Human Acquired Aplastic Anemia Patients’ Bone-Marrow-Derived Mesenchymal Stem Cells Are Not Influenced by Hematopoietic Compartment and Maintain Stemness and Immune Properties by Vandana Sharma, Sonali Rawat, Suchi Gupta, Sweta Tamta, Rinkey Sharma, Tulika Seth, Sujata Mohanty

“…Acquired aplastic anemia (aAA) is a bone marrow failure disorder characterized by pancytopenia and bone marrow aplasia. …”
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Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review by Yashbir Singh, ME, PhD, Quincy A. Hathaway, MD, PhD, Colleen Farrelly, MS, Matthew J. Budoff, MD, Bradley Erickson, MD, PhD, Jeremy D. Collins, MD, Michael J. Blaha, MD, Tim Leiner, MD, PhD, Francisco Lopez-Jimenez, MD, MBA, Jennifer Rozenblit, PhD, Deepa Sarkar, PhD, Gunnar Carlsson, PhD

“…Topological data analysis can evaluate coronary atherosclerosis in novel ways using variations in the cover and filtration functions of the algorithm, highlighting new ways to characterize calcified and noncalcified plaques. …”
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Modulation of Protein Dynamics by Glycerol in Water-Soluble Chlorophyll-Binding Protein (WSCP) by Mina Hajizadeh, Maksym Golub, Inga Bektas, Leonid L. Rusevich, Jan P. Embs, Wiebke Lohstroh, Harald Paulsen, Jörg Pieper

“…Proteins are inherently dynamic entities that rely on flexibility across multiple timescales to perform their biological functions. The surrounding environment plays a critical role in modulating protein dynamics by exerting plasticizing or stabilizing effects. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…SYVN1, an E3 ubiquitin ligase, is characterized by its significant functions in regulating various biological processes, including molecular mechanisms related to gene expression, signaling pathways, and cell death, among others. …”
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From structure to therapy: the critical influence of cartilaginous endplates and microvascular network on intervertebral disc degeneration by Yu Sun, Zhaoyong Li, Jiahao Duan, Enxu Liu, Lei Yang, Fei Sun, Long Chen, Shaofeng Yang

“…Therefore, this paper comprehensively reviews the structure and physiological functions of CEP and its role in the cascade of IDD, exploring the intrinsic relationship between CEP degeneration and Modic changes from various perspectives. …”
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From Biomphalaria glabrata to Drosophila melanogaster and Anopheles gambiae: the diversity and role of FREPs and Dscams in immune response by Hongyu Li, Hongyu Li, Qingzhi Zhao, Jialu Xu, Xianwei Li, Xintong Chen, Yijie Zhang, Hairun Li, Yunhuan Zhu, Mingcheng Liu, Ling Zhao, Dingji Hua, Xiaofen Zhang, Keda Chen

“…Although they are found in different taxonomic groups and possess unique functions, both exhibit high diversity and adaptability. …”
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Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus by Bonnie Reinhart, Lucia Mazzacurati, Adriana Forero, Chang-Sook Hong, Junichi Eguchi, Hideho Okada, Wendy Fellows, Ajay Niranjan, Justus B. Cohen, Joseph C. Glorioso, Paola Grandi

“…Indoleamine-2,3-dioxygenase (IDO) is expressed in response to interferon γ (IFNγ) and has been linked to both antiviral functions and to the immune escape of tumor cells. …”
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Uncovering Diversity within the Glomeromycota: Novel Clades, Family Distributions, and Land Use Sensitivity by Camille S. Delavaux, Alexis Aellen, Sidney L. Stürmer, Silmar Primieri, Ursel M. E. Schütte, Devin M. Drown, Robert J. Ramos, Thomas W. Crowther, James D. Bever

“…ABSTRACT Arbuscular mycorrhizal fungi (AMF, phylum Glomeromycota) are essential to plant community diversity and ecosystem functioning. However, increasing human land use represents a major threat to native AMF globally. …”
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Discovery of Arbuscular Mycorrhizae in Mosses of the Pottiaceae Family from the Chaco Serrano (Tucumán, Argentina) by Myriam del V. Catania, Patricia L. Albornoz, Atilio O. Rausch, Tamara M. Ledesma, Shanshan Dong, Yuqing Cai, Yuying Zeng, Yang Liu, Guillermo M. Suárez, Javier E. Moreno

“…This finding expands our understanding of the interactions between AMF and non-vascular plants and prompt us to further characterize this interaction by considering the diversity of mycorrhizal associations with concurrent implications for the ecology of mosses and the functionality of the ecosystems.…”
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Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development in Coprinopsis cinerea by Benedek Szathmári, Balázs Bálint, Botond Hegedüs, Máté Virágh, Zhihao Hou, Zhihao Hou, Xiao-Bin Liu, Hongli Wu, Csenge Földi, Julien Gagneur, Julien Gagneur, Johann Promeuschel, Árpád Csernetics, László G. Nagy, László G. Nagy

“…Our findings reveal fruiting-related functions for ort2, a novel conserved RNA-binding protein, and may serve as a novel entry point for understanding the molecular basis of dark stipe development.…”
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Purinergic ecto-enzymes in human and ovine aortic valves: indicators of bacterial nanocellulose scaffold cellularization by Barbara Kutryb-Zając, Ada Kawecka, Gabriela Harasim, Michał Bieńkowski, Klaudia Stawarska, Krzysztof Urbanowicz, Ryszard T. Smoleński, Maciej M. Kowalik, Magdalena Kołaczkowska, Piotr Siondalski

“…Purinergic signalling pathways play a vital role in the biological functions of the aortic valve (AV) through nucleotide and adenosine-dependent receptor effects. …”
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The Role of Physical Activity in Reducing Endometriosis Pain by Emilia Bąk, Daria Michałka, Natalie Papachristoforou, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Żaneta Góra, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

“…This leads to pain, inflammatory states, and disruptions in the functioning of pelvic organs, including infertility. …”
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Endothelial Cell‐Derived Extracellular Vesicles Promote Aberrant Neutrophil Trafficking and Subsequent Remote Lung Injury by Shuang‐Feng Zi, Xiao‐Jing Wu, Ying Tang, Yun‐Peng Liang, Xu Liu, Lu Wang, Song‐Li Li, Chang‐De Wu, Jing‐Yuan Xu, Tao Liu, Wei Huang, Jian‐Feng Xie, Ling Liu, Jie Chao, Hai‐Bo Qiu

“…Using single‐cell RNA sequencing (scRNA‐seq), it identified functionally activated neutrophils exhibiting the rTEM phenotype in the lung of a sepsis mouse model using cecal ligation and puncture. …”
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Chemical Modification of Acrylonitrile-Divinylbenzene Polymer Supports with Aminophosphonate Groups and Their Antibacterial Activity Testing by Ileana Nichita, Lavinia Lupa, Aurelia Visa, Ecaterina-Stela Dragan, Maria Valentina Dinu, Adriana Popa

“…We were interested in obtaining new polymeric functionalized compounds with antibacterial properties. …”
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Advancements in Targeting Ion Channels for the Treatment of Neurodegenerative Diseases by Yuxuan Li, Jingxuan Fu, Hui Wang

“…Ion channels are integral membrane proteins embedded in biological membranes, and they comprise specific proteins that control the flow of ion transporters in and out of cells, playing crucial roles in the biological functions of different cells. They maintain the homeostasis of water and ion metabolism by facilitating ion transport and participate in the physiological processes of neurons and glial cells by regulating signaling pathways. …”
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Physicochemical Properties and Biological Activities of Polysaccharides from <i>Dendrobium officinale</i> Leaves in Response to Different Extraction Methods by Yang Chen, Gonglin Cai, Hufu Chen, Huabin Zhou, Hang Qu, Hailong Yang

“…Extraction techniques play a crucial role in determining the structural attributes and biological functions of polysaccharides. This study aimed to evaluate the physicochemical and biological properties of <i>Dendrobium officinale</i> leaf polysaccharides (DLPs) extracted using various methods, including hot water, acidic, alkali, ultrasound-assisted, and enzyme-assisted extraction. …”
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Tertiary lymphoid structures: exploring opportunities to improve immunotherapy in ovarian cancer by Aaron Varghese, Aaron Varghese, Suzanne M. Hess, Shanmuga Chilakapati, Shanmuga Chilakapati, Jose R. Conejo-Garcia, A.J. Robert McGray, A.J. Robert McGray, Emese Zsiros

“…This review explores the roles of TLS, their maturity, functionality, identification, and related gene signatures; specific immune cells and cytokines that play a role in TLS formation and antitumor response; and other modifiable elements, including gut microbiota, that may drive improving OC survival by leveraging a TLS-driven antitumor response to bolster immunotherapy outcomes.…”
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Estimation of fractional cover based on NDVI-VISI response space using visible-near infrared satellite imagery by Zhaoyang Han, Qingjiu Tian, Jia Tian, Tianyu Zhao, Chenglong Xu, Qing Zhou

“…Remote sensing observations of green vegetation (GV), impervious surface (IS), and bare soil (BS) fractional cover are essential for understanding climate change, characterizing ecosystem functions, monitoring urbanization process. …”
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Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes by Angela Maria Cozzolino, Valeria Noce, Cecilia Battistelli, Alessandra Marchetti, Germana Grassi, Carla Cicchini, Marco Tripodi, Laura Amicone

“…Furthermore, standard cultivation of liver stem/precursor cells impedes an efficient execution of the epithelial/hepatocyte differentiation program, leading to the expansion of a cell population expressing only partially liver functions and products. Overcoming these limitations is mandatory for any approach of liver tissue engineering. …”
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Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome by Luigi Tarani, Valentina Carito, Giampiero Ferraguti, Carla Petrella, Antonio Greco, Massimo Ralli, Marisa Patrizia Messina, Debora Rasio, Enrica De Luca, Carolina Putotto, Paolo Versacci, Mauro Ceccanti, Marco Fiore

“…Although DS individuals are mostly perceived as characterized by some distinct physical features, cognitive disabilities, and cardiac defects, they also show important dysregulations of immune functions. …”
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