Modulatory effect of various essential oils on different GABAA receptor subtypes present in the central nervous system by Christian Böhm, Anna-Lena Wiessler, Dieter Janzen, Julian Nausester, Benedikt Slavik, Helene M. Loos, Carmen Villmann, Andrea Buettner

“…EOs were functionally investigated on transfected HEK293 cells with GABAARs by patch-clamp whole-cell recordings. …”
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In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies by Yekaterina Galat, Yuchen Du, Mariana Perepitchka, Xiao-Nan Li, Irina V Balyasnikova, William T Tse, Svetlana Dambaeva, Sylvia Schneiderman, Philip M Iannaccone, Oren Becher, Douglas K Graham, Vasiliy Galat

“…NK cytotoxicity was validated using in vitro and in vitro K562 assays and further corroborated on lymphoma, diffuse intrinsic pontine glioma (DIPG), and GBM cell lines in vitro.Results HPCs demonstrated engraftment in peripheral blood samples, and hPSC-NKs showcased morphology and functionality akin to same donor peripheral blood NKs (PB-NKs). …”
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The cyclase-associated protein contributes to antifungal susceptibility and virulence in Aspergillus fumigatus by Xinyu Yang, Qian Wang, Binghan Xiao, Qiqi Wang, Weiwei Deng, Nir Osherov, Ruoyu Li, Wei Liu

“…Aspergillus fumigatus is the most prevalent pathogenic mould that contributes to high morbidity and mortality in immunocompromised patients. Here, we characterized the functions of the cyclase-associated protein (CAP) in A. fumigatus. …”
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<i>Cirsium setosum</i> Extract-Loaded Hybrid Nanostructured Scaffolds Incorporating a Temperature-Sensitive Polymer for Mechanically Assisted Wound Healing by Xiaojing Jiang, Shaoxuan Zhu, Jinying Song, Xingwei Li, Chengbo Li, Guige Hou, Zhongfei Gao

“…Electrospinning offers a versatile platform for fabricating nanoscale scaffolds with tunable functionality, making them ideal for drug delivery and tissue engineering. …”
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Cutaneous leiomyoma of muscles lifting hair: description of a new clinical syndrome - myalgia in the rem sleep phase (clinical case) by I. A. Kuklin, M. M. Kokhan, V. A. Iglikov, I. D. Kuznetsov, M. K. Kuklina, E. V. Redkina

“…A new clinical syndrome of the disease is described – myalgia in the rem sleep, which can be explained by the predominance of the sympathetic nervous system and the activation of physiological functions of the body during dreams.…”
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HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy by Valeria Spadotto, Chiara Ripamonti, Andrea Ghiroldi, Elisabetta Galbiati, Pietro Pozzi, Roberta Noberini, Tiziana Bonaldi, Tiziana Bonaldi, Christian Steinkühler, Gianluca Fossati

“…In vivo, ITF3756 treatment led to reduced tumor growth in a colon cancer model.DiscussionThese findings demonstrate that selective HDAC6 inhibition by ITF3756 modulates myeloid cell functionality by diminishing inhibitory signals and promoting T cell activation. …”
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In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells by Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter

“…Transcriptomic analysis further revealed seven overlapping DEGs between IFN-γ– and TGF-β1–licensed MSCs, including both upregulated (GPR68, LIMK2, LIPG) and downregulated (EFNA5, PRKG1, DCLK1, TRIM2) genes, several of which are functionally implicated in EV-mediated immune regulation. …”
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Technology Effects and Child Health: Wellness Impact and Social Effects (TECHWISE): Protocol for a Prospective, Observational, Real-World Study by Scott H Kollins, Jessica Flannery, Karen Goetz, Samir Akre-Bhide

“…To date, studies have generally been small and exploratory, relying on youth self-reports to characterize technology and social media use patterns. …”
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Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression by Jingya Zhang, Xinru Wang, Xu Wang, Songyue Li, Jianli Hou, Yibin Zhang, Xinyue Song, Shukun Cao, Ya Xu, Jing Qi, Baoshan Zhao, Xiaodong Zheng, Yan Xing

“…Background Pulmonary hypertension is a pathophysiological condition characterized by multiple forms of regulated cell death. …”
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Optimization of the treatment of patients with severe chronic urticaria by Ye.M. Dytiatkovska, N.O. Nedohybchenko

“…According to our data, patients with SCU are mostly people of working age, more than half of whom have a history of the disease for five years or more, in 70% of cases of a valid study, they are characterized by an increased content of total IgE and have a low level of indicators according to the questionnaire SKINDEX-29 at the level of physical symptoms, emotional sphere and functioning. …”
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Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics by Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif, Declan G. Murphy

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Maternal and paternal infant directed speech is modulated by the child’s age in two and three person interactions by Manuela Filippa, Hervé Tissot, Tiffany Mancinelli, Nicolas Favez, Didier Grandjean

“…Abstract Prosody in infant-directed speech (IDS) serves important functions for the infant’s attention, regulation, and emotional expression. …”
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Intraoperative picture of hip joint lesion in ankylosing spondylitis: data from a retrospective analysis by A. O. Dubinin, A. E. Khramov, T. V. Dubinina, E. V. Ilinykh, E. I. Bialik

“…In population of Russian patients with ankylosing spondylitis (AS), the frequency of clinical manifestations (pain and limitation of functions) of coxitis reaches 56%. Total hip arthroplasty (THA) can be considered as the only alternative that can relieve the suffering of the patient. …”
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Assessing the suitability of the Langevin equation for analyzing measured data through downsampling by Pyei Phyo Lin, Matthias Wächter, Joachim Peinke, M Reza Rahimi Tabar

“…The measured time series from complex systems are renowned for their complex stochastic behavior, characterized by random fluctuations stemming from external influences and nonlinear interactions. …”
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Synthesis of 5-Fluorouracil (5-FU) coated platinum nanoparticles and apoptotic effects on U87 human glioblastoma cells by Atena Abed, Merat Karimi, Majid Nejati, Michael R. Hamblin, Seyed Abbas Mirzaei, Mostafa Sarvizadeh, Hamed Mirzaei

“…Conclusion PtNPs effectively functioned as a delivery platform for 5-FU, improving its release kinetics and promoting apoptotic responses while potentially minimizing systemic toxicity. …”
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A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells by Rui Guo, Xiaoyang Chen, Lu Ying, Wenjing Zhang, Zufa Sabeel, Lianhui Zhao, Jian Dong, Yiyang Dong, Zhao Yang

“…In addition, based on A549, HepG2 cells and Jurkat cells, the functions and mechanisms of HLB-apt acting simultaneously with A549, HepG2 cells and Jurkat cells were verified through in vivo and in vitro experiments.ResultsHLB-apt demonstrated specific binding capacity to both HER2-expressing tumor cells (A549 and HepG2) and LAG3-positive Jurkat cells. …”
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Low-Cost Monitoring of Airborne Heavy Metals Using Lichen Bioindicators: Insights from Opole, Southern Poland by Liubomyr Bahinskyi, Paweł Świsłowski, Oznur Isinkaralar, Kaan Isinkaralar, Małgorzata Rajfur

“…., a species whose vital functions or morphological structure can reveal the qualitative state of the environment. …”
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Monitoring and benchmarking Earth system model simulations with ESMValTool v2.12.0 by A. Lauer, L. Bock, B. Hassler, P. Jöckel, L. Ruhe, M. Schlund

“…While the examples shown here focus on atmospheric variables, the new functionality can be applied to any other ESM component such as land, ocean, sea ice, or land ice. …”
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235 Root cause analysis of barriers and facilitators to accrual to a pragmatic, EHR-embedded clinical trial by Lindsay Lennox, Bethany M Kwan, Adit A Ginde, Thomas W. Flaig, Sarah V Kautz, Matthew Mimnall, Andrew Nicklwsky, Goldie Komaie, Christine Velez, Aaron Babour, Laurie Blmberg-Romero, Cecilia C. Low Wang

“…Discussion/Significance of Impact: While pragmatic EHR-embedded trials are often characterized as lower-burden, these trials still require active engagement by providers, as well as ongoing attention from both research and informatics teams to ensure that EHR-embedded processes are functioning as designed, and that they are effective in recruiting study participants.…”
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Study on Stress Deformation of Pipe Shed in Shallow Buried Tunnel Considering Micro-Arch Effect by Yao Rong, Wanxu Du, Yang Sun, Fuyang Xiong, Lin Liu, Sufan Yu, Gang Jie

“…The study shows that the initial support application status and the tunneling position of the working surface significantly affect the functioning mechanism of the pipe shed, causing it to play different roles at different stages. …”
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