Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer by Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu

“…Biological information analyses, IC50, immunofluorescence assays, qPCR and western blot analyses were conducted to elucidate the functions of FASN in CC. In vivo studies were conducted to examine the antitumor effects of the combination of TVB-2640 and cisplatin. …”
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Abstract 203: Predicting Outcomes After Mechanical Thrombectomy: Early vs Delayed Neurological Improvement in the SELECT Database by K. Rose Duncan, Deep Pujara, Amrou Sarraj

“…Introduction Understanding of patient benefit and improvement following mechanical thrombectomy in ischemic stroke has made tremendous strides in recent years, however clinicians still struggle to accurately predict patient outcomes and long‐term neurological functioning following large vessel occlusion and endovascular therapy. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Mechanistically, CD25-biased IL-2cx selectively stimulated expansion and effector functions of tumor-specific CD8+ T cells in a CD25-dependent manner, overcoming Treg cell-mediated suppression. …”
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Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…The results demonstrated a notable decline in liver and kidney functions in all mycotoxins-treated rats. The studied organs (liver, kidney and spleen) exhibited significant damage, with the most severe alterations observed in the Mix1 and Mix2-treated group in comparison with the groups receiving individual treatment. …”
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STRUCTURE OF PERIODONTAL TISSUE DISEASES IN WORKERS OF AGRICULTURAL PRODUCTION IN THE OPEN AND COVERED SOIL by V.T. Dyryk

“…Practically no one economy is not functioning without pesticides, which grows industrial and food crops, regardless of the form of ownership and land use system. …”
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The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Data collection and analysis Of 22,226 potential studies, 14 met the inclusion criteria. …”
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Nous reptes de l'orientació en el context educatiu by Manuel Álvarez González, Rafael Bisquerra Alzina

“…The paper then goes on to propose the new roles and functions that should be fulfilled by guidance and tutorial support in today’s educational context if established objectives are to be achieved. …”
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Sequence, characterization and pharmacological analyses of the adipokinetic hormone receptor in the stick insect, Carausius morosus by Gerd Gäde, Jinghan Tan, Salwa Afifi, Jean-Paul V. Paluzzi, Graham E. Jackson, Heather G. Marco

“…AKH/HrTH are important peptidergic metabolic regulators in insects that are crucial to provide energy during periods of high output mobility or when large amounts of energy-rich substrates are synthesized (for example, during vitellogenesis). AKH functions via a G protein-coupled receptor. Understanding which residue of the peptide (the ligand), activates the receptor with high efficacy is an important step to get insights into the ligand-receptor interaction, which is essential for further research on creating a model of how the ligand behaves in the binding pocket of the receptor. …”
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Improved estimation of two-phase capillary pressure with nuclear magnetic resonance measurements via machine learning by Oriyomi Raheem, Misael M. Morales, Wen Pan, Carlos Torres-Verdín

“…By predicting vector functions from vector input features, we effectively reduced prediction errors. …”
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Characteristics of the Epidemiological Situation in Patients with Tuberculosis of Various Age Groups Based on the Numerical Criteria of Selective Rating with the Help of the Comput... by Ilnуtskуy G.

“…The results were processed with the use of the statistical and mathematical functions of the MS Excel, parametric and nonparametric, for the establishing of the correlational relation assessing the dynamics of epidemiological parameters. …”
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Common Neighborhood Energy of the Non-Commuting Graphs and Commuting Graphs Associated with Dihedral and Generalized Quaternion Groups by Hanaa Alashwali, Anwar Saleh

“…We derive explicit formulas for the CN characteristic polynomials and corresponding CN eigenvalues for both the NCM-graph and CM-graph as functions of <i>n</i>. Consequently, we establish closed-form expressions for the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>E</mi><mrow><mi>C</mi><mi>N</mi></mrow></msub></semantics></math></inline-formula> of these graphs, which are parameterized by <i>n</i>. …”
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Arterial and venous thromboembolic events in patients with cancer treated with targeted therapies: a population-based cohort studyResearch in context by Florian Moik, Erzsébet Horváth-Puhó, Cihan Ay, Ingrid Pabinger, Frits Mulder, Nick van Es, Henrik Toft Sørensen

“…We computed cumulative incidence functions and 95% confidence intervals (CIs) of ATE/VTE after therapy initiation, considering death as competing event. …”
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SYN-RIFT SANDSTONЕS: THE FEATURES OF BULK CHEMICAL COMPOSITIONS, AND POSITIONS ON PALEOGEODYNAMIC DISCRIMINANT DIAGRAMS by A. V. Maslov, V. N. Podkovyrov, E. Z. Gareev, N. D. Sergeeva

“…The article examines: (1) the position of the syn-rift sandstone compositions (fields) on the log(SiO2/Al2O3)–log(Na2O/K2O) classification diagram and the F1–F2 diagram, which gives the possible composition of the catchment areas rocks; (2) the position of the syn-rift sandstone compositions, as well as the average values of various indicator ratios and discriminant functions, in the K2O/Na2O–SiO2/Al2O3, F3–F4, SiO2–K2O/Na2O and DF1–DF2 diagrams. …”
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Assessment of Aerodynamic Properties of the Ventilated Cavity in Curtain Wall Systems Under Varying Climatic and Design Conditions by Nurlan Zhangabay, Aizhan Zhangabay, Kenzhebek Akmalaiuly, Akmaral Utelbayeva, Bolat Duissenbekov

“…Ultimately, a correct understanding of thermophysical processes in such structures will support the advancement of trends such as Lightweight Design, Functionally Graded Design, and Value Engineering in the development of curtain wall systems, through the optimized selection of façade configurations, accounting for temperature loads under specific climatic and design conditions.…”
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Infant Parent Support (IPS): a multidisciplinary intervention to improve the mental health of children with a social worker - a study protocol for a feasibility randomised controll... by Jaycee Pownall, Karen Crawford, Lindsay Dalgarno, Judith Fisher, Sharon Graham, Fiona Turner, Helen Minnis, Kathleen Boyd, Abril Seyahian, Alex McConnachie, Nicola Cosgrave, Matt Forde, Carol Atkinson, Janet McCullough, Kapil Sayal, Dennis Ougrin

“…IPS will i) adopt a relationship-focused approach to comprehensive understanding of family functioning, ii) incorporate child and parent mental health and neurodevelopmental awareness, and iii) ensure a poverty aware approach throughout. …”
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The Relationship Between Psychosocial Factors and Response to Epidural Steroid Injection for Chronic Lumbosacral Radicular Pain: A Prospective Pilot Study by Stensland M, Sanford E, Houle TT, McGeary C, Cobos BA, Lugosi S, Lehman L, Nabity PS, Covell C, Fitzgerald E, Mojallal M, Reed DE, Pangarkar S, Eapen BC, Nanda U, McCormick ZL, McGeary D

“…Future research with a larger sample should focus on deepening our understanding of the role of psychosocial functioning as a potential mechanism of treatment response in patients undergoing ESI procedures. …”
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Effects of Dendrobium nobile Lindl. alkaloids on behavior and hippocampal tissue damage in manganese-exposed rats by Qian LEI, Xiaodong YAO, Yan LI, Mengheng ZOU, Zongyang PAN, Yu CHEN, Jinping LIU, Jida LI, Yuyan CEN

“…The ICP-MS analysis showed elevated manganese concentrations in the blood and hippocampus of the exposed rats (P<0.05), and the histopathological observation revealed hippocampal damage. …”
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On Numerical Characteristics of а Simplex and their Estimates by M. V. Nevskii, A. Yu. Ukhalov

“…Applying this valuein numerical computations we achive the value$$\varkappa_4 = \frac{4+\sqrt{13}}{5}=1.5211\ldots$$Denote by \(\theta_n\) the minimal normof interpolation projection on the space of linear functions of \(n\)variables as an operator from\(C(Q_n)\)in \(C(Q_n)\). …”
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Synthesis, chemical and biological properties of the new mono- and bis-derivatives of imidazoles by E. V. Welchinska

“…This reaction made possible a new strategy of synthesis of selectively poly-functionalized molecules, the chemical structure of which is available for incorporation of new pharmacophore fragments into molecule. …”
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CAMELS-IND: hydrometeorological time series and catchment attributes for 228 catchments in Peninsular India by N. K. Mangukiya, K. B. Kumar, P. Dey, S. Sharma, V. Bejagam, P. P. Mujumdar, P. P. Mujumdar, A. Sharma, A. Sharma

“…However, many of these gauge stations lack reliable metadata, and data are not in an analysis-ready format for large-sample hydrological studies. …”
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