Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Psychometric validation showed high internal consistency, overall high reliability, and moderate fit indices in the confirmatory factor analysis for all five domains. Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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Increased long-term central memory T cells in patients with retreatment pulmonary tuberculosis by Xin Yao, Xin Yao, Haomin Cai, Jianxia Chen, Fangyong Yu, Xiaocui Wu, Yarong Shi, Yarong Shi, Yang Hu, Yuyan Xu, Qinghua Xu, Zhonghua Liu, Zhonghua Liu

“…Nevertheless, the specific functions and changes of T lymphocyte subsets in retreatment tuberculosis remain poorly understand. …”
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PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway by Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu

“…Platelet factor 4 (PF4), a chemokine with diverse biological functions, has an unclear role in ICH and its impact on neuronal ferroptosis. …”
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Hepatic irradiation persistently eliminates liver resident NK cells. by Ryosuke Nakano, Masahiro Ohira, Takuya Yano, Yuki Imaoka, Yuka Tanaka, Hideki Ohdan

“…The aim of this study was therefore to investigate how hepatic irradiation influences the functions and characteristics of liver resident NK cells. …”
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California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of AC... by Lauren Y. Kim, Sophia Miryam Schüssler-Fiorenza Rose, Summer Mengelkoch, Daniel P. Moriarity, Jeffrey Gassen, Jenna C. Alley, Lydia G. Roos, Tao Jiang, Arash Alavi, Durga Devi Thota, Xinyue Zhang, Dalia Perelman, Tamar Kodish, Janice L. Krupnick, Michelle May, Katy Bowman, Jenna Hua, Yaping Joyce Liao, Alicia F. Lieberman, Atul J. Butte, Patricia Lester, Shannon M. Thyne, Joan F. Hilton, Michael P. Snyder, George M. Slavich

“…To address these issues, we developed a combined cross-sectional study and randomized controlled trial, called the California Stress, Trauma, and Resilience Study (CalSTARS), to (a) characterize how ACEs influence multisystem biological functioning in adults with all levels of ACE burden and current perceived stress, using multiomics and other complementary approaches, and (b) test the efficacy of our new California Precision Intervention for Stress and Resilience (PRECISE) in adults with elevated perceived stress levels who have experienced the full range of ACEs. …”
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Treating nightmares in post-traumatic stress disorder with the α-adrenergic agents clonidine and doxazosin: protocol for a phase II randomised, double-blind, placebo-controlled par... by Christian Schmahl, Jürgen Gallinat, Andreas J Fallgatter, Christian Otte, Stefan Roepke, Robert Roehle, Nikola Schoofs, Kathlen Priebe, Felix Wuelfing, Tolou Maslahati, Katharina Stieglbauer, Sarah Biedermann, Ingo Schaefer, Thomas Ethofer, Bernd Hanewald, Christoph Mulert, Stefanie Koglin

“…Introduction Intrusive nightmares are a hallmark symptom of post-traumatic stress disorder (PTSD), contributing significantly to psychiatric comorbidities, impaired physical health and diminished social functioning. Currently, no pharmacological treatments are specifically approved for managing PTSD-related nightmares. …”
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Characteristics and significance of γδ T cells in colorectal cancer by Henna Karjalainen, Jouni Härkönen, Päivi Sirniö, Hanna Elomaa, Ville K. Äijälä, Meeri Kastinen, Vilja V. Tapiainen, Sara A. Väyrynen, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Anne Tuomisto, Markus J. Mäkinen, Juha P. Väyrynen

“…Their role in cancer remains controversial, since both anti- and protumor functions have been reported. We aimed to shed light on the distinct characteristics of γδ T cells in colorectal cancer (CRC). …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…In conclusion, PDK1 functions as an oncogene, facilitating EOC progression by upregulating BGN and activating the NF-κB pathway. …”
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In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands by Christian A. Di Buduo, Francesca Careddu, Samuele Metti, Marco Lunghi, Santo Diprima, Virginia Camilotto, Giovanna Bruni, Umberto Gianelli, Delfina Tosi, Cesare Perotti, Claudia Del Fante, Mario Cazzola, Paola Braghetta, David L. Kaplan, Giampaolo Minetti, Luca Malcovati, Alessandra Balduini

“…This scaffold facilitates critical macrophage-RBC interactions and incorporates fibronectin functionalization to support the formation of erythroblastic island (EBI)–like niches. …”
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Perceptual constancy of pareidolias across paper and digital testing formats in neurodegenerative diseases by Gajanan S. Revankar, Tatsuhiko Ozono, Maki Suzuki, Hideki Kanemoto, Kota Furuya, Kazue Shigenobu, Kenji Yoshiyama, Yuki Yamamoto, Issei Ogasawara, Natsuki Yoshida, Susumu Iwasaki, Chizu Saeki, Yoshiyuki Nishio, Daisaku Nakatani, Kanako Asai, Yuta Kajiyama, Mikito Shimizu, Tatsuya Hayashi, Seira Taniguchi, Yu Suzuki, Rino Inada, Tomoya Taminato, Yoshitaka Nagai, Mamoru Hashimoto, Manabu Ikeda, Etsuro Mori, Hideki Mochizuki, Ken Nakata

“…Our findings demonstrate a practical way of testing pareidolias on smartphones without compromising on the functionality of the test.…”
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Strategies for Construction and Optimization of the Ecological Security Pattern for Human Settlements in the Wuding River Basin by Xiaomeng WANG, Anrong DANG, Biao TONG, Xinyi LIU

“…First, the research identifies ecological source areas through a comprehensive assessment of four core ecosystem functions — water conservation, soil and water retention, windbreak and sand fixation, and biodiversity maintenance. …”
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Interplay of health-related quality of life and comorbidities in people with type 2 diabetes mellitus treated in primary care settings in Austria: a countrywide cross-sectional stu... by Faisal Aziz, Martin Clodi, Michael Resl, Julia K Mader, Harald Kojzar, Susanne Kaser, Harald Sourij, Peter Fasching, Norbert Joachim Tripolt, Kehkishan Azhar, Caren Sourij, Bernhard Ludvik, Gersina Rega-Kaun, Claudia Ress, Lars Stechemesser, Harald Stingl, Thomas Wascher

“…Depression (p<0.001) and multimorbidity (p<0.05) severely deteriorated all HRQoL domains: physical functioning (Depression:−25.34 [95% CI −33.84 to −16.84], p<0.001); (Multimorbidity: −19.37 [95% CI −26.30 to −12.44], p<0.001), physical role limitations (−22.96 [95% CI −36.65 to −9.27], p<0.001); (−18.53 [95% CI −29.59 to −7.48], p<0.001), social functioning (−24.38 [95% CI −32.41 to −16.35], p<0.001); (−8.86 [95% CI −15.66 to −2.07], p<0.05), emotional well-being (−19.80 [95% CI −26.22 to −13.38], p<0.001); (−9.54 [95% CI −14.95 to −4.13], p<0.001), emotional role limitations (−28.26 [95% CI −41.01 to −15.52], p<0.001); (−8.15 [95% CI −18.78 to 2.49], p=0.133), bodily pains (−23.09 [95% CI −32.21 to −13.97], p<0.001); (−14.52 [95% CI −22.08 to −6.95], p<0.001), fatigue (−16.47 [95% CI −23.40 to −9.55], p<0.001); (−13.71 [95% CI −19.39 to −8.03], p<0.001), general health (−7.09 [95% CI −10.40 to −3.78], p<0.001); (−7.14 [95% CI −9.83 to −4.46], p<0.001).Conclusions Our analysis showed that advanced age, obesity, depression, cardiovascular disease, chronic lung diseases and multimorbidity were associated with poor HRQoL of individuals with T2DM at the primary care level. …”
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Inhaled Nitric Oxide ReDuce postoperatIve pulmoNAry complicaTions in patiEnts with recent COVID-19 infection (INORDINATE): protocol for a randomised controlled trial by Hui Zhang, Xiaomei Wang, Xue Yang, Ziyu Zheng, Gang Luo, Qianqian Fan, Huang Nie, Baobao Gao, Lini Wang, Chong Lei, Shuxiu Wang, Bingqing Zhao, Hailong Dong

“…Accumulating evidence suggests that nitric oxide (NO) inhalation might be effective in treating COVID-19. NO functions in COVID-19 by promoting vasodilation, anticoagulation, anti-inflammatory and antiviral effects. …”
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Recycling waste for energy: Reusing methyl orange dye-adsorbed polythiophene/Fe3O4 nanorods/reduced graphene oxide nanocomposite as a supercapacitor electrode by Ahmad Husain, Asim Ali, Sara A. Alqarni, Khalid Ansari, Mohtaram Danish, Prem Gunnasegaran, Mohammad Kanan, Jayant Giri, M. Kandasamy, M.M.A. Khan, Kyeong Tae Kang

“…This study presents a sustainable waste-to-wealth approach by repurposing methyl orange (MO) dye-adsorbed polythiophene/iron oxide/reduced graphene oxide nanocomposite (PTh/Fe3O4/RGO) for dual functionality in wastewater treatment and energy storage. …”
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Alpine peatland degradation enhances soil nitrogen losses and alters plant nitrogen uptake strategies: evidence from nitrogen isotopes by Xiaodong Zhang, Lijuan Cui, Xin Jia, Liang Yan, Yong Li, Zhongqing Yan, Kerou Zhang, Ao Yang, Yuechuan Niu, Enze Kang, Xiaoming Kang

“…Abstract Background Nitrogen plays a critical role in sustaining ecosystem functions in peatlands; however, the degradation of approximately 12% of global peatlands substantially alters nitrogen cycling. …”
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FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…Mouse orthotopic HCC models and a coculture system were constructed, and cytometry by time-of-flight analysis was performed to investigate the functions and mechanisms of specific CAFs in the immune context of HCC.Results We identified a distinct flavin-containing monooxygenase 2 (FMO2)+ CAF subset associated with a favorable response to anti-PD-1 therapy and better clinical outcomes. …”
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Effects of High-Concentrate Diets on Growth Performance, Serum Biochemical Indexes, and Rumen Microbiota in House-Fed Yaks by Ben Zhang, Xingdong Wang, Ziqiang Ding, Yandong Kang, Shaoke Guo, Mengli Cao, Liyan Hu, Lin Xiong, Jie Pei, Xian Guo

“…In conclusion, high-concentrate diets can enhance growth performance and alter the compositions and functions of ruminal bacterial communities in yaks.…”
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Bullying and depression among adolescents in East Asia: a scoping review on prevalence rates, risk and protective factors by Jennifer Sie Hee Kiing, Jennifer Sie Hee Kiing, Elizabeth Sarah Ragen, Mohamed Sufyan Bin Mohmed Sulaiman, Wei Sheng Goh, Norman Jun Hao Tan, Sok Hui Ng, Yang Luo, Miny Samuel, Doris Young, Doris Young, Victor Weng Keong Loh, Victor Weng Keong Loh

“…Psychosocial associations of bullying and depression which were similarly found in Western cultures include individual factors of coping style and gender; family factors of functioning and sibling relationships; and community factors of friendship and school-connectedness. …”
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Flow-based Text Style Transfer Model by Zihan ZHANG, Jinqiao DAI, Pin YANG

“…It constructs a transformation function based on neural spline flows to address the issue of preserving text content during the TST task. …”
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In-depth chromatographic and spectrally defined phytocompounds in super-critical-CO2 extracted Phyllanthus emblica seeds oil show robust anti-microbial/biofilm effects in the non-m... by Acharya Balkrishna, Priya Rani Maheswari, Monali Joshi, Yash Varshney, Himanshu Jangid, Manisha Kabdwal, Savita Lochab, Pardeep Nain, Anurag Varshney

“…In addition, NMR technique was applied to evaluate the physico-chemical parameters of PeSSO. Functionally, PeSSO demonstrated significant bactericidal activity against Escherichia coli and Klebsiella pneumoniae (MIC50 of 1.3 and 2.4 mg/mL, respectively); and inhibiting the biofilm formations, indicating its potential as a robust antimicrobial agent. …”
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