Asociación de la resistencia cardiorrespiratoria con rendimiento académico, concentración y comportamiento hiperactivo-desatento en escolares TDAH (Association of cardiorespiratory... by Sara Suárez Manzano, Alba Rusillo Magdaleno, Teresa Martínez Redecillas, Alberto Ruiz Ariza

“…Keywords: learning, executive functions, physical fitness, hyperactivity, students …”
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Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“… Buffaloes are excellent converters of highly fibrous feeds into edible products like milk and meat due to the rumen microbiome structure and their functionality. About 37– 44% of global methane emissions, mainly due to enteric fermentation of feeds by fibrolytic bacteria and formation of methane by methanogenic archaea, present in the rumen, is contributed by ruminants and a major source of methane production in the agriculture sector. …”
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Combined Application of High-Throughput Sequencing and Metabolomics to Evaluate the Microbial Mechanisms of Plant-Growth-Promoting Bacteria in Enhancing the Remediation of Cd-Conta... by Shan-Shan Gao, Ying-Jun Zhang, Yang Shao, B. Larry Li, Han Liu, Yu-Ying Li, Xue-Min Ren, Zhao-Jin Chen

“…High-throughput sequencing and metabolomics were used to determine the effects of inoculation on the soil bacterial community composition and microbial metabolic functions associated with hybrid Pennisetum. The results suggest that mutation of <i>Brevibacillus</i> sp. …”
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Active learning for advanced biodegradable film design by Yi Gao, Chengcheng Liu, Yang Zhao, Peng Zhao, Feihui Chen, Qinghai Li, Yanguo Zhang, Bin Yang, Hui Zhou

“…Ultimately, it provides an economically viable and environmentally friendly pathway toward reducing plastic waste while enhancing the functionality and commercial viability of biodegradable films.…”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…A Genome-wide association study (GWAS) was conducted to identify candidate genes associated with the five indicators of body conformation traits, thereby establishing a foundation for subsequent investigations into the biological functions of these genes. Results A total of 19.89 Tb of raw data was generated with an average sequencing depth of about 20×. …”
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Impact of multi-strain probiotics supplementation on growth, immune responses and physiological traits in backyard poultry of Andaman and Nicobar Islands, India by Neha Halder, Neha Halder, Siddhartha Narayan Joardar, Jai Sunder, Arun Kumar De, Debasis Bhattacharya, Ahmed Abd El Wahed, Rea Maja Kobialka, Madathiparambil Gopalakrishnan Madanan, Samiran Mondal

“…After histomorphological analysis, an increase (p ≤ 0.001) in villus height (μm) and crypt depth (μm) in duodenum and jejunum were noticed in T1 and T2. …”
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Barriers to and facilitators of clinician acceptance and use of artificial intelligence in healthcare settings: a scoping review by Alex Federman, Yufei Wang, Jalayne J Arias, Catherine E A Scipion, Margaret A Manchester

“…Overall, drivers of clinician AI acceptance and use were ambivalent, functioning as either barriers or facilitators depending on context. …”
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Fitts’ law-based identification of motor development stages for the upper limb: proof of concept in three age groups by Cristina Sanchez, Eloy Urendes, Alejandra Aceves, María Martínez-Olagüe, Rafael Raya

“…This process is closely tied to neurological maturation, with “reaching and pointing tasks” considered fundamental upper limb functions. According to Fitts’ law, movement time (MT) depends on the task’s index of difficulty (ID). …”
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Multifunctional metal oxides synthesized via a solvo-hydrothermal process for photocatalytic degradation of organic dye and bacteria in wastewater by Emile Salomon Massima Mouele, Htet Htet Kyaw, Myo Tay Zar Myint, Mohammed Al-Abri, Mohammed A.Al Belushi, Sergey Dobretsov, Jean-Luc Mukaba, Alechine Emmanuel Ameh, Leslie F. Petrik, Francis Ntumba Muya, Bernard Bladergroen, Kingsley Ehi Ebomah, Mike Ojemaye, Anthony Ifeanyi Okoh, Omobola O. Okoh

“…Various techniques, including SEM-EDS, FTIR, XRD, BET, TGA, and XPS characterized the as-prepared metal oxide (MO) catalysts. The multi-functionality of the catalysts was assessed on the degradation of Congo red dye and the inhibition of gram-positive B. subtilis in simulated wastewater. …”
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Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…IntroductionThe HIV regulatory protein Tat enhances viral transcription and also modifies host gene expression, affecting cell functions like cell cycle and apoptosis. Residual expression of Tat protein is detected in blood and other tissues even under antiretroviral treatment. …”
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Long Noncoding RNA Expression Profiles of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment in Response to Static Mechanical Strain by Jia Liu, Yan Zhao, Qiannan Niu, Ni Qiu, Shuangyun Liu, Chunrong Li, Cuixia Li, Pei Miao, Libo Yan, Qiang Li, Zuolin Jin

“…However, our previous studies verified that the periodontitis microenvironment causes damage to the biological functions of PDLSCs and abnormal mechanical sensitivity. …”
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The triple-helix model as foundation of innovative entrepreneurial ecosystems by Klaus Bruno Schebesch, Horațiu Florin Șoim, Radu Lucian Blaga

“…This study aims at leveraging the city-based view on entrepreneurial ecosystems, to enable new ways of boosting the functionality of triple-helix minded programs, especially so for emerging economies and their cross-border regions. …”
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Thinning intensity influences the C:N:P stoichiometry in forest ecosystems: A global synthesis by Chongwei Fan, Guiyao Zhou, Hongyang Chen, Zhenggang Du, Ruiqiang Liu, Yanghui He, Changjiang Huang, Shuying Qiu, Yimin Zhu, Jie Li, Xuhui Zhou

“…Future forest management could implement an appropriate forest thinning intensity to ensure ecosystem functionality and maintain the balance and stability of ecosystem elements.…”
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Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer by Yongzhi Wu, Chengen Deng, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Weizhong Tang, Xiaoliang Huang

“…Furthermore, using transcriptome data from 23 CRC patients, we constructed an immune cell infiltration matrix to deeply explore the biological functions associated with LNM. Eventually, using the characteristics of the gut microbiota associated with LNM, we developed random forest (RF) and multilayer perceptron (MLP) machine learning models to predict the LNM status of CRC patients. …”
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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…NeoExpand led to improved phenotypes and functions of neoantigen-reactive TILs. Our data warrant its clinical evaluation.Trial registration number NCT00068003, NCT01174121, and NCT03412877.…”
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Endophytic Bacterial Communities in Wild Rice (<i>Oryza eichingeri</i>) and Their Effects on Cultivated Rice Growth by Liang Xie, Jinlu Li, Suqin Xiao, Hao Jiang, Li Liu, Qiaofang Zhong, Ling Chen, Wang Kan, Fuyou Yin, Tengqiong Yu, Yun Zhang, Bo Wang, Cong Jiang, Jiaxin Xing, Zaiquan Cheng

“…Additionally, culturable endophytic bacteria were isolated. The metagenomic analysis showed that, compared to those in other tissue compartments, the endophytic bacterial community in the roots had a more complex structure and enhanced functions, and each compartment had its own specific endophytic bacterial biomarkers. …”
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Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions by Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A. Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

“…Summary: The transcription factor interferon regulatory factor 4 (IRF4) is crucial for the fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing group of immunomodulatory regulatory T (Treg) cells. …”
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Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis by Hisako Akatsuka, Tomohiro Kashikawa, Kaori Masuhara, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Chisa Okada-Yamaguchi, Yoshinori Okada, Masayuki Tanaka, Takahiro Suzuki, Norio Yamamoto, Katsuto Hozumi, Tomoaki Tanaka, Hirofumi Nakaoka, Kazuyoshi Hosomichi, Yu Hamaguchi, Michiaki Hamada, Yoshiki Shiraishi, Akihide Kamiya, Yoshihiko Nakamura, Kaito Harada, Abd Aziz Ibrahim, Takashi Yahata, Masato Ohtsuka, Naoya Nakamura, Hiroyuki Hosokawa, Minoru Kimura, Ituro Inoue, Takehito Sato

“…Summary: AMBRA1, which was initially reported to be essential for nervous system development via autophagy and cell proliferation control, also functions as a tumor suppressor by regulating the ubiquitination of D-type cyclins through interaction with DDB1-Cullin4A/4 B E3 ligase. …”
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Some epidemiological indicators and results of surgical treatment of children with unstable and complicated spine injuries using different models of medical care based on the examp... by I.V. Basankin, S.V. Vissarionov, A.A. Gyulzatyan, A.A. Afaunov, K.K. Takhmazyan, V.K. Shapovalov, L.A. Tarasenko, A.M. Efremov, A.V. Sobolev, A.A. Danileichenko

“…Centralization of specialized medical care for children with spinal injuries in a functioning spinal surgery department of an adult hospital with the appropriate material and technical base, including instrumentation for children of all age groups, and the routine use of various surgical techniques ensures a unified approach to the principles of diagnosis and treatment of this category of patients with the achievement of good results.…”
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A novel regulatory axis of MSI2-AGO2/miR-30a-3p-CGRRF1 drives cancer chemoresistance by upregulating the KRAS/ERK pathway by Runhui Lu, Yafan Zhang, Ran Chen, Lian Li, Caihu Huang, Zihan Zhou, Yingting Cao, Hongyan Li, Junya Li, Yixin Zhang, Yanli Wang, Jian Huang, Xian Zhao, Jing Feng, Jianxiu Yu, Chunling Du

“…Specifically, MSI2 recruits UAG-miRNA miR-30a-3p to facilitate its loading onto AGO2, efficiently inhibiting the expression of CGRRF1. Further analysis reveals that CGRRF1 functions as a new ubiquitin E3 ligase for KRAS, mediating the ubiquitination and proteasome degradation of KRAS. …”
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