Identification of A1/A2 β-Casein Genotypes and Comparison of Their Digestive Properties by Shihang LI, Hongtao XU, Xiao LI, Meiling SUN, Xinyan YANG, Pengyu XIANG, Zhihao YANG, Chaoxin MAN, Yujun JIANG

“…To more comprehensively explore the possible biological activity effects on the human body, by analyzing and monitoring the changes of this protein during the digestion process, the exploration of the biological functions of A1/A2 β-casein is further achieved. In this study, allele-specific PCR was initially performed on milk samples collected from different cows in the pasture to identify A1 and A2 milk types. …”
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Evaluating the anticancer efficacy of Chara vulgaris ethanolic extract and selenium nanoformulation in Ehrlich carcinoma mice: role of autophagy and apoptosis by Maha Alsunbul, Thanaa A. El-Masry, Maisra M. El-Bouseary, Enas I. El Zahaby, Mostafa M. El-Sheekh, Mohamed M. S. Gaballa, Eman Wahsh, Heba Kamel Badawy, Jawaher Abdullah Alamoudi, Reem ALQahtani, Naifa Alenazi, Maysa M. F. El-Nagar

“…Abstract Background Bioactive compounds with a wide range of chemical compositions and biological functions are found in the Chlorophyceae family. The present work investigated the anticancer effect of ethanolic extract from Chara vulgaris (C. vulgaris) and its selenium nanoformulation (CvSeNPs) against solid Ehrlich carcinoma (SEC). …”
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Spatiotemporal analysis of Anopheles gambiae larval sites and malaria transmission in Djilakh, Central Senegal by Assane Ndiaye, Camille Morlighem, Aminata Niang Diène, Moussa Kane, Abdoulaye Diallo, Fassiatou Tairou, Mohamed Abderemane Nourdine, Pape Cheikh Sarr, Lassana Konaté, Ousmane Faye, Oumar Gaye, El Hadji Amadou Niang, Catherine Linard, Ousmane Sy

“…The correlation between malaria morbidity and functioning breeding sites varied throughout the rainy season, depending on the size and stability of the existing breeding sites. …”
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When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP by Fatemeh Farhid, Hadi Rezaeeyan, Reza Habibi, Ehsan Kamali Yazdi, Michael R. Hamblin, Jalal Naghinezhad

“…Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by immune-mediated destruction of platelets and impaired platelet production. …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…BackgroundPost COVID-19 condition (PCC) is increasingly recognized as a debilitating condition characterized by persistent symptoms following SARS-CoV-2 infection. …”
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Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness by Martina Cacciatore, Francesca Giulia Magnani, Filippo Barbadoro, Camilla Ippoliti, Mario Stanziano, Mario Stanziano, Letizia Clementi, Anna Nigri, Lorenzo Nanetti, Silvia Marino, Fabio La Porta, Lucia Francesca Lucca, Francesco Prada, Francesco Prada, Matilde Leonardi

“…However, it is divided into several nuclear groups each composed of functionally heterogeneous nuclei, and, to date, an agreement on which nuclei are most involved in the generation, maintenance, and modulation of consciousness is still lacking.MethodsTo fill this gap, we performed a systematic review by querying 5 electronic databases (MEDLINE/Pubmed, Scopus, EMBASE, Web of Science, and Cinahl Complete) about studies published in the last 20 years exploring the relationship between specific thalamic nuclei/nuclear groups and consciousness. …”
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In Vitro Digestion Characteristics of Tilapia Myofibrillar Proteins under Different Heating Conditions by Zirui FU, Hui HUANG, Jianwei CEN, Shuxian HAO, Huan XIANG, Shengjun CHEN, Ya WEI, Xiao HU, Chunsheng LI

“…In summary, thermal processing not only promoted the digestion of myofibrillar proteins and the release of free amino acids, but also improved the bioactive functions of tilapia digestion products. Mild oxidation in baking group caused minor structural changes and partial unfolding of proteins, which increasing the susceptibility to proteases. …”
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LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis by Tingli Liu, Guiting Pu, Liqun Wang, Ziyu Ye, Hong Li, Rui Li, Yanping Li, Xiaola Guo, William C. Cho, Hong Yin, Yadong Zheng, Xuenong Luo

“…Interestingly, its knockdown leads to liver fibrosis resolution, accompanied by a substantial suppression of parasite growth. Gm40262 functions by targeting miR-193b-5p to activate HSCs and stimulate their proliferation in a TGF-β-dependent manner, thereby promoting ECM production by upregulating Col1α1. …”
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Nursing Students' Perspectives on Integrating Artificial Intelligence Into Clinical Practice and Training: A Qualitative Descriptive Study by Moustaq Karim Khan Rony, Sumon Ahmad, Dipak Chandra Das, Sabren Mukta Tanha, Tuli Rani Deb, Mosammat Ruma Akter, Mst. Amena Khatun, Md Ibrahim Khalil, Umme Rabeya Peu, Mst. Rina Parvin, Daifallah M. Alrazeeni, Fazila Akter

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Piezo1-specific Deletion in Macrophage Protects the Progression of Chronic Inflammatory Bowel Disease in MiceSummary by Yuman Wang, Tianjiao Chu, Chengzhen Meng, Yifei Bian, Jing Li

“…This study aimed to investigate the effect of Piezo1 channels in macrophage polarization and its associated functions in IBD. Methods: DSS-induced inflammatory bowel disease model was established in Piezo1td/Tdt or Piezo1fl/fl and Piezo1△LysM male mice. …”
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Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer by Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which exert anti-T-cell functions through multiple mechanisms, especially JAK2/STAT3-regulated arginase activity. …”
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Sewage sludge-derived biochar modified with MgCl2: Used as adsorbent material for phosphorus removal from aqueous medium by Valber Georgio de Oliveira Duarte, Jader Alves Ferreira, Denise Eulálio, Guilherme Max Dias Ferreira, Vera Regina Leopoldo Constantino, Gustavo Franco de Castro, Jairo Tronto

“…The P adsorption isotherm followed the Langmuir model, with a maximum adsorption capacity of 176 mg·g⁻1 after 48 h. Magnesium-functionalized biochar produced from SS has a high capacity for P removal from an aqueous medium, which represents a promising alternative for applying this material as a P fertilizer.…”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…ABSTRACT Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research. …”
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The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system by Loïc Joannes, Laura Dupont, Louis Stock, Esther Arpigny, Pascale Hubert, Marie Ancion, Margaux Luyckx, Joan Abinet, Wen Peng, Didier Calaldo, Agnes Noel, Thomas Marichal, Michael Herfs, Christophe Deroanne, Alain Colige

“…These data identify ADAMTS2 as a cancer regulator with antagonistic functions, limiting initial progression but promoting efficient metastatic dissemination.…”
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Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma by Lin Shi, Lin Shi, Lin Shi, Lin Shi, Dongqi Yuan, Dongqi Yuan, Dongqi Yuan, Fuyi Zhu, Yuchao He, Yuchao He, Ran Zuo, Ran Zuo, Liwei Chen, Liwei Chen, Yi Luo, Yi Luo, Yu Wang, Yu Wang, Dingzhi Huang, Dingzhi Huang, Peng Chen, Peng Chen, Hua Guo, Hua Guo

“…Finally, the biological functions of the key gene were examined by in vitro and in vivo experiments.ResultsThe score model was used to divide patients with MPM into low- and high-risk groups. …”
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Structural brain network organization in children with prenatal alcohol exposure by Xiaoyun Liang, Claire E. Kelly, Chun-Hung Yeh, Thijs Dhollander, Stephen Hearps, Peter J. Anderson, Deanne K. Thompson

“…Complex structural network analyses can provide insight into the neurobiological underpinnings of these functions, as they may be sensitive for characterizing the effects of PAE on the brain. …”
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Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2 by Lin Zhang, Fang Fang, Danrui Liu, Geman Xia, Tong Feng, Jingzhu Lv, Jinying Qi, Tengteng Li, Hui Liu, Tao Xu, Fengjiao Wu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Zhongqing Qian

“…To address this, we used cultured THP-1(A) macrophages to characterize the effects of secreted ESAT-6 on cellular host defenses and apoptosis. …”
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Effects of stand structure and soil depth on soil properties in Cryptomeria japonica plantations by Laicong Luo, Kang Lin, Lingjian Tao, Chao Luo, Jianming Wang, Tianze Duan, Yubing Liu, Xiaobin Fu, Siqin Guo, Yuanqiu Liu

“…These findings provide a scientific basis for sustainable forest management, suggesting that optimizing stand structure can enhance soil health and overall ecosystem functionality.…”
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Effects of Various Direct-acting Antivirals in the Quality of Life of Patients with Chronic Hepatitis C by Hatun ÖZTÜRK ÇERİK, Şaban ESEN, Betül ALTINTAŞ ÖNER, Merve ÇELİK, Tuğba ÖZDEMİR, İlkay BOZKURT, Esra TANYEL

“…Among SF-36 parameters, a significant improvement was observed in physical functioning, physical role limitations, body pain, and vitality in groups 1 and 3 at the end of the treatment (p<0.001, p<0.001, p=0.001, and p<0.001). …”
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Impact of gut microbial diversity on egg production performance in chickens by Liping Wu, Tao Zhang, Zhihua Luo, Huiyuan Xiao, Di Wang, Cailong Wu, Xinyan Fang, Jiawei Li, Jing Zhou, Junjie Miao, Hongli Tan, Yanan Wang, Qing Liu, Jianhua Huang

“…These differences in gut microbiota influence key physiological functions, including nutrient absorption and hormone regulation through metabolic pathways, and directly affect egg production performance. …”
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