Biocontrol potential of newly isolated Streptomyces noursei D337-11 from disease suppressive soil and its metabolites against Fusarium oxysporum f. sp. cubense in banana plants by Dengbo Zhou, Xinxin He, Yufeng Chen, Chunting Li, Wei Wang, Zhiqiang Pan, Yankun Zhao, Yongzan Wei, Junting Feng, Miaoyi Zhang, Dengfeng Qi, Xiaojuan Li, Kai Li, Tao Jing, Jianghui Xie

“…Here, we identified Streptomyces noursei D337-11 from disease suppressive banana soils, which exhibited dual functionality in controlling F. oxysporum f. sp. cubense tropical race 4 (Foc TR4), achieving a 65.35% suppression of disease, and promoting plant growth in pot experiments. …”
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A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei by Mohammad Zeeshan, Igor Blatov, Ryuji Yanase, David JP Ferguson, Sarah L Pashley, Zeinab Chahine, Yoshiki Yamaryo-Botté, Akancha Mishra, Baptiste Marche, Suhani Bhanvadia, Molly Hair, Sagar Batra, Robert Markus, Declan Brady, Andrew R Bottrill, Sue Vaughan, Cyrille Y Botté, Karine G Le Roch, Anthony A Holder, Eelco Tromer, Rita Tewari

“…These defects block development in the mosquito and parasite transmission, highlighting the essential functions of this complex.…”
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Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy by Lu Liu, Yuanlai Qiu, Yuying Suo, Siyao Tong, Yiqing Wang, Xi Zhang, Liang Chen, Yue Huang, Huchen Zhou, Hu Zhou, Ze Dong, Cai-Guang Yang

“…The fat mass and obesity-associated protein (FTO) is an RNA demethylase required for catalytic demethylation of N6-methyladenosine (m6A); it is highly expressed and functions as an oncogene in acute myeloid leukemia (AML). …”
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Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing by Jiale Zhou, Ding Zhao, Jinze Li, Deqiang Kong, Xiangrui Li, Renquan Zhang, Yuru Liang, Xun Gao, Yuqiang Qian, Di Wang, Jiahui Chen, Liangxue Lai, Yang Han, Zhanjun Li

“…We anticipate that the DRAM system could pave the way for uncovering further biological functions of m5C modifications.…”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…Other isoforms are produced (C to H) but have unknown functions. Here, we investigated the expression of the most abundant transcripts, cmvIL-10 and LAcmvIL-10, in productively and latently infected cells and in peripheral blood mononuclear cells from renal transplant recipients up to 60 days post-transplantation. …”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…ABSTRACT Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research. …”
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Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo by Xiaowen Yang, Yiting Zhan, Yifei Li, Yifei Li, Xinzhuang Shen, Xinzhuang Shen, Yuqiu Ma, Zongjun Liu, Zongjun Liu, Yipeng Liu, Chengjin Liang, Xiaoyuan Zhang, Yehao Yan, Wenzhi Shen

“…This research underscores the potential of MPM-1 as a tumor suppressor and lays a robust foundation for the future development of innovative anticancer therapies that target mitochondrial functions.…”
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Telehealth cancer-related fatigue clinic model for cancer survivors: a pilot randomised controlled trial protocol (the T-CRF trial) by Jane Turner, Nicolas H Hart, Patsy Yates, Laisa Teleni, Joanne F Aitken, Lee Jones, Steven M McPhail, Rahul Ladwa, Fiona Crawford-Williams, Raymond J Chan, Mark B Pinkham, Elizabeth P Pinkham, Brigid Hanley, Gemma Lock, Jodie Nixon, Oluwaseyifunmi Andi Agbejule, Carmen P Escalante

“…Feasibility outcomes include the identification of recruitment methods; recruitment rate and uptake; attrition; adherence; fidelity; apathy; and intervention functionality, acceptability and satisfaction. Clinical and resource use outcomes include cancer survivor fatigue, symptom burden, level of physical activity, productivity loss, hospital resource utilisation and carer’s fatigue and productivity loss. …”
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A small heat shock protein Fmp28 influences virulence by regulating Als3 expression via the cAMP-PKA signaling pathway in Candida albicans by Junjun Tan, Qiong Liu, Zhiping Liu, Yanli Cao, Xiaomin Yu, Qianjun Zhao, Niya Hu, Yanling Liu, Yuwei Wan, Yeming Zhang, Huizhen Tian, Lingbing Zeng, Xiaotian Huang

“…However, our understanding of their functions in pathogenic microorganisms remains limited. …”
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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening by Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A. Comini

“…Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular target for drug development against pathogens causing severe and fatal diseases in mammals. …”
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Integrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decocti... by Wenbin Huang, Xiaoju Liu, Xingjia Li, Ruixiang Zhang, Guofang Chen, Guofang Chen, Xiaodong Mao, Shuhang Xu, Chao Liu, Chao Liu

“…They were mainly enriched in the biological processes of positive regulation of gene expression, positive regulation of MAPK cascade, signal transduction, protein phosphorylation, negative regulation of apoptotic process, positive regulation of protein kinase B signaling and positive regulation of MAP kinase activity; and molecular functions of identical protein binding, protein serine/threonine/tyrosine kinase activity, protein kinase activity, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding and protein binding. …”
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Contribution of Human Resources for Health competence and skill mix on compliance with healthcare quality standards among Primary Healthcare Facilities in Tanzania: evidence from d... by Syabo M. Mwaisengela, Patricia A. Materu, Chrisogone J. German, Issa I. Mmbaga, Danny J. Temba, Raymond R. Kiwesa, Martin S. Mapunda, Erick S. Kinyenje, Nathanael Sirili, Pankras W. Luoga, Simon P. Ernest, Joseph M. Burra, Joseph C. Hokororo, Godfrey Kacholi, Ntuli A. Kapologwe, Mackfallen G. Anasel, Claud J. Kumalija, Michael Habtu, Grace E. Saguti, Janeth S. Masuma, Talhiya A. Yahya, Eliudi S. Eliakimu

“…Inadequate numbers with poor skill mix compromise health system functioning that negatively affect delivery of quality healthcare services. …”
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Who gets referred for knee or hip replacement? A theoretical model of the potential impact of evidence-based referral thresholds using data from a retrospective review of clinic re... by Andrew J Price, Andrew Judge, Alastair Gray, Rachael Gooberman-Hill, David Beard, Adrian Sayers, Rob Middleton, Stephanie Smith, Karen L Barker, David Murray, Sujin Kang, Elena Benedetto, James Smith, Ray Fitzpatrick, Helen A Dakin, Peter Eibich, Nigel Arden, Andy Carr, Kristina Harris, Elizabeth Gibbons, Jill Dawson, Laura Miller, Elsa Marques, Ashley Blom

“…Those referred typically have low OHS/OKS, and introducing evidence-based OKS/OHS thresholds would prevent few inappropriate (high-functioning, low-pain) referrals. However, our findings suggest that some patients not currently referred could benefit from arthroplasty based on OKS/OHS. …”
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Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…However, they can exacerbate disease outcomes in most bacteria and blood-borne viral conditions by impairing immune functions, such as neutrophil recruitment and antibody response, leading to more severe infections and higher viral loads. …”
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Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC by Shunxi Wang, Xiaoxue Yuan, Zetao Yang, Xuan Zhang, Zhiling Xu, Li Yang, Xian Yang, Wei Zhou, Wanqian Liu

“…Results: Here, we revealed that matrix stiffness-induced PD-L2 functions as a suppressor of xCT-mediated ferroptosis to promote cancer growth and sorafenib resistance in patients with HCC. …”
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Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma by Kenji Mizumura, Yasuhiro Gon, Norihiro Harada, Shiho Yamada, Asami Fukuda, Ryosuke Ozoe, Shuichiro Maruoka, Sumiko Abe, Kazuhisa Takahashi, Akihiko Tanaka, Hironori Sagara, Taisuke Akamatsu, Toshihiro Shirai, Katsunori Masaki, Koichi Fukunaga, Konomi Kobayashi, Hiroyuki Nagase, Nobuaki Miyahara, Arihiko Kanehiro, Noboru Kitamura, Naruhiko Sugihara, Fumio Kumasawa, Junko Terada-Hirashima, Masayuki Hojo, Kazuyuki Chibana, Etsuko Tagaya

“…Exacerbations and respiratory functions were monitored for 24 weeks. Asthma control was evaluated using the Asthma Control Questionnaire-5. …”
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Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis by Jiayu Cao, Yuhui Yang, Xi Liu, Yang Huang, Qianqian Xie, Aliaksei Kadushkin, Mikhail Nedelko, Di Wu, Noel J. Aquilina, Xuehua Li, Xiaoming Cai, Ruibin Li

“…Results The nano-bio interactions induced diverse changes in the 4 characteristics of MeONPs and had variable effects on the 14 cellular functions, which were quantitatively evaluated in chemico and in vitro. …”
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Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells by Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu

“…We investigated the biological functions of JAG2 in immune evasion using in vitro co‐culture systems, flow cytometry, tumor‐bearing mouse models, and PDTOs. …”
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Treatment decision-making and care among older adults with kidney failure: protocol for a multicentre, prospective observational cohort study with nested substudies and linked qual... by Martin Gallagher, Vasi Naganathan, Gian Luca Di Tanna, Celine Foote, Angela Makris, Chris Gianacas, Nicholas A Gray, Isaac Yeboah Addo, Amanda Siriwardana, Chenlei Kelly Li, Kenneth Yong, Yachna Mehta, Jannel Ramos, Sarah Roxburgh

“…There are limited data on several key outcomes for the elderly population including survival, quality of life, symptom burden, changes in physical functioning and experienced burden of healthcare. Patients, caregivers and clinicians consequently face significant uncertainty when making life-impacting treatment decisions. …”
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Optical and electron microscopy imaging of model circulating tumour cells by Марина Оленчук, Григорій Монастирський, Олена Гнатюк, А. Бойзен, Ч. Чжан, Галина Солянік, Денис Колесник, Сергій Карахім, Галина Довбешко

“…Objectives: This study aimed to visualize Lewis lung carcinoma (LLC) cells cultured under de-adhesive conditions using various microscopy techniques for their characterization and to examine the cancer cells' structure and functionality. The goal was to evaluate each method's individual capabilities and combined strengths in revealing cellular morphology, internal structure, and nanoparticle interactions. …”
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