Estrogen-related receptor alpha (ERRα) controls the stemness and cellular energetics of prostate cancer cells via its direct regulation of citrate metabolism and zinc transportatio... by Taiyang Ma, Wenjuan Xie, Zhenyu Xu, Weijie Gao, Jianfu Zhou, Yuliang Wang, Franky Leung Chan

“…Nuclear receptor ERRα (ESRRA) is a key regulator of energy metabolism. Previous studies characterize that ERRα exhibits an upregulation in prostate cancer and can perform multiple oncogenic functions. …”
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Nylon/Graphene Oxide Electrospun Composite Coating by Carmina Menchaca-Campos, César García-Pérez, Iván Castañeda, Miguel A. García-Sánchez, René Guardián, Jorge Uruchurtu

“…Potentiostatic oxidation and reduction curves were applied to further oxidize carbon species and then reduced them, forming the nylon 6-6/functionalized graphene oxide composite coating. Electrochemical impedance measurements were performed to evaluate the coating electrochemical resistance and compared to the silica or nylon samples.…”
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Elucidation of the biosynthetic pathway of hydroxysafflor yellow A by Zi-Long Wang, Hao-Tian Wang, Guowei Chang, Guo Ye, Meng Zhang, Jiang Chen, Min Ye

“…Notably, Ct2OGD1 coordinates with CtCGT to convert carthamidin or isocarthamidin to HSYA. Functions of these genes are confirmed by VIGS (virus-induced gene silencing) in C. tinctorius, de novo biosynthesis of HSYA in Nicotiana benthamiana, semi-synthesis in yeast, and in vitro enzyme assays. …”
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Combining Prior Knowledge and Reinforcement Learning for Parallel Telescopic-Legged Bipedal Robot Walking by Jie Xue, Jiaqi Huangfu, Yunfeng Hou, Haiming Mou

“…The parallel dual-slider telescopic leg bipedal robot (L04) is characterized by its simple structure and low leg rotational inertia, which contribute to its walking efficiency. …”
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Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment by Si-Jie Zhang, Ran Xu, Shao-Bin He, Rong Sun, Guan-Nan Wang, Shu-Yi Wei, Xi-Yun Yan, Ke-Long Fan

“…Factors such as bacterial infections, hyperglycemia, and oxidative stress disrupt cellular functions and impair angiogenesis, substantially delaying wound repair. …”
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Phycobacteria Biodiversity, Selected Isolation, and Bioactivity Elucidation of New Bacterial Species of Highly Toxic Marine Dinoflagellate <i>Alexandrium minutum</i> amtk4 by Xiaoling Zhang, Zekang Pan, Jinkai Zhang, Bingqian Liu, Qiao Yang

“…Phycosphere niches host rich, unique microbial consortia that harbor complex algae–bacteria interactions with fundamental significance in underpinning most functions of aquatic ecological processes. Therefore, harvesting the uncultured phycobacteria is crucial for understanding the intricate mechanisms governing these dynamic interactions. …”
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Turtle shell-inspired exosuit with large output, model-based torque estimation, and load compensation by Chen-Hao LIU, Yu GU, Shuo-Yu WANG, Jin-Gang YI, Tao LIU

“…In this paper, we present a bio-inspired exosuit for elbow assistance that mimics the morphology and functionality of a turtle shell. Mathematical models are established to characterize the force output of the actuators and predict the output torque of the exosuit. …”
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Exploring a novel approach for computing topological descriptors of graphene structure using neighborhood multiple M-polynomial by Tumiso Kekana, Kazeem Olalekan Aremu, Kazeem Olalekan Aremu, Maggie Aphane

“…Topological indices (TIs) play a crucial role in studying graphene's structure as mathematical functions mapping molecular graphs to real numbers, capturing their topological characteristics. …”
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A Multifunctional Fe-EGCG@RSL3 Nanomedicine Synergizes Ferroptosis Induction and Tumor Microenvironment Remodeling for Enhanced Bladder Cancer Immunotherapy by Chengjunyu Zhang, Sen Liu, Jianhui Zhang, Junlin Lu, Zehua Chen, Bolin Pan, Chu Liu, Ming Huang, Hengji Zhan, Hongjin Wang, Siting Chen, Kaiwen Jie, Baoqing He, Jingdie Wu, Ye Li, Haifeng Wang, Jing Zhao, Qiang Zhang, Xu Chen

“…Overall, Fe-EGCG@RSL3 has dual functions as a multifaceted nanomedicine that integrates ferroptosis induction with immunomodulation, offering a novel and clinically translatable strategy for bladder cancer therapy.…”
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Integrated Single-Step Terahertz Metasensing for Simultaneous Detection Based on Exosomal Membrane Proteins Enables Pathological Typing of Gastric Cancer by Qingzhe Jia, Zhaofu Ma, Yujia Wang, Mingjin Zhang, Guijun Zou, Bin Lan, Songyan Li, Zeqiu Lao, Wenbin Shen, Jing Lou, Yanan Jiao, Xiaohui Du

“…Herein, we propose an integrated terahertz metasensing platform for the discrimination of Exos in distinct subtypes of GC in a single step—through the simultaneous evaluation of the category and richness level of Exos membrane proteins. Characterized by dual-sided independent sensing capabilities with enhanced sensitivity (169 and 325 GHz per refractive index unit, respectively), the metasensor functionalized with antibodies simultaneously reflects the content of 2 membrane proteins in the terahertz spectral response. …”
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Early Alterations in De Novo Parkinson’s Disease Revealed by Diffusion Tensor Imaging: Preliminary Study by Francesca Di Giuliano, Noemi Pucci, Maria Lina Serio, Eliseo Picchi, Silvia Minosse, Valentina Ferrazzoli, Valerio Da Ros, Tommaso Schirinzi, Matteo Conti, Roberta Bovenzi, Davide Mascioli, Francesco Garaci

“…<b>Background/Objectives</b>: Parkinson’s disease (PD) is characterized by progressive neurodegeneration affecting both motor and non-motor functions. …”
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Role of calcineurin and ionotropic glutamate receptors in Alzheimer's disease: A systematic review by Awgichew Behaile Teklemariam, Edgeit Abebe Zewde, Melaku Mekonnen Agidew, Sisay Ayalkibet Siyamrew, Lemlemu Maru, Zelalem Tilahun Muche

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. …”
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Suicidal thoughts and behaviors in adults with hoarding disorder by Dariana Gil-Hernández, Elizabeth McCarthy, Tatevik Avanesyan, Pavithra Mukunda, Marcos Ortiz, Randy O. Frost, Peter J. van Roessel, Michele S. Berk, Carolyn I. Rodriguez

“…Background: Hoarding disorder (HD) is characterized by difficulty discarding possessions and clutter that impairs daily functioning. …”
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Fuzzy System for the Quality Assessment of Educational Multimedia Edition Design by Vsevolod Senkivskyy, Liubomyr Sikora, Nataliia Lysa, Alona Kudriashova, Iryna Pikh

“…A multilevel model of fuzzy logical inference is constructed, representing the dependency between quality factors. Membership functions for linguistic variables are formed and their weight coefficients are determined using pairwise comparison matrices. …”
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Scream’s roughness grants privileged access to the brain during sleep by Guillaume Y. T. Legendre, Maëva Moyne, Judith Domínguez-Borràs, Samika Kumar, Virginie Sterpenich, Sophie Schwartz, Luc H. Arnal

“…Abstract During sleep, recognizing threatening signals is crucial to determine when to wake up and when to continue vital sleep functions. Screaming is perhaps the most efficient way for communicating danger at a distance or in conditions of limited visibility. …”
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Cardiomyocyte proliferation: Advances and insights in macrophage-targeted therapy for myocardial injury by Tao Wang, Xueyao Wang, Weibin Ren, Zeyu Sun, Yanhui Zhang, Nanping Wu, Hongyan Diao

“…In this review, we discuss the novel functions of macrophages in triggering cardiac regeneration and repair after myocardial infarction and provide recent advances and prospective insights into the phenotypic transformation and heterogeneous features involving cardiac macrophages. …”
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Fast Determination of Furocoumarins in Food Supplements Containing <i>Heracleum sphondylium</i> L. Using Capillary Electrophoresis by Eszter Laczkó Zöld, Csenge Kis, Erzsébet Nagy-György, Erzsébet Domokos, Elek Ferencz, Zoltán-István Szabó

“…., commonly known as hogweed, is a plant species that has been employed as an ingredient in food supplements aimed at enhancing reproductive organ functionality, restoring hormonal equilibrium, and producing an aphrodisiac effect. …”
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The mechanisms and clinical significance of CD8+ T cell exhaustion in anti-tumor immunity by Tao Zhong, Shuo Sun, Mingsheng Zhao, Bin Zhang, Huabao Xiong

“…CD8+ T cell exhaustion, a critical challenge in the immune response to cancer, is characterized by a profound decline in the functionality of effector CD8+ T cells. …”
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HIF-2α level in adolescents with chronic inflammatory pathology of the upper gastrointestinal tract by N. S. Shevchenko, N. V. Krutenko, L. L. Sukhova, O. M. Tsiura, H. O. Shlieienkova, K. V. Voloshyn

“…A significant role in the pathogenesis of gastrointestinal tract diseases is given to the functioning of the oxygen sensor system, the main mediator of which is hypoxia-inducible factor 2 (HIF-2α). …”
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Lomentospora prolificans synthesizes several types of melanin by Livia C. Liporagi-Lopes, Christine Chrissian, Emma Camacho, Arlind Kacirani, Ruth E. Stark, Arturo Casadevall

“…Melanins are biological compounds with important functions that contribute to the virulence of many pathogenic fungi. …”
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