text

Study protocol: a randomized controlled clinical trial on the use of electroacupuncture for postoperative abdominal distension following laparoscopic cholecystectomy by Qi Kong, Qi Kong, Qi Kong, Wei Wang, Xin-Yi Chen, Li-Ming Chen, Long-Kai Sun, Long-Kai Sun, Shao-Hua Qu, Wen-Tao Wu, Jia-Hua Yang, Yu Shu, Sen Li, Pei-Hao Yin, Pei-Hao Yin, Pei-Hao Yin, Wei Li, Wei Li

“…Previous studies have confirmed the effectiveness of acupuncture intervention for gastrointestinal functionality.MethodThis study is a randomized, single-blind, controlled pilot clinical trial. …”
Get full text

Construction and validation of a necroptosis-related lncRNA signature for predicting the prognosis of gastrointestinal cancer patients by Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Chi Feng, Chi Feng, Chi Feng, Chi Feng, Jiehua Wu, Jiehua Wu, Jiehua Wu, Jiehua Wu, Xing Sun, Xing Sun, Xing Sun, Xing Sun, Pengfei Zhu, Pengfei Zhu, Pengfei Zhu, Pengfei Zhu, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…The robustness of the score was further supported by cluster analysis, and the biological functions of the selected lncRNAs were experimentally validated through phenotypic assays.ResultsWe constructed a prognostic signature comprising five necroptosis-related lncRNAs, referred to as the Necro-lnc score. …”
Get full text

Unraveling the Impact of Inter-Basin Water Transfer on Soil Salinity and Sodicity and the Crop Yield Response in the Karamay Irrigation District of China by Wei Liu, Xinwei Yin, Meng Zhu, Jutao Zhang, Wen Liu, Yingqing Su, Naying Chai, Yuhui Chen

“…We conducted a case study on the Karamay irrigation district (KID), an artificial oasis with a 30-year history of inter-basin water transfer in northwestern China, using trend and correlation analyses, water–salt balance analyses, and salt-controlled yield reduction functions as well as field comprehensive measurements over 1996–2023. …”
Get full text

Edaphic and climatic effects on soil water dynamics and infiltration patterns in tropical rainforests by Xin Zou, Ankit Shekhar, Yuxuan Mo, Ashutosh Kumar Singh, Xiaojin Jiang, Wenjie Liu

“…The preservation of forests’ hydrological functions is pivotal for alleviating land degradation and enhancing ecosystem services. …”
Get full text

DKK1 promotes migration and invasion of non–small cell lung cancer via β-catenin signaling pathway by Jing Zhang, Xintong Zhang, Xiaoting Zhao, Mei Jiang, Meng Gu, Ziyu Wang, Wentao Yue

“…Disregulation of dickkopf-related protein 1 (DKK1) has been reported in a variety of human cancers. However, how DKK1 functions in Non-small cell lung cancer has not been revealed. …”
Get full text

Parameter Estimation Precision with Geocentric Gravitational Wave Interferometers: Monochromatic Signals by Manoel Felipe Sousa, Tabata Aira Ferreira, Massimo Tinto

“…Similar precision functions are then derived for gLISA_<i>d</i> by using the amplitudes resulting in the gLISA average SNR being equal to 10 at the selected frequencies. …”
Get full text

The influence of natural immunostimulant on some indicators of specific immunity of carp by O. V. Krushelnytska

“…An important aspect of industrial fish farming is the increase in technogenic influence on the habitat of aquatic organisms, which suppresses the functions of the fish immune system or promotes the development of hypersensitivity and autoimmune reactions due to disruption of the mechanisms of immune system regulation, which leads to disruption of the homeostasis of the fish organism. …”
Get full text

The essence and structure of the scientific outlook of future teachers of natural and mathematical specialties by Zelinha Yulia, Halitsan Olha

“…The article highlights the author’s position regarding the algorithms for structuring the scientific outlook, as a category characterized by multidimensionality and a complex multifunctional composition. …”
Get full text

Poly-Lysine-Derived Carbon Quantum Dots Promote the Repair of Bone Defects in Osteomyelitis Through Antibacterial and Osteogenic Effects by Wu J, Yan H, Yang X, Qiao L, Rao X, Zhou R

“…The biological functions of PL-CQDs were evaluated through CCK-8 assays, scratch wound healing assay, osteogenic differentiation experiments, and transcriptome sequencing. …”
Get full text

The novel tRNA-derived fragment, tiRNA-Met, inhibits the malignant progression of triple-negative breast cancer by regulating RANBP3L via a targeted interaction with SNRPA by Jingjing Lu, Yangbai Sun, Xiufen Zhang, Bujie Xu, Ping Zhu, Linzi Zeng, Xue Wang, Wei Zhu, Ping Zhou

“…The biological functions of tiRNA-Met were assessed using CCK-8 assays, colony formation assays, and Transwell assays in vitro, alongside mouse xenograft models in vivo. …”
Get full text

Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 by Zheng Cui, Xiaobai Liu, Tiange E, Hongda Lin, Di Wang, Yunhui Liu, Xuelei Ruan, Ping Wang, Libo Liu, Yixue Xue

“…However, the precise functions of snoRNAs and ADARs in glycolipid metabolism within GBM cells remain elusive. …”
Get full text

Pioneering the IBD specialist nurse role in China: a shared decision-making model for clinical practice innovation by Shuyan Li, Zijun Ni, Yan Ma, Yan Chen, Hongling Sun, Jingfen Jin, Jingfen Jin, Jingfen Jin

“…This initiative defined the organizational structure, selection criteria and processes, role functions, core competencies, and training and assessment standards for the position. …”
Get full text

Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for imm... by Hongwei Wang, Yu-nan Zhu, Sifan Zhang, Kexin Liu, Rong Huang, Zhigao Li, Lan Mei, Yingpu Li

“…However, the compositional patterns of ECM in breast cancer and their underlying biological functions remain elusive. Methods Transcriptome and genome data of breast cancer patients from TCGA database was downloaded. …”
Get full text

Comparative assessment of machine learning algorithms for retrieving colored dissolved organic matter (CDOM) from Sentinel-2/MSI images in the coastal waters of the Persian Gulf by Bonyad Ahmadi, Mehdi Gholamalifard, Seyed Mahmoud Ghasempouri, Tiit Kutser

“…Colored Dissolved Organic Matter, a pivotal component of aquatic biogeochemical cycles, plays a critical role in regulating water quality and ecosystem functionality. This study provides the first comprehensive assessment of CDOM dynamics in the Persian Gulf's industrialized coastal waters, focusing on the Pars Special Economic Energy Zone (PSEEZ)—a global energy epicenter and the world's largest natural gas reserve. …”
Get full text

Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments by Xue Kong, Wei Wang, Sunan Chen, Manzong Song, Ying Zhi, Yuefeng Cai, Haibin Zhang, Xin Shen

“…Abstract Background The deep-sea cold seep zone is characterized by high pressure, low temperature, darkness, and oligotrophy. …”
Get full text

The influence of social media and cultural ideals on body dysmorphic disorder among adult males in the UAE by Kholod Haj Hussain, Abdul Rahman Al Midani, Abdul Rahman Al Midani, Mohamad Abdallah, Aisha Alyassi, Haya Alzubaidy, Shahad Alrashed, Jibran Sualeh Muhammad, Hamid A. Alhaj

“…IntroductionBody Dysmorphic Disorder (BDD) is a psychiatric condition characterized by an excessive preoccupation with perceived flaws in physical appearance, often resulting in significant emotional distress and impaired functioning. …”
Get full text