YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression by Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong

“…Poly(ADP-ribose) polymerase 1 (PARP1), a key enzyme catalyzing polyADP-ribosylation (PARylation), plays critical roles in various cellular processes, and contributes to tumorigenesis and aggressiveness. However, the functions and regulatory mechanisms of PARP1 in NB progression still remain to be determined. …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…To date, many components of RSs and their functions in human sperm flagella remain unclear. Methods We recruited a cohort of 323 infertile males with ASZ between August 2019 and June 2024. …”
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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina by Sol A. Cataldo, Andrea Micciulli, Laura Margulis, Melina Cibeyra, Sabrina Defeo, Silvina G. Horovitz, Analía Martino, Raul Melano, Milagros Mena, Francisco Parisi, Diego Santoro, Florencia Sarmiento, Martin A. Belzunce

“…Neuroimaging studies have identified structural alterations in brain regions linked to cognitive functions. However, most of these studies have focused on patients within months of their initial infection. …”
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Vermicompost application improves leaf physiological activity, 2-acetyl-1-pyrroline, and grain yield of fragrant rice through efficient nitrogen assimilation under Cd stress by Anas Iqbal, Xiaoyuan Chen, Rayyan Khan, Maid Zaman, Aamir Hamid Khan, Marcin Kiedrzyński, Mohamed Ebaid, Abdulwahed Fahad Alrefaei, Sobhi F. Lamlom, Xiangru Tang, Muhammad Zeeshan, Muhammad Zeeshan

“…This study investigated the effects of VC on the soil chemical properties and the physio-biochemical functions of fragrant rice, as well as nitrogen (N) metabolism and assimilatory enzyme activities, 2-acetyl-1-pyrroline (2AP) content in rice grains, and the grain yields of fragrant rice cultivars, i.e., Xiangyaxiangzhan (XGZ) and.Meixiangzhan-2 (MXZ-2) under Cd stress condition. …”
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Integrating proteomics and machine learning reveals characteristics and risks of lymph node-independent distant metastasis in colorectal cancer by Chenxiao Zheng, Baiwang Zhu, Yanyu Chen, Numan Shahid, Yiwang Hu, Hajar Mansoor Ahmed Ali Husain, Binbin Ou, Qiongying Zhang, Haobo Jin, Yating Zheng, Peng Li, Yifei Pan, Xiaodong Zhang, Xiaodong Zhang

“…Tumor Mutation Burden (TMB), Microsatellite Instability (MSI) score, immune functions and immune checkpoint gene expression were analyzed to evaluate immunotherapy response. …”
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Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress by Zongmao He, Yi Yan, Xijun Guo, Tong Wang, Xinqiao Liu, Ren-Bo Ding, Yuanfeng Fu, Jiaolin Bao, Xingzhu Qi

“…The present study provided valuable insights towards understanding the importance of Trp31 residue of hTrx-1 in maintaining the correct conformation of the Trx fold structure, the antioxidant functionality of hTrx-1 and the cellular redox defense capability against oxidative stress.…”
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Deciphering the anticoccidial mechanism of Qinghao Changshan formula through network pharmacology and molecular docking by Dong Tian, Hui Fu, Hongxia Tao, Miaolan Li, Qinghua Zhang, Weidong Deng

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to explore relevant biological functions and pathways. Molecular docking was used to validate interactions between selected active compounds (isorhamnetin, kaempferol, quercetin) and key targets (epidermal growth factor receptor [EGFR], estrogen receptor 1 [ESR1], progesterone receptor [PGR]). …”
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RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch by Yuefang Liu, Shujun Gao, Zhanghui Li, Lei Yin, Shiyao Ge, Yangjing Zhao, Hui Wang, Bing Wan, Qixiang Shao

“…The results of in vitro studies declared that rhIL-11 promoted differentiation of BM cells into M-MDSCs phenotypically and functionally via activating STAT3 signaling, which was cross-regulated by the mTORC1. …”
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Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial by Kenny A Rodriguez-Wallberg, Judith Bruchfeld, Michael Runold, Peter Lindholm, Anders Kjellberg, Jan H Kowalski, Adrian Hassler, Sara El Gharbi, Sarah Al-Ezerjawi, Emil Boström, Marcus Ståhlberg, Malin Nygren-Bonnier, Anna Schening, Katarina Fischer

“…We excluded pregnant women, patients with RAND-36 (role limitations due to physical health (RP) and physical functioning (PF)) above 70, diabetes, hypertension and contraindications for HBOT.Interventions Subjects were randomly assigned to 10 sessions of HBOT or sham (placebo) treatments over 6 weeks. …”
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Characterization of the small RNAs carried by outer membrane vesicles produced by hlyF-positive Shiga toxin-producing Escherichia coli by Giorgia Barbieri, Giorgia Barbieri, Alessia Stefano, Agostina Pietrantoni, Federica Fratini, Serena Cavallero, Rosangela Tozzoli, Paola Chiani, Arianna Boni, Stefano Morabito, Valeria Michelacci

“…Our results indicate that OMVs release may exert regulatory functions, putatively influencing the crosstalk with the host and the gut microbiota during the infection process.…”
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History and development direction of iterative upgrading of deep coalbed methane reservoir reconstruction technology：Taking the Daji Block in the eastern margin of the Ordos Basin... by Fengyin XU, Huaibin ZHEN, Shuguang LI, Feng WANG, Lei ZHANG, Yubin WANG, Weichu YU, Weiping ZHU, Borui XU, Yun YANG, Haifeng ZHAO, Kunsen BAI

“…Additionally, a brief analysis of the performance of corresponding fracturing fluid systems is provided.The technological progression evolved from pursuing matrix stimulation to achieving large-scale fracture networks, from maximizing stimulation volume to optimizing well-to-fracture network integration, and eventually to adopting innovative technologies and advanced concepts for reservoir stimulation. …”
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Potential therapeutic effects of ibudilast and retinoic acid against cuprizone-induced behavioral and biochemical changes in mouse brain by Kholoud A. Alyami, Gadah A. Alshahrany, Kholoud M. Al-Otaibi, Kholoud M. Al-Otaibi, Mohammad Z. Alam, Mohammad Z. Alam, Badrah S. Alghamdi, Badrah S. Alghamdi, Hadeil M. Alsufiani, Hadeil M. Alsufiani, Nouf O. Alshareef, Hanna M. Alhoraibi, Sahar A. Alkhodair, Ulfat M. Omar, Ulfat M. Omar

“…This was indicated as an improvement in locomotor activity, motor coordination and muscular strength as well as improving the cognition and memory functions. The mRNA expression pattern of various MS associated genes indicated that the treatments effectively mitigated the detrimental effects of CPZ in mouse brain. …”
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ERK2-mediated phosphorylation of ZEB1 at S322 enhances PD-L1 expression and EMT, leading to pancreatic cancer progression by Mi Kyung Park, Hye Ja Lee, Jee Young Sung, Hyun Jung Byun, Hyun Ji Kim, Eun Ji Kim, Tuan Minh Nguyen, Gyeoung Jin Kang, Seung Hyun Oh, Jae Gal Shim, Ho Lee, Ki Taek Nam, Yong Yun Kim, Seung Bae Rho, Sang Gun Kim, Chang Hoon Lee

“…However, the precise mechanisms underlying individual phosphorylation sites and their relationship with ZEB1’s functions in vivo remain inadequately understood. Methods We assessed EMT using various techniques, including reverse transcription-quantitative polymerase chain reaction (RT-qPCR), immunoblotting, microscopy, migration, and invasion assays. …”
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Regional network covariance patterns of white matter integrity related to cardiorespiratory fitness in healthy aging by Samantha G. Smith, Samantha G. Smith, Pradyumna K. Bharadwaj, Pradyumna K. Bharadwaj, David A. Raichlen, David A. Raichlen, Matthew D. Grilli, Matthew D. Grilli, Matthew D. Grilli, Jessica R. Andrews-Hanna, Jessica R. Andrews-Hanna, Georg A. Hishaw, Matthew J. Huentelman, Matthew J. Huentelman, Matthew J. Huentelman, Theodore P. Trouard, Theodore P. Trouard, Theodore P. Trouard, Gene E. Alexander, Gene E. Alexander, Gene E. Alexander, Gene E. Alexander, Gene E. Alexander, Gene E. Alexander

“…Cardiorespiratory fitness (CRF), measured by VO2max, is an indicator of vascular functioning that can influence the integrity of brain microstructural white matter tracts in aging. …”
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NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice by Cher-Chia Chang, Yea-Hwey Wang, Jiin-Cherng Yen, Chia-Ching Liaw, Keng-Chang Tsai, Wen-Chi Wei, Wen-Fei Chiou, Chun-Tang Chiou, Kuo-Tong Liou, Yuh-Chiang Shen, Yi-Chang Su

“…However, NRICM101 treatment in these animals ameliorated all these cognitive functions. S1 protein administration in mice induced notable inflammation, leading to the death of neurons (NeuN+) and neural stem cells (DCX+) in hACE2 transgenic mice. …”
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Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota by Cheng Wang, Siyu Wei, Bojing Liu, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang

“…In addition, the MFD significantly accelerated the maturation of the gut microbiota of neonates and increased the abundance of gut Lactobacillus and the microbial functions of amino acid-related enzymes and glucose metabolism on the weaning day. …”
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Root-sourced H2O2 is essential for maintaining jasmonic acid and Na+/K+ homeostasis to delay leaf senescence during salt stress in Paspalum vaginatum by Ling Pan, Tingchen Xu, Jing Wang, Junming Zhao, Quanquan Sun, Xu Hu, Xu Tao, Jinlin Zhang, Li Liao, Zhiyong Wang

“…However, the extent to which root-derived H2O2 fulfils similar functions in halophytic plants remains uncertain. Therefore, our study aimed to explore the potential contribution of root-sourced H2O2 in delaying leaf senescence induced by high salinity, utilizing seashore paspalum as a model halophytic plant. …”
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Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration by Yue-Qi Zhang, Rong Nie, Zi-Yuan Feng, Ming-Hui Fan, Zhi-Xue Shen, Xiu-Zhen Zhang, Qing-Yi Zhang, Chen-Yu Zou, Ji-Ye Zhang, Kai Huang, Li-Ping Mou, Hui-Qi Xie

“…The manuscript is structured to first establish a fundamental understanding of efferocytosis, encompassing its core concepts, molecular mechanisms, and physiological functions within tissue repair. Subsequently, it provides an in-depth analysis of the regulatory role of efferocytosis in inflammatory response modulation during tissue repair cascades. …”
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The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis by Tianshu Yang, Wei Huang, Tianyu Ma, Xin Yin, Jingyao Zhang, Miaomiao Huo, Ting Hu, Tianyang Gao, Wei Liu, Die Zhang, Hefen Yu, Xu Teng, Min Zhang, Hao Qin, Yunkai Yang, Baowen Yuan, Yan Wang

“…Abstract Circadian rhythms, as physiological systems with self‐regulatory functions in living organisms, are controlled by core clock genes and are involved in tumor development. …”
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FRB Line-of-sight Ionization Measurement from Lightcone AAOmega Mapping Survey: The First Data Release by Yuxin Huang, Sunil Simha, Ilya S. Khrykin, Khee-Gan Lee, J. Xavier Prochaska, Nicolas Tejos, Keith W. Bannister, Jason Barrios, John Chisholm, Jeff Cooke, Adam T. Deller, Marcin Glowacki, Lachlan Marnoch, R. M. Shannon, Jielai Zhang

“…Additionally, we describe our approach to generating angular masks and calculating the target selection functions, setting the stage for the impending reconstruction of the matter density field.…”
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