Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis by Manshu Yu, Junyi Zhao, Yun Shan, Huibo Dai, Lei Tang, Li Sheng, Lu Zhang, Meixiao Sheng

“…DNA methylation has been characterized as an important regulatory mechanism on multiple fibrosis. …”
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Transcriptome remodeling drives acclimation to iron availability in the marine N2-fixing cyanobacterium Trichodesmium erythraeum IMS101 by Xin Zhong, Ran Duan, Shengwei Hou, Meng Chen, Xiaoming Tan, Wolfgang R. Hess, Tuo Shi

“…ABSTRACT While enhanced phytoplankton growth as a result of iron (Fe) fertilization has been extensively characterized, our understanding of the underlying mechanisms remains incomplete. …”
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Novel application of ribonucleoprotein-mediated CRISPR-Cas9 gene editing in plant pathogenic oomycete species by Erika N. Dort, Nicolas Feau, Richard C. Hamelin

“…ABSTRACT CRISPR-Cas9 gene editing has become an important tool for the study of plant pathogens, allowing researchers to functionally characterize specific genes involved in phytopathogenicity, virulence, and fungicide resistance. …”
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Histone H3 K4 trimethylation occurs mainly at the origins of polycistronic transcription in the genome of Leishmania infantum promastigotes and intracellular amastigotes by Aurora Diotallevi, Stefano Amatori, Giuseppe Persico, Gloria Buffi, Enrica Sordini, Marco Giorgio, Mirco Fanelli, Luca Galluzzi

“…These pathogens present unique mechanisms of gene expression characterized by functionally unrelated genes positioned in tandem and organized into polycistronic transcription units transcribed in a large pre-mRNA by RNA Polymerase II. …”
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Clinical and genetic characteristics of type 7 distal arthrogryposis caused by a pathogenic variant in the <i>MYH8</i> gene by I. V. Sharkova, S. S. Nikitin, T. V. Markova, A. E. Voskanyan, E. A. Melnik, O. A. Shchagina, E. L. Dadali

“…In all patients described in the literature from different populations with type 7 distal arthrogryposis, the same pathogenic variant c.2021G&gt;A(p.Arg674Gln) was found in the MYH8 gene, the protein product of which is one of the myosin isoforms functioning in the embryonic period and providing the formation of muscle fiber structures.The aim of the work is to describe the clinical and genetic characteristics of the first family case of type 7 distal arthrogryposis in Russian patients. …”
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PSYCHOLOGICAL AND PEDAGOGICAL BASES OF FORMATION OF THE FUTURE SPECIALISTS’ INDIVIDUAL STYLE OF PROFESSIONAL ACTIVITIES by Lavrentieva Olena, Krupskyi Oleksandr

“…The article studies the problem of the future specialist’s professional formation as a subject of professional activity, which is characterized by originality and peculiarity in the realization of labour functions. …”
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Morphofunctional changes in the immune system in colitis-associated colorectal cancer in tolerant and susceptible to hypoxia mice by Dzhuliia Dzhalilova, Maria Silina, Anna Kosyreva, Nikolai Fokichev, Olga Makarova

“…During inflammation, NF-κB is activated, which is connected with the hypoxia-inducible factor—HIF, regulating the immune cells functioning and influences the CAC development. Organisms differ according to their hypoxia resistance and HIF expression. …”
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Models of symmetric three-layer waveguide structures with graded-index core and nonlinear optical liners by S. E. Savotchenko

“…The analytical methods of mathematical physics and the theory of special functions applied to nonlinear and waveguide optics are used herein.Results. …”
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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune dysregulation, heterogeneous clinical phenotypes, and a complex interplay of pathogenic mechanisms. …”
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Molecular classification of hepatocellular carcinoma based on zoned metabolic feature and oncogenic signaling pathway by Tomoko Aoki, Naoshi Nishida, Yutaka Kurebayashi, Kazuko Sakai, Naoto Fujiwara, Masakatsu Tsurusaki, Kohei Hanaoka, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Yasunori Minami, Atsushi Takebe, Takaaki Murase, Keiko Kamei, Takuya Nakai, Ippei Matsumoto, Kazuto Nishio, Masatoshi Kudo

“…Background/Aims Previously, we advocated the importance of classifying hepatocellular carcinoma (HCC) based on physiological functions. This study aims to classify HCC by focusing on liver-intrinsic metabolism and glycolytic pathway in cancer cells. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…Huntington's disease (HD) is a debilitating neurodegenerative disorder characterized by severe motor deficits, cognitive decline and psychiatric disturbances. …”
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Surface charge modulation in metal-crosslinked sodium alginate-chitosan composite adsorbent: Optimized anionic-to-cationic polysaccharide component ratio for Cd and Cr removal from... by Aminat Mohammed Ahmed, Mhamed Berrada, Menbere Leul Mekonnen, Ayalew H. Assen, Ephriem Tadesse Mengesha, Redouane Beniazza, Kebede Nigussie Mekonnen, Youssef Belmabkhout

“…The Zr/Fe-SA/CS beads were characterized by FTIR, XRD, SEM-EDX, BET, and TGA to confirm that the polysaccharides were well incorporated and functionalized within the adsorbent. …”
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Presentation of Financial Assets in the Monetary Statistics by V. N. Salin, O. Y. Sitnikova, L. Y. Arhangelskaya

“…In the paper, the authors considered the essence, functions, classifications of financial assets and liabilities, applied structural and dynamic data analysis, as well as methods of theoretical research in the form of generalization, comparison and special analytical procedures based on official statistics from Rosstat, the Bank of Russia, the Ministry of Finance and international statistical organizations.Results. …”
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A Sociological Study of Monetary Attitudes among Citizens of Tehran by Nahid Abdoli, Asadollah Babaiefard

“…Currently, the cultural and social functions of money—understood as a "fait social total"—are undergoing significant changes. …”
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Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus by Pattanachat Lertpeerapan, Songphon Kanlayaprasit, Surangrat Thongkorn, Kasidit Kasitipradit, Pawinee Panjabud, Kwanjira Songsritaya, Thanawin Jantheang, Masanobu Morita, Takaaki Akaike, Valerie W. Hu, Depicha Jindatip, Thanit Saeliw, Tewarit Sarachana

“…Ingenuity Pathway Analysis (IPA) was used to predict associated biological functions, diseases, and molecular interaction networks. …”
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Western Mediterranean shelf-incised submarine canyons: multi-proxy evidence of Late Holocene natural and human-induced environmental changes by Adrián López-Quirós, Ángel Puga-Bernabéu, Francisco José Lobo, Elvira Ruíz-Caballero, Elvira Ruíz-Caballero, Javier Cerrillo-Escoriza, José N. Pérez-Asensio, Isabel Mendes, Anxo Mena, Natalia Puche-Polo, Natalia Puche-Polo, Tomás Alberjón-Peñas, Tomás Alberjón-Peñas, Lukas Wacker

“…Submarine canyons play a critical role in continental margin sediment transport, functioning both as sediment traps and conduits. This study examines the depositional dynamics of the Motril, Carchuna, and Calahonda canyons in the northern Alboran Sea (western Mediterranean) to assess their role in Holocene sediment storage and transfer. …”
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Genome-Wide Identification of the <i>DOG1</i> Gene Family in Pepper (<i>Capsicum annuum</i>) and Its Expression Profiles During Seed Germination by Zhichao Zhao, Jingbo Sun, Feng Zhang, Chunjuan Dong

“…However, a genome-wide analysis of <i>DOG1</i> genes has not been performed for pepper (<i>Capsicum annuum</i>), one of the agriculturally important species, and no studies have been conducted to characterize their expression profiles. Based on <i>C. annuum</i> genome information, the identification and expression analysis of <i>CaDOG1</i> gene family members through bioinformatics approaches can provide a theoretical foundation for subsequent studies on the biological functions of <i>CaDOG1s</i> and the improvement of seed traits in <i>C. annuum</i> breeding. …”
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Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development by Piotr Jaholkowski, Shahram Bahrami, Vera Fominykh, Guy F.L. Hindley, Markos Tesfaye, Pravesh Parekh, Nadine Parker, Tahir T. Filiz, Kaja Nordengen, Espen Hagen, Elise Koch, Nora R. Bakken, Evgeniia Frei, Viktoria Birkenæs, Zillur Rahman, Oleksandr Frei, Jan Haavik, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Alexey A. Shadrin, Ole A. Andreassen

“…To provide biological insights loci were functionally characterized. Subsequently, we constructed a Structural Equation Model (SEM) to determine if the polygenic foundation of cognition has a direct impact on Alzheimer's disease risk, or if its effect is mediated through established risk factors for the disease, using a case-control sample from the UK Biobank. …”
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Altered Monocyte Populations and Activation Marker Expression in Children with Autism and Co-Occurring Gastrointestinal Symptoms by Rachel J. Moreno, Yasmin W. Azzam, Serena Eng, Destanie Rose, Paul Ashwood

“…In humans, circulating monocytes are often categorized into three subpopulations—classical, transitional (or “intermediate”), and nonclassical monocytes, which can vary in functions, including archetypal inflammatory and/or reparative functions, as well as their effector locations. …”
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Impacts of loading thymoquinone to gold or silver nanoparticles on the efficacy of anti-tumor treatments in breast cancer with or without chemotherapeutic cisplatin by Soha Gomaa, Mohamed Nassef, Ahlam Abu-Shafey, Mona Elwan, Asmaa Adwey

“…Furthermore, the results indicated moderate alterations in the functionality of both the liver and kidney. Conclusion To conclude, AuNPs, AgNPs, AuNPs/TQ, and AgNPs/TQ may hold great promise as potential nanoparticle-based therapies for cancer treatment. …”
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