Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer by Matthew Dietz, Travis J. Gates, Rakesh Sikdar, Subbaya Subramanian, Mikael H. Elias, Christopher Staley

“…Aims Here, we hypothesized that microbial communication, mediated through quorum sensing (QS), was a critical component regulating microbial functions related to cancer progression and metastasis. …”
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HOW IMPORTANT EDUCATION IS? AN EXPLORATIVE ANALYSIS OF THE DROPOUT PHENOMENON IN EASTERN EUROPE by Piera CASCIOLI, Emiliano COLANTONIO, Daniel BADULESCU

“…Improving the quality of the education system is therefore crucial (this is also confirmed by the variance decomposition analysis), even if it may not be enough: from the impulse response functions analysis, indeed, a shock exerted on the government expenditure on R&D in higher education produces positive effects on the (declining) dropout rate, but only for a short period. …”
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Wetland restoration suppresses microbial carbon metabolism by altering keystone species interactions by Huijie Zheng, Huijie Zheng, Deyan Liu, Ye Li, Zengming Chen, Junjie Li, Junjie Li, Yanhong Dong, Yanhong Dong, Cong Yang, Cong Yang, Yuncai Miao, Junji Yuan, Weixin Ding, Weixin Ding

“…Soil bacteria play a pivotal role in regulating multifaceted functions of terrestrial ecosystems. Unraveling the succession of bacterial communities and the feedback mechanism on soil organic carbon (SOC) dynamics help embed the ecology of microbiome into C cycling model. …”
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The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…Objective: Ischemia is characterized by an inadequate supply of nutrients and oxygen due to reduced blood circulation to specific tissues or organs. …”
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BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma by Xi Zhang, Zijie Yu, Lu Yin, Qiang Li, Shaohua He, Heng Li, Jian Li, Lian Sheng, Hongfei Wu, Hongqi Chen, Xiaoxu Zhu, Yang Lv

“…Abstract Background ccRCC (clear cell renal cell carcinoma) is characterized by metabolic reprogramming and immunosuppression, leading to poor clinical prognosis. …”
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Proteomic analysis of infiltrating neutrophils from rheumatoid arthritis synovial fluid and their contribution to protein carbamylation by Xueting Chen, Rong Du, Pan Wang, WenLin Qiu, Lu Chen, Jian Wan, Hui Qiu, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Rikard Holmdahl, Hui Geng

“…In addition, we specifically identified many carbamylated proteins and observed an increased frequency of protein carbamylation in RA-SF samples. Functionally, neutrophils from RA-SF showed a significantly increased level of MPO release and HH2O2 generation. …”
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Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection by Yuanli Zuo, Yang Jin, Gang Li, Yue Ming, Ting Fan, Yitong Pan, Xiaojun Yao, Yong Peng

“…Besides, HIV-ESCC exhibited an immune desert phenotype, characterized by a low degree of immune cell infiltration, with only a few SPP1+ macrophages showing immune resistance functions. …”
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Intratumor microbiome-derived butyrate enhances progesterone sensitivity by inducing ferroptosis in endometrial cancer by Xingchen Li, Yiqin Wang, Yuman Wu, Jingyuan Wang, Yue Qi, Xinyi Bi, Jianliu Wang

“…Targeted qPCR and metabolomic analyses confirmed the presence of these bacteria and elevated butyrate levels in tumor tissues. Functionally, butyrate suppressed tumor cell proliferation and enhanced MPA sensitivity both in vitro and in vivo. …”
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Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells by Huilong Li, Huilong Li, Haotian Lin, Haotian Lin, Tinghui Fan, Linfei Huang, Li Zhou, Xiaoyu Tian, Ruzhou Zhao, Yanhong Zhang, Xiaopan Yang, Luming Wan, Hui Zhong, Nan Jiang, Congwen Wei, Wei Chen, Wei Chen, Lihua Hou, Lihua Hou

“…Differentially expressed proteins in syncytia-derived exosomes (Syn-Exos) and their functions was analyzed by Proteomic sequencing. Syn-Exo-mediated promotion of hepatocellular carcinoma cells was measured by CCK-8 and Transwell migration assays. …”
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Matching Trees to Streets by Street Type: A Case Study of Street Tree Suitability and Services in a Highly Urbanized City by Heejung Nam, Seunghyun Hong, Dohyuk Im, Ayun Maeng, Sunmi Je, Wanmo Kang, Hanna Chang

“…Appropriate tree species were selected for each street type, taking into account tree traits and functions as well as street environments. Then, we analyzed the structure and ecosystem-regulating services of street trees by type, also comparing the services of appropriate and non-appropriate trees. …”
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Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells by Kelly Velasco, Janniche Torsvik, Johanna L. St-Louis, Sarah Baghestani, Jonas S. G. Silvander, Rohit N. Kulkarni, Diana M. Toivola, Anders Molven

“…Conclusions We propose that the SCHAD protein interacts with K8 in a way that might be relevant for proper functioning of the pancreatic β-cell. Whether the SCHAD-K8 interaction influences the phenotype of CHI remains to be demonstrated.…”
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Quality of life assessment in schwannomatosis – A systematic review by Anna C. Lawson McLean, Steffen K. Rosahl, Aaron Lawson McLean, Pascal Fehringer, Anna Freier, Denise Löschner, Marcel A. Kamp, Christian Senft, Andreas K. Demetriades

“…Introduction: The term schwannomatosis refers to rare genetic disorders characterized by the development of multiple tumors within the central and/or peripheral nervous system. …”
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Data enhanced iterative few-sample learning algorithm-based inverse design of 2D programmable chiral metamaterials by Zhao Zeyu, You Jie, Zhang Jun, Du Shiyin, Tao Zilong, Tang Yuhua, Jiang Tian

“…Meanwhile, according to the impact of geometric parameters on the chiroptical response, a new functionality is added to interpret the experimental results of DEIFS algorithm from the perspective of data, improving the interpretability of the DEIFS. …”
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Deciphering the microbiome–metabolome landscape of an inflammatory bowel disease inception cohort by Shiva T. Radhakrishnan, Benjamin H. Mullish, Marton L. Olbei, Nathan P. Danckert, Maria A. Valdivia-Garcia, Jose I. Serrano-Contreras, Despoina Chrysostomou, Sharmili Balarajah, Robert W. Perry, John P. Thomas, Lejla Potari-Gul, Dezso Modos, Lucy C. Hicks, Nick Powell, Timothy R. Orchard, Jia V. Li, Julian R. Marchesi, Tamas Korcsmaros, James L. Alexander, Horace R. T. Williams

“…The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and the recruitment of patients with well-established disease (introducing potential confounders, such as immunomodulatory medication). …”
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Assessment of the In Vitro Biological Activities of Schiff Base-Synthesized Copper Oxide Nanoparticles as an Anti-Diabetic, Anti-Alzheimer, and Anti-Cancer Agent by Abdulrahman A. Almehizia, Ahmed M. Naglah, Sadeem S. Aljafen, Ashraf S. Hassan, Wael M. Aboulthana

“…Also, various applications of Schiff-base functionalized nanoparticles and copper oxide nanoparticles (CuO-NPs) such as therapeutic applications have been discovered. …”
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A bioactive composite scaffold enhances osteochondral repair by using thermosensitive chitosan hydrogel and endothelial lineage cell-derived chondrogenic cell by Tzu-Hsiang Lin, Hsueh-Chun Wang, Yau-Lin Tseng, Ming-Long Yeh

“…However, their roles and functions in cartilage regeneration are not well understood. …”
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Soil Bacterial and Fungal Community Composition in Top- and Subsoil From Irrigated Mediterranean Orchards by Mohamed Mdaini, Mohamed Mdaini, Mohamed Mdaini, Eva Lloret, Eva Lloret, Nadhem Brahim, Najet Shimi, Raúl Zornoza, Raúl Zornoza

“…The soil microbiome, crucial for nutrient cycling and soil health, has been extensively studied in topsoil, yet the subsoil microbiome remains relatively unexamined despite its potential contributions to agroecosystem functionality. This research aimed to bridge this knowledge gap by investigating the interconnections between soil properties and the microbial communities residing in the topsoil and the subsoil of irrigated orchards under a semiarid Mediterranean climate. …”
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Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study by Elke Rücker-Braun, Elke Rücker-Braun, Bose Falk, Henning Baldauf, Carolin Massalski, Gesine Schäfer, Heidi Altmann, Jürgen Sauter, Ute V. Solloch, Vinzenz Lange, Katharina Egger-Heidrich, Desiree Kunadt, Friedrich Stölzel, Christoph Röllig, Jan M. Middeke, Malte von Bonin, Christian Thiede, Alexander H. Schmidt, Alexander H. Schmidt, Alexander H. Schmidt, Martin Bornhäuser, Johannes Schetelig, Johannes Schetelig, Falk Heidenreich, Falk Heidenreich

“…DiscussionBased on these findings, further studies should confirm the presence and functionality of neoepitope-specific T cells and characterize specific T-cell receptors (TCR). …”
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Ketorolac, melatonin and latanoprost tri-loaded PLGA microspheres for neuroprotection in glaucoma by Miriam Ana González-Cela-Casamayor, María J. Rodrigo, Marco Brugnera, Inés Munuera, Teresa Martínez-Rincón, Catalina Prats-Lluís, Pilar Villacampa, Julián García-Feijoo, Luis E. Pablo, Irene Bravo-Osuna, Elena Garcia-Martin, Rocío Herrero-Vanrell

“…Treated glaucomatous rats reached the lowest intraocular pressure, enhanced functionality of bipolar and retinal ganglion cells and showed greater neuroretinal thickness by optical coherence tomography (p < 0.05) compared to not treated glaucomatous rats at 24 weeks follow-up. …”
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Changes in the distribution of elements in the liver and various brain regions in suicides from southeastern Poland by Jacek Baj, Alicja Forma, Kaja Karakuła, Wojciech Flieger, Michał Flieger, Beata Kowalska, Iwona Kamińska, Dariusz Majerek, Grzegorz Teresiński, Ryszard Maciejewski, Elżbieta Radzikowska-Büchner, Jolanta Flieger

“…Many of them play a key role in the proper functioning of the brain by controlling oxidative metabolism, neurotransmission and the production of neurotransmitters. …”
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