Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Two months of treatment of 5x-FAD mice with IBC at 25 and 50 mg/kg significantly improved cognitive functions, as evidenced by enhanced memory and motor performance in behavioral tests. …”
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IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression by Hui Wang, Hui Wang, Jirui Li, Yinghai Wang, Yang Chen, Yang Chen, Weifeng Zhang, Xinyan Pan, Xinyan Pan, Chanjuan Su, Ziteng Li, Li Wang, Li Wang, Jiang Gu, Jiang Gu

“…Tertiary lymphoid structures (TLS) in the TME have important immune-related functions. This study aims to analyze the distribution characteristics of IgG4-expressing cells, regulatory T cells (Tregs), and M2-type macrophages as well as to elucidate the relationship between IgG4 and the polarization of M2 macrophages within TLS in esophageal cancer.ObjectTo elucidate the distribution of IgG4, Treg cells, and M2 macrophages in TLS and to assess the impact of IgG4 on macrophage polarization.MethodsEsophageal cancer tissue were analyzed with multiplex immunofluorescence to determine the spatial distribution and density of B cells, T cells, and their subtypes. …”
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High-throughput method for improving rice AGB estimation based on UAV multi-source remote sensing image feature fusion and ensemble learning by Jinpeng Li, Jinpeng Li, Jinxuan Li, Jinxuan Li, Dongxue Zhao, Dongxue Zhao, Qiang Cao, Qiang Cao, Fenghua Yu, Fenghua Yu, Fenghua Yu, Yingli Cao, Yingli Cao, Yingli Cao, Shuai Feng, Shuai Feng, Shuai Feng, Tongyu Xu, Tongyu Xu, Tongyu Xu

“…Feature selection combined statistical analysis and modeling techniques, with collinearity removed through the Variance Inflation Factor (VIF). …”
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CircRNA ZFR promotes cell progression by regulating miR-96a-5p/SLC1A1 axis in hepatocellular carcinoma by Christian Cedric Bongolo, Yu Zhang, ShengBao Duan, Louise Virginie Mounoume Lobe, Erick Thokerunga, Peter kisembo, HongMei Wang, ShaoHua Ding, JingJing Tian, YeZhou Chen, YuJue Wang, Liu Jie, YuQin Chao, JianCheng Tu

“…This study assessed circRNA ZFR expression in clinical samples and HCC cells using qRT-PCR and Fluorescent In Situ Hybridization assays. Cell functions were evaluated through colony formation, transwell, and wound healing assays. circRNA ZFR and miR-96a-5p interaction was investigated using luciferase reporter assays and qRT-PCR, while miR-96a-5p and SLC1A1 interaction was examined using luciferase reporter assays, western blot analysis, and Chromatin Isolation by RNA Purification/Mass Spectrometry (CHIRP/MS). …”
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Barriers and facilitators to maternal death surveillance and response at a busy urban National Referral Hospital in Uganda [version 2; peer review: 2 approved] by Jolly Beyeza-Kashesya, Dan K.Kaye, Joseph Rujumba, Noah Kiwanuka, Moses Mukuru, Imelda Namagembe, Annettee Nakimuli, Josaphat Byamugisha, Ashley Moffett

“…We conducted thematic analysis drawing on the Theory of Planned Behaviour (TPB).   …”
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Molecular insights into glioblastoma progression: role of CHCHD2P9 in tumor heterogeneity and prognosis by Yanyu Ding, Yanyu Ding, Lizhi Xiao, Lizhi Xiao, Xiaoling Zhou, Xiaoling Zhou, Jiaxin Zhao, Jiaxin Zhao, Jianli Ke, Jianli Ke, Huabao Cai, Mengyu Zhao, Cunzhi Wang, Tianhang Yu, Zhijie Zhao, Yucai Wang, Yucai Wang, Yucai Wang, Jiyuan Ke, Jiyuan Ke

“…Trajectory analysis identified CHCHD2P9 as a pivotal marker for the terminal subpopulation. …”
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MiRNA-455-5p regulates the growth and development of adipose tissue by targeting IGF-1R gene by Min Wu, Lingli Feng, Yubin Wang, Kun Zhang, Ganqiu Lan, Jing Liang

“…These findings may improve our understanding of mechanism of the molecular regulation of miRNA-455-5p and IGF-1R in pigs, and provide a theoretical basis for increasing pork production.TEASER TEXT The miRNA-455-5p was involved in the negative regulation of adipose tissue development by inhibiting the expression of its target gene IGF-1R.ABSTRACT Adipose tissue is an organ with metabolic, endocrine and immune functions, affecting the life span of animals and their susceptibility to diseases. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Transforming growth factor beta 1 (TGF-β1) is a pleiotropic cytokine with a profibrogenic and immunosuppressive effect that can have a definite effect on the liver transplant functioning.Aim. To determine the diagnostic efficacy of TGF-β1 in blood when assessing the risk of developing graft dysfunction in liver recipient children. …”
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POLYMORPHISM OF THE TP53 GENE IN PATIENTS WITH GASTRIC CANCER IN PROSPECTIVE AND CLINICAL CASE-CONTROL STUDIES by A. V. Belkovets, S. A. Kurilovich, V. N. Maksimov, Yu. I. Ragino, L. V. Scherbakova, O. V. Cheremisina, N. V. Cherdyntseva, M. V. Parulikova, M. I. Voevoda

“…Background. A functionally significant TP53Arg72Pro polymorphism can contribute to the development of gastric cancer (GC).The aim: to study the associations of genotypes and alleles of the TP53Arg72Pro 4 polymorphism with GC and biomarkers of gastric ucosal atrophy in population-based prospective and case-control clinical trials among the population of Siberia.Material and methods. …”
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Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis by Wesley Freppel, Viviana Andrea Barragan Torres, Olus Uyar, Anaïs Anton, Zaynab Nouhi, Mathilde Broquière, Clément Mazeaud, Aïssatou Aïcha Sow, Alexanne Léveillé, Claudia Gilbert, Nicolas Tremblay, Jonathan Eintrez Owen, Cheyanne L. Bemis, Xavier Laulhé, Alain Lamarre, Christopher J. Neufeldt, Ian Gaël Rodrigue-Gervais, Andreas Pichlmair, Denis Girard, Pietro Scaturro, Laura Hulea, Laurent Chatel-Chaix

“…Summary: During infection, dengue virus (DENV) and Zika virus (ZIKV), two (ortho)flaviviruses of public health concern worldwide, induce alterations of mitochondria morphology to favor viral replication, suggesting a viral co-opting of mitochondria functions. Here, we performed an extensive transmission electron microscopy-based quantitative analysis to demonstrate that both DENV and ZIKV alter endoplasmic reticulum-mitochondria contact sites (ERMC). …”
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Effectiveness of a multicomponent intervention to promote physical activity during the school day: rationale and methods of the MOVESCHOOL study by Francisco J. Bandera-Campos, Francisco J. Bandera-Campos, Alberto Grao-Cruces, Alberto Grao-Cruces, Daniel Camiletti-Moirón, Daniel Camiletti-Moirón, Fátima Martín-Acosta, Fátima Martín-Acosta, Raúl Muñoz-González, María González-Pérez, María González-Pérez, Abel Ruiz-Hermosa, Abel Ruiz-Hermosa, Miguel Vaquero-Solís, Miguel Vaquero-Solís, Carmen Padilla-Moledo, Carmen Padilla-Moledo, David Sánchez-Oliva, David Sánchez-Oliva, David Sánchez-Oliva

“…Primary outcomes included accelerometer-based PA and sedentary time, health-related physical fitness, academic indicators, and executive functions. For statistical analyses, descriptive, correlational, regression, and repeated measures ANOVA analyses will be applied. …”
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C-type lectin (SpCTL) through its binding to Spβ-integrin regulates antimicrobial peptide synthesis in mud crab (Scylla paramamosain) during Vibrio parahaemolyticus infection by Wei Yang, Yuyong He, Huifen Liang, Junyuan Lin, Ngoc Tuan Tran, Zhinuo Du, Ming Zhang, Ruhan Chen, Yuqing Zheng, Xu Meng, Shengkang Li

“…In this study, the mud crab SpCTL cDNA was cloned and functionally characterized. Phylogenetic analysis showed that SpCTL was closely related to Eriocheir sinensis with 81 % homology. …”
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Exosomal lncRNA Mir100hg from lung cancer stem cells activates H3K14 lactylation to enhance metastatic activity in non-stem lung cancer cells by Lei Shi, Bowen Li, Jiyu Tan, Ling Zhu, Sicheng Zhang, Yuhan Zhang, Meng Xiang, Jie Li, Yan Chen, Xue Han, Jiacheng Xie, Yao Tang, H. Rosie Xing, Jingyu Li, Jianyu Wang

“…Previous studies on the role of EVs in metastasis have been primarily focused on cancer cell-derived EVs in modulating the functions of stromal cells. However, whether cancer stem cells (CSCs) can alter the metastatic properties of non-CSC cells, and whether EV crosstalk can mediate such interaction, have not been demonstrated prior to this report. …”
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Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study by Carlos Cortés, Julio Ruiz-Ruiz, Fernando Rivero, Ramón López-Palop, Octavio Jiménez, Alfonso Freites, Luis R. Gonçalves-Ramírez, María Rosario Ortas Nadal, Sara Blasco, Mario García-Gómez, Clara Fernández, Luca Scorpiglione, J. Alberto San Román Calvar, Ignacio J. Amat-Santos

“…This study aims to determine the prognostic value of the global plaque volume (GPV) in patients with stable coronary artery disease without functionally significant lesions at a 5-year follow-up. …”
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Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode by Haeun Kwon, Hyun-U Cho, Jeongeun Sim, Kyung-Jun Boo, Kyung-Jun Boo, Yumin Kang, Sangmun Hwang, Youngjong Kwak, Jaehyun Jang, Kyung Min Kim, Se Jin Jeon, Chan Young Shin, Kevin E. Bennet, Kevin E. Bennet, Yoonbae Oh, Yoonbae Oh, Hojin Shin, Hojin Shin, Kendall H. Lee, Kendall H. Lee, Dong Pyo Jang, Dong Pyo Jang

“…To improve mechanical robustness and long-term functionality, we fabricated 30 µm diameter CFMEs and modified their geometry via electrochemical etching to form cone-shaped tips. …”
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Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac by Binbin Tan, Yang Liu, Qianqian Chen, Weijie Yang, Wenhan Yang, Kaiping Gao, Li Fu, Tiantian Zhang, Penglong Chen, Yongyi Huang, Yuting Wang, Guoqiang Zhang, Juan Xiong, Rihong Zhai

“…Integrated RNA-seq and Ribo-seq analysis revealed that MCM5 was a target of FIBCD1. …”
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Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction by Yiming Chen, Baochao Fan, Jingchun Zeng, Yutian Zou, Chenyang Tao, Chen Chen, Peiming Zhang, Jian Liang, Fangfang Qi, Hailin Tang, Liming Lu

“…Our findings revealed that acupuncture may activate the defense response to viruses, with altered immune cell functions in classical monocytes correlating with clinical responses to reduced methadone doses. …”
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The prevalence and correlates of low resilience in patients prior to discharge from acute psychiatric units in Alberta, Canada by Ernest Owusu, Wanying Mao, Reham Shalaby, Hossam Eldin Elgendy, Belinda Agyapong, Ejemai Eboreime, Mobolaji A. lawal, Nnamdi Nkire, Yifeng Wei, Peter H. Silverstone, Pierre Chue, Xin-Min Li, Wesley Vuong, Arto Ohinmaa, Valerie Taylor, Carla T. Hilario, Andrew J. Greenshaw, Vincent I. O. Agyapong

“…Although such traumatic events can precipitate psychiatric disorders, many individuals exhibit high resilience by adapting to such events with little disruption or may recover their baseline level of functioning after a transient symptomatic period. Low levels of resilience are under-explored, and this study investigates the prevalence and correlates of low resilience in patients before discharge from psychiatric acute care facilities. …”
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Impact on the microstructure of deep gray matter in unvaccinated patients after moderate-to-severe COVID-19: insights from MRI T1 mapping by Masia Fahim, Elke Hattingen, Alina Jurcoane, Jan R. Schüre, Svenja Klinsing, Julia Koepsell, Kolja Jahnke, Michael W. Ronellenfitsch, Ulrich Pilatus, Maria J. G. T. Vehreschild, Ralf Deichmann, Christophe T. Arendt

“…Baseline characteristics and results of tests assessing neurological functions (standardized exam), ability to smell (4-Item Pocket Smell Test), depression (Beck Depression Inventory-II), sleepiness (Epworth Sleepiness Scale), sleep quality (Pittsburgh Sleep Quality Index), health-related quality of life (EQ-5D), and cognitive performance (Montreal Cognitive Assessment) were evaluated. …”
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Design and Evaluation of Real-Time Data Storage and Signal Processing in a Long-Range Distributed Acoustic Sensing (DAS) Using Cloud-Based Services by Abdusomad Nur, Yonas Muanenda

“…We employ the DynamoDB functionality of Amazon Web Services (AWS), which allows highly expandable storage capacity with latency of access of a few tens of milliseconds. …”
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