Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming by Cosetta Ciliberti, Zbigniew Lazar, Kacper Szymański, Evgeniya Yuzbasheva, Tigran Yuzbashev, Ivan Laptev, Luigi Palmieri, Isabella Pisano, Gennaro Agrimi

“…For the first time, complete gene set of the itaconate biosynthetic pathways from both fungal species were functionally expressed and compared in a yeast system with a similar genetic background. …”
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Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment by Kin Man Au, Siqing Li, Tian Zhang, Andrew Z. Wang

“…The immune-related side effects associated with the systemic administration of hCA-9-targeted MINPs were characterized. Results Human CA-9-targeted multifunctionalized immunotherapy NPs (MINPs) functionalized with anti-CA-9, anti-4-1BB, and anti-CD27 antibodies outperformed hCA-9-targeted bifunctionalized immunotherapy NPs (BINPs), non-targeted BINPs, and the combination of free antibodies in activating mouse CD8+ T cells and NK cells to kill hCA-9-expressing RCC cells in vitro. …”
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Patient Experience of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Qualitative Exploration of Signs, Symptoms, and Health-Related Quality of Life Impacts by Anna Roberts, Natasha Griffiths, Kieran Thiara, Sophie Wallace, Alyson L. Young, Nicola Williamson, Adam Gater, Omar Saeed, Charles Minor, Natalia Hawken

“…CIDP impacted health-related quality-of-life (HRQoL), including physical functioning (e.g., walking difficulties), activities of daily living (e.g., difficulty with personal care), work (e.g., being unable to work), emotional wellbeing (e.g., depression), social wellbeing (e.g., participation in social/leisure activities), sleep (e.g., difficulty falling asleep), and cognition (e.g., brain fog). …”
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Arsenic Trioxide Enhances the Efficacy of PD‐1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway by Xionghui Wang, Simo Cheng, Yannan Xu, Tianxiao Zheng, Changquan Ling, Juan Du

“…ATO‐treated HCC cells exhibited enhanced immunogenicity, functioning as prophylactic and therapeutic vaccines to stimulate antitumor immunity. …”
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Manifestations of Stereotypical Behavior in Autistic Children by Jabbar Frayyeh Shraida Shraida, Amar Aziz Latif, Joulan Hussain Khalil

“…In the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the American Psychiatric Association defines autism spectrum disorder as a state of persistent deficiency in a child’s social communication skills, characterized by a deviation and delay in the development of basic psychological functions associated with the growth of social, linguistic, and sensory skills and the emergence of stereotypical and routine behavior in addition to interests. …”
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New Indicators of Myocardial Work in Healthy Individuals by V. E. Oleynikov, A. V. Babina, V. A. Galimskaya, A. V. Golubeva, K. N. Makarova, N. A. Donetskaya

“…To study in healthy individuals the gender and age characteristics of left ventricular (LV) myocardial work indicators, their correlations with global LV deformity indicators and echocardiographic parameters characterizing LV systolic and diastolic functions.Materials and methods. 70 Healthy individuals (n=70; 34 men and 36 women; aged 39.3±8.9 years) were included in the study. …”
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Enhanced wombat optimization algorithm for multi-objective optimal power flow in renewable energy and electric vehicle integrated systems by Karthik Nagarajan, Arul Rajagopalan, Mohit Bajaj, Valliappan Raju, Vojtech Blazek

“…Further, the authors also used Weibull, lognormal and normal probability distribution functions (PDFs) for characterizing the uncertainties faced in solar PV, wind energy and PEV sources. …”
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Formation of a Generalized System of Indicators of Regional Economic Security by L. P. Bakumenko, N. S. Vasileva

“…The topic of the study is relevant, since the prevention of crisis situations, the organization of stable functioning of regional economies, the development of territories and the growth of the standard of living of the population necessitate constant monitoring of the economic security of the regions of Russia, which is based on the modeling of a system of indicators, because socioeconomic development is a complex system of interconnections, various components of the economy.Data and methods. …”
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Novel dihydroxybenzohydrazide grafted deoxycellulose for efficient removal of anionic food colorants and hexavalent chromium from wastewater by Magda A. Akl, Azza A. H. Fahim, El-Sayed R. H. El-Gharkawy

“…The results showed that the adsorption of E122, E124, and Cr(VI) follows pseudo-2nd-order kinetic and Langmuir isotherm models due to the more subordinate error functions and increased correlation coefficient (R2 ≥ 0.999). …”
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Dual-Frequency Multi-Constellation Global Navigation Satellite System/Inertial Measurements Unit Tight Hybridization for Urban Air Mobility Applications by Gianluca Corraro, Federico Corraro, Andrea Flora, Giovanni Cuciniello, Luca Garbarino, Roberto Senatore

“…In-flight tests were performed to validate the HNU functionalities demonstrating its effectiveness in UAM scenarios even in the presence of cyber threats. …”
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Cartographic and analytical assessment of land price formation depending on the physical and geographical conditions of the territory under military aggression in Ukraine by Петро Трофименко, Анна Мінженер, Віталій Зацерковний, Ірина Стахів, Світлана Кобилянська

“…The lack of clear legal regulation and the high risk of property loss lead to land purchase and sale transactions being carried out with significant restrictions, which do not meet the criteria for the full functioning of a market mechanism. Methods. Used research methods: geospatial data analysis (kriging method), mathematical statistics, cartographic-analytical assessment. …”
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Effects of <i>Lactiplantibacillus-plantarum</i>-ZG7-Fermented Feed on Laying-Hen Productivity and Intestinal Health by Zhaolong Li, Wenjing Liu, Huini Wu, Song Peng, Mengshi Zhao, Fengqiang Lin, Lu Zhao

“…The downregulated metabolites were functionally linked to ABC transporters and neuroactive ligand–receptor interactions. …”
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Influence of soluble factors from the M2 phenotype macrophages on hematopoiesis in depression-like state by I. A. Orlovskaya, L. B. Toporkova, M. A. Knyazheva, I. V. Savkin, E. V. Serenko, E. V. Goiman, Yu. A. Shevchenko, E. V. Markova

“…The longitudinal stress-induced neuroendocrine signals may alter functioning of immune (central and peripheral) organs. …”
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HIGH LEVEL OF GLYCOSAMINOGLYCANS OF BLOOD SERUM AS AN INDEPENDENT PREDICTOR OF THE DEVELOPING PERITONEUM ADHESIVE DISEASE by I. F. Sufiyarov, A. G. Khasanov, M. A. Nurtdinov, A. V. Samorodov, G. R. Jamalova

“…Peritoneal commissures is the phenomenon of adhesions formation with apparent symptom group of violations in functioning of the gastrointestinal tract and small pelvis. …”
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Pragmastilistic Analysis of Migration Discourse (Based on Speeches by British Politicians) by V. N. Matveeva, N. V. Stepanova

“…Similar tactics are also relevant in the framework of pro-migration rhetoric, namely, when comparing the local elite and the visiting population, which performs all the work necessary for the functioning of society. In most cases the main stylistic technique for tactics actualization is antithesis (or the convergence of antithesis and epithet). …”
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Type III interferon, age and IFNL gene single nucleotide polymorphisms determine the characteristics of H1N1 influenza infection by Wenbo Zhu, Shao Wang, Chenchen Guan, Shuangquan Liu, Hongbo Zhang

“…However, the molecular mechanisms underlying these clinical associations remain poorly characterized, particularly regarding IFN-λ-mediated antiviral responses.MethodsWild-type mice and IL-28B-/- mice were used to systematically investigate the antiviral and anti-inflammatory functions of IL-29 or IL-28, respectively. …”
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Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1 by Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y

“…Finally, drug docking was performed on INSIG1, and the expression levels of INSIG1 in psoriasis were verified through clinical and in vivo experiments, and further in vivo experiments established the efficacy of tetrandrine in the treatment of psoriasis.Results: T cells were initially categorized into seven states, with differentially expressed genes in T cells (TDEGs) identified and their functions and signaling pathways. INSIG1 emerged as a characteristic gene for psoriasis and was found to be downregulated in psoriasis and potentially negatively associated with T cells, influencing psoriasis fatty acid metabolism, as inferred from enrichment and immunoinfiltration analyses. …”
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Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6 by Hanning Zhang, Ruru Li, Qianqian Huo, Li Li, Min Li, Shunxin Hu, Changjie Ren, Zongyin Wu, Chenghu Zhang

“…Abstract Background Atherosclerosis is characterized by complex pathological processes, including endothelial dysfunction and inflammation. …”
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Integrative analyses of 16S rDNA sequencing and serum metabolomics demonstrate significant roles for the oral microbiota and serum metabolites in post-kidney transplant diabetes me... by Chao Liu, Sheng Chao, Lei Jia, Qizhen Yang, Qian Chen, Yulin Niu

“…Dysbiosis in the oral microbiota of the PTDM patients was associated with changes in the serum metabolites and alterations in their functions. These findings provide new insights toward identifying mechanisms by which oral microbiota and serum metabolites contribute to the development of PTDM.IMPORTANCEThis study reveals an imbalance in oral microbiota in patients with post-transplant diabetes and uncovers the potential relationship between oral microbiota and serum metabolites. …”
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Anthropology of Religion as a Bridge between East and West: A Cultural Anthropological Distinction between Intercultural Communication and Worldviews by Pieter BOERSEMA

“…In the Structural Functionalism of the mid-20th century (Malinowski, Radcliffe Brown), religion was part of society and could be described in an agnostic way. …”
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