Pharmacokinetic profile and in vivo anticancer efficacy of anagrelide administered subcutaneously in rodents by Kirsi Toivanen, Luna De Sutter, Agnieszka Wozniak, Karo Wyns, Nanna Merikoski, Sami Salmikangas, Jianmin Duan, Mikael Maksimow, Maria Lahtinen, Tom Böhling, Patrick Schöffski, Harri Sihto

“…Anagrelide (ANA) is a phosphodiesterase 3A (PDE3A) inhibitor, commonly prescribed for essential thrombocythemia. It also functions as a molecular glue, inducing complex formation between PDE3A and Schlafen 12. …”
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KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism by Li Chen, Kaikai Shi, Nicholas Ditzel, Weimin Qiu, Michaela Tencerova, Louise Himmelstrup Dreyer Nielsen, Florence Figeac, Alexander Rauch, Yuhang Liu, Jiuyuan Tao, Veronika Sramkova, Lenka Rossmeislova, Greet Kerckhofs, Tatjana N. Parac-Vogt, Sébastien de Bournonville, Thomas Levin Andersen, Mikael Rydén, Moustapha Kassem

“…Abstract An increasing number of studies have characterized the bone as an endocrine organ, and that bone secreted factors may not only regulate local bone remodeling, but also other tissues and whole-body metabolic functions. …”
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Transcriptome Study in Sicilian Patients with Huntington’s Disease by Michele Salemi, Vincenzo Di Stefano, Francesca A. Schillaci, Giovanna Marchese, Maria Grazia Salluzzo, Angela Cordella, Ilenia De Leo, Concetta Simona Perrotta, Giuseppe Nibali, Giuseppe Lanza, Raffaele Ferri

“…The GSEA results highlighted significant associations between HD and GO pathways related to ribosomal functions and structure. These pathways were predominantly characterized by negative expression, with a substantial number of genes showing dysregulation. …”
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Evaluating DNA damage in earthworms (Eisenia fetida’s): toxicological insights from carbon, gold, and silver nanoparticles using enzyme and comet assays by Ramsha Latif, Shazia Perveen, Sumaira Kanwal, Saima Nasreen, Fariha Latif, Mommna Khan, Sadaf Ahmad, Ali Irfan, Gamal A. Shazly, Yousef A. Bin Jardan

“…Earthworms are crucial for soil health and ecosystem functioning, and understanding their impact is essential. …”
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A Sustainable Energy Management Evaluation and Decision-Making Framework of Hybrid Solar Geyser-Stove System in Domestic buildings by Muhammad Nauman Fazal, Abdullah Altamimi, Syed Ali Abbas Kazmi, Zafar A. Khan, Faisal Asfand

“…In an era characterized by mounting environmental concerns and growing demand for sustainable energy solutions, this study comprehensively evaluates hybrid solar geyser and stove systems tailored for the domestic building sector. …”
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Deciphering the Neurotoxic Effects of <i>Karenia selliformis</i> by Ambbar Aballay-González, Jessica Panes-Fernández, Catharina Alves-de-Souza, Bernd Krock, Juan José Gallardo-Rodríguez, Nicole Espinoza-Rubilar, Jorge Fuentealba, Allisson Astuya-Villalón

“…Given the high toxicity and impact on marine life, our study aimed to functionally characterize the neurotoxic metabolites in the exudate of <i>K. selliformis</i> cultures. …”
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Change Readiness and Positive Orientation in Professional Helpers in the Polish Welfare System during the COVID-19 Pandemic by Marta Czechowska‑Bieluga, Patrycja Zielińska, Renata Krawczyk, Barbara Sordyl-Lipnicka

“…The present study investigated positive orientation and change readiness, as important predictors of professional functioning of persons in the sample group. The questionnaires were distributed among 189 professional helpers working in the Polish welfare system. …”
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Land cover classification for Siberia leveraging diverse global land cover datasets by Munseon Beak, Kazuhito Ichii, Yuhei Yamamoto, Ruci Wang, Beichen Zhang, Ram C. Sharma, Tetsuya Hiyama

“…Abstract Understanding the land cover is crucial to comprehending the functioning of the Earth’s system. The land cover of Siberia is characterized by uncertainty because it is wide-ranging and comprises various classification types. …”
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Increased intra-subject variability in reward behavior relates to symptom severity in schizophrenia by I-Fei Chen, Yu-Chen Chan, Chih-Min Liu, Yi-Ting Lin, Ming H. Hsieh, Tzung-Jeng Hwang, Tai-Li Chou, Chen-Chung Liu, Yi-Ling Chien, Georg Northoff

“…Abstract Schizophrenia (SZ) is a complex disorder characterized by positive and negative symptoms that have been linked to dysfunction in cognition and reward motivation. …”
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Ozone patterns in Maceió: Insights into seasonal and geographic varibility by Amaury de Souza, Celina M. Takemura, Deniz Özonur, Elias Silva de Medeiros, Ivana Pobocikova, Janice F. Leivas, José Francisco de Oliveira-Júnior, Kelvy Rosalvo Alencar Cardoso, Marcel Carvalho Abreu, Wagner Alessandro Pansera, Jose Roberto Zenteno Jimenez, Sneha Gautam

“…Descriptive statistical analyses characterized the temporal distribution of TCO values, and probability density functions (PDFs) identified the best-fitting statistical distribution.The findings indicate significant homogeneity in annual and seasonal TCO concentrations, with an annual mean of 263.24 ± 9.91 DU. …”
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Obstructive Sleep Apnea – Current State of Knowledge, Impact on Work Productivity and Treatment Methods by Aleksandra Dudek, Aleksandra Sadowska, Aleksandra Welkier, Adam Sobiński, Joanna Miśkiewicz, Patrycja Pietrusińska, Jakub Moder, Anna Dziewierz, Paula Kwaśniewska, Patrycja Śliwa-Tytko

“…At a societal level, OSA leads to a reduced productivity levels caused by impaired cognitive functions and absenteeism and an increased risk of motor vehicle accidents. …”
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Component specific responses of the microbiomes to common chemical stressors in the human food chain by Wasimuddin, Aurea Chiaia-Hernandez, Céline Terrettaz, Lisa Thoenen, Veronica Caggìa, Pierre Mateo, Miquel Coll-Crespi, Matheus Notter, Mohana Mukherjee, Teresa Chavez-Capilla, Francesca Ronchi, Stephanie C. Ganal-Vonarburg, Martin Grosjean, Moritz Bigalke, Sandra Spielvogel, Andrew Macpherson, Adrien Mestrot, Siegfried Hapfelmeier, Matthias Erb, Klaus Schlaeppi, Alban Ramette

“…Abstract Along a food chain, microbiomes occur in each component and often contribute to the functioning or the health of their host or environment. …”
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Microstructure, electrical properties, bioactivity, biocompatibility and osteogenic differentiation ability of bio-piezocomposite fabricated by hydroxyapatite and (Ba,Ca)(Ti,Sn)O3-... by Geng Tang, Hong Yang, Bingqing Zhao, Dunying Wang, Fangfang Zeng, Qibin Liu

“…The rapid repair of bone defects remains a challenging clinical goal, with bio-piezoelectric composites emerging as promising materials due to their ability to replicate bone's natural composition and electrical functionality. This study developed hydroxyapatite (HA)-based composites incorporating (Ba,Ca)(Ti,Sn)O3-based piezoceramics, achieving piezoelectric coefficients of 28.7 ± 2.48 pC/N, 11.1 ± 0.57 pC/N, and 5.7 ± 0.98 pC/N at HA mass fractions of 10%, 20%, and 30%, respectively, with a porosity around 20%. …”
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Improved optimization based on parrot’s chaotic optimizer for solving complex problems in engineering and medical image segmentation by Adil Sayyouri, Ahmed Bencherqui, Hanaa Mansouri, Hicham Karmouni, Hassane Moustabchir, Mhamed Sayyouri, Abderrahim Bourkane, Abdeljabbar Cherkaoui, S. S. Askar, Mohamed Abouhawwash

“…The effectiveness of the CPO algorithm has been rigorously evaluated through in-depth statistical analysis, using 23 benchmark functions as well as IEEE CEC 2019 and CEC 2020 benchmarks, covering a wide range of optimization challenges. …”
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Innovative 3D microfluidic intestinal organoid model for assessing cadmium bioavailability in food: implications for enhanced exposure risk assessment by Yan Li, Wen Sun, Qiao Wang, Wan Shi, Yu Chen, Zhiyong Gong, Xiao Guo, Xin Liu, Yongning Wu

“…Caco-2 cells were cultured on the chip to mimic small intestinal villi’s 3D structure, mucus production, and absorption functions. The model’s physiological relevance was thoroughly characterized, demonstrating the formation of a confluent epithelial monolayer with well-developed tight junctions (ZO-1), high microvilli density (F-actin), and significant mucus secretion (Alcian blue staining), closely resembling the physiological intestinal epithelium. …”
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Nutrition and Dietary Habits Associated with Risk of Colorectal Cancer in the Population of Omsk region: Case-Control Study by N. G. Shirlina, V. L. Stasenko, D. V. Turchaninov, I. A. Sohoshko

“…Nutrition is the most important biological factor on which the functioning of the human body depends. The link between the development of colorectal cancer and nutrition and eating habits is well known: excessive consumption of red meat, fats, alcohol, lack of dietary fiber, obesity. …”
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Analysis of Hydrological and Meteorological Conditions in the Southern Baltic Sea for the Purpose of Using LNG as Bunkering Fuel by Ewelina Orysiak, Jakub Figas, Maciej Prygiel, Maksymilian Ziółek, Bartosz Ryłko

“…It identifies operational constraints, such as wind speed, wave height, visibility, and ice cover, and assesses their impact on LNG logistics and terminal functionality. Thresholds for safe operations are evaluated in accordance with IMO and ISO safety standards. …”
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Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer by Zige Liu, Xingning Mao, Yuli Xie, Yunkun Yan, Xiang Wang, Junhao Mi, Hao Yuan, Jiange Zhang, Caisheng Huang, Jianxin Chen, Mujia Jili, Shengzhu Huang, Qingyun Zhang, Fubo Wang, Zengnan Mo, Rirong Yang

“…Abstract Muscle-invasive bladder cancer (MIBC) is characterized by a complex tumor microenvironment (TME) that drives aggressive progression and treatment resistance. …”
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Canine and Human Red Blood Cells: Biochemical Mechanisms for the Control of Heat Dissipation by Annamaria Russo, Giuseppe Tancredi Patanè, Stefano Putaggio, Ester Tellone, Silvana Ficarra, Davide Barreca, Giuseppina Laganà

“…The study aims to investigate the metabolic differences between canine and human red blood cells (RBCs) and the hemoglobin (Hb) functionality focusing on their roles in heat dissipation. …”
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Unraveling the Complete Mitochondrial Genome of Potamalpheops Sp. (Purple Zebra Shrimp) (Crustacea: Decapoda) Provides Insights Into Its Phylogenetic Relationships and Gene Order R... by Sofia Priyadarsani Das, Yu‐Kai Kao, Huu‐The Nguyen, Yu‐Ru Lin, Zhen‐Hao Liao, Yeh‐Fang Hu, Fan‐Hua Nan

“…ABSTRACT Understanding the functions of mitochondrial genomes is crucial for studies related to the evolution of genomes, phylogenomics, and species identification. …”
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