Comparison of dCas9-activator complexes for the activation of PDX1 and NGN3 pancreatic genes using the CRISPR system by Ersin Akıncı, Mehmet Fatih Cengiz, Fatma Akçakale Kaba, Adem Kaba

“…Diabetes mellitus is a prevalent metabolic disorder characterized by persistently high blood glucose levels due to insufficient insulin production or response. …”
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Reconstruction and reinterpretation as post-secular bricolage phenomena by Konstantin Gipp

“…The reinterpretation product can also be characterized as a post-secular hybrid. Our proposed analysis of the features of the functioning of the mechanism of intellectual bricolage in the post-secular era, consideration of the phenomena of reconstruction and reinterpretation in this perspective gives, in our opinion, new tools for studying the processes of formation of modern religious consciousness. …”
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JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases by Yimeng Dai, Chunguo Cui, Dan Jiao, Xuewei Zhu

“…This study reviews the intricate relationship between ferroptosis and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions across multiple biological processes. Dysregulation of the JAK/STAT pathway is implicated in promoting or inhibiting ferroptosis, depending on the context. …”
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Clinical application and immune infiltration landscape of stemness‐related genes in heart failure by Wenting Yan, Yanling Li, Gang Wang, Yuan Huang, Ping Xie

“…Moreover, the biological functions of the key genes were evaluated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes Genomes (KEGG) pathway analyses, and gene set variation analysis (GSVA) and enrichment analysis (GSEA) were performed between the high‐ and low‐risk groups. …”
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Intensive Care for Anaphylaxis in Children: Current Trends by Yu. V. Bykov, A. N. Obedin, V. V. Fischer, E. V. Volkov, O. V. Zinchenko

“…Intensive care for anaphylaxis in children begins with stabilization of the condition: stopping the entry of a possible allergen into the body, hospitalization in the anesthesiology and intensive care unit, restoring patency of the URT, conducting oxygen therapy, monitoring vital functions. The first-line drug for the treatment of anaphylaxis in children is adrenaline at a dose of 0.01 mg/kg, which stops all the main pathophysiological links of anaphylaxis. …”
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Evolution of Theranostic Nanoparticles Through the Lens of Patents by Danielle Teixeira Freire, Júlio Abreu Miranda, Douglas Dourado, Éverton do Nascimento Alencar

“…Data extraction focused on nanoparticle composition, synthesis methods, functionalization strategies, and theranostic applications. …”
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Improving the Quality of Reshaped EoL Components by Means of Accurate Metamodels and Evolutionary Algorithms by Antonio Piccininni, Angela Cusanno, Gianfranco Palumbo, Giuseppe Ingarao, Livan Fratini

“…Data were then fitted by accurate Response Surfaces trained by means of interpolant Radial Basis Functions and anisotropic Kriging algorithms, subsequently used to carry out a virtual optimization managed by multi-objective evolutionary algorithms (MOGA-II and NSGA-II). …”
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DEMOGRAPHIC MODERNIZATION OF KABARDIN-BALKARIA: HISTORY AND NOWADAYS PROBLEMS by A. Kh. BOROV, M. M. BERBEKOVA

“…There is a model of population reproduction in the republic now, which is characterized with low birthrate and low death rate. …”
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The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model by S. N. Sergina, V. A. Ilyukha, I. V. Baishnikova, T. N. Ilyina

“…It was found that the functioning of both RO S generation and neutralization systems was genotypespecific. …”
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Results of intra-articular and combined interventions in patients with ischemic deformity of the femoral head by Mikhael P. Teplenkiy, Vyacheslav S. Bunov, Alina V. Akimova, Eduard M. Parfenov

“…Conducting a reducing osteotomy of the head in the conditions of a functioning growth plate is considered debatable. Conclusion Intra-articular interventions that change the shape and improve the congruence of articular surfaces may be an alternative to early arthroplasty in adolescents and young adults in certain clinical situations.…”

Fungal planktonic community related to salinity and temperature in an oligotrophic sea by Ashwag A. Asseri, Alexandra Coello-Camba, Susana Agustí

“…These findings underscore the importance of further research to better understand the role of marine fungi in ecosystem functioning.…”
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Relationship between skin temperature and blood flow during exposure to radio frequency energy: implications for device development by Georgia E. H. Robles, David A. Nelson

“…The objective of this study is to determine the extent to which the magnitude and depth of heating as well as device sensitivity are functions of (i) RF frequency and (ii) thickness of the dermal tissue layer. …”
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TRain: T-cell receptor automated immunoinformatics by Austin Seamann, Maia Bennett-Boehm, Ryan Ehrlich, Anna Gil, Liisa Selin, Dario Ghersi

“…We illustrate the basic functionality of TRain with a case study, while further information can be found in a dedicated manual. …”
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Impact of polyethylene terephthalate nanoplastics (PET) on fibroblasts: a study on NIH-3T3 cells by Maria Elena Giordano, Francesca Lionetto, Maria Giulia Lionetto, Maria Giulia Lionetto

“…These findings highlight the potential risks of PET NPs to fibroblasts, emphasizing the need for further research into their impact on cellular functions and mechanisms.…”
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MANIPULATIVE TACTICS IMPLEMENTATION IN POLITICAL DISCOURSE by Tatyana P. Paliy, Inna N. Poteryakhina

“…The political discourse of modern society is a complex, multi-faceted and multi-level entity characterized by a variety of goals and objectives and functioning within the framework of current political, economic, geopolitical, cultural and other realities. …”
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Applying the Consensus Criteria for Traumatic Encephalopathy Syndrome Retrospectively to Case Studies of Boxers from the 20th Century by Grant L. Iverson, Andrew J. Gardner, Rudolph J. Castellani, Alicia Kissinger-Knox

“…For the core clinical features, cognitive impairment was noted in 63.1%, and in 28.7% of cases the person's cognitive functioning appeared to be broadly normal. Neurobehavioral dysregulation was present in 25.5%. …”
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The effect of water soluble pentosanes on baking properties of winter rye by E. N. Shabolkina, A. A. Bisharev, N. V. Anisimkina, M. V. Belyaeva

“…Estimation of the variation coefficients showed that non-starch polysaccharides influence by genotypic and environmental factors are characterized by low variability CVf = 8.2%. The experiments confirm that when baking rye bread, water-soluble pentosanes perform the following functions: they absorb water, increase the viscosity of the dough, and improve the dimensional stability of bread. …”
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Metaphorical maps as a means of developing speech imagery at classes of Russian as a foreign language by Nina L. Fedotova, Alexandra V. Burtseva, Inna V. Ryzhkova

“…The metaphorical map increases students’ creativity, allows them to move from combining template constructions to creating an original text idea. The study characterizes the functions of a metaphorical associative map at different stages of a student’s speech activity, gives recommendations for using them for developing creative speech abilities of foreign students and their speech imagery, and suggests scenarios for working with them at the classes of Russian as a foreign language. …”
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Novel immunotargets in multiple myeloma: biological relevance and therapeutic potential by Jana Kotulová, Klára Baďurová, Zuzana Chyra, Sabina Ševčíková, Nikola Garbová, Tomáš Jelínek, Roman Hájek, Matouš Hrdinka

“…This review provides an overview of emerging immunotargets, summarizing their biological functions, roles in disease pathogenesis and immune evasion, and potential for therapeutic interventions. …”
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Experience in vegetable waste burning in furnace block TBR-2.0 by A. V. Golubkovich, L. I. Belen'kaya, A. N. Dadyko, V. B. Lovkis

“…As well the maximum efficiency is reached, and extent of air heating provides functioning of the dryer at a temperature of external air not below 5 degrees Celsius. …”
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