Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human by Delia Susan-Resiga, Nabil G Seidah, Nathalie Labrecque, Jean-Sebastien Delisle, Leila Jafarzadeh, Chloé Porcheron, Mailys Le Devehat, Anna Roubtsova, Hadi Bayat, Alexandra Evagelidis, Vatsal Sachan, Alexie Fonta Holder, Rachid Essalmani, Gabrielle Boudreau, Annik Prat, Rebecca Cusseddu, Jean-François Côté, Abdel-Majid Khatib

“…In the present studies, we report synergistic and complementary functions of PCSK7 and PCSK9, as the loss of each one of the convertases reduced by twofold the number of liver metastases, but the strongest reduction (>90%) was observed in double KO (Pcsk7−/−, Pcsk9−/−) mice. …”
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Membrane-associated ring–CH–type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase by Dongsheng Ni, Zhaolai Qi, Shuang Ma, Yuefeng Wang, Dehuan Liang, Xiyue Zhang, Yong Man, Jingzhou Chen, Kefei Dou, Guoping Li

“…Methods: By employing a range of methodologies, including recombinant adeno-associated virus (rAAV) transduction, lentiviral transduction, immunoblotting, quantitative PCR, tissue section staining, ubiquitination assays, serum biochemical analysis, immunoprecipitation, and mass spectrometry, this study investigated the functions and mechanisms of MARCH2 in the progression of MAFLD at the molecular, cellular, and organismal levels. …”
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Chicken liver meal as an effective fishmeal replacement for Litopenaeus vannamei diets: A comprehensive evaluation of growth, non-specific immunity and gut health by Huaxing Lin, Wanting Huang, Xuehe Li, Jiahua Wu, Beiping Tan, Shuyan Chi, Qihui Yang

“…This experiment was conducted to evaluate the effect of chicken liver meal (CLM) on growth, protein synthesis, antioxidative functions, non-specific immunity, and gut microbiota community for juvenile Litopenaeus vannamei. …”
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Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic quantification by Christy Wing Tung Wong, Joyce Zhi Xuen Lee, Anna Jaeschke, Sammi Sze Ying Ng, Kwok Keung Lit, Ho-Ying Wan, Caroline Kniebs, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki

“…When introduced into microvascular networks (MVNs) in microfluidic devices, EMT-IC did not affect MVN stability and physiologically relevant barrier functions.To model lung cancer intravasation on-a-chip, EMT-IC was supplemented into co-cultures of lung tumor micromasses and MVNs. …”
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Demand and Influencing factors for community health services during chemotherapy of patients with advanced cancer by Qianqian Li, Xunrui Chen, Wenying Zhang, Haihua Yuan, Yanjie Zhang, Bin Jiang, Feng Liu

“…The top five demands were “preparation for pathological tests such as routine blood, liver and kidney functions before chemotherapy” (2.48 points), “education on chemotherapy knowledge” (2.48 points), “care for peripherally inserted central catheter(PICC) catheterization during chemotherapy” (2.45 points), “management of myelosuppression after chemotherapy” (2.43 points) and ''providing updated information on treatment, examination and rehabilitation” (2.42 points), primarily focusing on the medical care demand dimension. …”
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Study of the effect of human placenta hydrolysate in a new model of metabolic-associated fatty liver disease with iron overload by T. E. Bogacheva, O. A. Gromova, I. Yu. Torshin, V. I. Demidov, A. G. Kalacheva, A. A. Garanin, I. V. Gogoleva, L. E. Fedotova, O. A. Limanova, А. N. Mnatsakanyan, N. Yu. Zhidomorov, T. R. Grishina

“…The model was used to test the effectiveness of using standardized HPH and to characterize complex changes in more than 20 biomarkers of liver and kidney functions, hematopoiesis, inflammation, and thrombus formation.Results. …”
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Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism by Qianjiao Zhao, Qianjiao Zhao, Qianjiao Zhao, Yueting Zhong, Yueting Zhong, Yueting Zhong, Zheng Li, Zheng Li, Zheng Li, Jia Tang, Jia Tang, Jia Tang, Chao Pi, Chao Pi, Wenwu Zheng, Peng Shi, Ying Zuo, Jun Jiang, Yan Yang, Shifeng Chu, Yumeng Wei, Ling Zhao, Ling Zhao, Ling Zhao

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Phasic and periodic change of drought under greenhouse effect by Yang Li, Zhicheng Zheng, Yaochen Qin, Haifeng Tian, Zhixiang Xie, Peijun Rong

“…Drought variation was predominantly influenced by interannual oscillations, with the periods of the components of intrinsic mode functions 1 (IMF1) and 2 (IMF2) being 3.1 and 7.3 years, respectively. …”
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The Effect of Iron Deficiency Stress on the Relative Expression of ZIP3, ZIP6, and ZIP7 Genes in Bread Wheat (Triticum aestivum L.) Cultivars by Saeed Rezaei Musa Dargh, Babak Abdollahi Mandoulakani, Raheleh Ghasemzadeh

“…Due to the existence of a large allohexaploid genome and technical challenges in wheat transformation, few genes involved in iron and zinc uptake, transfer, and storage have been characterized functionally. Considering the important role of ZIP proteins in iron uptake efficiency, investigating the expression of the ZIP genes in Fe-efficient and -inefficient bread wheat cultivars can be effective in improving Fe-efficient cultivars in this valuable crop. …”
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A study on toxicity, local irritative effect of and allergic response to a novel intranasal medication containing N-phenylacetyl-L-prolylglycine ethyl ester by B. S. Burlaka, I. F. Bielenichev

“…These conditions lead to impairment of mnestic and intellectual brain functions, to a decrease in mental alertness and memory in particular, which results in deterioration in the quality of life, sometimes in disability and patients’ partial or complete dependence on other people. …”
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Poeetiline mõtlemine, kirjandus ja fenomenoloogia Peter Handke teadvuspoeetika näitel / Poetic Thinking, Literature and Phenomenology—on the Example of Peter Handke’s Poetics of Aw... by Marko Pajević

“…Handke’s view of ‘life without poetry’ is characterised by a lack of feeling and detachment from the world, functioning mechanically within it. Conversely, poetry brings a sense of connection and self-awareness. …”
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COMPARATIVE PARADIGM IN WORKS OF Y. BOYKO-BLOKHYN: APPROACHES “INTERWEAVING AND INTERCROSSING” by Olga B. Teterina

“…The author interprets functionality problem of inter-literary/ intercultural communication preeminently as a national literature stylistic development factor. …”
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The Mission of the Neocatechumenal Way in Times of Covid-19 by Bogumił Gacka

“…The argument  ̶  the secularization hypothesis  ̶  is that as education spreads, as incomes rise, and as the state takes over many functions of the church, people turn away from religion. …”
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Sodium arsenite influences proliferation and apoptosis in normal thyroid cells via modulation of ER-PI3K/AKT signaling pathway by Zhihong JIANG, Hongyun LI, Xiaowei MA, Yuanyan LAI, Jun WU

“…BackgroundRecent advances in understanding the toxic effects of inorganic arsenic have revealed that arsenic exposure impacts multiple endocrine organs, thereby altering their functions. However, the mechanisms underlying arsenic-induced thyroid injury remain unclear. …”
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Thank you, government! Your support facilitated my intention to use mobile payment in the new normal era by Pick-Soon Ling, Xin-Jean Lim, Lim-Jin Wong, Kelvin Yong Ming Lee

“…Based on the moderation analysis, GS strengthened attitude-based impacts on BI towards m-payment adoption. …”
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GESTÃO DEMOCRÁTICA NO ESTADO DE MATO GROSSO: conquista ameaçada pela implantação de políticas educacionais conservadoras by Cassia Domiciano, Márcia Cossetin, Nádia Drabach

“…It makes the appointment for public school principals an executive power decision since the majority of the Supreme Federal Court ministers understood that the appointment of trust functions is the responsibility of the executive power, thus ruling against the democratic election of candidates for this position. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews by Xinglong Liu, Zhengfeng Li, Xiao Li, Xiaoyan Zhang, Yali Zheng, Wan Su, Ying Feng, Yutong Liu, Weixuan Wu, Xikui Sun, Nana Wang, Xianmiao Ye, Zhichao Zhou, Wenkuan Liu, Jun He, Wei Wang, Linbing Qu, Rong Zhou, Ling Chen, Liqiang Feng

“…In tree shrews that are permissive for HAdV55 infection and disease, mAb 29C12 effectively prevented HAdV55-caused pneumonia. Further analysis revealed that fibre-targeting mAbs blocked the attachment of HAdV55 to host cells, whereas hexon-targeting mAbs, regardless of their targeting HVRs, mainly functioned at post-attachment stage via inhibiting viral endosomal escape. …”
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Diffuse gliomas: insights into clinical and histopathological features and survival rates from two centers in a middle-income country by Edgar G. Ordóñez-Rubiano, Edgar G. Ordóñez-Rubiano, Edgar G. Ordóñez-Rubiano, Cristian Siabato, Nicolás Rincón-Arias, Nicolás Rincón-Arias, Paula A. Pulido, Paula A. Pulido, Hebert D. Pimienta-Redondo, Hebert D. Pimienta-Redondo, Sebastián Espinosa-Gaona, Sebastián Espinosa-Gaona, Santiago Useche-Diosa, Santiago Useche-Diosa, María Andrea Moreno, María Andrea Moreno, Hernando A. Cifuentes-Lobelo, Oscar F. Zorro-Guio, Javier G. Patiño-Gómez, Javier G. Patiño-Gómez, Alba Lucía Cómbita, César Payán-Gómez, Luz D. Gutierrez-Castañeda, Luz D. Gutierrez-Castañeda, Alexandra Ramos-Márquez, Alexandra Ramos-Márquez, Diego F. Gómez, Oscar Mendoza, Matias Baldoncini, Matias Baldoncini, Rafael Parra-Medina, Rafael Parra-Medina

“…Clinical findings and overall survival trends are similar to those reported worldwide, however, further molecular analysis is needed for adequate diagnosis and classification…”
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Construction and validation of a scale for measuring obstetric violence in Colombia by Luisa Alejandra Aguilar-Bernal, Marta Lucía Ospina-González, Fabio Alexander Sierra-Matamoros

“…Results. Factor analysis allowed us to find a three-factor structure. …”
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